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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 11 Documents
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Search results for , issue "Vol 37 No 4 (2020)" : 11 Documents clear
GAMBARAN ELEKTROENSEFALOGRAFI PADA MENINGITIS TUBERKULOSIS YANG MENGALAMI BANGKITAN SIMTOMATIK AKUT Hendra Irawan; Suryani Gunadharma; Sobaryati Sobaryati
NEURONA Vol 37 No 4 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.169

Abstract

Introductions: Electroencephalography (EEG) can detect abnormal cortical excitability, causing epileptic seizure. Acute symptomatic seizure can caused by tuberculous meningitis (TBM) which can further develope to symptomatic epilepsy. We are interested to study the characteristic of EEG pattern in TBM patients with acute symptomatic seizure. Aims: To investigate characteristic of EEG pattern in TBM with acute symptomatic seizure. Methods: This was an descriptive observational study, from secondary medical record datas and EEG reports from acute symptomatic seizure patients caused by TBM during admited in Hasan Sadikin General Hospital, in 11 years periode from January 2006 to December 2016. Results: Fourty four subjects were enrolled in this study. The EEG pattern showed focal slowing 70.5%, 61.4% had unilateral focal slowing, and 9.1% had bilateral focal slowing. Focal epileptogenic waves were only found in 25.0% and 4.5% showed triphasic waves. Discussion: Electroencephalogram in acute symptomatic seizure due to TBM showed abnormality in 100% subjects. Almost all EEG abnormality concordances with neuro imaging findings. Keyword: Acute symptomatic seizure, EEG, tuberculous meningitis
KADAR GLIAL FIBRILLARY ACIDIC PROTEIN SERUM TINGGI SEBAGAI FAKTOR RISIKO NYERI NEUROPATIK PADA KUSTA TIPE MULTIBASILER Sofyan Faridi; I Made Oka Adnyana; I Putu Eka Widyadharma; Luh Made Mas Rusyati
NEURONA Vol 37 No 4 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.170

Abstract

Introduction : Leprosy is one of the most common causes of non-traumatic peripheral neuropathy in the world. There are many factors causing neuropathic pain in multibacillary (MB) type leprosy, one of which is an increase in serum levels of glial fibrillary acidic protein (GFAP). Aim: To prove high serum GFAP levels is a risk factor for neuropathic pain in MB type leprosy in Sanglah General Hospital Denpasar. Methods: This study was an observational analytic study with a case control design conducted at the Dermato-Venerology Department outpatient and in Pathological Clinic Laboratory in Sanglah General Hospital from November 2019 to January 2020. The sample of this study is all multibacillary leprosy patients with neuropathic pain who met inclusion criteria. A total of 60 patient were willing to participate in this study, the pain scales were measured using DN4 questionnaire and GFAP serum levels were examined. Chi-square test was performed to prove high serum GFAP levels is a risk factor of neuropathic pain in multibacillary leprosy. Results: High serum GFAP levels increase the incidence of neuropathic pain of MB type leprosy 5 times higher than controls (OR 5.72; p = 0.003), anxiety (OR 2.1; p = 0.24), and leprosy reaction (OR 2.2; p = 0.052). Discussion: High serum levels of GFAP is a risk factor of neuropathic pain in MB type leprosy in Sanglah General Hospital Denpasar. Keywords: GFAP, MB type leprosy, neuropathic pain
EVALUASI TAJAM PENGLIHATAN DAN INDEKS PROPTOSIS PASIEN MENINGIOMA SPHENOORBITA PASCAOPERASI KRANIEKTOMI Renindra Ananda Aman; Ryan Rhiveldi Keswani; Syaiful Ichwan; Samsul Ashari; Setyo Widi Nugroho
NEURONA Vol 37 No 4 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.171

