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The International Journal of Medical Science and Health Research, published by International Medical Journal Corp. Ltd. is dedicated to providing physicians with the best research and important information in the world of medical research and science and to present the information in a format that is understandable and clinically useful. Committed to publishing multidisciplinary research that spans the entire spectrum of healthcare and medicine access, The American Journal of Medical Science and Health Research aims at an international audience of pharmacists, clinicians, medical ethicists, regulators, and researchers, providing an online forum for the rapid dissemination of recent research and perspectives in this area.

Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran

Articles 449 Documents

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The Effect of Vitamin D Supplementation on Recurrence-Free Survival in Melanoma Patients: A Systematic Review and Meta-Analysis Aldila Ardine; Raisa Khairuni
The International Journal of Medical Science and Health Research Vol. 26 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/h8fwcx38

Introduction: Vitamin D has been proposed as a potential adjunctive therapy in melanoma based on its biological effects on tumor cells and immune modulation. However, the clinical benefit of vitamin D supplementation in reducing melanoma recurrence or progression remains uncertain. Objective: To systematically evaluate the impact of vitamin D supplementation on recurrence-free survival in patients with melanoma. Methods: A systematic review and meta-analysis were conducted according to PRISMA guidelines. Eligible studies included randomized controlled trials and cohort studies comparing vitamin D supplementation to placebo or no supplementation in melanoma patients and reporting recurrence-free, disease-free, or progression-free survival. Data were synthesized using a random-effects model, and hazard ratios (HRs) were pooled. Results: Three studies (n=739) were included, encompassing both adjuvant and advanced melanoma settings. The pooled analysis demonstrated no statistically significant association between vitamin D supplementation and improved recurrence-free survival (HR 0.83, 95% CI: 0.52–1.32; p = 0.43). Moderate heterogeneity was observed. Only one study, involving patients treated with anti–PD-1 immunotherapy, showed a significant benefit, whereas randomized trials in the adjuvant setting did not. Discussion: Although preclinical and observational data support a potential role for vitamin D in melanoma, clinical trial evidence does not demonstrate a significant effect on recurrence-free survival. Heterogeneity in study populations, supplementation regimens, and timing may influence outcomes. Conclusion: Vitamin D supplementation cannot currently be recommended solely to prevent recurrence or progression in melanoma, but remains important for general health. Further research, particularly in the context of immunotherapy, is warranted.

Management of Corneal Ulcers : A Systematic Review of Treatment Options Afriadi; Miftakhul Baiti
The International Journal of Medical Science and Health Research Vol. 26 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/yztg8y02

Introduction: Corneal ulcers represent a significant cause of ocular morbidity and potential vision loss worldwide. The management landscape is diverse, encompassing antimicrobial therapy, anti-inflammatory agents, surgical interventions, and novel adjunctive treatments. A systematic synthesis of high-quality evidence is crucial to inform optimal, evidence-based clinical strategies. Methods: A systematic review was conducted following a pre-defined protocol. Eighty studies, including randomized controlled trials (RCTs), systematic reviews, and meta-analyses, were included after screening based on strict criteria focusing on human studies of corneal ulcers reporting clinical outcomes. Data extraction covered study design, ulcer characteristics, interventions, healing, visual, and safety outcomes. Results: For bacterial keratitis, fluoroquinolone monotherapy (e.g., moxifloxacin) demonstrated equivalent efficacy to fortified antibiotic combinations but with a better ocular tolerability profile (McDonald et al., 2014; Sharma et al., 2013). Adjunctive corticosteroids showed no overall benefit in the SCUT trial but provided significant visual improvement in severe, centrally-located, non-Nocardia ulcers when initiated early (≤3 days) (Srinivasan et al., 2012; Ray et al., 2014). For fungal keratitis, natamycin was superior to voriconazole for filamentary fungi, particularly Fusarium (Sharma et al., 2015; Qiu et al., 2015). Surgical adjuncts like amniotic membrane transplantation (AMT) reduced healing time by approximately 4 days (Ting et al., 2021), while photoactivated chromophore for keratitis-corneal cross-linking (PACK-CXL) showed promise in expediting healing but with variable results based on ulcer severity and etiology (Ting et al., 2019). Discussion: The evidence supports a stratified treatment approach. Key determinants of management success include accurate etiological diagnosis, consideration of ulcer severity and location, and the timing of adjunctive interventions. Geographic variations in causative organisms and antibiotic resistance patterns necessitate local guideline adaptations. Conclusion: Effective management of corneal ulcers requires a tailored, multi-modal strategy. First-line antimicrobial choice should be guided by suspected etiology and local resistance patterns. Adjunctive corticosteroids and surgical interventions like AMT or CXL have defined, selective roles based on specific clinical and microbiological parameters. Future research should focus on high-quality RCTs in diverse populations, standardized outcome measures, and the development of personalized treatment algorithms.

