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Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Published by Universitas Indonesia
ISSN : -     EISSN : 28284070     DOI : https://doi.org/10.69951/proceedingsbookoficeonime
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience Public Health
This proceeding book encompasses various themes within the realm of general medicine. Selected articles from the International Conference and Exhibition of The Indonesian Medical Education Research Institute undergo peer review and editorial management before being published as an open-access digital proceeding book. The published articles include original pieces, case reports, case series, systematic reviews, narrative reviews, and technical notes.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 54 Documents
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Gluxsystem: Real-Time Monitoring of Diabetic Wounds Using an App-Iot Integrated Hydrogel Patch Azizah Nur Sya'bani; Dea Ocha Nerissa Arviana; Raudhah
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.324

Abstract

Introduction: Diabetes mellitus is a metabolic disorder associated with severe complications, including diabetic foot ulcers (DFU). The World Health Organization estimates that more than 830 million people worldwide are affected. DFU remains a leading cause of infection, amputation, and mortality, largely due to delayed detection of changes in the wound microenvironment. Objective: This study presents a theoretical design and conceptual framework for GLUXSYSTEM, an intelligent hydrogel-based patch integrating pH and glucose sensing with an application–IoT platform for non-invasive monitoring of diabetic wounds. Methods: The proposed sensing mechanisms are derived from established biochemical principles. pH sensing is conceptualized using a chitosan hydrogel containing glycerol and Bromothymol Blue (BTB), in which colorimetric changes result from pH-dependent protonation of the indicator. Glucose sensing is modeled using a PEGDA–APBA hydrogel embedded in a photonic crystal, in which glucose binding induces hydrogel swelling and structural color shifts. The system architecture envisions optical signal capture via a smartphone application for cloud-based data interpretation. Results: As a design-based study, the system is projected to produce distinguishable colorimetric responses corresponding to wound conditions. Based on the underlying chemical models, pH changes from acidic to alkaline would generate yellow-to-blue transitions, while increasing glucose concentration would produce structural color shifts from blue to purple and pink. These theoretical responses are consistent with reported associations between elevated pH/glucose levels and DFU severity. Conclusion: GLUXSYSTEM offers a conceptual, non-invasive approach to wound monitoring. While this study focuses on the design and integration framework, it provides a necessary foundation for future experimental validation and the development of accessible digital solutions in diabetic wound care.
Anesthetic Considerations in a Neonate Undergoing Thoracoscopic Removal of a Thoraco-Amniotic Shunt Following Prenatal Management of Fetal Pleural Effusion: A Case Report Nugroho, Nugroho; Andi Ade Wijaya Ramlan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.325

Abstract

Fetal pleural effusion is a condition characterized by the accumulation of fluid in the chest cavity of a developing fetus. It may be primary, often caused by lymphatic leakage such as chylothorax, or secondary to immune causes like Rh or ABO incompatibility, as well as nonimmune factors including chromosomal abnormalities, genetic disorders, infections, and congenital heart defects. These effusions may be associated with hydrops fetalis. The preferred prenatal treatment is thoraco-amniotic shunt (TAS), which drains pleural fluid into the amniotic sac. TAS improves lung development and has a survival rate of up to 85% in nonhydropic fetuses. A 34-week pregnant woman (gravida 2, para 1) was referred with suspected fetal lung fluid and diagnosed with fetal pleural effusion by ultrasound. After multidisciplinary evaluation, an ultrasound-guided thoraco-amniotic shunt (TAS) was performed under maternal spinal anesthesia, with fetal analgesia and paralysis achieved using fentanyl and vecuronium. The procedure was successful without complications. The patient delivered by cesarean section at 38 weeks. Postnatal imaging showed the shunt in place without residual effusion. On day six of life, the neonate underwent successful thoracoscopic shunt removal under general anesthesia, with stable intraoperative and postoperative outcomes. Conclusion, Thoraco-amniotic shunt placement and postnatal thoracoscopic removal require careful anesthetic planning and multidisciplinary coordination. Understanding maternal-fetal physiology and neonatal immaturity is essential. With thorough assessment and precise anesthetic management, both intrauterine and neonatal procedures can be performed safely with favorable outcomes.
Quantitative Flavonoids and Antioxidant Profiles by DPPH Assay of Centella Asiatica Serum Cosmetic Products Versus Ethanol Extract Habibie, Sutan Farrell; Dwijayanti, Adisti; Fachri, Wilzar
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.326