Abstract

Introduction: Sphenoorbital meningioma (SOM) is an exophytic tumor mass that infiltrates the bone at the sphenoid wing, lateral orbital walls, orbital roofs, and extends to superior orbital fissures. The classic triad of clinical features are proptosis, decreased visual acuity, and ophthalmoplegia. The outcomes of our postoperative patients have not been evaluated before. Aim: We would like to evaluate the clinical characteristics of the sphenoorbital menigioma patients before and after surgery. Methods: A cross sectional study was performed. Subjects were patients with sphenoorbital meningiomas who came to Cipto Mangunkusumo General Hospital from January 2014 through December 2015. All patients underwent craniectomy and lateral orbitotomy. We evaluated the visual acuity using the Snellen chart and proptosis index before and after surgery by measuring the protuded eye in an axial CT scan. Results: There were 66 samples in this study, and 65 of the samples were females. The age range is from 31 to 64 years. The mean proptosis index of preoperative is 18.27 and the post operative is 16.43. The mean proptosis index reduction is 1.84. Post operative visual acuity was improved only in 3 (9.7%) samples. Discussion: Sphenoorbital meningioma patients after surgery were shown markedly improvement in the proptosis index. However, the visual acuity was not markedly improved after surgery. Keywords: Proptosis index, sphenoorbital meningioma, visual acuity
KESINTASAN PASIEN DENGAN METASTASIS LEPTOMENINGEAL YANG DIRAWAT DI BAGIAN NEUROLOGI RUMAH SAKIT KANKER DHARMAIS DAN RSUPN DR CIPTO MANGUNKUSUMO Elsa Susanti; Rini Andriani; Tiara Aninditha; Henry Riyanto Sofyan
NEURONA Vol 37 No 4 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.172

Abstract

Introduction: Leptomeningeal metastasis is a condition where malignant cells spread to the leptomening and subarachnoid space. This is an emergency state with incident tends to increase each year. Prognosis is very poor and survival rate is only 10-15 weeks. Aim: To determine survival of leptomeningeal metastasis patients in Cancer Dharmais Hospital and Cipto Mangunkusumo Hospital. Methods: This is a retrospective cohort research based on medical records of leptomeningeal metastasis patients in Cancer Dharmais Hospital and Cipto Mangunkusumo Hospital from January 2018 to June 2019. Clinical examination, liquor cerebral examination, MRI, and histopathological of primary tumours were written. Subjects or family of the subjects were contacted to obtain information about subject’s wellbeing whether they’re still alive or dead. If they’re unreachable they will be excluded. Survival of each subject was determined based on how long the subject remain alive since being diagnosed with leptomeningeal metastasis until the end of observation, which is the end of the research. Results: Sixty two patients were included in the research, 21 were males and 41 were females. Headache was the most frequent symptoms found in the patients (46.8%) followed by cranial nerves deficits (45.2%). Median survival in this research was 13 weeks, no significant differences in survival from haematologic malignancy and solid tumor. Discussion: Median survival of leptomeningeal metastasis patients was 13 weeks, there was no statistically significant difference between survival of heamotologic malignancy and solid tumor. Median survival in leptomeningeal metastasis in this research remain poor regardless the origin of the metastasis. Keywords: Haematologic malignancy, leptomeningeal metastasis, solid tumor, survival
MIKROALBUMINURIA SEBAGAI PREDIKTOR LUARAN BURUK STROKE ISKEMIK AKUT DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR Hesti Heptaningrum; I Made Oka Adnyana; Thomas Eko Purwata
NEURONA Vol 37 No 4 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.173

Abstract

Introduction: Microalbuminuria is one of indicators for systemic endovascular damage related to endothelial damage and dysfunction. Microalbuminuria has become an important risk factor for predicting the risk and prognosis of cerebrovascular disease. However, its association with acute ischemic stroke remains unclear, particularly those related with other comorbidities. Aim: To address the role of microalbuminuria as a predictor of poor neurological outcome among patients with acute ischemic stroke at Sanglah Hospital Denpasar. Methods: This was a prospective cohort study involving acute ischemic stroke patients admitted at Sanglah Hospital Denpasar during October to December 2018. All patients who fulfilled inclusion and exclusion criteria and provided consent to participate in the study were included. Microalbuminuria was measured with albumin to creatinine ratio with concentration of 30–300mcg/mg. Stroke outcome was classified into either good or poor according to early and late National Institutes Health Stroke Scale (NIHSS) score (during patient’s admission and 7th day, respectively). Bivariate and multivariate statistical analyses were conducted. Results: Sixty patients were recruited. Microalbuminuria increased poor neurological outcome among stroke patients significantly (RR 5.47; 95% CI 2.17–13.8; p<0.001). Multivariate analysis demonstrated that microalbuminuria (RR=21.99; 95% CI 2.01-240.41; p=0.011), DM (RR=11.66; 95% CI 2.00–67.65; p=0.006), and dyslipidemia (RR 11.45; 95% CI 1.10–119.23; p=0.041) as an independent predictor of poor neurological outcome among acute ischemic stroke patients. Discussion: Therefore, microalbuminuria is consistently independent predictors of poor outcome in admitted acute ischemic stroke patients. Keywords: acute ischemic stroke, microalbuminuria, poor neurological outcome
KARAKTERISTIK METASTASIS SISTEM SARAF PUSAT DARI KANKER PARU Tan Yosephine; Tiara Aninditha; Henry Riyanto Sofyan; Jonathan Odilo; Rini Andriani
NEURONA Vol 37 No 4 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.174

