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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 432 Documents
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Hubungan Kadar Malondialdehida (MDA) Serum dan Fraksi Ejeksi Ventrikel Kiri pada Pasien Hemodialisis Reguler Amir, Teguh Setiadi; Indrajaya, Taufik; Ali, Zulkhair
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Introduction. Malondialdehyde (MDA) is a marker of oxidative stress that is elevated in chronic kidney disease (CKD) patients undergoing regular hemodialysis. Oxidative stress can affect cardiac function especially left ventricular function. This study aimed to evaluate the relationship between serum MDA levels with left ventricular function in regular hemodialysis patients at Dr. Mohammad Hoesin Genaral Hospital, Palembang. Methods. This study was an analytic observational study with a cross-sectional design conducted on regular hemodialysis patients in the Hemodialysis Installation of Dr. Mohammad Hoesin Genaral Hospital, Palembang. The MDA levels were examined from the serum of post-hemodialysis patients using ELISA method. Echocardiography was then performed to determine left ventricular function. Statistical analysis was performed using STATA version 15 with Spearman correlation and Chi-square tests. Results. Among 121 subjects, median serum MDA levels was 4.05 (0.68-27.21) μmol/L. Correlation analysis demonstrated a significant moderate negative correlation between serum MDA levels and LVEF (r = −0.38, p < 0.0001). Mann–Whitney analysis showed that patients with reduced LVEF had significantly higher MDA levels than those with normal LVEF (median: 10.035 vs. 3.112 μmol/L). Furthermore, elevated MDA levels were significantly associated with reduced LVEF, with patients having high MDA levels exhibiting a 4.8-fold greater odds of reduced LVEF (OR 4.826, 95% CI 1.611–17.310). Conclusions. Elevated serum MDA levels were significantly associated with impaired left ventricular function in patients with stage V CKD undergoing regular hemodialysis at Mohammad Hoesin General Hospital, Palembang. Patients with high serum MDA levels had a 4.8-fold higher odds of reduced LVEF than those with lower MDA levels.
Takikardia Ventrikel Berulang Pasca Coronary Artery Bypass Grafting (CABG): Laporan Kasus Berbasis Bukti Wijaya, Ika Prasetya; Salim, Simon; Nabila, Audina Dhiya
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Coronary artery bypass grafting (CABG) remains the treatment of choice for patients with complex multivessel coronary artery disease but carries a risk of serious perioperative complications, including ventricular arrhythmias such as ventricular tachycardia (VT). Although VT following CABG is rare, it is potentially life-threatening and often results from multiple interrelated factors. This report presents a case of recurrent ventricular tachycardia after CABG and to highlight the underlying mechanisms, risk factors, and evidence-based management strategies aimed at preventing adverse outcomes.We report a 54-year-old woman with diabetes, hypertension, prior myocardial infarction, and severe left ventricular dysfunction who underwent urgent CABG for three-vessel disease. Postoperatively, she developed recurrent VT associated with fluctuating electrolytes and early vein graft occlusion. Management included urgent graft revascularization, aggressive metabolic correction, repeated defibrillation, and intravenous antiarrhythmic therapy, resulting in VT cessation. Ventricular tachycardia following CABG illustrates the interplay between a vulnerable arrhythmogenic substrate and modifiable perioperative factors. Comprehensive perioperative monitoring, early identification of high-risk conditions, and prompt correction of reversible triggers are essential to prevent serious outcomes and improve prognosis in this patient population.

Page 44 of 44 | Total Record : 432

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