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Jurnal MedScientiae
Published by Universitas Kristen Krida Wacana
ISSN : -     EISSN : 28291166     DOI : https://doi.org/10.36452/jmedscientiae
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal MedScientiae adalah jurnal yang dikelola oleh Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana. Jurnal ini mempublikasikan artikel-artikel secara open access dalam lingkup bidang kedokteran dan kesehatan seperti kedokteran dasar, bioetika kedokteran, biologi sel, biologi molekuler, genetika, fisiologi, biokimia, bioinformatika, anatomi, farmakologi, kesehatan masyarakat, dan ilmu biomedik lainnya. Tim editorial menerima naskah berupa artikel penelitian, literature dan systematic review, dan laporan kasus. Naskah yang dikirimkan hendaknya belum pernah diterbitkan sebelumnya di jurnal maupun media yang lain dan disiapkan sesuai dengan template atau format yang telah ditentukan. Setiap naskah yang memenuhi kriteria jurnal akan direview oleh pakar yang sesuai (peer reviewer). Jurnal MedScientiae tidak mengenakan biaya selama proses mulai dari penerimaan naskah hingga publikasi. Jurnal MedScientiae terbit 3 kali dalam satu tahun, yaitu pada bulan April, Agustus dan Desember dengan cakupan keilmuan yang telah disebutkan di atas. Edisi pertama jurnal akan diterbikan di bulan Mei tahun 2022 dengan nomor ISSN 2829-1166.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 249 Documents
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Evaluasi Mikrovaskuler dengan Near Infrared Spectroscopy pada Pasien Kaki Diabetes Kartika, Ronald Winardi; Timotius, Kris Herawan
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3074

Abstract

Peripheral Arterial Disease (PAP) requires good evaluation to reduce amputation rate. The aim of this study is to assess non-invasive detection methods in evaluating microvascular conditions in PAP. The potential use of Near Infrared Spectroscopy (NIRS) in identifying disorders in patients with PAP, either with or without DM, was also assessed. A systematic literature search was conducted through PUBMED until October 2023. Based on the literature review, it can be concluded that the use of NIRS in evaluating microvascular status in PAP is a non-invasive testing method that has expanded its role. Evaluation with NIRS provides metrics such as recovery time, deoxygenation, oxygen consumption (VO2), tissue oxygen saturation (StO2), total haemoglobin (HbT), and oxyhemoglobin area under the curve (O2 HbAUC). NIRS also has the potential to assist multidisciplinary teams in treating high-risk patients, especially in diabetic patients whose symptoms are compensated by peripheral neuropathy. This study shows that NIRS can be used as a useful tool in evaluating microvascular status in PAP, by providing important information that can be used to optimise patient care and prevent more serious complications. It is concluded that NIRS can be used as a tool to evaluate the effectiveness of treatment and prevent worsening of the condition of patients with PAP in diabetic foot.
Current Management of Fluorometholone Steroids in Pediatric Vernal Conjunctivitis: A Literature Review Fajar, Muhammad Fauzi; Siallagan, Maria; Nabighah, Gladis Salsabila Najla; Wijaya, Pande I Gede Indra; Anugrahsari, Santi
Jurnal MedScientiae Vol 3 No 2 (2024): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3079

Abstract

Vernal conjunctivitis is a rare allergic eye disease, usually affecting children in the prepubertal years and can last between 5 to 10 years. Treatment of this condition is often challenging, requiring effective therapies to reduce symptoms. This literature review, conducted between 2015 and 2023, aimed to evaluate the effectiveness of fluorometholone steroid use in the treatment of pediatric vernal conjunctivitis. Recent studies comparing the effectiveness of Fluorometholone 0.1% in the treatment of Vernal Keratoconjunctivitis (VKC) were analyzed. The results showed that Fluorometholone was effective compared to Cyclosporine in reducing VKC symptoms. However, the use of Fluorometholone should be done with caution due to potential side effects such as increased intraocular pressure and risk of infection.Fluorometholone is an effective treatment option for vernal conjunctivitis in children. However, it is important to have close monitoring by an ophthalmologist to avoid serious side effects. With careful monitoring and proper dose adjustment, Fluorometholone can be a safe and effective therapy in managing this condition.  
A Overview of the 2023 FKIK UKRIDA Study Program Students Breakfast Menu Variations Kurniawan, Inge; Winaktu, Gracia JMT; Susanto, Lucianana Budi; Hartanto, Hartanto
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3107

