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The International Journal of Medical Science and Health Research
ISSN : 30481376     EISSN : 30481368     DOI : -
Core Subject : Health,
The International Journal of Medical Science and Health Research, published by International Medical Journal Corp. Ltd. is dedicated to providing physicians with the best research and important information in the world of medical research and science and to present the information in a format that is understandable and clinically useful. Committed to publishing multidisciplinary research that spans the entire spectrum of healthcare and medicine access, The American Journal of Medical Science and Health Research aims at an international audience of pharmacists, clinicians, medical ethicists, regulators, and researchers, providing an online forum for the rapid dissemination of recent research and perspectives in this area.
Articles 577 Documents
The Effectiveness of Limbal Stem Cell Transplantation on Ocular Surface Restoration and Corneal Clarity : A Systematic Review Faidil Akbar
The International Journal of Medical Science and Health Research Vol. 47 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/9feq8x34

Abstract

Introduction: Limbal stem cell deficiency (LSCD) leads to corneal conjunctivalization, neovascularization, and vision loss. This systematic review evaluates the effectiveness of various limbal stem cell transplantation (LSCT) techniques on ocular surface restoration and corneal clarity. Methods: A systematic review of human studies (RCTs, etc) reporting quantitative outcomes of LSCT for LSCD or severe ocular surface disorders was performed. Studies had a minimum 3-month follow-up. Outcomes extracted included anatomical success, visual acuity changes, corneal clarity, neovascularization regression, and safety profiles. Results: Across 24 included studies, LSCT consistently achieved anatomical surface restoration in 67-92% of eyes. Techniques such as SLET, CLET, CLAU, and MSCT showed equivalent surface stabilization. However, visual acuity gains were often modest in bilateral or severe LSCD due to underlying stromal scarring (Zakaria et al., 2014; Calonge et al., 2019). Corneal clarity improved significantly with SLET, MSCT, and COMET, but not with CLET alone (Sharma et al., 2024; Calonge et al., 2019; Tandon et al., 2024). Neovascularization consistently regressed across all techniques (Arora et al., 2017; Jurkunas et al., 2025). In pterygium, LSCT reduced recurrence rates to 0-12.5% compared to 17.5-30.4% with excision alone (Mu et al., 2012; Yu, 2026). Safety was favorable, with no serious cell-related adverse events. Discussion: A key dissociation exists between successful surface restoration and visual recovery, as LSCT addresses epithelial but not stromal pathology. Etiology is a major moderator: chemical burns respond best, while autoimmune diseases have poorer outcomes. Adjunctive amniotic membrane sustains long-term effects only when combined with stem cells. Manufacturing quality and cell confluence predict success. Conclusion: LSCT is effective for ocular surface restoration and neovascularization reduction. However, visual recovery requires sequential keratoplasty for stromal opacity. Technique selection should be etiology-driven, and standardized manufacturing protocols are recommended for future trials.
The Effect of Vitamin D Administration on Glycemic Control in Patients with Type 2 Diabetes Mellitus : A Systematic Review Fahmi Iskandar Aminullah; Jazilatul Hikmia
The International Journal of Medical Science and Health Research Vol. 47 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/mnz8n239

Abstract

Introduction: Vitamin D deficiency is highly prevalent among patients with type 2 diabetes mellitus (T2DM) and has been linked to impaired insulin secretion and insulin resistance. However, the effects of vitamin D supplementation on glycemic control remain controversial. Methods: This systematic review synthesized evidence from 80 randomized controlled trials, etc identified through structured screening. Studies enrolling adults with T2DM receiving vitamin D supplementation (cholecalciferol, ergocalciferol, calcitriol, or analogs) with a control group and reporting glycemic outcomes (HbA1c, fasting glucose, HOMA-IR) were included. Results:  HbA1c (WMD −0.20% to −0.32%), fasting plasma glucose (WMD −5.02 mg/dL), and HOMA-IR (WMD −0.42 to −0.66). However, effects were highly heterogeneous. Positive outcomes were predominantly observed in vitamin D‑deficient (25(OH)D <30 nmol/L), poorly controlled (HbA1c >8%), non‑obese patients, particularly in Middle Eastern and South Asian populations. Null results consistently emerged from well‑controlled European/American cohorts with baseline 25(OH)D near sufficiency. Effect modifiers included baseline vitamin D status, obesity, intervention duration (short‑term >12 weeks showed benefit; long‑term did not), dose (>2,000 IU/day more effective), and co‑supplementation with calcium. Safety was excellent, with no clinically significant hypercalcemia. Discussion: The apparent contradiction between positive meta-analyses and null individual trials is resolved by recognizing that benefits are restricted to specific subpopulations. Vitamin D supplementation likely improves glycemic control through enhanced insulin secretion and insulin sensitivity, but only when baseline deficiency is corrected and patients have sufficient glycemic headroom for improvement. Obese patients require higher doses due to adipose sequestration. Conclusion: Vitamin D supplementation produces small but real improvements in glycemic control in T2DM patients who are vitamin D deficient, poorly controlled, and non‑obese, or who receive dose‑adjusted high‑dose therapy. Routine supplementation is not recommended for vitamin D‑replete or well‑controlled patients. Future trials should focus on personalized dosing based on baseline 25(OH)D, BMI, and HbA1c.
Association Between Postnatal Steroid Use and Long-term Neurodevelopmental Impairment : A Systematic Review Deskafiani Putri; Firman Syahbana
The International Journal of Medical Science and Health Research Vol. 47 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/swdy1825

