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Ruth Rize Paas Megahati S
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RADINKA JAYA UTAMA PUBLISHER Radinka Jaya Utama Building 1 st Floor Jl. Kp. Baru Berok RT 005 RW 004 No. 100, Kurao Pagang Village, Nanggalo District PADANG, WEST SUMATRA, INDONESIA 25147
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Radinka Journal of Health Science
Published by Radinka Jaya Utama Publisher
ISSN : -     EISSN : 30257751     DOI : https://doi.org/10.56778/RJHS
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
The Radinka Journal of Health Science (RJHS) accepts manuscripts in the fields of : 1. Medical laboratory engineering 2. Health information management 3. Pharmacy 4. Midwifery 5. Occupational health and safety 6. Nursing 7. Physiotherapy 8. Health promotion 9. Public health 10. Medicine (miscellaneous) 11. Environmental health 12. Dental health 13. Dental engineering 14. Radiology 15. Nutrition 16. Sanitation 17. Epidemiological supervision 18. Health psychology 19. Health technology 20. Health law 21. Hospital management, etc.
Arjuna Subject : Profesi Kesehatan - Menejmen Informasi Kesehatan
Articles 58 Documents
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A Review Potential Radioprotective Mechanism of Molecular Hydrogen via Regulation of Cellular Signaling Pathways JAMAN, MD SADIKUJ
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 2 (2025): Radinka Journal of Heatlh Science RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i2.591

Abstract

Molecular hydrogen is a biologically significant molecule with diverse applications in the treatment and prevention of diseases in both humans and animals. Exposure to radiation from medical procedures such as CT scans, X-rays, and radiotherapy can disrupt normal cellular functions and cause abnormal cellular behavior. These radiation-induced effects are linked to multiple signaling pathways that contribute to cellular damage. Molecular hydrogen has emerged as a promising therapeutic agent capable of mitigating radiation-related injuries and supporting the recovery of affected cellular pathways. A thorough literature search was carried out using databases including Google Scholar, PubMed, Scopus, and ScienceDirect to obtain detailed information on radiation-related cellular signaling pathways and the possible radioprotective roles of molecular hydrogen. We identified several cellular signaling pathways associated with radiation exposure. Among them are the cell cycle checkpoint pathway, DNA repair pathways, EGFR/tyrosine kinase-mediated pro-survival signaling, Rac1-mediated signaling, ERK1/2 signaling, PI3k/AKT signaling, NF-kB signaling, autophagy signaling, HIF-1α signaling, and YAP signaling pathways. Molecular hydrogen can be administered through various delivery methods and supports the recovery of many of these pathways. It also exhibits multiple beneficial effects in both humans and animals, including antioxidant, anti-apoptotic, anti-inflammatory, and gene regulatory properties. Molecular hydrogen has emerged as one of the most promising radioprotective agents, given that radiation exposure is a major contributor to carcinogenesis and cellular damage. The objective of this review is to elucidate the cellular signaling pathways influenced by radiation and to examine the potential radioprotective mechanisms of molecular hydrogen in mitigating radiation-induced biological effects.
Water Fraction of Beetroot (Beta Vulgaris L.) as Antilipemic in Swiss Webster Male White Mice Indriati, Gustina; Ruth Rize pAAS Megahati S
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 2 (2025): Radinka Journal of Heatlh Science RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i2.597

Abstract

This research was motivated by whether the water fraction of beets can reduce total cholesterol levels in male Swiss Webster white mice. The aims of this study were: to determine the effect of giving beetroot water fraction in reducing total cholesterol levels of male Swiss Webster white mice; Knowing the most optimum dose of tuber water fraction variation in reducing total cholesterol levels of male Swiss webster white mice compared to simvastatin. The method used in this study was experimental research using Swiss Webster male white mice as test animals. The beetroots used for the research were beetroots with the criteria of 2,900 grams per tuber weighing 200-250 grams. Completely Randomized Design (CRD) with 5 treatments and 5 replications. The data obtained was processed statistically using SPSS to determine the effect of the water fraction of beets on reducing total cholesterol levels which were analyzed using the ANOVA test. The results obtained in this study were (1) The water fraction of beets had activity in reducing total cholesterol levels in male Swiss webster white mice. (2) Statistical test results of the beetroot water fraction showed that dose III (6.980 mg/20g BW) had the most optimum antilipemic activity compared to dose I (1.742 mg/20g BW) and dose II (3.484 mg/20g BW). Conclusion: The results of statistical tests of the water fraction of beetroot showed that dose III (6,980 mg/20g BW) had the most optimal antilipemic activity compared to dose I (1,742 mg/20g BW) and dose II (3,484 mg/20g BW).
Cytotoxicity Test of Ethyl Acetate Fraction and Ethanol Fraction of Papaya Leaf Extract (Carica papaya. L) Against Hep-2 Laryngeal Cancer Cells Lora Purnamasari
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 2 (2025): Radinka Journal of Heatlh Science RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i2.598

