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Malacca Pharmaceutics
ISSN : -     EISSN : 29881064     DOI : https://doi.org/10.60084/mp
Malacca Pharmaceutics is a premier interdisciplinary platform dedicated to fostering the exchange of cutting edge research and ideas in the rapidly evolving fields of pharmaceutical science and technology. Our mission is to provide a comprehensive and authoritative forum for scientists, researchers, and practitioners from diverse disciplines to share and advance their knowledge in the development, optimization, and application of innovative therapeutic strategies. The scope of the Malacca Pharmaceutics Journal encompasses a wide range of topics, including, but not limited to:Pharmaceutical formulation, delivery and controlled-release systems for drugs, vaccines, and biopharmaceuticals, pharmaceutical process, engineering, biotechnology, and nanotechnology, devices, cells, molecular biology, and materials science related to drugs and drug delivery pharmacogenetics and pharmacogenomics, biopharmaceutics,nanomedicine, drug targeting, drug design, pharmacokinetics, toxicokinetics, pharmacodynamics, drug discovery, drug design, medicinal chemistry, combinatorial chemistry, SAR, structure-property correlations, molecular modeling, pharmacophore, and bioinformatics
Articles 31 Documents
Evaluating the Effects of Young Areca catechu Seed Extract on FSH and Testosterone Levels in Male Rats: Insights into Natural Anti-Fertility Agents Noviyanti, Noviyanti; Sugito, Sugito; Akmal, Muslim; Saidi, Nurdin
Malacca Pharmaceutics Vol. 4 No. 1 (2026): March 2026 (In Press)
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v4i1.338

Abstract

Male participation in contraception remains limited worldwide because few safe and acceptable male contraceptive options exist. Natural products are being explored as potential regulators of male reproductive hormones. Areca catechu (areca nut), traditionally used in Southeast Asia, contains phytochemicals that may influence reproductive function. This study evaluated the effects of the ethanolic extract of young A. catechu seeds on serum follicle-stimulating hormone (FSH) and testosterone levels in male Wistar rats. Twenty-five rats were randomly assigned to five groups (0, 20, 40, 60, and 80 mg/kgbody weight) and treated daily for 48 days. Serum FSH and testosterone were measured by ELISA and analyzed by one-way ANOVA with Duncan’s post-hoc test. Mean FSH and testosterone values varied across doses, with the 40 mg/kg group showing the highest means (10.001 ± 10.413 ng/mL and 2.196 ± 1.254 ng/mL, respectively), but no statistically significant differences were detected for either hormone (FSH p = 0.043; testosterone p = 0.425). The results provide preliminary, hypothesis-generating evidence that the extract may influence the hypothalamic–pituitary–gonadal axis; however, any role in male fertility regulation remains unproven. Larger studies including sperm-quality assessment, mechanistic analyses, and toxicological evaluation are required before considering potential applications in male reproductive health.

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