Abstract

Introduction: As much as 40% of lung cancer patients will experience central nervous system (CNS) metastasis in the course of the disease. From those 40%, as much as 3-9% will experience leptomeningeal metastasis, but the clinical profile of CNS involvement in lung cancer has never been studied before in Indonesia. Aim: To give a description of CNS metastasis from lung cancer inCipto Mangunkusumo General Hospital and National Cancer Referral Dharmais Hospital. Methods: This is a cross-sectional study done in patients consulted to Neurology Department inCipto Mangunkusumo General Hospital and National Cancer Referral Dharmais Hospital in 2018. Inclusion cirteria is adult patients diagnosed with lung cancer based on histopathology with complete medical record to the extent of CT scan or Head MRI with contrast. Results: There were 48 subjects with median age of 57 (36-76) years, men were more than women (56.2% vs 44.8%) and 31.3% had history of smoking. The most frequent lung cancer type is non-small cell lung cancer (NSCLC) (93,8%). Neurological symptoms found were motoric deficits (62.5%), headache (43.8%), cognitive dysfunction (20.8%), and seizure (18.8%). Majority of subjects suffered from brain metastasis (93.8%) and 8.3% were leptomeningeal metastasis. Discussion: The majority of CNS metastasis were brain metastasis from NSCLC (93.8%) with main neurological deficits were motoric deficits (62.5%) and headache (43.8%). Keywords: Brain metastasis, lung cancer, non-small cell lung carcinoma
HUBUNGAN WAKTU TUNGGU MENUJU OPERASI PENGANGKATAN TUMOR INTRAKRANIAL DENGAN SKALA PERFORMA KARNOFSKY PASCAOPERASI Setyo Widi Nugroho; Aryandhito Widhi Nugroho; Renindra Ananda Aman; Hanif Gordang Tobing
NEURONA Vol 37 No 4 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.175

Abstract

Introduction: The waiting time to elective intracranial tumor removal surgery in Indonesia is unknown, let alone its association with postoperative functional outcome. Aim: To identify the waiting time to elective intracranial tumor removal and to analyze its association with poor functional outcome, defined by 3-months postoperative Karnofsky Performance Scale (KPS score) of <70. Methods: This medical record-based retrospective study was performed on intracranial tumor patients underwent elective tumor removal surgery in 2016. Multivariable logistic regression analyses were utilized to determine any significant association between waiting time to elective intracranial tumor removal surgery and poor functional outcome, adjusting for age, sex, preoperative KPS score, pre- and postoperative tumor volume, percentage of tumor removal, tumor histopathology, and grading. Results: Data were obtained from 191 patients, with histopathology distributions as follows: 49% meningiomas, 22% pituitary adenomas, 9% astrocytomas, 3% metastatic tumors, 3% primary central nervous system lymphomas, 2% oligodendrogliomas, 2% craniopharyngiomas, and 10% others. Overall median (min-max) of waiting time to elective intracranial tumor removal surgery was 35 (0-529) days. Significant association between waiting time to elective intracranial tumor removal surgery and poor functional outcome was evident in univariable analysis (OR 1.004), but not in multivariable analysis. The collinearity value of pre- and postoperative tumor volume, percentage of tumor removal with waiting time were, respectively, 5.92; 5.69; and 3.2. Discussion: There was no significant association between waiting time to elective intracranial tumor removal surgery and poor functional outcome. Strong collinearities were identified between pre- and post-operative tumor volume, percentage of tumor removal and waiting time to elective intracranial tumor removal surgery. Keywords: functional outcome, intracranial tumor, removal surgery, waiting time
UJI VALIDITAS DAN RELIABILITAS KUESIONER THE 15-ITEM MYASTHENIA GRAVIS QUALITY OF LIFE SCALE VERSI BAHASA INDONESIA (MG-QOL15 INA) Fitri Octaviana; Ahmad Yanuar Safri; Fikry Syahrial; Luh Ari Indrawati; Winnugroho Wiratman; Manfaluthy Hakim
NEURONA Vol 37 No 4 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.176