The Comprehensive Systematic Review of What is The Relationship Between Pleural Effusion Characteristics and The Occurrence of Compressive Atelectasis in Adult Patients, as Evaluated Through Radiological Imaging Techniques? Anisa Ayu Prasanti; Charles Sanjaya
The International Journal of Medical Science and Health Research Vol. 26 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/dzn49b80

Introduction: Pleural effusions are a common clinical finding across diverse medical and surgical conditions, often leading to respiratory compromise. Compressive atelectasis, the collapse of lung tissue due to external pressure from pleural fluid, is a significant contributor to this morbidity. However, the precise relationship between specific characteristics of the effusion (e.g., volume, composition, laterality) and the occurrence of compressive atelectasis remains inadequately defined in adult populations (Chiumello et al., 2013; Muruganandan et al., 2020). Methods: A comprehensive systematic review was conducted, screening sources based on predefined criteria including adult population, presence of pleural effusion, assessment of effusion characteristics, evaluation of compressive atelectasis via radiological imaging, and appropriate study designs. Data were extracted from 80 heterogeneous sources, encompassing observational studies, randomized trials, and meta-analyses, focusing on population details, effusion characteristics, imaging methods, atelectasis definitions, and reported statistical relationships. Results: Direct evidence quantitatively linking effusion characteristics to compressive atelectasis was scarce. Larger effusion size (e.g., >500 mL) was associated with increased incidence of atelectasis, particularly in specific populations like lung transplant recipients (Krumm et al., 2024). Indirect evidence from drainage studies showed consistent improvements in oxygenation (PaO2/FiO2 ratio) and end-expiratory lung volume post-thoracentesis, especially in mechanically ventilated patients with hypoxemia (Goligher et al., 2011; Vetrugno et al., 2019; Chiu et al., 2024). Key thresholds emerged, suggesting drainage is most beneficial for effusions >400-500 mL or occupying ≥25% of the hemithorax, particularly when baseline P:F ratio is <200. The relationship is modulated by factors such as body position, underlying lung and pleural disease (e.g., trapped lung), and effusion etiology (Cortes-Puentes et al., 2018; Razazi et al., 2014). Discussion: The findings indicate that the development of compressive atelectasis is a multifactorial process, not solely dependent on effusion volume. Underlying pleural physiology (elastance), parenchymal compliance, patient positioning, and diaphragm function critically influence the outcome. Radiographic lung re-expansion post-drainage is a poor surrogate for physiological success, often discordant with pleural pressure measurements (Lester et al., 2022). The clinical implication is that management should be guided by physiology and symptoms, not just imaging appearance. Conclusion: While larger pleural effusions increase the risk of compressive atelectasis, the relationship is non-linear and significantly confounded by patient-specific factors. A standardized definition for compressive atelectasis and more studies directly correlating detailed effusion characteristics with radiologically defined atelectasis are needed. Clinically, drainage should be considered for symptomatic patients or mechanically ventilated patients with significant hypoxemia and effusions above volume thresholds, with an understanding that underlying lung condition dictates the response.

A Comprehensive Systematic Review of The Relationship Between The Duration of Catheterization And The Risk of Urinary Tract Infection Following Ureteroplasty Peter Darmawan
The International Journal of Medical Science and Health Research Vol. 26 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/jn3cg487

