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QSAR Classification of Beta-Secretase 1 Inhibitor Activity in Alzheimer's Disease Using Ensemble Machine Learning Algorithms Noviandy, Teuku Rizky; Maulana, Aga; Emran, Talha Bin; Idroes, Ghazi Mauer; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i1.12

Abstract

This study focuses on the development of a machine learning ensemble approach for the classification of Beta-Secretase 1 (BACE1) inhibitors in Quantitative Structure-Activity Relationship (QSAR) analysis. BACE1 is an enzyme linked to the production of amyloid beta peptide, a significant component of Alzheimer's disease plaques. The discovery of effective BACE1 inhibitors is difficult, but QSAR modeling offers a cost-effective alternative by predicting the activity of compounds based on their chemical structures. This study evaluates the performance of four machine learning models (Random Forest, AdaBoost, Gradient Boosting, and Extra Trees) in predicting BACE1 inhibitor activity. Random Forest achieved the highest performance, with a training accuracy of 98.65% and a testing accuracy of 82.53%. In addition, it exhibited superior precision, recall, and F1-score. Random Forest's superior performance was a result of its ability to capture a wide variety of patterns and its randomized ensemble approach. Overall, this study demonstrates the efficacy of ensemble machine learning models, specifically Random Forest, in predicting the activity of BACE1 inhibitors. The findings contribute to ongoing efforts in Alzheimer's disease drug discovery research by providing a cost-effective and efficient strategy for screening and prioritizing potential BACE1 inhibitors.
Evaluation of Gradient Boosted Classifier in Atopic Dermatitis Severity Score Classification Suhendra, Rivansyah; Suryadi, Suryadi; Husdayanti, Noviana; Maulana, Aga; Noviandy, Teuku Rizky; Sasmita, Novi Reandy; Subianto, Muhammad; Earlia, Nanda; Niode, Nurdjannah Jane; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.85

Abstract

This study investigates the application of the Gradient Boosting machine learning technique to enhance the classification of Atopic Dermatitis (AD) skin disease images, reducing the potential for manual classification errors. AD, also known as eczema, is a common and chronic inflammatory skin condition characterized by pruritus (itching), erythema (redness), and often lichenification (thickening of the skin). AD affects individuals of all ages and significantly impacts their quality of life. Accurate and efficient diagnostic tools are crucial for the timely management of AD. To address this need, our research encompasses a multi-step approach involving data preprocessing, feature extraction using various color spaces and evaluating classification outcomes through Gradient Boosting. The results demonstrate an accuracy of 93.14%. This study contributes to the field of dermatology by providing a robust and reliable tool to support dermatologists in identifying AD skin disease, facilitating timely intervention and improved patient care.
Evaluating Geothermal Power Plant Sites with Additive Ratio Assessment: Case Study of Mount Seulawah Agam, Indonesia Azhar, Fauzul; Misbullah, Alim; Lala, Andi; Idroes, Ghazi Mauer; Kusumo, Fitranto; Noviandy, Teuku Rizky; Irvanizam, Irvanizam; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v2i1.158

Abstract

Indonesia, a country rich in geothermal resources, has yet to fully exploit its potential, particularly in volcanic regions like Mount Seulawah Agam. This study investigates the application of the Additive Ratio Assessment (ARAS) method for the site selection of Geothermal Power Plants (GPP) in Indonesia. The ARAS method provides a systematic approach to evaluating and prioritizing geothermal development sites by integrating multiple criteria, including geological, environmental, and socio-economic factors. The study collects data from various sources and weights criteria using the Ordinal Priority Approach (OPA), incorporating expert opinions. The findings demonstrate the effectiveness of the ARAS method in identifying optimal locations for GPP development, ensuring sustainability and feasibility. The study also tests the ARAS method in existing GPP locations in Jaboi, Sabang, Indonesia, to investigate alignment with the results and validate the approach. Furthermore, the study presents recommendations for GPP site selection. This research emphasizes the significance of multi-criteria decision-making techniques in facilitating renewable energy projects. It promotes a more systematic and informed approach to geothermal energy development in Indonesia and other geothermal-rich regions.
Explainable Deep Learning Approach for Mpox Skin Lesion Detection with Grad-CAM Idroes, Ghazi Mauer; Noviandy, Teuku Rizky; Emran, Talha Bin; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 2 No. 2 (2024): September 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v2i2.216

