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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 9 Documents
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Search results for , issue "Vol. 5, No. 3" : 9 Documents clear
Cedera Hati Hipoksik pada Infark Miokard Akut Jasirwan, Chyntia Olivia Maurine
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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Hypoxic Liver Injury as Predictor of Major Adverse Cardiac Events in Acute Myocardial Infarction patients admitted to Intensive Coroner Care Unit of Cipto Mangunkusumo National General Hospital Muhadi, Muhadi; Prihartono, Nurhayati Adnan
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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Introduction. Major adverse cardiac events (MACE) is a complicating myocard infarct which consist of acute heart failure, cardiogenic shock, and fatal arrhytmia. An accurate, easy and cost-effective biomarker is needed to predict MACE and mortality in patients with myocard infarct. Hypoxic liver injury (HLI) is a potential biomarker using serum glutamic-oxaloacetic transaminase (SGOT) level as the parameter. This study is aimed to discover HLI’s role in predicting MACE in non ST elevation myocard infarct (NSTEMI). Methods. This study was designed as cross sectional to predict MACE and prospective cohort for survival analysis. Study population was all NSTEMI patients admitted to ICCU of Cipto Mangunkusumo Hospital and study sample were NSTEMI patients admitted to ICCU of Cipto Mangunkusumo Hospital that meets all criteria during 2006-2016. Cut-off level of SGOT for HLI to predict MACE and mortality was analyzed using ROC curve and AUC. Survival analysis was done using Kaplan Meier curve and the difference was tested with log-rank. Results. A total of 277 subjects were included in this study. Incidence of MACE in this study was 51.3% (acute heart failure 48.4%, fatal arrhytmia 6.5%, and cardiogenic shock 7.2%). The mortality rate was 6.13%. The median of SGOT level on all subject was 35 U/L, 40 (range 8-2062) U/L in subjects with MACE and 31 (range 6-1642) U/L in subjects without MACE (p = 0.003). Cut-off level for SGOT used to predict MACE was 101 U/L (sensitivity 21.8%; specificity 89.6%; POR 2.727 (CI 95% 1.306- 5.696), p = 0.006). In multivariate analysis, HLI was insignificantly related to MACE. Cut-off level for SGOT used to predict survival was 99 U/L (sensitivity 23.5%; specificity 83.8%; likelihood ratio +1.46). There were no significant difference of survival between groups with HLI level below and above the cut-off SGOT level. Conclusion. Hypoxic liver injury (HLI) cannot be used to predict MACE in NSTEMI patients unless combined with other variables. There is no significant difference of survival between subjects with or without HLI.
Composite Lymphoma: Hodgkin and Non-Hodgkin Lymphoma A Case Report Soetandyo, Noorwati; Rebecca, Ruth Vonky; Yunti, Maria; Reksodiputro, Arry Harryanto
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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Composite lymphoma (CL) is a rare disease. Composite lymphoma is two or more different type of lymphoma that sequentially or simultaneously occur in one anatomical site. Making a diagnosis of CL is a challenge and there is still no guidelines about the treatment. This case report is about a 36 y.o female with CL, sequentially consisted of Hodgkin and non-Hodgkin lymphoma.
The Association between D-dimer Concentration and Laboratory Parameters for Plasma Leakage in Dengue Infection Suwarto, Suhendro; Diahtantri, Riyanti Astrid; Hudiya, Elian
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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Introduction. Plasma leakage and activation of the coagulation system are the pathological hallmark of dengue hemorrhagic fever (DHF) that causes an increase in D-dimer concentration due to the degradation of fibrin clots. This study was conducted to determine the association between of D-dimer and laboratory parameters of plasma leakage, namely: thrombocytopenia, hypoalbuminemia, hemoconcentration and concentration serum glutamic oxaloacetic transaminase (SGOT) in dengue infected patients. Methods. A retrospective study was conducted at private hospitals in Jakarta, from December 2016 to March 2018. Patients >14 years with dengue infection and positive NS-1 were included in this study, and were classified into dengue fever (DF) group or DHF group. The Mann Whitney test was used for non-parametric variables and the Spearman test was used for the correlation for non-normally distributed numeric variables. Results. Seventy-three dengue infected patients included in this study consists of 29 (39.7%) female and 44 (60.3%) male. Total of 43 (58.9%) were classified as DD group, 30 (41.1%) were classified as DHF group. The D-dimer concentration of the DHF group in the fever phase was higher compared to the DD group (p = 0.004). There was a weak correlation in the fever phase between D-dimer concentration and the degree of thrombocytopenia (r = 0.35; p = 0.003) and weak inverse correlation in the fever phase between D-dimer concentration and albumin concentration (r = -0.34; p = 0.049). We found a weak correlation in the critical phase between D-dimer concentration and the degree of thrombocytopenia (r = 0.39; p = 0.034) and the moderate inverse correlation in the critical phase between the D-dimer concentration and albumin concentration (r = -0.43; p = 0.032). Conclusions. D-dimer concentrations in DHF patients in the fever phase are higher compare to DD patients. D-dimer concentration correlates with the degree of thrombocytopenia and hypoalbuminemia.
