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Anak Agung Gde Putra Wiraguna
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Dermatology and Venereology Department, Medical Faculty, Universitas Udayana/Prof. dr. I G. N. G. Ngoerah General Hospital, 3rd Floor (Jl. Diponegoro, Dauh Puri Klod, Kecamatan Denpasar Barat, Kota Denpasar, Bali 80113)
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Bali Dermatology Venereology and Aesthetic Journal
Published by Universitas Udayana
ISSN : 30467985     EISSN : 30467993     DOI : https://doi.org/10.51559/balidervenaesthj.v6i1.33
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Bali Dermatology Venereology and Aesthetic Journal is an open access; peer-reviewed journal aiming to communicate high-quality research articles, reviews, and general articles in the Dermatology, Venereology and Aesthetic field. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of Dermatology, Venereology and Aesthetic and to encourage a vigorous dialogue between researcher, medical scholars and practitioners. The scope of this journal includes: General dermatology Venereology Cosmetic dermatology/aesthetic Pediatric dermatology Allergy and immunology Skin and tumor surgery Tropical dermatology Genodermatosis (hereditary skin disease) Travel dermatology Traditional, Complementary, and Integrative medicine in dermatology Diagnostic method and artificial intelligence in dermatology
Arjuna Subject : Kedokteran - Dematologi
Articles 75 Documents
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Diagnosis of Kaposi’s sarcoma Alvian Arifin Saiboo; Dwi Murtiastutik; Etty Hary Kusumastuti; Putri Halla Shavira
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 2 (December 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/9hqvm129

Abstract

Kaposi’s sarcoma has a picture reminiscent of several skin conditions, so further testing is needed to show the diagnosis of Kaposi’s sarcoma. Lymphatic endothelium cells infected with KSHV or human herpesvirus 8 form the basis of Kaposi’s sarcoma (KS), a multicentric tumor (HHV-8). These macules and plaques might be purple, reddish-blue or dark brown-black in color. KS is distinguished by this look.” Inflamed, ulcerated nodular lesions are common. They are neither unpleasant or uncomfortable, and the overlying skin or underlying tissues seldom die as a result of them. The gold standard examination in establishing the diagnosis of KS is histopathology. Several techniques that can be used for histopathological tissue retrieval are punch biopsy, shave biopsy, excision biopsy and incision biopsy. Immunohistochemical examination can also be performed to rule out the differential diagnosis. Immunohistochemical examination that we can do is with LANA-1, CD 34, CD 31, D2-40. Diagnosis of Kaposi’s sarcoma is difficult to diagnose only from a clinical picture, so similar diagnoses, i.e. histopathological and immunohistochemical examinations, are required.
Differences in the diagnosis of sweat gland tumors with other histopathologically similar skin tumors Maylita Sari; Arisia Fadila
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 2 (December 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/9jb27493

Abstract

Sweat gland tumors are still relatively rare compared to other skin tumors. The clinical features of sweat gland tumors are non-specific and are rarely encountered in daily diagnostic practice. This article aims to explain the features of benign sweat gland tumors based on clinical and histopathological features. Many sweat gland tumors have overlapping clinical features with other tumors, whether from other adnexal tumors or even malignant tumors. Fulton et al. divided eccrine and apocrine gland tumors into six groups based on the similarity of the basic histopathological features, which could help clinicians better establish benign sweat gland tumors. The histopathological examination could complement history taking and physical examination to establish benign sweat gland tumors.
Large acrochordon of labium majora: an unusual location Citrashanty, Irmadita; Luthfidyaningrum, Hamidah; Murtiastutik, Dwi; Hidayati, Afif Nurul; Widyantari, Septiana; Astindari, Astindari; Sari, Maylita
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/93p62v41

Abstract

Background: Acrochordon is a soft, round or oval, pedunculated papilloma that can be tan or brown in color. Although acrochordons most commonly appear in the neck, axilla, and groin, they can also appear in unusual sites, such as penis, vulva, and perineum. Most of the lesions are small pedunculated papules or nodules approximately 2–6 mm, but rarely, particularly on the lower section of the trunk, large pedunculated acrochordons can be found. Here we present a large acrochordon on the labium majora. Case Description: A 25 years old woman came to an outpatient clinic because there was a mass on her right labium majora ever since she gave birth three years prior. The size of the mass started off relatively small but has grown significantly over time. From dermatological examination in external genitalia region, there was a solitary, pedunculated, skin-colored mass measuring 10 × 3 cm, attached to right labium majora. There was no redness, ulceration, bleeding or discharge. Cautery excision with local anesthetic was performed to removed the mass. The histopathological examination of the specimen revealed polypoidal tissue lined by epidermal layer, there are proliferation and dilation of capillaries containing erythrocytes in the dermis layer, mild infiltration of lymphocytes and histiocytes. No evidence of malignancy. Conclusion: We report an unusual location of acrochordon presenting with large size. Due to its atypical presentation, it may be confused with a malignancy, necessitating a pathological test. Total excision of the mass is recommended.
Epidermolysis bullosa in a twins infant: a rare case Medisika Hertanti, Dhea; Indrawati, Ditya; Zulkarnain, Iskandar; Sawitri; Citrashanty, Irmadita; Widia, Yuri; Rahmadewi
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/yxcw3527

