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Anak Agung Gde Putra Wiraguna
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Dermatology and Venereology Department, Medical Faculty, Universitas Udayana/Prof. dr. I G. N. G. Ngoerah General Hospital, 3rd Floor (Jl. Diponegoro, Dauh Puri Klod, Kecamatan Denpasar Barat, Kota Denpasar, Bali 80113)
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Bali Dermatology Venereology and Aesthetic Journal
Published by Universitas Udayana
ISSN : 30467985     EISSN : 30467993     DOI : https://doi.org/10.51559/balidervenaesthj.v6i1.33
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Bali Dermatology Venereology and Aesthetic Journal is an open access; peer-reviewed journal aiming to communicate high-quality research articles, reviews, and general articles in the Dermatology, Venereology and Aesthetic field. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of Dermatology, Venereology and Aesthetic and to encourage a vigorous dialogue between researcher, medical scholars and practitioners. The scope of this journal includes: General dermatology Venereology Cosmetic dermatology/aesthetic Pediatric dermatology Allergy and immunology Skin and tumor surgery Tropical dermatology Genodermatosis (hereditary skin disease) Travel dermatology Traditional, Complementary, and Integrative medicine in dermatology Diagnostic method and artificial intelligence in dermatology
Arjuna Subject : Kedokteran - Dematologi
Articles 75 Documents
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Incidence and characteristic of psoriasis patients at Sanjiwani Gianyar Regional Hospital 2018-2019 Annisa Alviariza; Sayu Widyawati
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/e49bmc59

Abstract

Introduction: Psoriasis is a chronic inflammatory skin disease characterized by firmly demarcated red plaque covered by a thick squama due to impaired proliferation and differentiation of the epidermis. Diagnosis of psoriasis is based on history taking and clinical features. Treatment is determined based on the patient's clinical characteristics and the severity of the disease. This retrospective study aims to determine the incidence, characteristics, and treatment options of psoriasis patients in the Dermatology and Venereology Polyclinic of Sanjiwani Gianyar Regional Hospital in 2018-2019. Methods: A retrospective study of psoriasis patients at Sanjiwani Gianyar Regional Hospital in 2018-2019. Data collected from medical records includes sociodemographic data, clinical data, and patient treatment history. Results: Within two years, there were 53 cases of psoriasis. The dominance of psoriasis cases was found in men with a ratio of women and men 1:2.31. Of total 53 patients, 37 were male (69.81%)and 16 female patients (30.19%). The most common type was psoriasis vulgaris (73.58%). The most age group was 31-45 years. The most commonly given regimen of therapy was topical corticosteroids plus oral antihistamines (45.28%). The most widely given systemic therapy was methotrexate. Accompanying skin infections were found in 6 cases of psoriasis (11.32%). Conclusion: Based on the results of the study, there were 53 new cases of psoriasis in 2018-2019, psoriasis vulgaris was the most common, the most age group was 31-45 years old, topical corticosteroids with antihistamines were still the main treatment options for psoriasis patients in Sanjiwani Gianyar Regional Hospital.
Focus on the dabrafenib, vemurafenib, and trametinib in the clinical outcome of melanoma: A systematic review and meta-analysis Ida Ayu Widya Anjani; Anak Agung Bagus Putra Indrakusuma; I Gede Krisna Arim Sadeva; Putri Ayu Wulandari; Luh Made Mas Rusyanti; Prima Sanjiwani Saraswati Sudarsa; I Gede Putu Supadmanaba; Desak Made Wihandani
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/myphje28

Abstract

Background: Melanoma is the most severe lethal skin cancer, affecting melanin producer cells (melanocytes). Surgery is the most common treatment, whereas, for the advanced stage, the development of treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is the most frequently targeted melanoma therapy due to more than 80% of patients with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome. Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by three different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2 and Chi2 statistic Result: There are 20 studies used in this article (13 RCT and seven cohorts). The overall survival (OS) and progression-free survival (PFS) of the survey that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other treatments (chemotherapy, immunotherapy, etc.) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17; I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13; I2=99%; p<0,00001). Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other treatments for better clinical outcomes rather than monotherapy.
Secondary syphilis with HIV infection in Men Who Have Sex with Men (MSM) patient treated with azithromycin and doxycycline: a case report Hani Lusyana; Agus Walujo; Lina Damayanti
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 1 (June 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/38dh4737