Validation of A2DS2 Score as Predictor of Pneumonia among Patients Hospitalized for Acute Ischemic Stroke Nababan, Toman; Pitoyo, Ceva Wicaksono; Harris, Salim; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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Introduction. Pneumonia is the leading cause of morbidity and mortality in acute ischemic stroke patients admitted to hospital. Thus required a valid scoring system which is easy to apply, to predict and stratify the risk of pneumonia in patients with acute ischemic stroke. This study aimed to assess the performance of calibration and discrimination of A2 DS2 score in predicting the incidence of pneumonia in patients with acute ischemic stroke. Methods. A retrospective cohort study was conducted among adult acute ischemic stroke patients who are hospitalized in Cipto Mangunkusumo Hospital, Jakarta. Age, atrial fibrillation, dysphagia, sex (male), and stroke severity (rated with National Institute of Health Stroke Scale/NIHSS) were obtained at the beginning of admission. The subjects were followed up for up to seven days after the onset of ischemic stroke to assess the outcome (pneumonia). Calibration properties of the A2 DS2 score were assessed by Hosmer-Lemeshow test and calibration plot. Discrimination properties of the A2 DS2 score were assessed by the area under the curve (AUC). Results. A total of 281 subjects were followed up. The incidence of pneumonia in acute ischemic stroke patients was observed in 118 patients (42%). Hosmer Lemeshow test of A2 DS2 score showed p = 0,222 and calibration plot showed r = 0,982. Discrimination of A2 DS2 score was shown by the AUC value of 0,885 (95% CI 0,845-0,924). Conclusion. The A2 DS2 score has a good calibration and discrimination performance in predicting the incidence of pneumonia in patients with acute ischemic stroke.
Comparison of Renal Safety of Tenofovir and Telbivudine in Chronic Hepatitis B Patients: A Real World Study in Indonesia Gani, Rino Alvani
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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Introduction. Tenofovir disoproxil fumarate (tenofovir) and telbivudine are two available nucleos(t)ide analogue (NA) for the treatment of chronic hepatitis B (CHB) patients. Tenofovir has been known as a nephrotoxic agent in HIV patients, but still controversy in CHB patients. On the other hand, telbivudine had a renal protective effect and increased estimated glomerular filtration rate (eGFR). This studi aimed to address the renal safety of tenofovir and telbivudine in Indonesian patients. Method. A retrospective cohort study design was conducted in CHB patients who prescribed with tenofovir or telbivudine from January 2013 to December 2016. Patients who hade baseline eGFR
The Differences of Marital Satisfaction of ODHA Couples with and without Depression Symptoms Salahudin, Muhammad Ismail; Fitrikasari, Alifiati; Sofro, Muchlis Achsan Udji; Julianti, Hari Peni
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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Introduction. HIV/AIDS disease has caused physical, social, and emotional problems to infected individuals and their spouses. ODHA couples have a prevalence of depression symptoms with physical complaints, which amounted to 12.7%. There is a relationship between love, communication, and physical intimacy to satisfaction in marriage. Depression in ODHA couples is correlated with marital satisfaction. This study aimed to analyze the differences of marital satisfaction of ODHA HIV negative couples who experience depression symptoms with ODHA who do not experience depression symptoms Methods. The research design was cross-sectional. The samples were 52 official couples of ODHA aged 18-60 years who had outpatient treatment in Poly of Infection Tropical RSUP. Dr. Kariadi Semarang and met the criteria of research inclusion. Sampling technique was conducted with consecutive sampling method. Depression status was measured by the beck depression inventory (BDI) instrument and marital satisfaction was measured by ENRICH marital satisfaction scale (EMS). Processing and data analysis using SPSS program. The relationship analysis test using chi-square test. Results. Subjects who did not experience depression 78.8% and those with depression 21.2% consisted of mild 9.6%, moderate 11.6%, and severe 0%. No subjects were found to be unsatisfied with their marriage, 55.8% were very satisfied and 44.2% were satisfied. There was no significant difference between marital satisfaction of ODHA HIV negative couples with depression symptoms and without depression symptoms (p = 0,595). There was a significant difference between the marital satisfaction of ODHA HIV negative couples with depression symptoms and without depression symptoms in communication (p = 0.021), conflict resolution (p = 0.025), use of leisure activities (p = 0.025), and sexual activities (p = 0.007) Conclusion. There was no difference between the marital satisfaction of ODHA HIV negative couples with depression symptoms and without depression symptoms. There was a significant difference between the marital satisfaction of ODHA HIV negative couples with depression symptoms and without depression symptoms in communication, conflict resolution, the use of leisure activities, and sex activities.
Antibiotic Treatment based on Guidelines for Reducing Length of Stay (LOS) in Patients with Community Acquired Pneumonia (CAP) Munarsih, Fetri Charya; Natadidjadja, Ronald Irwanto; Syamsudin, Syamsudin
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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Introduction. Community acquired pneumonia (CAP) now is known as the most common infection presented. Empiric antibiotic administered followed by observing parameters. This study aimed to know how far the American Thoracic Society/ Infectious Disease Society of America (ATS/IDSA) antibiotic guidelines 2007 based treatment influenced the length of stay (LOS) of CAP subject in a private hospital ward between January 2014-August 2015 Methods. A retrospective cohort was conducted with bivariate analysis and multivariate analysis for reducing the confounding factor. Sample taken with proportional sampling formula at ward in a hospital in Jakarta. Results. The result showed that subjects with unproper empiric antibiotic based on ATS/IDSA 2007 guidelines tent to have hospital prolong stay 10.25 times (p <0.001) than others with proper on ATS/IDSA empiric antibiotic guidelines. Conclusion. By this result, we observed a very significant statistic result difference in LOS between a group with proper empiric antibiotic based on ATS/IDSA 2007 guidelines and other who unproper.
Efficacy and Safety of Oral Antidiabetic Drugs in Type 2 Diabetes Mellitus with Chronic Kidney Disease Sihotang, Retta C.; Ramadhani, Rizka; Tahapary, Dicky L.
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
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