Abstract

Introduction: Postnatal systemic corticosteroids are used to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants, but concerns persist regarding their association with long-term neurodevelopmental impairment (NDI). This systematic review synthesizes evidence on the association between postnatal steroid use (dexamethasone and hydrocortisone) and long-term neurodevelopmental outcomes. Methods: A systematic review was conducted following PRISMA guidelines. We screened studies based on predefined criteria: neonatal exposure to systemic postnatal corticosteroids, comparison groups, neurodevelopmental outcomes assessed at ≥12 months corrected age, and RCT or high-quality observational design. Data extraction covered study design, population, steroid regimen, neurodevelopmental outcomes, follow-up timing, association results, and confounding factors. A total of 80 studies were included. Results: Early dexamethasone (<7-8 days) consistently increased cerebral palsy (CP) risk (RR 1.77, 95% CI 1.21-2.58; Doyle et al., 2021). Late dexamethasone (≥7 days) showed no significant CP increase. Early hydrocortisone did not significantly increase CP (RR 1.06, 95% CI 0.67-1.67; Morris et al., 2019) and improved survival without moderate-severe NDI in some analyses. Late hydrocortisone showed neutral neurodevelopmental effects in large RCTs at 2 years and school age. Dose-response relationships were observed for both agents. Gestational age and baseline BPD risk modified treatment effects. Discussion: Apparent contradictions in the literature are reconciled by considering timing of initiation (early vs late), steroid type (dexamethasone vs hydrocortisone), cumulative dose, historical regimens versus current low-dose protocols, confounding by indication, competing mortality risk, and effect modification by gestational age and BPD risk. Early dexamethasone is consistently harmful, while hydrocortisone appears predominantly neutral but with dose-dependent signals. Conclusion: Early dexamethasone should be avoided. Late dexamethasone and hydrocortisone have more favorable profiles but require careful patient selection. The benefit-risk balance is most favorable for extremely preterm infants at highest BPD risk. Further school-age follow-up studies are needed.
The Effectiveness of Metformin in Reducing the Risk of Preeclampsia in Patients with Polycystic Ovary Syndrome (PCOS) : A Systematic Review Desi Dwi Nurchasanah; Lintang Dwi Marti
The International Journal of Medical Science and Health Research Vol. 47 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/0ek38k46

