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Andri Putra Kesmawan
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Perumahan Sidorejo, Jl. Sidorejo Gg. Sadewa No.D3, Sonopakis Kidul, Ngestiharjo, Kapanewon Kasihan, Kabupaten Bantul, Daerah Istimewa Yogyakarta 55184
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INDONESIA
Sciences and Clinical Pharmacy Research Journal
Published by Indonesian Journal Publisher
ISSN : -     EISSN : 30474493     DOI : https://doi.org/10.47134/scpr
Core Subject : Health,
Medicine & Pharmacology
Sciences and Clinical Pharmacy Research Journal is dedicated to the exploration of Pharmaceutical Sciences and Community and Clinical Pharmacy. In the realm of pharmaceutical sciences, the journal welcomes research articles spanning Pharmaceutical Biology and Pharmacognosy, Pharmaceutical Chemistry, pharmaceutics, Pharmacology and Toxicology, as well as Biotechnology. In the domain of Community and Clinical Pharmacy, the journal encompasses discussions on Hospital Pharmacy, Clinical Pharmacy, Pharmacy Management, and Social Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 3 Documents
 1 
Search results for , issue "Vol. 3 No. 1 (2026): April" : 3 Documents clear
Phytochemical Composition and Antibacterial Activity of Barringtonia asiatica (L.) Kurz Fruit Peel Extracts against Staphylococcus aureus and Escherichia coli Sriwulandari; Harfiansyah, M. Deddy
Sciences and Clinical Pharmacy Research Journal Vol. 3 No. 1 (2026): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v3i1.5573

Abstract

The present study investigated the phytochemical constituents and antibacterial potential of methanol, ethyl acetate, and n-hexane extracts obtained from the fruit peel of Barringtonia asiatica against the bacteria Staphylococcus aureus and Escherichia coli. The powdered peel material was initially extracted through a maceration process using methanol as the solvent, after which the extract was fractionated with ethyl acetate and n-hexane to obtain different polarity fractions. Qualitative phytochemical screening was conducted to determine the presence of secondary metabolites, whereas antibacterial activity was assessed using the agar diffusion technique at concentrations ranging from 100 to 500 mg/ml. The phytochemical evaluation revealed that the methanol extract contained several bioactive compounds, including flavonoids, tannins, and terpenoids. In the antibacterial test, the ethyl acetate fraction demonstrated the highest inhibitory effect on both test microorganisms at a concentration of 500 mg/ml, producing inhibition zones of 16.42 mm against S. aureus and 11.37 mm against E. coli. Meanwhile, the methanol extract produced inhibition zones of 13.30 mm and 10.63 mm, respectively. The n-hexane fraction exhibited comparatively weaker activity, with inhibition zones measuring 7.45 mm against  S. aureus and 7.32 mm against E. coli. Overall, these findings suggest that extracts  derived from the fruit peel of B. asiatica possess antibacterial properties, with the  ethyl acetate fraction showing the most pronounced inhibitory activity among  the tested extracts.
From Drug of Choice to Publich Health Tool: A Narrative Review of Ivermectin for Strongyloidiasis Control Nurmansyah, Dian; Gunasari, Lala; Puspawati
Sciences and Clinical Pharmacy Research Journal Vol. 3 No. 1 (2026): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v3i1.5600

Abstract

This narrative review analyses the gap between its clinical supremacy and inadequate public health translation. A structured literature search (2020-2025) using MeSH terms including Ivermectin, Strongyloides stercoralis, and soil-transmitted helminths was conducted via ScienceDirect and Google Scholar. The retrieved evidence synthesizes ivermectin's superior therapeutic profile over albendazole and critically examines the Indonesian context, where significant underdiagnosis and missed opportunities within mass drug administration programs perpetuate transmission. Key implementation barriers spanning diagnostics, policy, and health systems are identified. To address this, the review argues for a strategic paradigm shift: ivermectin must be reenvisioned from a curative agent to a cornerstone of preventative public health. Achieving this requires definitive guideline integration, targeted preventive strategies, and multi-sectoral collaboration
Re-evaluating Albendazole-Based Preventive Chemotherapy for Soil-Transmitted Helminths in Indonesia: A Narrative Review on Efficacy, Challenges, and Future Strategies Gunasari, Lala; Nurmansyah, Dian; Triana, Dessy
Sciences and Clinical Pharmacy Research Journal Vol. 3 No. 1 (2026): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v3i1.5601

Abstract

This narrative review seeks to critically analyze the efficacy of albendazole, the cornerstone anthelmintic of the program. Relevant literature (2020-2025) was identified through a systematic search of the ScienceDirect and Google Scholar databases. While evidence confirms albendazole's effectiveness, with cure rates up to 93%, its performance is inconsistent and influenced by a confluence of factors. A critical constraint identified is the absence of robust, large-scale national surveillance data on STH prevalence and drug efficacy, hindering a comprehensive assessment of albendazole's performance within the program. The persistent burden of STH underscores a gap between program implementation and its intended public health impact. While albendazole remains essential, its variable efficacy and operational barriers necessitate a critical reassessment of the current strategy.

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