Abstract

Mpox is a viral zoonotic disease that presents with skin lesions similar to other conditions like chickenpox, measles, and hand-foot-mouth disease, making accurate diagnosis challenging. Early and precise detection of mpox is critical for effective treatment and outbreak control, particularly in resource-limited settings where traditional diagnostic methods are often unavailable. While deep learning models have been applied successfully in medical imaging, their use in mpox detection remains underexplored. To address this gap, we developed a deep learning-based approach using the ResNet50v2 model to classify mpox lesions alongside five other skin conditions. We also incorporated Grad-CAM (Gradient-weighted Class Activation Mapping) to enhance model interpretability. The results show that the ResNet50v2 model achieved an accuracy of 99.33%, precision of 99.34%, sensitivity of 99.33%, and an F1-score of 99.32% on a dataset of 1,594 images. Grad-CAM visualizations confirmed that the model focused on relevant lesion areas for its predictions. While the model performed exceptionally well overall, it struggled with misclassifications between visually similar diseases, such as chickenpox and mpox. These results demonstrate that AI-based diagnostic tools can provide reliable, interpretable support for clinicians, particularly in settings with limited access to specialized diagnostics. However, future work should focus on expanding datasets and improving the model's capacity to distinguish between similar conditions.
Evaluation of atopic dermatitis severity using artificial intelligence Maulana, Aga; Noviandy, Teuku R.; Suhendra, Rivansyah; Earlia, Nanda; Bulqiah, Mikyal; Idroes, Ghazi M.; Niode, Nurdjannah J.; Sofyan, Hizir; Subianto, Muhammad; Idroes, Rinaldi
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.511

Abstract

Atopic dermatitis is a prevalent and persistent chronic inflammatory skin disorder that poses significant challenges when it comes to accurately assessing its severity. The aim of this study was to evaluate deep learning models for automated atopic dermatitis severity scoring using a dataset of Aceh ethnicity individuals in Indonesia. The dataset of clinical images was collected from 250 patients at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia and labeled by dermatologists as mild, moderate, severe, or none. Five pre-trained convolutional neural networks (CNN) architectures were evaluated: ResNet50, VGGNet19, MobileNetV3, MnasNet, and EfficientNetB0. The evaluation metrics, including accuracy, precision, sensitivity, specificity, and F1-score, were employed to assess the models. Among the models, ResNet50 emerged as the most proficient, demonstrating an accuracy of 89.8%, precision of 90.00%, sensitivity of 89.80%, specificity of 96.60%, and an F1-score of 89.85%. These results highlight the potential of incorporating advanced, data-driven models into the field of dermatology. These models can serve as invaluable tools to assist dermatologists in making early and precise assessments of atopic dermatitis severity and therefore improve patient care and outcomes.
Optimizing antimicrobial synergy: Green synthesis of silver nanoparticles from Calotropis gigantea leaves enhanced by patchouli oil Kemala, Pati; Khairan, Khairan; Ramli, Muliadi; Helwani, Zuchra; Rusyana, Asep; Lubis, Vanizra F.; Ahmad, Khairunnas; Idroes, Ghazi M.; Noviandy, Teuku R.; Idroes, Rinaldi
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.800

