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Benzena Pharmaceutical Scientific Journal
Published by Universitas Pekalongan
ISSN : -     EISSN : 29617375     DOI : http://dx.doi.org/10.31941/benzena.v2i01.3065
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology Public Health
Benzena Pharmaceutical Scientific Journal adalah jurnal peer-review yang diterbitkan dua kali setahun (Juni dan Desember) oleh Fakultas Farmasi Universitas Pekalongan. Ini tersedia online sebagai sumber akses terbuka dan juga dalam bentuk cetak. Pernyataan ini memperjelas perilaku etis semua pihak yang terlibat dalam tindakan penerbitan artikel di jurnal ini, termasuk penulis, pemimpin redaksi, Dewan Editorial, reviewer, dan penerbit. Pernyataan ini didasarkan pada Pedoman Praktik Terbaik COPE untuk Editor Jurnal. Focus dan scope : Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL" : 5 Documents clear
SMART INHALER DALAM PENATALAKSANAAN ASMA: STUDI TERKINI TENTANG PENINGKATAN KEPATUHAN TERAPI DAN HASIL KLINIS Salsabela
BENZENA Pharmaceutical Scientific Journal Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i02.7119

Abstract

Background: Asthma is the most common chronic respiratory disease worldwide, with suboptimal adherence to maintenance therapy, resulting in increased exacerbations, hospitalizations, and mortality. Digital interventions, including electronic monitoring devices, smart inhalers, smart spacers, mobile applications, and SMS reminders, have emerged as innovative strategies to improve adherence and clinical outcomes. Objective: To evaluate the effectiveness of digital interventions in enhancing adherence to maintenance therapy in asthma patients, assess clinical and economic impacts. Method: Review was conducted on eight RCTs and observational studies evaluating digital interventions in adult and pediatric asthma patients. Key outcomes included adherence, inhaler technique, asthma control, quality of life, exacerbation prediction, and cost-effectiveness. Result: Digital interventions consistently improved adherence by up to 23% compared with control, enhanced inhalation technique, and improved asthma control and quality of life. Machine learning algorithms integrated with smart inhalers accurately predicted impending exacerbations, allowing proactive management. Long-term studies indicated cost savings through reduced use of add-on biologic therapies. In children, adherence and inhaler technique were shown to be distinct aspects, requiring targeted educational strategies. Conclusion: Digital interventions effectively improve adherence and clinical outcomes in asthma patients. These strategies have potential to support personalized and cost-effective asthma management. Further research is needed to evaluate long-term effectiveness and real-world implementation.
A NARRATIVE REVIEW: PEMANFAATAN TEKNOLOGI DIGITAL OLEH APOTEKER DALAM PENINGKATAN KEPATUHAN PENGOBATAN PENYAKIT KRONIS Anisya, Kharina
BENZENA Pharmaceutical Scientific Journal Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i02.7146

Abstract

Background : The increasing prevalence of chronic diseases such as diabetes, hypertension, and cardiovascular disorders poses a major challenge to global health systems. A key determinant of successful chronic disease therapy is patient adherence to medication, which remains low, particularly among populations with limited access to healthcare services. Pharmacists play a crucial role in supporting medication adherence through digital technology–based interventions, such as telepharmacy and mobile health applications. The digitalization of pharmacy services enables improved access, therapy monitoring, and continuous communication between pharmacists and patients. Objective : This study aims to explore the implementation of digital technology by pharmacists in enhancing medication adherence among patients with chronic diseases. Method : A narrative review was conducted through a search of the PubMed, ProQuest, and Google Scholar databases for articles published between 2015 and 2025. Inclusion criteria were applied based on the relevance to pharmacist-led interventions and adherence outcomes among patients with chronic diseases. Ten eligible articles were selected and analyzed qualitatively. Result : The review findings indicate that digital interventions by pharmacists—including telepharmacy, mobile applications, web-based systems, and short message reminders—consistently improve medication adherence and clinical outcomes among patients. Several studies reported reductions in Drug-Related Problems (DRPs), improvements in quality of life, and better control of clinical parameters such as blood pressure and glucose levels. The success of these interventions is influenced by patients’ digital literacy, the support of the healthcare system, and the frequency of communication between pharmacists and patients. Identified barriers include limited internet access, low digital literacy among elderly patients, and insufficient interprofessional collaboration. Conclusion : The utilization of digital technology in pharmaceutical interventions has proven effective in improving medication adherence and clinical outcomes among patients with chronic diseases. The role of pharmacists as digital care facilitators serves as a key factor in achieving these positive results. The integration of telepharmacy and health applications into primary care services holds great potential to expand access and support a more inclusive and sustainable health system. Keywords: telepharmacy, digital technology, medication adherence, chronic disease.
ANTIOXIDANT ACTIVITY OF 96% ETHANOL, ETHYL ACETATE AND N-HEXANE EXTRACT OF GREEN GIRL EGGPLANT (Solanum Melongena L) USING DPPH METHOD Winda Nur Rahayu; Nita Fajaryanti; Azizah, Tri Nur; Andamari Wahyu Utami, Rose Malinda; Putri, Nabilla Andasari
BENZENA Pharmaceutical Scientific Journal Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i02.7194

