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RADINKA JAYA UTAMA PUBLISHER Radinka Jaya Utama Building 1 st Floor Jl. Kp. Baru Berok RT 005 RW 004 No. 100, Kurao Pagang Village, Nanggalo District PADANG, WEST SUMATRA, INDONESIA 25147
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Radinka Journal of Health Science
Published by Radinka Jaya Utama Publisher
ISSN : -     EISSN : 30257751     DOI : https://doi.org/10.56778/RJHS
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
The Radinka Journal of Health Science (RJHS) accepts manuscripts in the fields of : 1. Medical laboratory engineering 2. Health information management 3. Pharmacy 4. Midwifery 5. Occupational health and safety 6. Nursing 7. Physiotherapy 8. Health promotion 9. Public health 10. Medicine (miscellaneous) 11. Environmental health 12. Dental health 13. Dental engineering 14. Radiology 15. Nutrition 16. Sanitation 17. Epidemiological supervision 18. Health psychology 19. Health technology 20. Health law 21. Hospital management, etc.
Arjuna Subject : Profesi Kesehatan - Menejmen Informasi Kesehatan
Articles 58 Documents
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The Roles of Phytoalexin as Responsive Factors in Plant Disease Resistance and Its Benefit on Human Health Omeiza, Mamman Muazu; Joshua.O; Abdulkadir. A. O; Mujammed. H. O; Mubarak. S. O
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 2 No. 4 (2025): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v2i4.499

Abstract

The global challenge of food quality and safety urgently needed reform for safe consumption is closely linked to food insecurity and much emphasis is needed by farmers and plant scientists to understand the roles of phytoalexins and other natural products in the protection of economically important plants against pathogenic attacks.Despite limited experimental evidences and findings it has been suggested that phytoalexins plays major roles in disease resistance as some form of natural products which serves as antimicrobial metabolites of low molecular weight secretion which inhibit the growth of fungi pathogens while some are toxic to bacteria, nematodes and other organisms. This review provides an overview of the roles of phytoalexins a compound in plant defense and their diversity in selected plants families exploring the structural forms of its various groups as well as modes of accumulation from remote precursors through de novo synthesis of enzymes and complex defence mechanisms involving the actions of biotic and abiotic elicitors.. This article further highlight their biosynthesis and mechanisms of action delving into the distinctive metabolic pathways involved in the formation of novel synthetic phytoalexin models, mediated by enzymatic reactions and elicitor influences, shedding light on the complex interactions underlying plant defense strategies. Conclusion is drawn to emphasizes the potential of modern molecular tools in the elucidation of the mechanisms of phytoalexin synthesis and its accumulation,through the manipulation of gene(s) directly involved in their biosynthetic pathways.to produce the compounds for human therapeutic treatment for the promotion of human health.
Bacillus Penicillin Acelase, A Key Catalyst in the Modern Antibiotic Era: A Literature Review Purnamasari, Lora
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 2 No. 4 (2025): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v2i4.506

Abstract

Penicillin acylase from the genus Bacillus plays an irreplaceable role as a key catalyst in the modern antibiotic era. This enzyme essentially facilitates the production of 6-aminopenicillanic acid (6-APA), a vital precursor for various semisynthetic beta-lactam antibiotics that continue to be the mainstay in the fight against bacterial infections. The aim of this study was to review Bacillus Penicillin Acylase: A Key Catalyst in the Modern Antibiotic Era," a literature review. This method is a more rigorous and structured approach than a traditional literature review. The goal is to minimize bias and provide a reliable and comprehensive synthesis of research relevant to a specific research question. The expected findings, based on our previous discussions and general knowledge of the field, are as follows: A literature review on "Bacillus Penicillin Acylase: A Key Catalyst in the Modern Antibiotic Era" would likely yield a comprehensive overview of the enzyme's significance, characteristics, production, and applications. The review would highlight how important Bacillus-derived penicillin acylase is for making 6-aminopenicillanic acid (6-APA). 6-APA is always pointed out as the key building block for creating many types of semisynthetic beta-lactam antibiotics, which are essential for today's antibacterial treatments. Different types of bacteria and even different strains of the same type show differences in their enzymes, such as what substances they work best with (like penicillin G or V), how active they are, the best conditions for them to work (like pH and temperature), how stable they are, and whether they produce the enzyme inside or outside the cell.
More Than Just Resistance: Understanding Bacterial Defense Mechanisms as a Source of Future Antibiotics - A Literature Review Safitri, Elza
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 2 No. 4 (2025): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v2i4.507

