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INDONESIA
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat
Published by Politeknik Indonusa Surakarta
ISSN : 25486667     EISSN : 27759032     DOI : 10.46808
Core Subject : Health, Science,
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health
The journal includes various fields of pharmaceuticals sciences such as: Pharmacy, Pharmacokinetics, Community and Clinical Pharmacy, Medical, Alternative medicines, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Microbiology, Tissue Culture, Botany and Animals Related to Pharmaceutical Products, Midwifery, Health Analyst, Nutrition and Public Health, Pharmacology and Toxicology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 162 Documents
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FORMULASI SABUN PADAT TRANSPARAN MINYAK JELANTAH DENGAN PENAMBAHAN LIDAH BUAYA (Aloe vera L.) Umi Nafisah; Yunita Dian Permata Sari
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 1 (2025): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i1.254

Abstract

Used cooking oil, which is leftover cooking oil, can be reprocessed into goods or preparations that have added value, one of which is by processing it into solid soap. In soap preparations, additional ingredients are often added, such as aloe vera, because of its antibacterial activity and its properties that can moisturize and soften the skin. The purpose of this study was to determine the formula and physical properties of transparent solid soap, a combination of used cooking oil and coconut oil, with the addition of aloe vera. The study used an experimental method. The soap was made in 6 formulas with variations in used cooking oil: coconut oil (gram) F1 = 0:29; F2 = 29:0; F3 = 6:23; F4 = 12:17; F5 = 17:12; F6 = 23:6. The soap was tested for organoleptic, homogeneity, pH, water content, foam height, free alkali, and unsaponifiable fat. A homogeneous soap preparation was obtained, F1 is yellow, F3, F4, and F5 are orange, and F2 is brownish orange in color, lavender-smelling, and solid in form. pH is following the range of SNI 3532:2016, which is 9 - 11, except for formulas 2 and 4. The height of the foam after being shaken is in the range of 5.2 ± 0.83 - 7.2 ± 0.29, and after being left for 5 minutes, there is a decrease. All formulas meet the requirements for good water content for solid soap preparations, which is less than 15%. The results of the free alkali and free unsaponifiable fat tests show that all formulas have not met the required parameters.
ANALISIS TIGA ASPEK KELENGKAPAN RESEP PADA LAYANAN TELEFARMASI: ADMINISTRATIF, FARMASETIS, DAN KLINIS DI APOTEK JAYA PHARMA 9 KABUPATEN KEDIRI Anis Akhwan Dhafin; Eka Mahardika Putri; Luh Santhi Utami Wiryani; Setiaji Wisnu Wardana
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 1 (2025): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i1.255

Abstract

Completeness of prescription plays an important role in preventing medication errors that harm patients. This study aims to assess the completeness of prescriptions from administrative, pharmaceutical, and clinical aspects at Jaya Pharma 9 Pharmacy, Kediri Regency, based on the Regulation of the Minister of Health of the Republic of Indonesia No. 73 of 2016. The study was conducted descriptively retrospectively with a population of 224 prescriptions from January-March, then 100 prescription samples were taken that had met the inclusion and exclusion criteria for the period January-March 2025, which were taken using a simple random sampling technique, the data was copied on the Data Collection Sheet. The results showed that in the administrative aspect, the highest completeness was in the patient's name (100%) and the lowest in the prescription unit of origin (70%). In the pharmaceutical aspect, most elements were complete, except for incompatibility (0%). For the clinical aspect, indicators such as indications, doses, and allergies were recorded as complete (100%), while contraindications were not found (0%). In conclusion, there were still incompleteness in several aspects of the prescription, especially administrative and pharmaceutical, which needed to be improved to support standard pharmaceutical services.
UJI STABILITAS FISIK SEDIAAN EMULGEL MINYAK ATSIRI PALMAROSA (Cymbopogon martinii) Disa Andriani; Dian Puspitasari
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 1 (2025): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i1.256

Abstract

Topical anti-inflammatory treatment can be administered by formulating Palmarosa essential oil into an emulgel dosage form at concentrations of 2%, 4%, and 6%, which is then tested on rats. In topical preparations, storage conditions greatly affect stability; therefore, stability testing is necessary to determine whether the preparation remains suitable for use. This study aims to evaluate the stability of emulgel formulations containing Palmarosa essential oil. The essential oil was formulated into emulgel preparations at concentrations of 2%, 4%, and 6%. Each of the three formulations underwent physical stability tests, including organoleptic evaluation, spreadability, adhesiveness, pH, and viscosity tests, using the cycling test method for 6 cycles. Based on statistical analysis, all emulgel formulations of Palmarosa essential oil demonstrated good physical stability after the cycling test. Changes in pH, adhesiveness, and spreadability parameters were not statistically significant. Formula 3 was considered the most stable formulation, as changes across all parameters were statistically insignificant and it maintained the most consistent physical characteristics after stability testing.
FORMULASI DAN EVALUASI SEDIAAN GEL EKSTRAK KULIT BUAH SEMANGKA MERAH (Citrullus lanatus (Thunb.) Matsum & Nakai) Esti Febri Fatwami; Chaerunnisa Chaerunnisa; Dian Islamiyati
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 1 (2025): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i1.257