Abstract

Introduction: Myasthenia gravis (MG) is a chronic autoimmune disease in the neuromuscular junction characterized with fluctuating weakness symptoms. Advance in the diagnosis and management of MG cases increases the patient’s life expectancy therefore the evaluation of therapeutic success is no longer based solely on coping with the symptoms, but also in evaluating the quality of life of patients. The 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) is a questionnaire utilized today to evaluate the quality of life of MG patients. Aims: To obtain a valid and reliable Indonesian version of MG-QOL15 instrument. Methods: Forty four MG patients at the Cipto Mangunkusumo Neurology outpatient clinic who met the inclusion criteria were included in this cross sectional study. Patients filled in the MG-QOL15 questionnaire twice at two days interval. The concept used for the validity test of MG-QOL15 INA is cross-cultural validation according to World Health Organization (WHO) method. Reliability test was assessed using Cronbach alpha value. Results: We performed WHO cross-cultural validation on MG-QOL15 INA and obtained Spearman correlation coefficient values ranging from 0.568-0.789 at the first examination and 0.574-0.763 at the retest. Cronbach’s alpha value at the first examination was 0.917 and 0.909 for the retest. Discussion: MG-QOL15 INA is valid and reliable to be used as an instrument in evaluating the quality of life of MG patients. Keywords: Myasthenia gravis, MG-QOL15, quality of life
DRY NEEDLING SEBAGAI TERAPI NYERI MIOFASIAL SERVIKAL Hanik Badriyah Hidayat; Annisa Oktavianti
NEURONA Vol 37 No 4 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.177

Abstract

Cervical myofacial pain (CMP) is a common source of nonspecific chronic neck pain. Pain can be local, regional and can also it has many many trigger points (trigger points / TrPs). CMP causes pain in the area of the cervical muscles and surrounding fascia. Neck pain reduces quality of life, productivity; furthermore, it also causes disability so that it affects socioeconomically towards patients and the community.Treatment of cervical myofacial pain syndrome is still unsatisfactory due to its chronicity. Dry needing (DN) is one of the nonpharmacological therapy option that can be applied in CMP. DN reduces peripheral and central sensitization by eliminating sources of peripheral nociception (MTrPs area), modulating dorsal horn activity and activating central pain inhibitory pathways.Recently, the DN therapy has been rapidly develop in pain management. However, the effectiveness of DN therapy is still unclear. Therefore, knowledge about the role of DN in CMP is important to be known. This article will discuss the role of DN in cervical myofacial pain syndrome.Keywords: Cervical myofacial pain, dry needling, myofascial trigger points, therapy
PENGGUNAAN TOKSIN BOTULINUM-A DENGAN PANDUAN ULTRASONOGRAFI SEBAGAI TERAPI SINDROM PIRIFORMIS REKUREN: SERIAL KASUS Yusak Mangara Tua Siahaan
NEURONA Vol 37 No 4 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i4.178

Abstract

Piriformis syndrome (PS) is a clinical syndrome with complaints of buttock pain that radiates to the unilateral side leg caused by sciatic nerve entrapment of piriformis muscle. Several therapy modalities of PS are oral, physical, intervention, and surgical therapy. Intramuscular injection therapy is an intervention therapy for patients who experience severe pain or have failed oral therapy and/or physical therapy. It generally involves the use of local anesthetics, corticosteroids or the botulinum toxin A. This study represents five cases of short-period recurrent PS in 4 females and 1 male with age variations from 32 to 43 years-old. All cases complained classic symptoms with sub-acute to chronic onset and previously had a conservative-interventional therapy. Long-term improvement (>9 months) was experienced after intramuscular botulinum-toxin-A injection with ultrasound-guided. Keywords: Botulinum toxin, injection therapy, piriformis syndrome.

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