Abstract

The antibiotic resistance crisis is no longer just a medical issue, but has become an urgent global health threat that has the potential to cripple progress in treating infections. The aim of this study was to review More Than Just Resistance: Understanding Bacterial Defense Mechanisms as a Source of Future Antibiotics - A Literature Review. This method is a more rigorous and structured approach than a traditional literature review. Results of the study Studying bacterial defense mechanisms in depth can reveal new molecular targets that are essential for bacterial survival or virulence, but different from those of traditional antibiotics. Attacking these targets can disable bacteria or make them more susceptible to the immune system or existing antibiotics. Examples include targeting efflux pumps, biofilm-forming components, or bacterial DNA repair systems. Development of Defense Mechanism Inhibitors: Instead of killing bacteria directly, we can develop molecules that specifically inhibit their defense mechanisms.
Occupational Risk Assessment Using the Rapid Entire Body Assessment (REBA) Method in Furniture Work at Tiara Perabot, Padang City Danhas, Yunhendri; Prihartono, Agus Teguh
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 1 (2025): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i1.554

Abstract

World Health Organization (WHO) Tahun 2021 menyatakan bahwa sekitar 1,71 miliar orang mengalami gangguan Musculoskeletal Disorders (MSDs) di seluruh dunia. Hal ini disebabkan oleh faktor ergonomis yang ada di dunia kerja dan industri. Salah satu industri yang ada di Kota Padang adalah Tiara Perabot. Perusahaan ini memproduksi meja, pintu, lemari, dan lain lain. 3 orang di antara pekerja, telah mengalami ganngguan Musculoskeletal Disorders. Keadaan ini melatarbelakangi penelitian terkait dengan ergonomi dengan menerapkan metode REBA (Rapid Entire Body Assesment). Tujuan penelitian adalah untuk menilai potensi risiko cidera Muskuloskeletal Disorders pada pekerjaan industri mebel. Jenis penelitian yang digunakan adalah penelitian kuantitatif yang bersifat deskriptif. Populasi dalam penelitian ini adalah semua pekerja yang berjumlah 10 orang pekerja. Dari hasil penelitian didapat bahwa merakit kayu memiliki level risiko paling tinggi (8), dibanding dengan pekerjaan pengukuran kayu, memotong dan mengetam kayu, sampai pada ampelas dan pengecatan kayu.
The Genetic Methylation Testing: Assessing Important Genes MTHFR, MTRR, MTR, AHCY, and COMT Ahmed, Rashed; Tamim, MD.TANZIMUR RAHMAN
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 1 (2025): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i1.473

Abstract

Genetic methylation testing is a valuable method for understanding the complex biochemical processes of methylation, a core cellular function influencing gene expression, detoxification, neurotransmitter balance, and overall metabolic health. This study is interested in assessing five critical genes — MTHFR, MTRR, MTR, AHCY, and COMT — that regulate the methylation cycle and influence important physiological functions. Mutations in these genes can disrupt methylation processes and result in numerous health disorders, including cardiovascular disease, neurological diseases, and detoxification dysfunction.Through a literature review and mixed-methodology study, this research determines the individual functions of each gene in methylation. The MTHFR gene is crucial in the metabolism of folate to its active form, and its mutations link to elevated levels of homocysteine, which have cardiovascular implications. The MTR and MTRR genes regulate homocysteine to methionine conversion, and polymorphisms in them may result in metabolic disruptions. The AHCY gene regulates the breakdown of S-adenosylhomocysteine for efficient donation of methyl groups, and COMT plays a crucial role in catecholamine metabolism affecting mood and stress.The study calls attention to the clinical relevance of these genetic mutations, requiring tailored treatments such as tailored supplementation with methylated B vitamins, diet modification, and precision medicine interventions. Significant barriers are the complexity of gene-environment interactions and the need for standardization procedures for interpretation of genetic data. Future trends include extension of genetic screening with more extensive gene panels and integration of methylation insights into the art of medicine for more patient-specific care.
Prevalence and Associated Risk Factors of Pregnancy Induced Hypertension Among Pregnant Women at Burao General Hospital, 2024 Ahmed, Sadam Ismail; Awed, Abdiwahab Ahmed; Guled, Abdirizak Ahmed
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 1 (2025): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i1.513