Abstract

Due to its tropical climate, Indonesia is highly susceptible to various types of skin damage, and dry skin problems are widespread. The research aims to investigate the use of white gel extract, a natural ingredient that can be used as a moisturizer, to manufacture gels. The research process begins with sampling, extraction, preparation of moisturizing gel preparations, concentration variations of 3gr, 4gr, and 5gr, as well as preparation evaluation including organoleptic, homogeneity, uniformity, adhesion, pH, and skin moisture testing. The evaluation results showed that the entire formula meets the parameters of good availability. A moisture effectiveness test carried out on the inner arm skin of the panel for five days showed that the skin remained moist before and after use. The humidity values of F+, F0, F1, F2, and F3 are 40.28%, 27.88%, 38.92%, 40.88%, and 42.28%, respectively. Red watermelon peel extract (Citrullus lanatus) in the form of a gel can act as a skin moisturizer and meet good gel standards.
DETEKSI MOLEKULER DAN DISTRIBUSI PATOGEN RESPIRATORI PADA KASUS INFEKSI SALURAN PERNAPASAN AKUT MENGGUNAKAN PANEL PCR Yulia Ratna Dewi; Maryoto Maryoto; Emma Ismawatie; Arum Kusuma Putri; Resi Tondho Jimat
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 1 (2025): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i1.260

Abstract

Infeksi Saluran Pernapasan Akut (ISPA) merupakan masalah kesehatan utama di seluruh dunia, dengan virus sebagai penyebab utamanya. Penelitian ini bertujuan untuk mengidentifikasi distribusi patogen penyebab gejala ISPA menggunakan panel pernapasan PCR dan menganalisis karakteristik demografi pasien yang terkena. Sebanyak 216 pasien dari Rumah Sakit Y di Jakarta didaftarkan antara Januari dan Desember 2023. Klasifikasi patogen mengungkapkan bahwa virus terdeteksi pada 94% kasus, bakteri pada 4%, dan infeksi pada 2%. Mayoritas pasien adalah anak-anak di bawah lima tahun (56%), dan ditemukan hubungan yang signifikan antara jenis patogen dan kelompok usia (p < 0,05), sedangkan tidak ada hubungan yang signifikan yang diamati antara jenis patogen dan jenis kelamin (p > 0,05). Temuan ini menyoroti dominasi infeksi virus pada kasus ISPA, terutama di antara kelompok usia yang lebih muda. Penelitian ini menggarisbawahi pentingnya pernapasan panel PCR dalam memberikan resolusi klinis dan mengurangi penggunaan antibiotik yang tidak perlu. Peningkatan pendidikan kesehatan masyarakat dan tindakan preventif sangat penting untuk mengurangi penyebaran ISPA, terutama di antara populasi yang rentan.
PENGARUH VARIASI KONSENTRASI ASAM STEARAT DAN TRIETANOLAMIN TERHADAP EVALUASI FISIK SEDIAAN LOTION EKSTRAK DAUN STROBERI (Fragaria x ananassa var Duchesne) Vania Santika Putri; Putri Ayu Widiyanti
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 1 (2025): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i1.261

Abstract

Strawberry leaves contain flavonoid, tannin, and saponin compounds that have the potential as ultra protection sunscreen with an SPF value of 52.90. Therefore, strawberry leaves have the potential to be used as active ingredients in sunscreen in the manufacture of lotion formulations. This study aims to determine the formulation and physical evaluation and the effect of variations in emulsifier concentration on the physical properties of strawberry leaf extract lotion preparations (Fragaria x ananassa var duchesne). The manufacture of strawberry leaf extract uses the maceration method with 96% ethanol solvent with a ratio of simplicia and solvent of 1:10. Lotion is made by varying the concentration of triethanolamine and stearic acid F1 (2%: 10%), F2 (3%: 11%), and F3 (4%: 12.5%). The physical evaluation carried out includes organoleptic tests, homogeneity, pH, spreadability, adhesion, viscosity, lotion type and hedonic. The results of the homogeneity and homogeneity tests of the three formulas showed that homogeneous preparations had the same color, odor, and texture. All lotion test results have met the requirements with pH in the range of 5.30±0.03 - 5.44±0.04; spreadability 5.28±0.098 - 6.35±0.360 cm; adhesion 6.23±0.394 - 10.29±0.443 seconds; viscosity 3914.1±0.91 - 3914.8±0.50 cps. Variations in the concentration of stearic acid and triethanolamine significantly affect the pH test, spreadability, adhesion and do not significantly affect the viscosity test.
PENGARUH METODE EKSTRAKSI TERHADAP KADAR FLAVONOID TOTAL DAN KADAR FENOLIK DARI BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE SPEKTROFOTOMETRI Ratih Guswinda Lestari; Alip Desi Suyono
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 2 (2025): Desember
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i2.262