Abstract

Background: Syphilis frequently presents in tandem with HIV and the prevalence is increasing, particularly in men who have sex with men (MSM). The most common and recognizable manifestations are usually the secondary stage, characterized with or without constitutional symptoms. This case study aims to evaluate secondary syphilis with HIV infection in MSM patient treated with azithromycin and doxycycline Case Presentation: A 22-year-old man with secondary syphilis and HIV infection. The diagnosis was established based on erythema and hyperpigmented maculopapular lesions with the scale on the forearms, palms, back, feet, and soles without pruritic sensation, a history of the same-sex sexual partners, and the titer of VDRL 1:64, TPHA 1:2560. The patient also has a low CD4 level and HIV-1 RNA were detected on a blood test. Patients received azithromycin 2 grams orally and continued by doxycycline twice a day for 30 days and treated for the HIV Infection. Skin disorders have improved rapidly and are significantly accompanied by decreased VDRL titer. Conclusion: The therapy of 2-gram azithromycin improved clinical manifestation on the skin. The following treatment of 30 days doxycycline showed clinical improvement and significant decline in a nontreponemal serologic test.
COVID-19 and ophthalmic herpes zoster co-infection in immunocompetent patient Sissy; Adeline Santoso; Dewi Gotama; Luh Made Mas Rusyanti
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 1 (June 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/279pg511

Abstract

Background: Varicella-zoster virus (VZV) is a virus of human neurotropic that remains within ganglionic neurons in a latent state after the primary infection throughout the entire neuroaxis. Case: A male patient, 32 years old Javanese, consulted from the pulmonary division with complaints of vesicular eruption in the facial area on September 27, 2020. The patient was diagnosed with ophthalmic herpes zoster and a mild COVID-19 infection since 2 days ago and was hospitalized. Management in patients was acyclovir, methylprednisolone, with analgesics and vitamins. COVID-19 as co-infection and other viruses has been known, but infrequently affect the respiratory tract. Conclusion: Herpes zoster patient should ruled out the COVID-19 and maximize the precaution for personal safety equipment until the SARS-CoV-2 is excluded.
Discrepancy of PCR and serologic test on genital herpes: a case report Jhauharina Rizki Fadhilla; Wresti Indriatmi; Hanny Nilasari; Yudo Irawan
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 1 (June 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/s440xr58

Abstract

Background: Laboratory investigation for genital herpes (GH) includes serologic tests and polymerase chain reaction (PCR) with different sensitivity and specificity; occasionally, the results are not conclusive. Clinical symptoms are often atypical. We report a case of GH in HIV-infected patients with a non-reactive serologic test but positive PCR. Case Description: A 29-years old HIV-positive man presented with multiple painful shallow ulcers with pus on his penis in the last five days. PCR examination showed a positive result, whereas anti-HSV 1 IgM, anti-HSV 2 IgM, anti-HSV 2 IgG, VDRL, and TPHA were negative. The anti-HSV- 1 IgG result was reactive with a CD4 value of 122 cells/μL. The patient was given Acyclovir 3x400 mg for ten days and Co-amoxiclav 3x625 mg for seven days. Significant improvement was obtained, and the pain subsided. Conclusion: Clinical features of GH in infected HIV patients are often atypical and resemble other genital ulcers, thus requiring additional investigations. The serologic test may sometimes present a false negative, whereas PCR is much more sensitive and specific, nearing 100%. In patients with HIV infection, GH diagnosis at an early stage can shorten the course of the disease and prevent complications.
Secondary syphilis with stage III HIV in an adolescent deaf male with a history of sexual relationship with men: a case report Tritya Mudita; Ni Made Dwi Puspawati; I Gusti Ayu Agung Sattwika; Andrew Yoshihiro Wirya
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 1 (June 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/vv3kt473

Abstract

Introduction: Syphilis is an infection caused by Treponema pallidum of the spirochaete family. Case: A 19-year-old Balinese came with a complaint of red spots on the palms of the hands and feet one month ago. The patient has a hearing disability and is currently enrolled in a special-needs school in Denpasar. VDRL examination with reactive results with titer 1:256 and TPHA reactive with TPHA titer 1:5120. The patient received benzathine penicillin G 2.4 million units intramuscularly. Significant improvement was obtained, and the serological test was decreased. Discussion: Syphilis transmits through sexual contact, vertically from pregnant women to their fetuses, through needle sharing. People with hearing disabilities and adolescents are considered vulnerable as objects of harassment and sexual violence. Conclusion: People with disabilities and adolescents are vulnerable to sexually transmitted diseases. Information on reproductive health and sexually transmitted diseases need to be more readily available for people with disabilities. Secondary syphilis therapy with a single dose of benzathine penicillin is effective from clinical or serological observations.
The correlation between patient satisfaction treatment of narrowband ultraviolet B phototherapy and the improvement of psoriasis severity index Putti Fatiharani Dewi; Ambar Aliwardan; Arie Kusumawardani
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 1 (June 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/x6wxtf63