Abstract

This research, conducted as a cross-sectional study at Burao General Hospital in 2024, aimed to determine the prevalence and associated risk factors of pregnancy-induced hypertension (PIH). The study, which utilized a sample of 77 randomly selected pregnant women, found that a significant portion of participants, 27.3%, had been diagnosed with PIH, while the majority (72.7%) had normal blood pressure. The analysis, performed using SPSS version 21, identified several key risk factors strongly associated with PIH. The study found a statistically significant link between PIH and whether a woman had received antenatal care (ANC) follow-up before data collection, a personal history of chronic hypertension, and a family history of chronic hypertension. The p-values for these associations were 0.040, 0.000, and 0.001, respectively, indicating a high degree of statistical significance. These findings highlight a concerning prevalence of PIH in the study population and underscore the importance of targeted interventions. To improve maternal and fetal outcomes, the researchers recommend increasing initiatives for both pregnant women and healthcare providers regarding the risks and early signs of PIH. Additionally, they stress the need for regular ANC visits and lifestyle modifications to manage risk. For women identified as high-risk, the study recommends developing specific intervention strategies, such as tailored treatment plans, frequent monitoring, and specialized support services. These measures are crucial to mitigating the risks associated with PIH and improving overall maternal health.
HISTOLOGICAL EFFECT OF ANTIDIABETIC HERBAL TEA ON THE KIDNEY OF ALBINO RATS INDUCED WITH ALLOXAN (DIABETES) Uwuigbe , Matthew; OHIWEREI, WISDOM; Obeagu, Emmanuel; Uwuigbe, A.A; Edebiri, Ogbemudia
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 1 (2025): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i1.549

Abstract

Background: The kidneys are central to the human excretory system, crucial for maintaining homeostasis. Diabetes mellitus, a prevalent metabolic disorder, commonly leads to serious complications, including diabetic nephropathy. This study investigated the protective effects of an antidiabetic herbal tea on the kidneys of alloxan-induced diabetic albino rats, exploring its potential as a complementary treatment. Methods: Thirty albino rats were randomly assigned to five groups. Group A served as the non-diabetic control. Group B was the untreated diabetic group. Groups C, D, and E were diabetic rats that received varying doses of the herbal tea for 28 days. Body weights were monitored, and kidney tissues were examined via hematoxylin and eosin (H&E) staining to assess histological changes. Results: Untreated diabetic rats (Group B) exhibited significant weight loss and severe renal damage, characterized by interstitial edema, glomerular detachment, and inflammatory cell infiltration. In contrast, the treated groups (C-E) showed dose-dependent renal protection. Group E, receiving the highest dose, displayed the least damage with relatively intact glomeruli. While the herbal tea mitigated weight loss and kidney damage, it did not completely prevent nephropathy, as some tubular basement membrane disorganization persisted. Conclusion: This study confirms that untreated diabetes causes marked weight loss and significant kidney damage. The antidiabetic herbal tea provided a partial protective effect on the kidneys and moderated weight loss in diabetic rats. However, since complete prevention of nephropathy was not achieved, the herbal tea should be considered a beneficial complementary therapy rather than a standalone treatment for managing diabetic complications A concise and factual abstract is required (maximum length of 200 words). The abstract should state briefly the purpose of the research, the principal results, and major conclusions. An abstract is often presented separately from the article, so it must be able to stand alone. References should, therefore, be avoided, but if essential, they must be cited in full, without reference to the reference list. Non-standard or uncommon abbreviations should be avoided, but if essential they must be defined at their first mention in the abstract itself.  
Histological Effect of Antidiabetic Herbal Tea on The Spleen of Albino Rats Induced with Alloxan (Diabetes) Uwuigbe, Matthew; OHIWEREI, WISDOM; Ogbe, Clementina; Obeagu, Emmanuel; Ohiwerei, Faith
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 1 (2025): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i1.550

