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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 12 Documents
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Search results for , issue "Vol 38 No 1 (2020)" : 12 Documents clear
HUBUNGAN ANTARA KADAR SEROTONIN SERUM DENGAN FUNGSI KOGNITIF PADA PASIEN NYERI KEPALA TIPE TEGANG KRONIS Ega Primadona; Dwi Pudjonarko; Dani Rahmawati; Endang Kustiowati; Herlina Suryawati; Trianggoro Budisulystio
NEURONA Vol 38 No 1 (2020)
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Introduction: Chronic tension-type headache (CTTH) is a major health problem, although the previous data is very limited, especially in Indonesia. Cognitive disorders often occur in CTTH patients. In addition, stress factors (mental or physical), anxiety, depression, temperamental instability, that is, bigger emotional status are factors that can cause CTTH. Serotonin is involved in various behavioral functions, especially in the regulation of mood, aggressiveness and impulsiveness. Aim: To analyze the relationship between serotonin serum level with cognitive function on CTTH. Methods: This was a cross sectional study in the outpatient of neurological clinic dr. Kariadi Hospital Semarang between April - September 2019. The data consist ofserotonin levels, MoCA-Ina questionnaire, Hamilton Depression Rating scale (HDRS) score and Score Hamilton Anxiety Rating scale (HAM-A). Statistical analysis with fisher’s exact. Results: The data were obtained from 38 subjects which consisted of female (78.9%) and male (21.1%). There was a significant relationship between anxiety and cognitive function in CTTH. There was no significant relationship between depression and cognitive function on CTTH. Impaired cognitive function in CTTH is related to memory (90%) and executive domains (70%) in most cases. Discussion: There was no significant difference between normal and abnormal serum serotonin levels with impaired cognitive function. There was a significant association between low serum serotonin levels and anxiety in CTTH patients. There was no association between low serum serotonin levels and depression in CTTH patients. CTTH patients experienced cognitive impairments regarding memory and executive domains in most cases. Keywords: Chronic tension type headache, cognitive, MoCA-Ina, serotonin
PERBEDAAN PENGETAHUAN, SIKAP DAN PERILAKU PENDERITA, KELUARGA DAN MASYARAKAT TERHADAP EPILEPSI Suryani Gunadharma; Paranita Utama; Sobaryati Sobaryati; Ahmad Rizal; Lisda Amalia; Uni Gamayani
NEURONA Vol 38 No 1 (2020)
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Introduction: Achievement of epilepsy treatment depends on the understanding of patients about their disease, compliance of antiepileptic drugs,family and communities support. Gender, age, level of education, socio-cultural, economic status,and environment affect epilepsy perceptiont. Aim: To analyze the difference in knowledge, attitudes, and behavior of epilepsy patients, families and communities with different sociodemographic backgrounds. Methods: This was a cross sectional comparative analytic study. Chi-square test was used for statistical analysis. Three validated questioners were used for each groups. Results: About 264 subjects were enroled consist of 88 subjects for each groups. Men and women was almost the same amount. The most age was 36-45 years, high school was the majority of the education level. The most types of job were housewive, most of the economic level is low. There were differences in knowledge, attitudes, and behavior related to epilepsy in this 3 groups based on level of education, socio-economic and employment, except for age. Male has a better behaviour towards epilepsy . Discussion: Our results similar with the study about epilepsy patients in Ethiopia, similar with study about epilepsy families in Sudan, Korea, and similar with community study in Malaysia except for age. For counseling it’s better to separate the groups regarding level of education and sosio-economic. Keywords: Attitude, behavior, epilepsy, knowledge
PENGARUH DERAJAT KEGANASAN TUMOR TERHADAP POLA GAMBARAN EEG PADA PENDERITA TUMOR OTAK PRIMER DI SUMATERA SELATAN Wilasari Novantina; Yunni Diansari; Sri Handayani; Achmad Junaidi; Aspitriani Aspitriani; Irsan Saleh
NEURONA Vol 38 No 1 (2020)