Abstract

Background: Epidermolysis bullosa (EB) is a rare hereditary genodermatosis characterized by blisters due to trauma and temperature. Cases of EB in twin infants are rare. This report will discuss EB in twin infants to improve our knowledge about this genodermatosis. Case: A baby boy with a twins history aged 4 months was consulted by the Pediatric Department with complaints of fluid-filled blisters that have been present since birth. During examination, bullae appeared on the upper and lower extremities. The gram examination and culture results showed Staphylococcus aureus infection and gentamicin sensitivity. The histopathology results showed a subepidermal blister with the dermis layer showed lymphocytic infiltration, which was in accordance with EB. The baby was hospitalized for 5 days and then came back to the outpatient unit with his twin, who had the same complaint. Examination of the second infant revealed multiple erosions and hypopigmented macules on the superior and inferior extremities. Both babies were born at term, normal, adequate weight, and are the first twins. Direct immunofluorescence did not show immunoglobulin G (IgG) and complement C3 deposits in the basement membrane zone. Both infants received symptomatic therapy. Conclusion: Epidermolysis bullosa is a rare case, especially in twins. Electron microscopy is a gold standard for determining EB type. Symptomatic treatment is the main therapy in this population of EB.
Diagnosis and treatment of leprous neuropathy: a review Thiodorus, Fira; Thiodorus, Robert; Sadeli, Marrietta Sugiarti
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 7, Issue 1 (January 2024)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v7i1.78

Abstract

One significant subset of curable neuropathies brought on by Mycobacterium leprae is leprous neuropathy. Millions of people in most underdeveloped nations suffer from leprous neuropathy, which can lead to debilitating motor deficiencies, sensory loss, and skin deterioration. The peripheral nerve system and skin are the primary organs affected by leprosy. The clinical characteristics, cutaneous histology, and bacteriology may all be used to conclude the diagnosis. Leprosy neuropathy diagnosis also requires a nerve biopsy. Needles electromyography and nerve conduction investigations are two examples of electrophysiologic nerve examinations. Both studies offer details on the degree of nerve involvement, the location of lesions, and the underlying mechanism of injury. For patients with leprosy neuropathy, multiple medication therapies are recommended. Aside from standard medical care, acute neuropathy may sometimes require surgical intervention. In reversal reactions, corticosteroids can prevent or lessen nerve damage.
Steatocystoma multiplex suppurativa: a case report Rainamira, Arlene; Krisnanti, Inge Ade; Rihatmadja, Rahadi; Suprapto, Novita; Surya, Danny
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 2 (December 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/rzd0ak48

Abstract

Introduction: Steatocystoma multiplex (SM) suppurativa is an inflammatory variant of SM, a benign hamartomatous disorder of pilosebaceous unit that usually occurs in early adulthood. Treatment responses are often disappointing due to widespread lesions and late diagnosis. This case report aimed to describe a male diagnosed with SM suppurativa to increase the knowledge and management of SM suppurativa. Case: A 23-year-old male came with multiple lumps on his neck, chest, back, and extremities over the last four years. On dermatological examination, yellow to skin-colored papules, nodules, and cysts, 0.3 to 2 cm in diameter, were observed with erythematous-to-hyperpigmented macules and scars over the lesions. Histopathological examination of the lesion showed cysts with pilosebaceous-like lining and sebaceous glands adhered to the cyst’s wall. The patient diagnosed with steatocystoma multiplex SM suppurativa was treated only with a topical antibiotic and corticosteroid. Discussions: Although the histopathological findings showed pathognomonic findings for SM, SM suppurativa was established as the working diagnosis based on the clinical and dermoscopic findings of inflammatory lesions. The biopsy of noninflammatory lesions might cause no sign of inflammation in the histopathological findings. Conclusions: Dermoscopic findings showed a yellow structureless area with diffuse erythematous borders and histopathological findings of a pilosebaceous-like layer with sebaceous glands adhering to the cyst wall and chronic inflammation is the hallmark of SM suppurativa.
Cyclooxygenase-2 as potential intervention target of leprosy reactions: a systematic review Rusyati, Luh Made Mas; Sari, Luh Gede Melia Puspita; Winaya, Ketut Kwartantaya
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 2 (December 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/wf9qxd44