Abstract

This study investigated the effects of an anti-diabetic herbal tea on splenic histology and body weight in alloxan-induced diabetic Wistar rats. Thirty rats were divided into five groups (n=6): a positive control (Group A), a negative diabetic control (Group B), and three experimental groups (Groups C, D, and E) that received 3.4 ml, 6.7 ml, and 13 ml of the herbal tea, respectively, for 14 days. Body weight was recorded before and after treatment, and spleen tissues were analyzed histologically with H&E staining. The results showed that the diabetic control group (Group B) had a significant decrease in body weight (p=0.01), while the positive control group (Group A) showed no significant change (p=0.85). In the treatment groups, a low dose (Group C) resulted in a significant weight reduction (p=0.03), whereas higher doses (Groups D and E) showed non-significant trends toward weight loss (p=0.07 and p=0.08, respectively). Histological analysis revealed splenic infarcts and coagulative necrosis in the diabetic control group. The low-dose group (Group C) exhibited inflammatory changes and congestive splenomegaly. In contrast, the moderate-dose group (Group D) showed a near-normal splenic architecture, and the high-dose group (Group E) displayed a preserved fibroelastic capsule. These findings indicate that the anti-diabetic herbal tea has dose-dependent effects on body weight and spleen histology. Specifically, a moderate dose (6.7 ml) restored splenic structure, while a higher dose (13 ml) provided structural protection, suggesting its potential as a therapeutic agent for managing diabetes. The study underscores the importance of proper dosing to optimize therapeutic outcomes.  
The Gliadin and Casein Metabolism: Synthesis of Gliadomorphin and Casomorphin and Their Biological Consequences Mr. MD.TANZIMUR RAHMAN TAMIM, Mr. MD.TANZIMUR RAHMAN TAMIM; Rashed Ahmed
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 2 (2025): Radinka Journal of Heatlh Science RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i2.474

Abstract

Gliadin (from gluten) and casein (from milk) are major dietary proteins that, upon incomplete digestion, yield biologically active opioid peptides known as gliadomorphin and casomorphin, collectively referred to as "exorphins." These peptides are increasingly recognized for their role in numerous physiological and pathological processes, particularly concerning the gut-brain axis. Methodology and Findings: This analysis describes the intricate enzymatic hydrolysis of gliadin and casein, resulting in the creation of these opioid peptides. Gliadomorphin and casomorphin are shown to cross the intestinal and blood-brain barriers, subsequently binding to opioid receptors. Their activity influences pain sensitivity, immunity, mood regulation, and mental processing. Emerging evidence suggests their involvement in disease states such as celiac disease, autism spectrum disorder (ASD), schizophrenia, and irritable bowel syndrome (IBS) through mechanisms involving altered neurotransmission, immune activation, inflammation, oxidative stress, and increased intestinal permeability. Interventions and future directions: Current and potential interventions focus on mitigating these harmful effects. Strategies include the consumption of gluten-free and casein-free diets, supplemental enzyme use (e.g., Dipeptidyl Peptidase IV/DPP-IV), modulation of the gut microbiota, and pharmacological interventions like opioid receptor antagonists and zonulin blockers. Future research necessitates the development of sophisticated diagnostic instruments and tailored nutritional regimens based on genetic and microbiome evaluations to formulate targeted therapeutic strategies. The metabolism of gliadin and casein into potent exorphins highlights a critical link between diet and the health of the gut, immune system, and brain. Further studies of gliadomorphin and casomorphin development promise novel therapeutic strategies for individuals affected by their biological activity.
Assessment of Mothers’ Awareness and Practice in the Prevention of Malnutrition among under-five years Children in Tadnum Bogoro Local Government Area of Bauchi state Salisu, Umar Muhammad; SULEMAN AHMED WAN; Dambam, Fatima Muhammad; Muhammad Maimuna; Anas Babangida
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 3 No. 2 (2025): Radinka Journal of Heatlh Science RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v3i2.587

Abstract

The study was conducted in Tadnum Community, Bogoro Local Government Area, Bauchi State, to assess mothers’ awareness and practices in the prevention of malnutrition among under-five children. The main objective was to evaluate mothers’ awareness regarding malnutrition prevention. A descriptive survey design was used, involving 108 mothers selected through the snowball sampling technique. Data were collected using structured questionnaires and analyzed using SPSS version 29.0. Results were presented through frequency tables, percentages, means, pie charts, and standard deviations. Findings revealed that mothers had good awareness of malnutrition, as most agreed that proper nutrition during pregnancy supports fetal growth, with a mean score of 2.8. However, their preventive practices were found to be low. About 57% of mothers did not practice exclusive breastfeeding, while 54% failed to maintain a balanced diet during pregnancy. Factors hindering effective malnutrition prevention included food inaccessibility (57%) and cultural beliefs. The study recommends empowering health workers to strengthen nutrition education and support mothers in adopting good feeding practices. Promoting exclusive breastfeeding for the first six months of life and encouraging the introduction of nutritious complementary foods thereafter are essential strategies to reduce malnutrition among under-five children in the study area.

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