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Bioactivities
Published by Pandawa Institute
ISSN : -     EISSN : 2963654X     DOI : https://doi.org/10.47352/bioactivities
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Bioactivities is a double-blind peer-reviewed journal for research activity on bioactivities of materials or compounds. This journal aims to provide a means for sustained discussion of relevant issues that fall within the focus and scopes of the journal which can be examined empirically in the following fields: 1) antioxidant; 2) antibacterial; 3) antifungal; 4) antiviral; 5) antibiotic; 6) anticancer; 7) antitumoral; 8) anti-fouling; 9) anti-inflammatory; 10) antihypertensive; 11) anti-obesity; 12) antiproliferative; 13) anti-opioid; and 14) biosorption. The Bioactivities is an open-access journal containing original research articles, review articles, and short communications in the areas related to bioactivities. The Bioactivities publishes 2 issues in a year in June (first issue) and December (second issue). This journal has adopted a double-blind reviewing policy whereby the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 25 Documents
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Investigating the Antioxidant, Antimicrobial and Sensory Effects of Honey Propolis Extract as a Natural Preservative in Beef Burgers Forough Fakhraei; Alireza Masoud Nia; Fatemeh Zia Ziabari; Hamed Kioumarsi
Bioactivities Vol. 3 No. 2 (2025): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.335

Abstract

In this study, the antioxidant, antimicrobial and sensory effects of honey propolis extract as a natural preservative in beef burgers were investigated. First, propolis extract was produced at different percentages (0.5, 1.0, and 2.0%), and the control treatment, containing 0% propolis extract, was produced with a beef burger. The pH, antioxidant 2,2-diphenyl-1-picrylhydrazyl (DPPH), thiobarbituric acid (TBA), total volatile base nitrogen (TVB-N), and microbial characteristics (total microbial count, Escherichia coli, Staphylococcus aureus, mold, and yeast) and sensory characteristics (color, smell, texture and overall acceptance) during the storage period were subsequently investigated over a period of 8 days (0, 4, and 8). The results of the evaluation of different properties revealed that adding propolis extract to hamburger samples caused a significant decrease in pH, TBA, TVN, and microbial properties (total microbial count, E. coli, S. aureus, mold, and yeast) (p < 0.05). On the other hand, the amount of antioxidant property and sensory evaluation (color, smell, texture, and overall acceptance) also increased with the addition of propolis extract (p < 0.05). Additionally, the duration of storage caused a significant increase in pH, TBA, TVN, and microbial characteristics (total microbial count, E. coli, S. aureus, and mold and yeast), and a reduction in antioxidant properties and sensory evaluation (color, smell, texture, and overall acceptability) were found in hamburger samples (p < 0.05). The use of 2% propolis extract improved the oxidation properties and maintained the sensory properties during 8 days of storage for hamburger. Therefore, the use of 2% propolis extract improves the antioxidant and antimicrobial properties of hamburgers during storage and is a superior treatment.
Antimicrobial and CNS depressant activities of Premna obtusifolia R. Br. (Lamiaceae) Md. Monirul Islam; Jesmin Akter; Md. Zakir Sultan; Mohammad Shawkat Ali
Bioactivities Vol. 3 No. 2 (2025): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.336

Abstract

People in Bangladesh's rural areas have a long tradition of treating various diseases with medicinal plants. To investigate antimicrobial and central nervous system (CNS) depressant activity of Premna obtusifolia R. Br., the crude ethanolic extract of the whole plant with its various fractions (n-hexane, chloroform, and methanol soluble fractions) was used. The disc diffusion method was used to conduct an antimicrobial test at a dose of 400 µg/disc. Swiss albino mice's central nervous system activity was examined using the Open Field Test and Hole Cross Test at doses of 150 and 300 mg/kg BW. In the disc diffusion method, the various fractions didn’t show prominent antimicrobial activity. In the hole-cross test, a significant reduction (p < 0.05) in activity was observed at 30 min only for the higher dose of the crude extract and the methanol-soluble fraction. In contrast, both the n-hexane and chloroform-soluble fractions produced significant reductions at both dose levels tested. By 60 and 90 min, all treated groups exhibited statistically significant activity reduction compared to the control. Similarly, in the open-field test, all fractions significantly decreased the number of square visits at the 30-min mark. While the crude extract also reduced visits at 60 and 90 min, this effect was not statistically significant. The other fractions, however, maintained a significant reduction at these later time points. It is evident from the results above that different P. obtusifolia fractions have shown strong neuropharmacological potential in various in vivo experimental models. Therefore, it will be a possible source for a lead molecule that may be isolated to treat various diseases.
Critically Analysing Plant-based Bioactives as Anti-inflammatory Agents: A molecular Phytopharmacology Perspective Coupled with Bibliometric Data Riya Pal; Altamash Khan; Sinchan Das; Sanjay Kumar Bharti; Arjun Patra; Vivekananda Mandal
Bioactivities Vol. 3 No. 2 (2025): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.337