Introduction: Urinary tract infection (UTI) is a prevalent and consequential complication following urological surgeries involving catheterization, such as ureteroplasty. The duration of catheterization is a modifiable risk factor, yet optimal timing for catheter or stent removal to balance the risks of UTI against other surgical complications remains a significant clinical question (Visser et al., 2019). Methods: This systematic review synthesized evidence from 66 studies. A comprehensive search and screening process identified studies reporting on the relationship between catheterization duration and UTI risk in patients undergoing ureteroplasty and related urological procedures. Data on study design, population, catheterization details, UTI definitions, and outcomes were extracted and analyzed qualitatively and quantitatively where possible. Results: The synthesis demonstrates a strong, dose-dependent relationship between longer catheterization duration and increased UTI risk. Meta-analyses consistently showed that early stent removal (typically defined as ≤3 weeks) significantly reduces UTI incidence compared to later removal, with odds ratios ranging from 0.41 to 0.53 (Visser et al., 2019; Kusuma et al., 2025; Oka et al., 2020). Primary studies in kidney transplantation reported UTI rates of 2-10% with early removal (1-2 weeks) versus 25-35% with late removal (4-6 weeks) (Indu et al., 2012; Coskun et al., 2011; Ramamoorthy et al., 2018). Evidence from ureteroplasty and general urology settings supports a similar trend, with each additional day of catheterization increasing risk. Bacterial colonization of devices, a precursor to infection, rises significantly with time (Bouassida et al., 2023; Toprak et al., 2020). Discussion: The findings underscore that prolonged catheterization facilitates biofilm formation and bacterial ascension, leading to UTIs. The relationship exhibits threshold effects, with notable risk increases beyond 7, 14, and 30 days depending on the clinical context. While most evidence originates from kidney transplant populations, the biological mechanism is applicable to ureteroplasty. Confounding factors like female gender, diabetes, and lack of antibiotic prophylaxis modulate this risk (Hosseinpour et al., 2023; Marschall et al., 2013). Conclusion: Shorter durations of urinary catheterization and ureteral stenting are strongly associated with a lower risk of postoperative UTI without increasing major urological complications. For ureteroplasty and similar reconstructive procedures, adopting a protocol for early catheter removal (within 2-3 weeks where surgically safe) is recommended. Future research should focus on procedure-specific RCTs in ureteroplasty populations to refine optimal duration guidelines.

The Relationship Between Acupressure Technique And The Reduction Of Nausea And Vomiting In Early Pregnancy Faizal Akbar Farid Musliem
The International Journal of Medical Science and Health Research Vol. 26 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/0yyhyn40

Introduction: Nausea and vomiting in early pregnancy (NVP), commonly known as morning sickness, is a prevalent condition affecting a majority of pregnant women, significantly impacting their quality of life. While often managed with dietary adjustments or pharmacological interventions, there is a growing interest in safe, non-invasive, and non-pharmacological alternatives. Acupressure, a traditional Chinese medicine technique applying pressure to specific acupoints, has emerged as a potential intervention, with the P6 (Neiguan) point being the most commonly targeted. This systematic review synthesizes the current evidence on the effectiveness of acupressure techniques for reducing NVP. Methods: A systematic review methodology was employed. Electronic databases were searched for studies published up to 2025. Studies were screened based on pre-defined criteria focusing on pregnant women in the first trimester experiencing NVP, interventions using pressure-based acupressure techniques, and designs including randomized controlled trials (RCTs), quasi-experimental studies, and systematic reviews. Data were extracted on study design, population characteristics, intervention protocols (points, method, duration), outcome measures, and results. The findings from 71 included sources were synthesized narratively and quantitatively where appropriate. Results: The synthesis of evidence from 71 studies, including RCTs, quasi-experimental designs, and meta-analyses, indicates that acupressure is an effective intervention for reducing NVP. The P6 point was the most frequently studied and demonstrated significant efficacy. Meta-analyses reported strong pooled evidence; for instance, one found acupressure reduced nausea (RR=0.47) and vomiting (RR=0.59) significantly (R. Helmreich et al., 2006). Quasi-experimental studies showed substantial pre-post symptom reductions (e.g., B. Devi, 2020). Acupressure was found effective for mild to moderate NVP, with emerging evidence supporting its use even in hyperemesis gravidarum (HG), particularly as an adjunct (Nor Azila Mohd Nafiah et al., 2022; H. Shin & Young A Song, 2005). Combination therapies with ginger or aromatherapy often yielded enhanced effects (Nikmah Jalilah Ritonga et al., 2020; Risa Ayu Faturanti et al., 2025). The safety profile was consistently favorable with minimal adverse effects. Discussion: The evidence supports acupressure as a viable, safe, and effective non-pharmacological option for managing NVP. Effectiveness appears influenced by symptom severity, methodological rigor, intervention protocol (e.g., continuous vs. intermittent application), and comparator type. While placebo effects may contribute, especially in unblinded studies, the consistent positive findings across diverse study designs strengthen the case for its clinical utility. Acupressure offers a practical, self-administerable option that aligns with patient preferences for minimal intervention during pregnancy. Conclusion: Acupressure, particularly at the P6 point, is recommended as an effective first-line or adjunctive intervention for reducing nausea and vomiting in early pregnancy, especially for women with mild to moderate symptoms. It presents a favorable safety profile. Future research should focus on standardized protocols, long-term effects, and cost-effectiveness to facilitate integration into routine prenatal care.