Abstract

Butterfly pea (Clitoria ternatea L.) is a leguminous plant known for its pharmacological benefits. The selection of an appropriate extraction method is crucial, as it determines the amount of secondary metabolites that can be effectively extracted. This study aims to evaluate the effect of different extraction methods on the total flavonoid and phenolic content of butterfly pea flower extract (EBT). Five extraction methods were used: maceration, percolation, digestion, reflux, and Soxhlet extraction, using 96% ethanol as the solvent. Extract evaluations included tests for drying loss, ash content, ethanol-soluble extract content, and heavy metal contamination. Phytochemical screening revealed that extracts from all methods contained similar secondary metabolites, including alkaloids, flavonoids, steroids, phenolics, tannins, saponins, and essential oils. The highest total flavonoid content was found in the extract obtained by the reflux method (109.13 mg QE/g extract), while the highest phenolic content was observed in the extract obtained by the digestion method (13.87 mg GAE/g extract).
PERAN FAKTOR GENETIK DALAM PERKEMBANGAN KANKER PAYUDARA PADA WANITA USIA 30–60 TAHUN Yulita Maulani; Emma Ismawatie; Resi Tondho Jimat; Arum Kusuma Putri
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 1 (2025): Juni
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i1.263

Abstract

Breast cancer is among the most prevalent cancers in women and a leading cause of mortality worldwide. This study aims to analyze the role of genetic factors in the incidence of breast cancer among women aged 30–60 years. The study employed an analytical observational design with a cross-sectional approach, and participants were selected through purposive sampling. Data were collected from medical records and analyzed using the chi-square test. The results revealed a significant association between genetic factors—particularly a family history of breast cancer—and the occurrence of the disease. Other contributing factors included age at menarche, hormonal contraceptive use, and lifestyle habits. These findings underscore the importance of early detection and awareness of genetic risk factors to improve breast cancer prevention and management strategies.
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN ANTIBIOTIK LEVOFLOXACIN DAN AMPICILLIN SULBACTAM PADA PASIEN PNEUMONIA KOMUNITAS RAWAT INAP DI RSUD DR. MOEWARDI SURAKARTA Dyah Ayu Sudarsih; Annie Rahmatillah; Kharisma Jayak Pratama
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 2 (2025): Desember
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i2.266

Abstract

Antibiotics were commonly used for the treatment of pneumonia. Given the wide range of available antibiotic options, an analysis was necessary to determine the most effective antibiotic in terms of both therapeutic outcomes and cost. This study aimed to determine the most cost-effective antibiotic between levofloxacin and ampicillin sulbactam in the treatment of hospitalized patients with community-acquired pneumonia at Dr. Moewardi Hospital, Surakarta, during the period from January to December 2024. This observational study was designed descriptively with retrospective data collection. A total of 90 patients were selected using purposive sampling; these patients were inpatients aged ≥ 18 years with community-acquired pneumonia and complete medical records and therapy cost data. The study employed Cost Effectiveness Analysis (CEA) to assess the effectiveness and calculate the Average Cost-Effectiveness Ratio (ACER). The results showed equal usage of antibiotics: levofloxacin (50%) and ampicillin sulbactam (50%). Ampicillin sulbactam demonstrated higher therapeutic effectiveness (31.11%) compared to levofloxacin (22.22%). The ACER of ampicillin sulbactam was lower, at IDR 244,985, while levofloxacin’s ACER was higher, at IDR 370,680. It was concluded that ampicillin sulbactam was more cost-effective.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN FACE TONER KOMBINASI EKSTRAK ETANOL DAUN MINT (Mentha piperita L.) DAN BUNGA TELANG (Clitoria ternatea L.) METODE DPPH Azza Hasna Afiyah; Tiara Ajeng Listyani; Annie Rahmatillah
Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Vol. 9 No. 2 (2025): Desember
Publisher : Politeknik Indonusa Surakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/farmasindo.v9i2.267

Abstract

Mint leaves contain antioxidant compounds such as flavonoids, phenolic acids, triterpenes, vitamin C, provitamin A, mineral phosphorus, and iron. The telang flower plant is an anthocyanin antioxidant which includes natural antioxidants that have greater strength than vitamin C. The purpose of this study was to determine the antioxidant activity of a combination face toner preparation from mint leaf extract (Mentha piperita L.) and telang flower extract (Clitoria ternatea L.) DPPH method. The method used in this study was maceration extraction using 96% ethanol, preparation of the formulation by mixing mint leaf extract and butterfly pea flower extract, then adding Tween 80, glycerin, propylene glycol, nipagin, nipasol, and distilled water, stirring using a mortar and adding distilled water until reaching 100 ml. Following this, physical quality tests and physical quality data analysis were conducted using the Shapiro-Wilk test (SPSS) and antioxidant activity testing of the formulation using the DPPH method with a UV-Vis spectrophotometer. The overall physical quality test results showed good physical quality and met the physical quality test standards. The antioxidant test results for F1, F2, and F3 showed moderate antioxidant activity. The formula with good antioxidant activity was formula one with a concentration of (3:0.2), yielding a result of 115.55 ppm.

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