Abstract

Silver nanoparticles (AgNPs) synthesized from plant extracts have gained attention for their potential applications in biomedicine. Calotropis gigantea has been utilized to synthesize AgNPs, called AgNPs-LCg, and exhibit antibacterial activities against both Gram-positive and Gram-negative bacteria as well as antifungal. However, further enhancement of their antimicrobial properties is needed. The aim of this study was to synthesize AgNPs-LCg and to enhance their antimicrobial and antifungal activities through a hybrid green synthesis reaction using patchouli oil (PO), as well as to characterize the synthesized AgNPs-LCg. Optimization was conducted using the response surface method (RSM) with a central composite design (CCD). AgNPs-LCg were synthesized under optimal conditions and hybridized with different forms of PO—crude, distillation wastewater (hydrolate), and heavy and light fractions—resulting in PO-AgNPs-LCg, PH-AgNPs-LCg, LP-AgNPs-LCg, and HP-AgNPs-LCg, respectively. The samples were then tested for their antibacterial (both Gram-positive and Gram-negative bacteria) and antifungal activities. Our data indicated that all samples, including those with distillation wastewater, had enhanced antimicrobial activity. HP-AgNPs-LCg, however, had the highest efficacy; therefore, only HP-AgNPs-LCg proceeded to the characterization stage for comparison with AgNPs-LCg. UV-Vis spectrophotometry indicated surface plasmon resonance (SPR) peaks at 400 nm for AgNPs-LCg and 360 nm for HP-AgNPs-LCg. The Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the presence of O-H, N-H, and C-H groups in C. gigantea extract and AgNP samples. The smallest AgNPs-LCg were 56 nm, indicating successful RSM optimization. Scanning electron microscopy (SEM) analysis revealed spherical AgNPs-LCg and primarily cubic HP-AgNPs-LCg, with energy-dispersive X-ray spectroscopy (EDX) confirming silver's predominance. This study demonstrated that PO in any form significantly enhances the antimicrobial properties of AgNPs-LCg. The findings pave the way for the exploration of enhanced and environmentally sustainable antimicrobial agents, capitalizing on the natural resources found in Aceh Province, Indonesia.
Utilization of Drone with Thermal Camera in Mapping Digital Elevation Model for Ie Seu'um Geothermal Manifestation Exploration Security Bahri, Ridzky Aulia; Noviandy, Teuku Rizky; Suhendra, Rivansyah; Idroes, Ghazi Mauer; Yanis, Muhammad; Yandri, Erkata; Nizamuddin, Nizamuddin; Irvanizam, Irvanizam
Leuser Journal of Environmental Studies Vol. 1 No. 1 (2023): July 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ljes.v1i1.40

Abstract

Geothermal energy is a viable alternative energy source, particularly in Indonesia. This study was conducted at Ie Seu’um, Mount Seulawah Agam, which is a potential site for a geothermal power plant with an estimated electrical output of 150 megawatts. The objective of this study was to analyze and construct a digital elevation model (DEM) map of the geothermal manifestations. We analyzed water temperature, FLIR (Forward Looking Infrared) temperature, and temperature data from Landsat 8 satellite imagery. To map the heat signature of geothermal features, we utilized the DJI Phantom 4 Standard equipped with the FLIR One Gen 2 sensor. Additionally, we used the Milwaukee Mi306 to calculate the water temperature. Each test was conducted three times to obtain an optimal average level of accuracy. The DEM map was created to assess the level of safety in geothermal manifestation exploration. Elevation and slope values were analyzed to generate a 3D map display, providing a clearer image of the research site. In conclusion, drones prove to be an excellent method for ensuring the safety of exploration in geothermal manifestation areas.
TeutongNet: A Fine-Tuned Deep Learning Model for Improved Forest Fire Detection Idroes, Ghazi Mauer; Maulana, Aga; Suhendra , Rivansyah; Lala, Andi; Karma, Taufiq; Kusumo, Fitranto; Hewindati, Yuni Tri; Noviandy, Teuku Rizky
Leuser Journal of Environmental Studies Vol. 1 No. 1 (2023): July 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ljes.v1i1.42