Coexistence of Ovarian Endometrioma, Leiomyoma, and Genital Tuberculosis Mimicking Malignancy: A Case Report Kirana Paramitha Santosa; Anggar Jito
The International Journal of Medical Science and Health Research Vol. 27 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/hmzc6352

Introduction: Genital tuberculosis (TB) can present with nonspecific symptoms and clinical findings that resemble gynecologic malignancy, particularly when accompanied by elevated tumor markers, large pelvic masses, and ascites.1 Case Report: A 34-year-old female presented with progressive lower abdominal pain for five months, especially during menstruation. Additional symptoms included weight loss, abdominal distension, difficulty with defecation and urination. Abdominal MSCT demonstrated the presence of ascites and a large adnexal mass compressing the rectum, suggestive of malignancy. Laboratory testing showed an elevated CA-125 level of 372.70 U/mL. Initially, ovarian malignancy was the primary differential diagnosis. After thorough consideration, a bilateral oophorectomy and hysterectomy were performed, despite the patient not yet having borne children. Histopathological examination of the surgical specimens revealed a leiomyoma, ovarian endometrioma, and chronic granulomatous inflammation consistent with TB infection was found in both ovaries and endometrium. Discussion: This case underlines the importance of considering genital TB in the differential diagnosis of pelvic masses with elevated CA-125, especially in TB-endemic regions.2 This is crucial because both diseases can coexist in the same individual. When malignancy is initially suspected, it is important to conduct a thorough investigation to rule out or confirm TB, as the treatment and management strategies differ significantly, potentially avoiding unnecessary aggressive intervention.3 Conclusion: This study emphasizes the importance of including GTB in the differential diagnosis of pelvic masses associated with elevated tumor markers, particularly in TB-endemic regions. This consideration is essential because benign pelvic masses and GTB may coexist in the same patient. Given the wide variability in clinical presentation and the limited accuracy of current diagnostic modalities, it may be misdiagnosed as a gynecologic malignancy which has a significantly different treatment strategies. Keywords: leiomyoma, endometrioma, genital tuberculosis

The Comprehensive Systematic Review of Efficacy of Dietary Supplements for Headaches Adrian Saleh
The International Journal of Medical Science and Health Research Vol. 27 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/4aqnss60

Introduction: Migraine and other primary headache disorders represent a significant global health burden, often inadequately managed by conventional pharmacotherapy due to issues of efficacy, side effects, and patient preference. This has spurred interest in dietary supplements as potential prophylactic and therapeutic alternatives. This report synthesizes the current evidence on the efficacy and safety of various dietary supplements for headache management. Methods: A systematic approach was employed to identify relevant studies involving participants with primary headache disorders, interventions with standalone dietary supplements, and quantitative headache-related outcomes. Data were extracted on supplement details, headache types, participant characteristics, outcomes, efficacy results, study design, and safety profiles from included studies. Results: The analysis demonstrated significant efficacy for several supplements. Omega-3 fatty acids, particularly when combined with reduced omega-6 intake (H3-L6 diet), reduced headache days by 4.0 days per month (Ramsden et al., 2021). High-dose EPA/DHA outperformed FDA-approved prophylactic medications in a network meta-analysis (Tseng et al., 2023). Vitamin B2 (400 mg/day) significantly reduced migraine frequency and showed comparable efficacy to sodium valproate with fewer side effects (Chen et al., 2021; Rahimdel et al., 2015). Magnesium (500-600 mg/day), Coenzyme Q10, vitamin D, and butterbur also showed consistent benefits. B-vitamin combinations were effective, particularly in individuals with specific MTHFR genotypes (Lea et al., 2009; Menon et al., 2012). Probiotics, curcumin, alpha-lipoic acid, and minerals like zinc and selenium also demonstrated positive effects. Combination therapies (e.g., CoQ10 + L-carnitine, omega-3 + nano-curcumin) often showed synergistic benefits. Discussion: The efficacy of supplements is moderated by factors such as dosage, formulation, genetic makeup (e.g., MTHFR status), headache chronicity, and age. Supplements appear to work through diverse mechanisms including anti-inflammation, mitochondrial support, oxidative stress reduction, and neuromodulation. They present a favorable safety profile compared to many pharmaceutical preventatives. Conclusion: A robust body of evidence supports the use of specific dietary supplements—including omega-3 fatty acids, riboflavin, magnesium, CoQ10, and vitamin D—as effective and generally safe options for the prophylaxis of migraines and other primary headaches. They offer viable alternatives or adjuncts to conventional pharmacotherapy, especially for patients seeking fewer side effects or with specific biological predispositions. Future research should focus on long-term safety, optimal dosing protocols, and personalized supplementation strategies based on biomarkers and genetics.