Abstract

Background: Psoriasis is a chronic inflammatory disease of the skin affecting patients of all ages, both males and females. Currently, the psoriasis area and severity index (PASI) method is the gold standard in assessing the severity of psoriasis. Phototherapy narrowband ultraviolet B (NBUVB) is one of the modalities of psoriasis therapy which is relatively safe and effective for repairing psoriasis lesions. Patient satisfaction with phototherapy, which can be assessed using a questionnaire, serves to determine the patient's motivation in carrying out routine therapy. Objective: This study was designed to determine the correlation between the level of NBUVB phototherapy satisfaction with PASI improvement. Method: The study subjects were 22 plaque-type psoriasis vulgaris patients who underwent NBUVB phototherapy from May 2018 to October 2018 in the dermatovenereology outpatient clinic of Dr. Moewardi Hospital Surakarta. Subjects filled in the Treatment Satisfaction Questionnaire for Medication (TSQM) included questions about satisfaction with NBUVB phototherapy, and PASI scores were measured before and after NBUVB phototherapy. Results: The data were analyzed with the Pearson correlation test with a significance value of p <0.05. There are significant differences between PASI before and after giving 24 times phototherapy with a value of p<0.05. Conclusion: There was a significant correlation between the degree of PASI improvement and the global patient satisfaction with NBUVB phototherapy
Syphilis in pregnancy at Public Health Centre III North Denpasar Odilia Dea Novena; Gusti Ayu Vina Mery Giovani
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 2 (December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/73vn6f43

Abstract

Introduction: Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. Syphilis in pregnancy is often asymptomatic, so early detection of syphilis is needed to prevent a poor pregnancy outcome and transmission of infection to the baby. Case: A 25-year-old woman, pregnant with her second child at 24 weeks of gestation, came without any health complaint for a routine prenatal check-up. On syphilis screening, reactive TPHA and RPR titer of 1:2 were found. The patient was diagnosed with syphilis infection in pregnancy. The patient has been treated with Benzathine Benzylpenicillin 2.4 million IU intramuscular injection once a week for 3 consecutive weeks. Conclusion: Syphilis is a sexually transmitted infection that infects pregnant women. Treponemal transmission in pregnant women was detected early in the ninth week of pregnancy. The diagnosis of syphilis was made by dark-field microscopy, treponemal antibody tests (TPHA, FTA-ABS), and non-treponemal antibody tests (VDRL, RPR). Penicillin is the gold standard therapy for syphilis in pregnant women.
Management of diabetic foot ulcers: dermatology perspective Adi Agung Anantawijaya Daryogo; Fitriani; Soenarto Kartowigno; Inda Astri Aryani; Yulia Farida Yahya; Sarah Diba; Aurelia Stephanie
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 2 (December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/875dt635

Abstract

Diabetes mellitus (DM) is a chronic and complex disease that affects various parts of the body. It can lead to multiple systemic complications and also cutaneous manifestation. Diabetic foot ulcer (DFU) is one of the most devastating complications of DM in dermatology. The main etiology is an increase in plasma glucose, risk factors, or comorbidities due to DM itself. Neglected DFU can lead to further complications, including high amputation and mortality rates; thus, the healing of ulcers is the main objective of the treatment. Management is divided into the standard of care and adjuvant therapies. This study aims to optimize DFU management, so it can provide proper treatment and prevent complications.
Steroid-induced diabetes mellitus in pemphigus vulgaris patient at Bali Mandara Hospital: a case report Felicia Aviana; I Made Birawan
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 4 No. 2 (December 2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/8vc5nd62

Abstract

Background: Pemphigus vulgaris (PV) is a blistering autoimmune disease of the skin and mucous membranes defined histologically by intraepidermal blister due to acantholysis. Systemic corticosteroids and immunosuppressive agents had greatly improved the prognosis of pemphigus. However, steroid use often leads to metabolic complications, such as diabetes mellitus. This case report describes steroid-induced diabetes mellitus in PV, where the side effect of long-term high dosages steroid used and the method to manage it can be used as a study case. Case report: A 31-year-old man complained of new blisters from almost the entire body. He had a history of PV 1 year ago and no history of diabetes mellitus in the patient or family. He had a medication history of methylprednisolone 8 mg every 8 hours. Dermatological status showed erythema macules, extensive erosion almost on the entire body, the Nikolsky sign (+), and the Asboe-Hansen sign (+). Blood laboratory result: random blood glucose 451 mg/dl, HbA1c 12.3%. Histopathological examination: suprabasal blister, in which the basal cells still attached to the basement membrane show a “tombstone” appearance. The diagnosis was steroid-induced diabetes in pemphigus vulgaris. He was treated with steroids and insulin. Conclusion: Steroid use in PV treatment can lead to metabolic complications, such as diabetes mellitus. Regularly monitoring is needed to prevent complications due to steroid use.

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