Abstract

Forest fires have emerged as a significant threat to the environment, wildlife, and human lives, necessitating the development of effective early detection systems for firefighting and mitigation efforts. In this study, we introduce TeutongNet, a modified ResNet50V2 model designed to detect forest fires accurately. The model is trained on a curated dataset and evaluated using various metrics. Results show that TeutongNet achieves high accuracy (98.68%) with low false positive and false negative rates. The model's performance is further supported by the ROC curve analysis, which indicates a high degree of accuracy in classifying fire and non-fire images. TeutongNet demonstrates its effectiveness in reliable forest fire detection, providing valuable insights for improved fire management strategies.
Exploring Geothermal Manifestations in Ie Jue, Indonesia: Enhancing Safety with Unmanned Aerial Vehicle Aprianto, Aprianto; Maulana, Aga; Noviandy, Teuku Rizky; Lala, Andi; Yusuf, Muhammad; Marwan, Marwan; Afidh, Razief Perucha Fauzie; Irvanizam, Irvanizam; Nizamuddin, Nizamuddin; Idroes, Ghazi Mauer
Leuser Journal of Environmental Studies Vol. 1 No. 2 (2023): November 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ljes.v1i2.75

Abstract

Geothermal energy is a renewable resource derived from the Earth's interior that provides an environmentally friendly alternative. Indonesia is at the forefront of geothermal potential, possessing ample resources primarily concentrated in places like Sumatra. However, there is a requirement for greater exploitation of this potential. This research utilizes unmanned aerial vehicles (UAVs) and thermal imaging to detect geothermal indications in the Ie Jue region of Sumatra within the province of Aceh, Indonesia. The analysis focuses on three main manifestation locations using FLIR One thermal camera and water temperature gauges. The study leverages satellite imagery for comparative purposes. Temperature data highlights variations among distinct manifestations, underscoring the necessity for thorough exploration. Moreover, the study devises a secure pathway for researchers to access the site. This investigation contributes to comprehending geothermal activity and its possible role in sustainable energy and other domains.
Urban Air Quality Classification Using Machine Learning Approach to Enhance Environmental Monitoring Idroes, Ghazi Mauer; Noviandy, Teuku Rizky; Maulana, Aga; Zahriah, Zahriah; Suhendrayatna, Suhendrayatna; Suhartono, Eko; Khairan, Khairan; Kusumo, Fitranto; Helwani, Zuchra; Abd Rahman, Sunarti
Leuser Journal of Environmental Studies Vol. 1 No. 2 (2023): November 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ljes.v1i2.99