Endourological Management of Urinary Tract Strictures: A Systematic Review of Efficacy, Safety, and Durability across the Ureter and Urethra Regenio Akira Handoyo; Ilham Saptia Nugraha
The International Journal of Medical Science and Health Research Vol. 27 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/hm6hws79

Introduction Urinary tract strictures, a constellation of fibrotic conditions encompassing urethral stricture disease (USD) and benign ureteral strictures (US), impose significant morbidity due to the aggressive nature of recurrence after traditional mechanical endoscopic management (Yeow et al., 2024; Malkhasyan et al., 2013). While open surgical reconstruction remains the established gold standard for complex lesions, endourological methods are frequently attempted as the initial management strategy, especially for shorter strictures or patients with multiple comorbidities (Stein et al., 2001; Buckley et al., 2014). This systematic review provides an integrated, in-depth synthesis of recent, high-certainty evidence concerning the long-term efficacy, functional outcomes, and safety profiles of advanced endourological modalities, specifically focusing on Drug-Coated Balloons (DCB) for the urethra and precise laser-assisted endoureterotomy for the ureter (DeLong et al., 2025; Gökçe et al., 2022). Methods A rigorous systematic literature search, adhering strictly to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, was performed across major biomedical databases, targeting studies published between 1998 and 2025 (Page et al., 2021). Inclusion criteria required studies to report comparative outcomes or long-term follow-up (minimum 12 months) of procedures such as dilation, direct vision internal urethrotomy (DVIU), DCB, balloon ureteroplasty, and endoureterotomy (Patel et al., 2024). A highly selected cohort of at least fifteen high-quality clinical studies, including pivotal randomized controlled trials (RCTs) and prospective cohorts, were included for detailed quantitative synthesis (Patel et al., 2024). Methodological quality was assessed using the Cochrane Risk of Bias 2.0 tool for RCTs and the Newcastle-Ottawa Scale for non-randomized studies (Higgins et al., 2011). A total of eleven distinct clinical and mechanistic outcomes were quantified, including the five-year Freedom from Re-intervention (FFR), Maximum Urinary Flow Rate (Qmax), International Prostate Symptom Score (IPSS), and the histological quality of wound healing (DeLong et al., 2025; Gökçe et al., 2022). Results The combined analysis across the urinary tract demonstrated a significant clinical superiority of modern, adjunct-enhanced endourology (DeLong et al., 2025). Traditional mechanical management (dilation or DVIU) of anterior urethral strictures yields long-term recurrence rates ranging from 60% to 80%, confirming the inherent limitation of purely physical treatment against spongiofibrosis (Patel et al., 2024; Yu et al., 2024). In sharp contrast, the application of the paclitaxel-eluting DCB in recurrent bulbar USD (≤ 2 cm) demonstrated remarkable long-term durability, achieving an estimated FFR of 71.7% at five years in the ROBUST I trial (DeLong et al., 2025). This sustained success was functionally confirmed, with mean Qmax increasing from a severely obstructed 5.0 mL/s at baseline to 19.9 mL/s at the five-year follow-up, alongside a profound reduction in mean IPSS from 25.2 to 7.2 (DeLong et al., 2025). For ureteral strictures, combination techniques, such as balloon dilation coupled with endoureterotomy for lower ureteral strictures, achieved high success rates of 86.67% at one year (Diao et al., 2023). Preclinical data further indicated that Ho:YAG laser endoureterotomy yields superior histological remodeling and a reduced fibrotic response compared to mechanical balloon dilation alone (Gökçe et al., 2022). Discussion The synthesized data compels a major revision of clinical algorithms, strongly endorsing the deployment of DCB as a validated, durable, minimally invasive option for selected recurrent bulbar urethral strictures, effectively interrupting the pathological cycle of injury and re-scarring (Yeow et al., 2024). In the ureter, optimal outcomes rely heavily on technical refinement—specifically, utilizing precise laser incision and careful patient selection, emphasizing that shorter stricture length is the primary predictor of endourological success in both tracts (Gökçe et al., 2022; Heyns et al., 1998). The high complication risks observed in vulnerable cohorts, notably kidney transplant patients managed endourologically, further stress the need for conservative selection criteria, often favoring upfront open reconstruction for complex lesions (Wang et al., 2024). Conclusion Durable endourological success across the urinary tract is contingent upon the meticulous selection of patients and the strategic integration of modern, biologically or technically enhanced technologies (Buckley et al., 2014). The DCB is established as a highly effective, sustained treatment for recurrent short bulbar USD, offering objective and subjective relief comparable to long-term open reconstruction outcomes (DeLong et al., 2025; Stein et al., 2001). For ureteral strictures, precise laser endoureterotomy combined with optimal stenting offers the best endoscopic outcomes by promoting favorable tissue remodeling (Gökçe et al., 2022). Future research must prioritize validating DCB use in longer, complex urethral strictures and conducting definitive RCTs to confirm the long-term clinical superiority of Ho:YAG laser endoureterotomy in human ureteral stricture management (Ricketts et al., 2024; Gökçe et al., 2022).