Abstract

Background: Leprosy reaction is an acute inflammatory of leprosy complication that potentially cause disability. Prompt and appropriate treatment is needed to prevent this permanent neurological complication. As inflammation of this reaction is mediated by cyclooxygenase-2 (COX-2), therefore targeting this substance may potential to prevent disability. This systematic review aimed to define COX-2 as a potential target of intervention in leprosy reaction. Method: Medline, Cochrane library, PubMed, and Google scholar databases were searched for articles published at any time. Observational study and clinical trial, comparative, prospective, retrospective, and descriptive study were extracted, analyzed, and discussed. Results: We found 6 studies that met the inclusion and exclusion criteria, with 104 participants with leprosy reactions and 143 comparators included in this review. In leprosy reactions, COX-2 expression was found in the vessels and nerves of the dermis and subcutis. Macrophages are cell mostly abundantly expressing COX-2. The COX-2 expression was found higher in the leprosy reaction compare to the non-leprosy reaction. Genetically, genes PTGS2 and TNFAIP6 encode COX-2 production also tend to increase especially in type 1 reaction. Conclusions: Preclinically and genetically, COX-2 is a potential target for intervention of leprosy reaction.
Markedly clinical improvement of papulopustular rosacea with multimodality therapeutic approach: a case report Priyanto, Mufqi Handaru; Wardani, Amanda Nandi; Legiawati, Lili; Sitohang, Irma Bernadette Simbolon; Suseno, Lis Surachmiati
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/85p5m842

Abstract

Introduction: Rosacea is a chronic inflammatory skin disease that mainly affects the central area of the face. There are four subtypes, and they may progress between subtypes or span multiple subtypes. Due to its long course of the disease, optimum treatments are needed to control the disease progression. Case: We reported rapid improvement of combining topical metronidazole, doxycycline, and light emitting diode for treating a patient with papulopustular rosacea in a 44-years-old woman, a week from the initial therapy. Discussion: Therapeutic approaches to rosacea mainly focus on controlling the symptoms with anti-inflammatory agents. More recently, photodynamic therapy, especially light-emitting diodes, has been introduced as a valid alternative or an adjuvant therapy to conventional treatment through their synergic mechanism between therapeutic modalities. Conclusions: This combination treatment may be effective for treating papulopustular rosacea without any side effects.
Neutrophil-to-lymphocyte ratio (NLR) in dermatology perspective: a review Maharani, Pande Tiara; Mahariski, Pande Agung; Izawati, Elok; Anjani, Ida Ayu Widya
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/qqygxk83

Abstract

The neutrophil-to-lymphocyte ratio (NLR) is the ratio between the number of neutrophils and lymphocytes in the peripheral blood. Neutrophils are responsible for an initial immune response to pathogens that enter the body through the mechanisms of chemotaxis, phagocytosis, the release of reactive oxygen species (ROS), granular proteins, production and release of cytokines. Neutrophils also have an important role in the occurrence of the systemic inflammatory response (SIRS). There are several types of diseases in the field of dermatology that are also related to NLR. It is associated with the presence of an inflammatory process. In addition, NLR is considered an easy, inexpensive, and reproducible parameter associated with clinical outcomes and disease severity. Several diseases in the field of dermatology found to be associated with NLR include leprosy, Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), psoriasis, vitiligo, atopic dermatitis, systemic sclerosis, and skin cancer. In recent years, its role as an independent prognostic factor for neoplasms and as an inflammatory biomarker in various acute and chronic diseases has been increasingly established in the dermatology field. However, not all studies have found significant results. One of them is vitiligo which still finds controversial results. For this reason, this literature review will discuss specifics related to several diseases in dermatology associated with NLR.
Clinical features of allergic contact dermatitis to sandals: a case series Gotama, Sinta; Hapsari, Yunita; Kusuma, Dinie Ramdhani
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 2 (December 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/b596s971

Abstract

Background: Allergic contact dermatitis (ACD) is a skin inflammation caused by a type 4 delayed-type hypersensitivity reaction. One of the most common types of ACD is shoe dermatitis, characterized by pruritic or painful bilateral and symmetrical erythema, papules, vesicles, scaling, crusting, lichenification, or fissures at the site of footwear contact. Case series: We present seven patients with allergic contact dermatitis caused by rubber flip-flop sandals who presented with acute to chronic eczema and leukoderma. Patients range in age from 4 to 65 years old, with symptoms lasting from 5 months to 2 years. Two of the seven patients had a history of atopy. Conclusion: Flip-flop sandals are the most common offending footwear in Indonesian ACD patients because they are appropriate and comfortable in hot and humid climates like Indonesia. Rubber and rubber chemicals, preservatives, shoe adhesives, and leather materials are the most common offending allergens.

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