Abstract

Papaya leaves as a medicine for fever, malaria, increased appetite, constipation, and anti- cancer. In the previous study using the Brine Shrimp Lethality Test (BSLT) ethanol extract of papaya leaf had an LC50 value of 23.73 mg/ml. This suggests that the papaya leaves are a compound, which uses 70% ethanol extract of papaya leaves and has cytotoxic potential. Research objectives: This research aimed to determine the cytotoxic effect of ethanol and ethyl acetate fraction of 70 % ethanol extract of papaya leaf against Hep-2 cells. Performed in vitro by direct calculation method (viable cell count) so its LC50 is known. Ethanol and ethyl acetate fraction of papaya leaf extract as a test solution was made in 5 concentrations, with concentrations of 20.93; 16.26; 12.64; 9.82, and 7.63 µg/ml. Result: The results obtained LC50 ethanol fraction of 11.2616 μg/ml and the ethyl acetate fraction of LC50 12.4of 882 μg/ml. Conclusion: Based on this it can be concluded that the fraction of ethanol and ethyl acetate extracts of papaya (Carica papaya L.) have cytotoxic properties against Hep-2 cells in a range that goes very, very toxic ie 5-50 µg/ml and has the potential to be developed as an anticancer drug.
The effectiveness of Chest Physiotheraphy on Secretory Discharge in Children with Acute Respiratory Infection (ARI) at Ambacang Health Center Padang, Indonesia Widyastuti, Monna; Ainul Mardiah Sari; Rahmawati
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 3 (2026): Radinka Journal of Heatlh Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i3.653

Abstract

Acute Respiratory Infection (ARI) is the most prevalent disease at the Ambacang Health Center in Padang, with 966 recorded visits and many pediatric patients reporting significant difficulty in expelling phlegm. To address this, a study was conducted using a quasi-experimental design with a one-group pretest-posttest approach to determine the effectiveness of chest physiotherapy. From a population of 59 pediatric patients, 10 respondents were selected via purposive sampling for the study. Data processing involved univariate analysis through descriptive statistics and bivariate analysis using the paired t-test. The results revealed a notable increase in secretion discharge following the intervention; the average amount of secretions released rose from 1–2 ml before treatment to 2.5–4 ml afterward. Statistical analysis yielded a p-value of 0.000, confirming that chest physiotherapy is a highly effective non-pharmacological method for clearing secretions in children with ARI. Based on these findings, it is recommended that the Ambacang Health Center improve its health services by implementing chest physiotherapy as a standard clinical action for respiratory care.  
Phytochemical-Based In-Silico Study for Anti-Rabies Drug Discovery: A Pharmaceutical Perspective Ahmed, Rashed
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 3 (2026): Radinka Journal of Heatlh Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i3.480

Abstract

Rabies continues to pose a formidable global health threat, particularly in regions burdened by limited access to vaccines and effective antiviral therapies. This study utilized a high-throughput in silico approach to evaluate the antiviral potential of specific phytochemical compounds against two critical targets of the rabies virus: the glycoprotein (G protein) and the RNA-dependent RNA polymerase (RdRp). Through integrated computational methods—including molecular docking, ADMET profiling, and molecular dynamics (MD) simulations—curcumin, quercetin, and epigallocatechin gallate (EGCG) were identified as primary therapeutic candidates. Molecular docking results revealed robust binding affinity to both target proteins, suggesting a dual-action mechanism capable of inhibiting both viral entry and replication. Furthermore, absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis indicated favorable pharmacokinetic profiles, characterized by high oral bioavailability and significant blood-brain barrier permeability; the latter is a decisive factor for treating neurotropic infections. Molecular dynamics simulations further validated the structural stability of these protein-ligand complexes under physiological conditions. Collectively, these findings offer a compelling theoretical foundation for developing cost-effective and sustainable anti-rabies interventions, providing a clear trajectory for subsequent in vitro and in vivo experimental validation.
Assessing the Awareness of Risk Factors Associated with Puerperal Psychosis among Pregnant Women attending Antenatal Unit at Abubakar Tafawa Balewa University Teaching Hospital Bauchi UMAR, SALISU, Umar Muhammad; Muhammad Fatima DAMBAM; MUHAMMAD MAIMUNA; MUHMMAD Maryam Musa
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 3 (2026): Radinka Journal of Heatlh Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i3.616