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Introduction: Brain tumor is one of the major malignancies with high morbidity and mortality. Treatment options and prognosis in patients with primary brain tumors based on the type and degree of malignancy. Definitive diagnosis and degree of malignancy in patients with primary brain tumors obtained from histopathological features. But unfortunately, histopathological features are not always available in all primary brain tumor sufferers. Electrenefalography (EEG) examination is a non-invasive examination that can record biological activity and neuron changes in brain cells. Brain tumor itself is an abnormal mass in the brain tissue that interferes with the electrical and biological activity of normal cells in the brain. Aim: To determine the association between the degree of malignancy of brain tumors and EEG patterns in patients with primary brain tumors in RSUP Dr. Mohammad Hoesin Palembang. Methods: This was a cross sectional study. The study sample was primary brain tumor patients who had undergone surgery and had EEG record and histopathological features.Data were analysed using SPSS 22. Results: The data obtained from 36 samples consist of 30 samples of low grade brain tumor patients, and 6 high grade brain tumor patients. There was a weak correlation between the degree of malignancy with focal slowing EEG pattern (r = 0.378; p = 0.014). There was no correlation between the degree of malignancy with epileptiform discharge (r = 0.177; p = 0.281), focal slowing accompanied by epileptiform discharge (r = 0.215; p = 0.187) ) and normal EEG (r = 0.110; p = 0.506). Discussion: The focal slowing EEG pattern has a correlation with the degree of malignancy. This is due to changes in peri-tumoral metabolism which is common in brain tumors Keywords: brain tumor, eeg pattern, degree of malignancy
KORELASI KADAR D-DIMER DENGAN JUMLAH SINUS VENA SEREBRAL PADA PASIEN CEREBRAL VENOUS THROMBOSIS Aditya Kurnianto; Yovita Andhitara; Dodik Tugasworo; Retnaningsih Retnaningsih; Rahmi Ardhini; Vivi Kristiani Rumapea; Jethro Budiman
NEURONA Vol 38 No 1 (2020)
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Introduction: Cerebral venous thrombosis (CVT) is a rare yet potentially devastating disease. According to the Virchow Triad, one of the predisposing factors is the hypercoagulable state of the blood that can be measured with D-dimer. Aim: To evaluate the correlation of D-dimer level and number of venous sinus in patient with CVT. Methods: A retrospective study including 45 patients with CVT between January 2019-January 2020 in Dr. Kariadi General Hospital, Semarang were conducted. The diagnosis of CVT was confirmed by digital subtraction angiography (DSA). Data on coagulation profile including platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen level, and d-dimer level were collected. The correlation between the D-dimer level and the number of the venous sinus was analyzed by Spearman’s rank correlation test. Results: Most of the sample were female with the mean age of 39.6 years. Multiple venous sinus occurred in 24 patients, and the most location of the CVT was sagittal sinus. The mean platelet count was 296,000cells/mcL, mean fibrinogen 326.9mg/dL, mean APTT 34s, mean PT 12.4s, and the median D-dimer level was 556.5ng/mL. There was a moderate correlation of D-dimer level and number of venous sinus (p=0.000, r=0.529). Discussion: D-Dimer level in CVT patients were elevated. The increased level of D-dimer was associated with multiple cerebral venous sinus in CVT patients because the extension of thrombosis causing an increase in D-dimer level. Keywords: coagulation, CVT, D-dimer, cerebral venous sinus
KORELASI KADAR ASAM URAT DALAM DARAH TERHADAP LUARAN KLINIS STROKE ISKEMIK AKUT Daniel Mahendrakrisna; Aria Chandra Gunawan Triwibowo Soedomo
NEURONA Vol 38 No 1 (2020)
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Background: Uric acid is an end metabolism product of purine. It has been known as an important antioxidant in the serum. Correlation between uric acid serum with stroke has been reported controversial finding. However, Uric acid has been proposed to be a stroke risk factor. Aim: To determine the correlation between uric acid serum levels and acute stroke ischemic outcome. Method: This was a cross-sectional study at Surakarta Hospital. All of first experience stroke ischemic patients proven by CT-Scan were included as subjects. Demographic data (age, sex, blood pressure, etc) and laboratory results such as uric acid 24 hours, blood glucose test (random glucose test and fasting glucose test), lipid profile (cholesterol, triglyceride) were obtained from medical records. Data was analysed by software and p<0.05 was statistically accepted. Results: Of 49 acute stroke ischemic patients were include to this study. The mean of uric acid level serum as 5.71±2.64 mg/dL. 30,6% subjects had hyperuricemia and 8,2% subjects had hypouricemia. There were no correlation between uric acids levels with stroke clinical outcome (r= 0.08, p>0.05). Conclusion: There was no correlation between uric acid serum levels and acute stroke ischemic outcome.. Keywords: Ischemic, Modified Rankin Scale,