Abstract

The Balanced Nutrition Guidelines (PGS) presented by the Indonesian Ministry of Health in 2014 have a message, one of which is to get used to breakfast. Breakfast is an eating and drinking activity carried out between waking up and 9 am with the aim of meeting daily nutritional needs (15-30%). This research aims to get an overview of the variations in the breakfast menu of FKIK UKRIDA students. This research used a cross sectional descriptive design, taking subjects using purposive sampling. Data collection was carried out in October 2023. The research subjects consisted of 45 students who met the inclusion and exclusion criteria. The inclusion criteria are the 2020-2021 class who are aged 19-25 years and who eat breakfast. The results of this study showed that most of the subjects were female, namely 32 people (71.1%). Most of the subjects did not live with their parents/boarding house 27 (60%) with monthly pocket money mostly Rp. 1,000,000 – Rp. 2,500,000, namely 23 people (51.1%). Most of the subjects had normal weight nutritional status, namely 26 people (40%). The description of the subject's breakfast menu is quite varied, namely bread 14 (31.1%), fried chicken rice 11 (24.4%), and others 20 (42.1%), drinks namely water 22 (48.9%) , water and milk 5 (11.1%), and others 18 (37.8%).
Pharmacotherapy Study Of Albendazole And Mebendazole For Soil Transmitted Helminths Infections In Children Susanto, Inneke Kusumawati; William, William; Agatha, Nabila
Jurnal MedScientiae Vol 3 No 2 (2024): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3109

Abstract

Soil Transmitted Helminths (STH) infection is a nematode infection of the intestine that requires soil for its transmission. The worms that cause Soil Transmitted Helminths infection include; Ascaris lumbricoides, Trichuris trichiura, hookworms (Necator americanus and Ancylostoma duodenale. The incidence of STH infection is quite high with the highest spread of STH infection in the child age group. Treatment of cases of STH infection is by administering antihelmintic drugs or worming drugs. Although there are four The drugs recommended by WHO, only the two drugs most often used in the treatment of STH infections, namely albendazole and mebendazole. Both drugs have been used for more than 30 years, but cases of STH infection still have a high incidence. That is why this literature review was written aims to describe the efficacy of the two drugs for STH infection in children so that their effectiveness can be assessed.The research method used was a literature review, a literature search was sourced from Proquest, Google scholar, Pubmed, Elsevier and Europe PMC. keywords Albendazole, Mebendazole, Soil Transmitted Helminths Infections, Children. There are 10 selected literatures to be studied in this literature review. The results showed that albendazole had satisfactory efficacy in STH infections caused by Ascaris lumbricoides and hookworms, but reduced efficacy in Trichuris trichiura worms. Mebendazole has satisfactory efficacy in STH infections caused by Ascaris lumbricoides and Trichuris trichiura, but reduced efficacy in hookworms. Albendazole and mebendazole does not cause side effects.
E Efektivitas Albendazol Dosis Tunggal terhadap Infeksi Soil Transmitted Helminths (STH) Sari, Monica Puspa
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3110

Abstract

The problems of worm’s infection is still a problem for Indonesian people, especially children who live in endemic areas with a lack of sanitation and clean water. The two recommended treatment regiments are Albendazole 400 mg and Mebendazole 500 mg. Several studies report that the efficacy of albendazole varies. The aims of literature review is to assess the efficacy of albendazole against STH infections, and the factors that influence the efficacy of albendazole, factors that can increase efficacy and reduce efficacy. The research method used is a literature review with a descriptive approach based on literature from relevant research articles or journals. Library searches were searched via Google scholar, Pubmed, E-journal. The keywords and boolean operators used in the research are albendazole AND Soil transmitted helminths OR cure rate OR egg reduction rate. The CR of a single dose of albendazole against A. lumbricoides reaches 80-100%. 50-54% of hookworm infections occur due to frequent recurrent infections. There were differences in results regarding the CR of T. trichiura 12,8%-66,7% and 80-90%. This difference occurs due to differences in the degree of unfections. Single dose albendazole base on CR and ERR is less effective against T. trichiura infection. Albendazole should be given in combination with other drugs or in extra doses to eliminate STH infections.
Peran Vitamin D Dalam Menurunkan Risiko Penyakit Kardiovaskular Lim, Audi; Arsita, Elli
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3138

Abstract

Cardiovascular disease is the main cause of death in the world. Vitamin D is known to have an influence on the cardiovascular system through the role of the vitamin D receptor (VDR) expressed by vascular endothelial smooth muscle cells and cardiomyocytes. This literature review analyze the role of vitamin D in relation to the risk of cardiovascular disease through a study of scientific articles from Google Scholar and Pubmed. The results showed that patients with severe vitamin D deficiency (serum 25(OH) levels <10 ng/ml) had an increased risk of myocardial infarction with OR 4.5 (95% CI 2.2–9.2), and increased risk of PAD with OR 3.872 (95% CI: 1.168–12.841), while vitamin D deficiency (serum 25(OH) levels <20 ng/ml) caused an increased risk of acute ischemic stroke with OR 16.64 (95% CI: 5 .66–42.92; p < 0.001). Administration of 1x 600,000IU or 2x300,000IU intramuscular vitamin D in coronary heart disease patients with deficiency showed significant reduction in the inflammatory marker hsCRP and improved endothelial function. However, in clinical trials, significant but inconsistent results were obtained due to differences in the cut off value for Vit D deficiency, diversity in age, gender, variations in polymorphisms, smoking habits, physical activity, body weight, and various comorbidities suffered by patients.
Potensi Sekretom Mesenchymal Stem Cell pada Terapi Regeratif Penyakit Paru Fibrosis Kartika, Ronald Winardi; Timotius, Kris Herawan
Jurnal MedScientiae Vol 3 No 2 (2024): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3142