Abstract

Postpartum psychosis (PPP) is a severe mental health disorder characterized by the acute onset of psychotic symptoms such as delusions, hallucinations, and mood disturbances shortly after childbirth. Although it affects 1-2 per 1,000 women globally, its impact is particularly severe in low-resource settings like Nigeria, where cultural stigma, limited mental health infrastructure, and low awareness lead to under diagnosis and poor outcomes. This study aimed to assess the awareness of puerperal psychosis among pregnant women attending the Antenatal Care (ANC) unit at Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH) in Bauchi, Nigeria. A descriptive survey design was employed, and data were collected from 129 respondents selected via simple random sampling, using a structured questionnaire. The results indicated that while a majority (71.32%) of respondents had heard of postpartum psychosis, there was a significant deficit in detailed knowledge. Only 56.53% could accurately define it as a severe mental disorder post-childbirth, and misconceptions about causes and symptoms were common. Key risk factors such as sleep deprivation, family history of bipolar disorder, and impaired mother-infant bonding were correctly identified by most. For prevention, respondents strongly endorsed educational programs, postnatal screening for high-risk women, frequent ANC visits, family support, and ensuring adequate rest. The study concludes that despite basic recognition of PPP, profound knowledge gaps persist among pregnant women in this setting. It underscores the urgent need for integrated, educational interventions during antenatal care and the routine inclusion of mental health screenings to facilitate early identification, management, and ultimately, improved maternal and infant outcomes in Northern Nigeria.
Knowledge and Practice of informed Consent among Nurses in Specialist Hospital Bauchi, Bauchi State Muhammad, Salisu Umar; MUHAMMAD Maryam Musa; MUHAMMAD Maimuna; FATIMA MUHAMMAD DAMBAM; SULEMAN AHMED WAN
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 3 (2026): Radinka Journal of Heatlh Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i3.625

Abstract

The implementation of informed consent is a fundamental cornerstone for protecting patient rights and ensuring ethical nursing practice. This study aimed to assess the level of knowledge and clinical practice regarding informed consent among nurses at specialist hospital Bauchi, Nigeria. Utilizing a cross-sectional descriptive survey design, data were collected from 87 nurses selected through convenience sampling. The research instrument consisted of a structured questionnaire, which was validated and tested for reliability, with data subsequently analyzed using descriptive statistics via SPSS Version 29. The results indicated that the nurses possessed a relatively high level of knowledge concerning the legal and ethical dimensions of informed consent, including a robust understanding of patient mental competence and risk disclosure. In clinical practice, the majority of nurses were found to regularly explain medical procedures and maintain documentation according to established standards. However, significant gaps persisted in the consistency of explaining alternative procedures and facilitating family involvement, both of which were practiced by less than 50% of the respondents. Key barriers identified in this study included language barriers, inadequate communication skills, excessive workloads, and severe time constraints. The study concludes that while nurses demonstrate adequate theoretical knowledge, systemic and interpersonal challenges continue to hinder the consistency of informed consent procedures. These findings underscore the necessity for targeted managerial interventions and professional development to optimize nursing practice within the healthcare system of Northern Nigeria.
Assessment of Multidisciplinary Collaboration Among Healthcare Workers in Primary Health Care Center Nassarawa Jahun, Bauchi. UMAR, SALISU, Umar Muhammad; MUHAMMAD, Maryam Musa; MUHAMMAD Maimuna; Muhammad Fatima DAMBAM
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 3 (2026): Radinka Journal of Heatlh Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i3.642

Abstract

Effective multidisciplinary collaboration is a fundamental pillar of high-quality primary healthcare (PHC) services and a critical driver toward achieving Universal Health Coverage. This study evaluated the extent of multidisciplinary collaboration among healthcare practitioners at the Nasarawa Jahun Community Health Center in Bauchi, Nigeria. Utilizing a cross-sectional descriptive design, the study surveyed a total population of 57 healthcare workers, including nurses, community health practitioners, laboratory personnel, pharmacists, and other allied health professionals. Data were gathered via a structured questionnaire and analyzed using descriptive statistics. The findings revealed a high level of collaboration, underpinned by robust communication, shared decision-making, mutual respect, and clear role definition. Key facilitators of this effective teamwork include supportive leadership and a positive organizational culture. Respondents indicated that such collaboration significantly enhanced the quality of patient care, improved service efficiency, and increased overall job satisfaction. The study concluded that while multidisciplinary practices at the Nasarawa Jahun PHC are well-established, there is a continuous need to strengthen interprofessional education, maintain consistent leadership support, and implement regular team-building activities to sustain these high standards of integrated care.

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