PENGARUH POLA MAKAN TERHADAP KEJADIAN STROKE HEMORAGIK DI RUANG POLIKLINIK SARAF RSUD TGK CHIK DITIRO SIGLI Teuku Jauhardin; Rachmat Andi Hartanto; Endro Basuki; Ismail Setyopranoto
NEURONA Vol 38 No 1 (2020)
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Introduction: Intracerebral hemorrhage accounts for ~ 10% of all strokes and is associated with high mortality. Aceh province has a prevalence of stroke as much as 6.6 per mile. The diet pattern of Acehnese people tends to be high in fat and protein but low in fiber causes an imbalance in nutrient intake, a risk factor for hemorrhagic stroke. Aim: To determine the effect of eating patterns in the incidence of hemorrhagic stroke in the polyclinic of neurology at RSUD Tgk Chik Ditiro Sigli. Methods: Observational analytic with case control design. Cases were hemorrhagic stroke sufferers, controls were healthy subjects who did not suffer from hemorrhagic strokes and did not have risk factors for hypertension and diabetes mellitus. The number of subjects is 136 subjects.. Eating patterns data is collected using a modified qualitative food frequency form. The results of the study were analyzed using Chi-square, and logistic regression tests. Results: Data obtainained from this research is average age of study subjects was 46.69 years. As many as 73% of subjects were male. The results showed risk factors that were proven to have a significant relationship with the incidence of hemorrhagic stroke were low fiber consumption (OR= 3.61; p= 0.022), obesity (OR= 9.16; p<0,001), smoking (OR= 6,31; p= 0,004), lack of physical activity (OR= 5.53; p= 0,002), LDL-Cholesterol (OR= 8.74; p= 0.003). Discussion: Lack of fiber consumption were proven to increased the incidence of hemorrhagic stroke. Obesity is a risk factor that has the most influence on the incidence of hemorrhagic stroke. Keywords: eating patterns , hemorrhagic stroke, stroke risk factors.
SEBARAN GANGGUAN NEUROPSIKIATRI PADA STAF MEDIK NEUROLOGI SELAMA PANDEMI COVID-19 Rini Nindela; Yunni Diansari; Sri Handayani; Selly Marisdina; Bintang Arroyantri Prananjaya
NEURONA Vol 38 No 1 (2020)
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Introduction: Corona Virus Disease-2019 (COVID-19) is a new disease designated as a global pandemic by WHO after causing a large number of deaths in a short period of time in various parts of the world. The COVID-19 pandemic has not only caused physical impacts, but also mental fatigue on the community, especially health workers as the frontline in handling COVID-19. Aim: To determine the distribution of neuropsychiatric symptoms among neurological medical staff that have occurred since the COVID-19 pandemic. Methods: This research was a descriptive study with a cross-sectional approach, taking place from May to June 2020 and was conducted on neurological medical staff who were members of the PERDOSSI and students participating in the Neurology specialist education program. Data collection was carried out using a questionnaire, namely the Beck Anxiety Inventory to assess anxiety, the Beck Depression Inventory to assess depression, the Insomnia Severity Index to assess insomnia and a checklist of questions to assess headaches that were sent online.. Results: The data obtained in this study indicate that a total of 13.6% of neurological medical staff in this study experienced anxiety, 4.5% experienced depression, 6.1% experienced insomnia, and 24.2% experienced headaches suspected to be related to COVID-19. The severity of neuropsychiatric symptoms in this study ranged from mild to moderate, none of the subjects experienced severe symptoms. Generally the subjects with these complaints were women and they did not feel safe with the personal protective equipment/PPE used. Discussion: The distribution of neuropsychiatric disorders due to the COVID-19 pandemic among neurology medical staff in the PERDOSSI’s working area is still low. Keywords: COVID-19 pandemic, neuropsychiatric disorders, neurology medical staff
PENGARUH PEMBERIAN STIMULUS MUSICAL FRISSON TERHADAP PERFORMA MEMORI JANGKA PENDEK Christopher Alvaro Dharmawan; Yosef Purwoko; Maria Belladonna Rahmawati; Hexanto Muhartomo
NEURONA Vol 38 No 1 (2020)