Abstract

Terong umumnya mengandung metabolit sekunder yang merupakan sumber antioksidan termasuk karotenoid, antosianin, alkaloid, dan flavonoid, diketahui memiliki sifat antioksidan. Masyarakat Jawa sering mengonsumsi terong gelatik hijau (Solanum melongena L.) sebagai lauk. Tujuan penelitian ini adalah untuk mengetahui apakah ekstrak etanol 96%, etil asetat, dan N-heksana dari terong gelatik hijau (Solanum melongena L.) memiliki aktivitas antioksidan menggunakan metode DPPH dan ekstrak mana yang memiliki aktivitas antioksidan tertinggi. Metode ekstraksi yang digunakan adalah maserasi. Penelitian ini menggunakan tiga ekstrak: etanol 96%, etil asetat, dan N-heksana menggunakan metode DPPH. Penelitian ini menggunakan tiga pelarut hasil ekstraksi DPPH: etil asetat, N-heksana, dan etanol 96%. Berdasarkan data yang diperoleh dalam penelitian ini menunjukkan nilai IC50 rata-rata sebesar 16,85 µg/mL untuk ekstrak etanol 96%, 36,61 µg/mL untuk ekstrak etil asetat, dan 46,17 µg/mL untuk ekstrak N-heksana. Ekstrak etanol 96% dari terong gelatik hijau (Solanum melongena L.) memiliki aktivitas antioksidan tertinggi dibandingkan dengan ekstrak etil asetat dan N-heksana. Kata kunci: Antioksidan, DPPH, Ekstrak, Terong
KOLABORASI INTERPROFESIONAL APOTEKER DAN DOKTER PADA PENDERITA HIPERTENSI DI PUSKESMAS KOTA SEMARANG BERDASARKAN PERSPEKTIF APOTEKER Gloria, Fransisca; Ana Auleina, Revly; Rizki Al Farizi, Gilang
BENZENA Pharmaceutical Scientific Journal Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i02.6641

Abstract

The abstract in this section is written in English. Abstract consists of 200-500 words. typed in English and Bahasa Indonesia with 200-500 words in 1 column with 11pt font 1.0 spacing. Briefly explain backgrounds, objectives, methods, results and conclusion. Background : Interprofessional collaboration is a process of communication and joint decision-making with the aim of achieving successful patient therapy by respecting each other and the abilities of each health worker. Each health profession must be connected in one direction to achieve the same vision and must understand each other's roles and work tasks so that they can optimize clinical outcomes in treating chronic diseases. One of the diseases that requires effective and optimal collaboration between pharmacists and doctors is hypertension. This is because hypertension is one of the diseases with very high mortality and morbidity rates in the world. Objective : This study aims to see the picture of interprofessional collaboration between pharmacists and doctors in handling hypertension patients at Semarang City Health Centers. Method : This study was conducted through an observational approach with a cross-sectional design in the period June - July 2022 using the Collaborative Working Relationship (CWR) model. The population in this study were all pharmacists and doctors, each numbering 33 people who work at the Semarang City Health Center with a total of 33 Health Centers. The data analysis used in this study was descriptive univariate. Result : Based on the results of the study, the gender of the 33 pharmacist respondents was all female (100%), most respondents (51.5%) were 25-30 years old, and respondents were 41-55 years old (30.3%), the average level of education of respondents was S1+Profession (100%) and the length of work of some was 1-5 years (60.6%). In the trust domain, moderate results were obtained, the role specification domain obtained sufficient results, the initiation relationship domain obtained moderate results and in collaboration, quite effective results were obtained. Conclusion : Based on the trust domain, pharmacists have moderate trust in doctors, pharmacists have sufficient role specification towards doctors, pharmacists have moderate initiation relationships, and pharmacists' collaborative practices are quite effective towards doctors.
FORMULASI NANOEMULGEL MINYAK ATSIRI DAUN MINT (Mentha piperita L.) Fauzan Ashari Nur H; Disa Andriani
BENZENA Pharmaceutical Scientific Journal Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i02.7509

Abstract

Peppermint (Mentha piperita L.) essential oil exhibits therapeutic activities such as anti-inflammatory, analgesic, antioxidant, and antimicrobial effects, making it a potential active ingredient for topical pharmaceutical and cosmetic products. However, essential oils are highly volatile, resulting in instability and limited effectiveness. A nanotechnology-based approach, particularly nanoemulsion systems, has emerged as an effective strategy to improve stability, bioavailability, and skin penetration of essential oils. This study aimed to evaluate the particle size and physical properties of nanoemulgel formulations that meet acceptable quality requirements. Peppermint leaf essential oil was formulated into nanoemulgel preparations at a concentration of 5% in Formula 1 and 10% in Formula 2, followed by evaluation of particle size and physical characteristics. The results of the physical characterization showed that the nanoemulsion particle size was 111.66 ± 2.35 nm for Formula 1 and 134.06 ± 3.31 nm for Formula 2. All physical property evaluations of the nanoemulgel formulations met the requirements for a good gel preparation Keywords: peppermint leaf essential oil, nanoemulgel, physical properties, nanoparticle size

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