Abstract

Urban areas worldwide grapple with environmental challenges, notably air pollution. DKI Jakarta, Indonesia's capital city, is emblematic of this struggle, where rapid urbanization contributes to increased pollutants. This study employed the CatBoost machine learning algorithm, known for its resistance to overfitting and capability to handle missing data, to predict urban air quality based on pollutant levels from 2010 to 2021. The dataset, sourced from Jakarta's air quality monitoring stations, includes pollutants such as PM10, SO2, CO, O3, and NO2. After preprocessing, we used 80% of the data for training and 20% for testing. The model displayed high accuracy (0.9781), precision (0.9722), and recall (0.9728). The feature importance chart revealed O3 (Ozone) as the top influencer of air quality predictions, followed by PM10. Our findings highlight the dominant pollutants affecting urban air quality in Jakarta, Indonesia and emphasizing the need for targeted strategies to reduce their concentrations and ensure a cleaner and healthier urban environment.
Co-Authors Abas, Abdul Hawil Abd Rahman, Sunarti Adi Purnawarman, Adi Afidh, Razief Perucha Fauzie Afjal, Mohd Ahmad Watsiq Maula Ahmad, Khairunnas Ahmad, Noor Atinah Ahsya, Yahdina Al-Gunaid , Hala T. Alfharijy, Muhammad Daffa Amalia Amalia Amalina, Faizah Amirah, Kelsy Amri Amin Anisah Anisah Anisah Anisah Anisah Anisah Anisah Aprianto . Apriliansyah, Feby Asep Rusyana Azhar, Fauzul Baehaqi Bahri, Ridzky Aulia BAKRI, TEDY KURNIAWAN Cut Rahmawati Cut Rahmawati Dahlawy, Arriz Dharma, Aditia Dian Handayani Dian Lestari, Nova Dimas Chaerul Ekty Saputra Duta, Teuku F. Earlia, Nanda Effendy, Amalia Eko Suhartono El-Shazly, Mohamed Emran, Talha Bin Enitan, Seyi Samson Erkata Yandri Essy Harnelly Eva Herlina Faisal, Farassa Rani Fajri, Irfan Fatani, Muhammad Fauzi, Fazlin Mohd Furqan, Nurul Ghalieb Mutig Idroes Ghazi Mauer Idroes Hafizah, Iffah Haikal Azzuhry Hamoud, Lama MA. Hardia, Natasha Athira Keisha Hewindati, Yuni Tri Hidayatullah, Ferdy Hizir Sofyan Hizir Sofyan Husdayanti, Noviana Idroes , Ghalieb M. Idroes, Ghalieb Mutig Idroes, Ghazi M. Idroes, Ghifari M. Idroes, Ghifari Maulana Iin Shabrina Hilal Imelda, Eva Imran Imran Irma Sari Irsan Hardi Irvanizam, Irvanizam Isa, Illyas Md Isra Firmansyah, Isra Kadri, Mirzatul Kairupan, Tara S. Kemala, Pati Khairan Khairan Khairul, Mhd Khairul, Moh Khairun Nisa Kruba, Rumaisa Kurniadinur, Kurniadinur Kusumo, Fitranto Lala, Andi Lindawati Lindawati Lubis, Vanizra F. Maimun Syukri, Maimun Mardalena, Selvi Maria Paristiowati Marwan Marwan Maulana, Aga Maulydia, Nur Balqis Mikyal Bulqiah, Mikyal Misbullah, Alim Mohamed Yusof, Nur Intan Saidaah Mohd Fauzi, Fazlin Mohsina Patwekar Muhammad Adam, Muhammad Muhammad Faisal Muhammad Subianto Muhammad Yanis Muhammad Yusuf Muhammad Zardi Muhibbul Tibri Muhtadin Muhtadin Mukhlisuddin Ilyas Muksalmina Muksalmina Muliadi Muliadi Ramli Mursyida, Waliam Muslem Muslem Mutaqin, Raihan Nainggolan, Sarah Ika Nizamuddin Nizamuddin Novi Reandy Sasmita Nurdjannah J. Niode Nurleila, Nurleila Nurul Nazirah Patwekar, Faheem Patwekar, Mohsina Prakoeswa, Cita RS. Rahmat Sufri Rahmat Sufri Rahmat Sufri Rahmat Sufri Rahmawati, Cut Raihan Raihan, Raihan Ramadeska, Siti Raudhatul Jannah Ray, Samrat Razief Perucha Fauzie Afidh Rinaldi Idroes Ringga, Edi Saputra Rizkia, Tatsa Rusli Abdullah Ryan Setiawan Ryan Setiawan Ryan Setiawan Safhadi, Aulia Al-Jihad Sasmita, Novi Reandy Satrio, Justinus Sofyan, Rahmi Solly Aryza Souvia Rahimah Sufri, Rahmat sufriani, sufriani Sugara, Dimas Rendy Suhendra , Rivansyah Suhendra, Rivansyah Suhendrayatna Suhendrayatna Suryadi Suryadi Syafila Kamarudin Syahyana, Ahmad Tajul Abrar Taufiq Karma Tety Sriana Teuku Nadhif Al Fath Teuku Zulfikar TRINA EKAWATI TALLEI Utami, Resty Tamara Yosza Dasril Zahriah, Zahriah Zhilalmuhana, Teuku Zuchra Helwani, Zuchra Zulkarnain Jalil Zurnila Marli Kesuma