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Introduction: A person’s intelligence may be determined by the capacity of working and short-term memory. Stimulations restrain the early-onset neurodegenerative process and short-term memory loss. Musical frisson stimulation can increase the production of dopamine, blood flow, and activities of some parts of the brain that have roles in short-term memory process. Aims: To prove that musical frisson stimulation can increase short-term memory performance and association between the duration of frisson and short-term memory performance change. Methods: A quasi-experimental study with one group pre and post-test design was carried out among medical students of Diponegoro University. A total of 25 participants were selected by purposive sampling technique. The stimulation was by listening to mp3 of 5 researcher-selected songs that could induce frisson using an earphone before going to bed. Stimulation would last for 15 minutes in 3 consecutive days. The frisson that was felt measured by using a stopwatch in terms of minutes. Short-term memory was measured before and after the stimulation using Scenery Picture Memory Test (SPMT), so that the difference could be calculated. The collected data was then analyzed using Wilcoxon test and simple linear regression. Results: The pre-test score was 15.763.179, meanwhile the post-test score was 20 (13-23), so there was a significant increase on SPMT score (p < 0.001). Duration of the frisson had positive effect on SPMT score differences (p < 0.001). Discussion: Musical frisson stimulation can increase short-term memory performance. The frisson that lasts longer will have more significant improvement on short-term memory performance. Keywords: Duration, musical frisson, scenery picture memory test, short-term memory
FUNGSI KOGNITIF PADA PASIEN TUMOR OTAK METASTASIS PASCA RADIASI WHOLE BRAIN RADIOTHERAPY DI DUA RS RUJUKAN KANKER INDONESIA Rahmi Ardhini; Tiara Aninditha; Rini Andriani; Henry Riyanto Sofyan
NEURONA Vol 38 No 1 (2020)
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Brain metastases represent one of the most common neurological complications of systemic cancer, with an incidence was about 40%. Whole brain radiotherapy (WBRT) is a standard treatment to reduce tumor volume and increasing patient’s survival, but WBRT has a side effects due to radiation exposure to the brain parenchyma, including cognitive impairment. This was case series of 8 brain metastases patients, consist of 4 male and 4 female who have undergone radiation on April until June 2018. Cognitive function was assessed using Montreal Cognitive Assessment-Indonesian Version (MoCA-Ina) before and after WBRT. Collected data were age, sex, educational status, number of lesions, tumor site, clinical symptoms, Karnofsky Performance Status (KPS) score, extracranial metastases, radiation dose, primary cancer, hypertension, and diabetes mellitus. Most are multiple lesions and located in parietal lobe. The most common symptom was cognitive impairment. Seven patients already experienced cognitive impairment before WBRT and mostly have improved cognitive function after WBRT. Memory function was impaired in all subjects before WBRT that did not improved afterwards, but other domains including attention, language, executive function, and visuospatial were improved after WBRT. Key word: brain metastases, cognitive function, whole brain radiotherapy.
ABSES TUBERKULOSA OTAK PADA REMAJA DENGAN HIV NEGATIF Mayo Djitro; Yanto Budiman; Ronny Ronny
NEURONA Vol 38 No 1 (2020)
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Tuberculosis is highly prevalent in developing countries. It is most commonly seen infecting the lungs but can also be found as extrapulmonary tuberculosis (EPTB). Central nervous system (CNS) tuberculosis represented about 10% of EPTB. The primary form of CNS TB is meningitis TB. There are however, other rarer forms, such as tuberculous brain abscess (TBA). Abscesses are more commonly seen in immunocompromised patients. A 19 year old female came with a complaint of headache for 1 week accompanied with recurrent fever, nausea, and vomiting. Physical examination shows nuchal rigidity in the patient. Blood workup revealed that the patient was HIV negative. Primary lung tuberculosis was found in the patient on chest x-ray. On brain MRI abscesses were found. The patient was given anti-tuberculous drug regiment. Follow up brain MRI was performed 2 months after treatment with oral anti-tuberculous therapy 1x3 4 FDC (fixed drug combination). Before treatment, brain MRI with contrast showed two ring enhanced lesions with irregular border on the right cerebellum hemisphere with approximate size 2.8x2.6x1.8 cm (AP x transversal x height) with some satellite nodules and enhancements on right tentorium cerebelli. There’s also another ring enhanced lesion with irregular border on right frontal lobe pre central gyrus with approximate size 1.4x2x1.1 cm (AP x transversal x height) with perifocal oedema. Follow up MRI after oral anti-tuberculous therapy showed decreased in size for both lesions. We documented one case of brain tuberculosis in non HIV patient, which showed significant improvement after given oral anti-tuberculous drugs. Keywords: extrapulmonary tuberculosis, tuberculosis, tuberculous brain abscess

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