How do Laparoscopic and Open Surgical Approaches Compare in Terms of Post-Operative Complications, Recovery Time, and Quality of Life For Colorectal Cancer Patients? : A Systematic Review Sean Gerry Santoso; Habel Ryan Annerico Sianipar; Freddy
The International Journal of Medical Science and Health Research Vol. 27 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/vn0qh344

Introduction: Surgical resection is the primary curative treatment for colorectal cancer (CRC). While traditional open surgery has long been the standard, minimally invasive laparoscopic surgery has emerged as a widely used alternative. Its adoption is driven by potential short-term benefits, but a comprehensive understanding of its comparative impact on complications, recovery, and quality of life is essential for guiding clinical practice. This systematic review aims to synthesize and evaluate the evidence comparing laparoscopic and open surgical approaches for CRC. Methods: A systematic review was conducted adhering to PRISMA 2020 guidelines. Five electronic databases, including PubMed and Google Scholar, were searched for studies published since 2015 comparing laparoscopic versus open resection for CRC. The primary outcomes of interest were postoperative complications, recovery time, and quality of life. After screening thousands of records, 39 eligible studies, including randomized controlled trials and large meta-analyses, were included in the final qualitative and quantitative synthesis. Results: The analysis revealed that laparoscopic surgery was associated with significantly lower rates of overall postoperative complications in 23 of 26 reporting studies. Recovery was markedly faster with laparoscopy, with all 10 studies assessing hospital stay reporting shorter durations and a majority showing quicker return of bowel function. Long-term oncological outcomes, including survival and recurrence rates, were found to be equivalent between the two approaches in 12 of 16 studies. Data on quality of life were limited, with only one study reporting a short-term benefit for the laparoscopic group. Discussion: The consistent findings across multiple domains demonstrate a clear clinical advantage for the minimally invasive approach. The evidence strongly indicates that the short-term benefits of reduced patient morbidity and accelerated recovery do not compromise long-term oncological control, affirming the safety and efficacy of the laparoscopic technique. Conclusion: Laparoscopic surgery provides a superior short-term recovery profile and fewer complications than open surgery while offering equivalent long-term oncological safety. It should be considered the standard of care for most patients with colorectal cancer. Future research should prioritize investigating long-term, patient-reported quality of life to provide a more holistic comparison.

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Indra Hadi

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profesionaljournalmedicine@gmail.com

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Journal Mail Official
pt.internationalmedicaljournal@gmail.com

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Equity Tower. 49th Floor. Sudirman Street. Special Region of Jakarta, Indonesia

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Kota adm. jakarta selatan,

Dki jakarta

INDONESIA