Abstract

The cosmetic industry is currently leaning toward herbal skincare products due to strong consumer preference for natural ingredients. Centella asiatica (CA) is frequently used as it contains flavonoids and centelloids known for their beneficial antioxidant properties. This study aimed to assess the efficacy of CA extract when incorporated into cosmetic formulations by comparing the total flavonoid content (TFC) and antioxidant activity of five commercial serums (A-E) against a pure CA ethanol extract. The experimental study was conducted in vitro, utilizing the CA extract, Vitamin C (as a positive control), and the five commercial serum products. TFC was determined quantitatively using UV-Visible spectrophotometry and quercetin standard. Antioxidant activity was measured using DPPH assay to calculate the IC50 value. Pure CA extract showed a mean TFC of 37.10 ± 0.21 mg QE/g, with serum samples showing high variability; the highest being Sample C with a TFC of 216.6 (99.89 - 246.1) mg QE/g and the lowest being sample E with a TFC of 24.75 ± 1.88 mg QE/g. Crucially, the pure CA extract demonstrated strong antioxidant activity with a mean IC50 of 52.45 ± 4.96 ppm. In contrast, all serum products exhibited significantly weaker antioxidant activities. Samples C and D resulted in extremely high IC50 values of 244100 ± 116700 ppm and 319300 ± 95700 ppm respectively, categorized as lower than weak, while samples A, B, and E were unable to reach 50% inhibition, indicating an antioxidant capacity below the measurable range. In conclusion, despite the pure Centella asiatica ethanol extract showing robust antioxidant activity, the commercial cosmetic serums demonstrated a significantly lower range of activity and highly inconsistent TFC, suggesting that the raw extract's potency does not reliably transfer to the final product formulation.
Expression and Purification of Novel Peptide-Based Recombinant Proteins Targeting Breast Cancer Stem Cells Agusta, Istiqomah; Triwidyaningtyas, Silvia; Bela, Budiman; Mardiana, Mardiana; Wanandi, Septelia Inawati
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.327

Abstract

Introduction: Peptides with specific affinity toward breast cancer stem cells (BCSCs), including GYSASRSTIPGK and GAIRIRLSEPLS, have gained interest in targeted cancer diagnostics; however, the low abundance of BCSCs often results in limited detection sensitivity. This study addresses this limitation by conjugating BCSC-specific peptides to self-assembling Human Papillomavirus (HPV16) L1 protein, resulting in virus-like particles composed of 72 pentamers that provide substantial signal amplification. In addition, the SpyTag–SpyCatcher system derived from the Streptococcus pyogenes CnaB2 domain provides a robust strategy to enhance peptide–protein stability. Objectives: This study aimed to express and purify three recombinant proteins as key components for assembling a BCSC-specific diagnostic construct: HPV16 L1–SpyTag, SpyCatcher–GYSASRSTIPGK, and SpyCatcher–GAIRIRLSEPLS. Methods: Recombinant genes encoding the target proteins were expressed in Escherichia coli (E. coli) BL21(DE3) following IPTG induction for 1–4 hours. Bacterial cells were harvested and lysed under native or denaturing conditions, and recombinant proteins were purified using Ni-NTA affinity chromatography. Results: SDS–PAGE analysis showed clear bands at the expected molecular weights for HPV16 L1–SpyTag (58.5 kDa), SpyCatcher–GYSASRSTIPGK, and SpyCatcher–GAIRIRLSEPLS (~15 kDa), with induction-dependent increases in band intensity. The SpyCatcher–peptide fusions were predominantly soluble and purified under native conditions, whereas HPV16 L1–SpyTag was largely insoluble and required denaturing purification. Conclusion: HPV16 L1–SpyTag and SpyCatcher–peptide fusions were successfully expressed and purified in E. coli, establishing a versatile platform with potential to enhance BCSC-targeted detection and treatment strategies in breast cancer. 

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