Abstract

Fibrosis lung diseases such as chronic obstructive pulmonary disease, acute lung injury and post-Covid 19 fibrosis lung disease are considered as major health problems in the last decade. Cellular therapy with Mesenchymal Stem Cells (MSC) offers a novel therapeutic approach for fibrosis lung disease associated with anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties. Such therapeutic effects may be attributed to the MSC-secretome, which is made of free soluble proteins and extracellular vesicles (EVs). This review summarises some recent literature findings related to the efficacy and safety of MSC-derived products in pre-clinical models of lung diseases, demonstrating the biologically active substances contained in the MSC-secretome and its mechanisms involved in tissue regeneration. A perspective view is given on the secretome being a high-quality, safe and effective medicinal product,  
Perbandingan Efektivitas Injeksi Agen-Agen Anti-Vegf pada Pengobatan Age-Related Macular Degeneration Nahak, Petronela Bhoko; Arsita, Elli; Wastitiamurti, Ritsia Anindita
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3143

Abstract

Age-related macular degeneration (AMD) is one of the leading causes of blindness in people >60 years of age in developed countries. The pathogenesis of neovascular AMD involves increased choroidal vascular permeability, leading to hypoxia and the production of pro-inflammatory and pro-angiogenic factors, particularly vascular endothelial growth factor (VEGF). Treatment of neovascular AMD involves anti-VEGF therapy, which inhibits abnormal blood vessel growth. Numerous studies have demonstrated the effectivity and side effects of each Anti-VEGF agent. Based on this background, the author is interested in conducting a literature review that summarizes the effectivity and side effects of each Anti-VEGF agent. The method used was Literature Review. Journals were collected using GoogleScholar or Google Scholar, PubMed and Proquest within the last 10 years. A total of 10 journals that met the inclusion-exclusion criteria were reviewed and tested for eligibility with the Ottawa score. The results of this literature review showed that anti-VEGF agents including bevacizumab, ranibizumab, aflibercept, pegaptanib sodium, brolucizumab and abicipar pegol have been shown to be equally effective in improving vision and maintaining stable vision in neovascular AMD patients. However, these anti-VEGF treatments can also cause side effects such as intraocular inflammation, increased intraocular pressure and vascular problems.
GAMBARAN FOTO THORAX DAN DISTRIBUSI BAKTERI PATOGEN PADA PASIEN PNEUMONIA Finaldi, Fauzan
Jurnal MedScientiae Vol 3 No 2 (2024): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3144

Abstract

Pneumonia is an acute infectious or inflammatory disease that affects the lung parenchyma which can be caused by microorganisms such as bacteria, viruses and fungi. This study aims to determine the chest x-ray picture and the distribution of pathogenic bacteria in pneumonia patients, as well as to look at the chest x-ray picture of certain pathogens. The method in this study is to search for articles via Google Scholar and Pubmed. The results showed that the distribution of pathogenic bacteria in pneumonia cases varied, but the most common bacteria that cause pneumonia were Streptococcus pneumoniae, Klebsiella pneumoniae, and Mycoplasma pneumonia. On chest x-rays, the chest x-ray images obtained are quite diverse, and the commonly found results are consolidation, infiltrates and pleural effusion. In patients with pneumonia due to Mycoplasma pneumoniae, the chest x-ray picture that is often found is lobar pneumonia or lobar consolidation.
Risk Factors for Urinary Incontinence in the Elderly Regina, Kezia; Tamba, Ernawaty; Soesanto, Aries
Jurnal MedScientiae Vol 3 No 2 (2024): August
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3145

Abstract

Individuals aged sixty years or older who require more care are referred to as seniors. Urinary incontinence in the elderly is a common problem. Uncontrolled urine production is known as urinary incontinence. Elderly people often experience this health problem. As we age, pelvic muscles weaken, resulting in changes in the anatomical function of the urinary tract organs and an increased risk of urinary incontinence. The aim of the research is to review related research on risk factors for urinary incontinence in the elderly. This research uses literature study. Where using a search for journals in Indonesian and English for 2013 - 2023 which was carried out using the WHO, PubMed, NCBI databases with the keywords Urinary incontinence in the elderly and found 10 journals selected according to the inclusion criteria with elderly subjects ≥ 45 years, cross sectional design and descriptive. The results show that urinary incontinence in the elderly has a significant relationship with risk factors for urinary incontinence such as diabetes, smoking, vaginal delivery and quality of life in the elderly. It can be concluded that there is a relationship between the two variables and most studies show that urinary incontinence is an important factor that can cause stress in the elderly.  

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