Abstract

This study presents a critical, mechanistic, and bibliometric analysis of plant-derived bioactive compounds for the treatment of inflammation. From a molecular phytopharmacological perspective, this review critically examines the anti-inflammatory potential of key phytochemical classes, including polyphenols, alkaloids, glycosides, tannins, and essential oils, highlighting their ability to modulate cytokines and signalling pathways such as NF-κB, MAPK, and COX/LOX. Using the Scopus database (2020–2024); 17,129 publications were evaluated to identify global research trends, co-authorship networks, and journal participation. China and India demonstrated the highest research output, while Portugal, Turkey, and Italy showed notable international collaboration and influence. A preference for open-access publishing was also observed, enhancing visibility and citation impact. Integrating bibliometric and mechanistic insights, the analysis underscores a growing shift toward evidence-based and integrative approaches in phytochemical research. Overall, plant bioactives represent a promising, multi-targeted strategy for developing safer anti-inflammatory therapeutics.
In vitro Selective Effect of Imidazole Derivatives as Inhibitors of Human Laryngeal Carcinoma Vasyl Kovalishyn; Sergiy Rogalsky; Diana Hodyna; Petro Borysko; Larysa Metelytsia
Bioactivities Vol. 3 No. 2 (2025): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.338

Abstract

Laryngeal cancer represents a significant portion of head and neck malignancies, greatly affecting quality of life. Despite advancements in treatment, late-stage mortality remains high. The HEp-2 cell line, derived from human laryngeal carcinoma, serves as an in vitro model for studying this cancer. We present in vitro results highlighting the activity of imidazole-based ionic liquids and lysosomotropic detergents as selective inhibitors of laryngeal cancer growth using the HEp-2 cell line, alongside non-oncogenic MRC-5 and HEK-293 cell lines. A comparative analysis of the selectivity coefficients reflecting the action of these imidazole derivatives on HEp-2 cancer cells, compared to their effects on MRC-5 fibroblasts and HEK-293 kidney cells, revealed that the compounds 1-dodecyl-3-methylimidazolium chloride, 1-decyloxycarbonylmethylimidazole, and 1-dodecyloxycarbonylmethyl-3-methylimidazolium chloride appear to be promising candidates with selective activity against laryngeal cancer, with anticancer selectivity coefficients ranging from 2.8 to 11.5 and 2.2 to 20.1, respectively. Especially promising is 1-dodecylimidazole, which has an average selectivity coefficient of 47,675 based on IC₅₀ values for the two non-oncogenic cell lines. Notably, the selectivity coefficients of these compounds were significantly higher—by two or more times—than those of the drug cisplatin.
A Comparative Study on Bioactivities of Aqueous Extracts from Various Parts of Moringa Oleifera Annissa Annissa; Hanif Amrulloh; Hamed Kioumarsi
Bioactivities Vol. 3 No. 2 (2025): Bioactivities
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/bioactivities.2963-654X.457

Abstract

Moringa oleifera (M. oleifera) is widely recognized as a rich source of natural antioxidants; however, systematic comparisons of the phytochemical composition and biological activities of aqueous extracts obtained from different plant organs remain limited. This study aimed to comparatively evaluate the phytochemical profiles, antioxidant capacity, antibacterial activity, and antifungal activity of aqueous extracts prepared from the leaves, twigs, stem bark, and wood of M. oleifera. Qualitative phytochemical screening, determination of total phenolic and total flavonoid contents, Fourier-transform infrared spectroscopy, 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay, and resazurin-based microdilution assays against representative bacterial and fungal pathogens were performed. Leaf and twig extracts exhibited the greatest phytochemical diversity, whereas the wood extract showed the simplest composition. The leaf extract contained the highest total phenolic content (683.95 ± 16.74 μg gallic acid equivalents mL⁻¹) and total flavonoid content (514.08 ± 26.12 μg catechin equivalents mL⁻¹), followed by the twig, bark, and wood extracts. Consistently, the leaf extract demonstrated the strongest antioxidant activity, with 64.60 ± 0.69% radical scavenging activity, approaching that of the reference antioxidant (71.72 ± 0.56%). Fourier-transform infrared spectroscopy confirmed the presence of hydroxyl, carbonyl, aromatic, and ether functional groups associated with phenolic and flavonoid compounds, particularly in leaf and twig extracts. Antibacterial and antifungal activities followed the same overall trend, with leaf extracts exhibiting the greatest inhibitory effects, followed by twig, bark, and wood extracts. These findings demonstrate that the distribution of bioactive phytochemicals is strongly organ-dependent and closely associated with antioxidant and antimicrobial activities. The study identifies M. oleifera leaves as the most promising source of water-extractable antioxidant compounds and supports their potential application in the development of sustainable functional foods, nutraceuticals, and phytopharmaceutical products.

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