Abstract

Introduction: Polycystic Ovary Syndrome (PCOS) affects a significant proportion of women of reproductive age and is associated with an elevated risk of adverse pregnancy outcomes, including preeclampsia (PE). Metformin, an insulin sensitizer, has been proposed as a potential intervention to reduce this risk. However, the evidence regarding its effectiveness in preventing PE specifically in pregnant women with PCOS remains inconsistent. Methods: This study conducted a systematic synthesis of evidence from 41 sources, including major randomized controlled trials (RCTs) etc. The primary outcome was the incidence of preeclampsia. Secondary outcomes included early pregnancy loss, preterm delivery, gestational diabetes mellitus (GDM), and gestational weight gain. A methodological quality assessment was performed, distinguishing between evidence from RCTs and non-randomized studies. Results: The findings were discordant. Non-randomized studies reported a significant reduction in PE risk with metformin (e.g., Zheng et al., 2013: OR 0.53; Zhao & He, 2022: RR 0.61). However, analyses restricted to high-quality RCTs found no significant benefit. In the PregMet trial (Vanky et al., 2010), PE rates were 7.4% in the metformin group vs. 3.7% in the placebo group (p=0.18). The PregMet2 trial (Løvvik et al., 2019) also found no significant reduction. A meta-analysis of PCOS-specific RCTs (Nascimento et al., 2018) produced a pooled RR of 1.96 (0.81–4.77), trending toward harm. Conversely, consistent benefits were observed for secondary outcomes, including reduced early pregnancy loss, preterm delivery, and gestational weight gain. Discussion: The discrepancy between study designs highlights the risk of selection bias and confounding in non-randomized studies. Women who continue metformin throughout pregnancy may differ systematically from controls. While metformin improves metabolic parameters and reduces weight gain, the highest-quality evidence from placebo-controlled RCTs does not support its use for preeclampsia prevention in PCOS. The drug may reduce pregnancy-induced hypertension but not the specific pathophysiology of PE. Conclusion: Current high-level evidence does not support a clinically meaningful reduction in preeclampsia risk with metformin in pregnant women with PCOS. However, metformin is beneficial for reducing other maternal complications, such as preterm delivery and miscarriage. Future research should focus on specific high-risk PCOS phenotypes.
Effectiveness of Lifestyle Modifications on Blood Sugar Control in Type 2 Diabetes Mellitus Patients : A Systematic Review Yukmin Rotama Panjaitan; Reski Dwi Indah Sari; Kristian Yanuar Lase
The International Journal of Medical Science and Health Research Vol. 9 No. 5 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/ehg2p341

Abstract

Introduction: Type 2 Diabetes Mellitus (T2DM) is a progressive metabolic disorder associated with significant morbidity and healthcare costs. While pharmacological treatments are central, there is growing interest in lifestyle modifications as adjunct or primary interventions. However, the comparative effectiveness of different lifestyle components and the consistency of their glycemic benefits remain unclear. Methods: This systematic review synthesized evidence from 80 studies (including RCTs, etc) identified through systematic screening of abstracts and full texts. Inclusion criteria required adult T2DM populations (≥18 years), lifestyle interventions (diet, exercise, behavioral support, education, or digital tools), and blood glucose outcomes (HbA1c, fasting plasma glucose, postprandial glucose). Data extraction focused on lifestyle intervention details, study population characteristics, glycemic outcomes, secondary cardiometabolic outcomes, and study design. Results: Across the corpus, multicomponent lifestyle interventions produced pooled HbA1c reductions of approximately −0.51% to −0.63% compared to usual care. Exercise interventions, particularly supervised combined aerobic and resistance training, reduced HbA1c by −0.34% to −0.53%, with combined training showing superiority over either modality alone. Dietary interventions (Mediterranean, DASH, low-carbohydrate) achieved HbA1c reductions ranging from −0.39% to −0.82%; however, long-term low-carbohydrate diets (≥12 months) showed non-significant effects (SMD −0.11, p=0.32). Diabetes self-management education (DSME) in group formats reduced HbA1c by −0.44% to −0.87% over 6–24 months, while individual education showed benefit only in those with baseline HbA1c >8%. Digital interventions (mobile apps, SMS) reduced HbA1c by −0.40% to −0.53%, with healthcare professional feedback as a key moderator. Yoga produced consistent improvements (HbA1c MD −0.47%). Intensive lifestyle interventions achieved diabetes remission in 7–12% of participants. Secondary benefits included weight loss, blood pressure reduction, improved lipids, and reduced medication requirements. Discussion: The heterogeneous effect sizes across studies are systematically explained by three interacting mechanisms: baseline glycemic status (individuals with HbA1c ≥8% show twice the benefit), intervention intensity (supervised, high-frequency, and multicomponent programs produce larger effects), and sustainability (benefits attenuate beyond 12 months without ongoing contact). Weight loss is an important mediator but not the sole pathway; direct improvements in skeletal muscle glucose uptake, reduced postprandial carbohydrate load, and enhanced insulin sensitivity contribute independently. Specific recommendations are derived for clinically relevant subgroups. Conclusion: Lifestyle modifications significantly improve blood sugar control in T2DM, with clinically meaningful effects that are comparable to some pharmacological add-on therapies. The greatest benefits occur in patients with higher baseline HbA1c (≥8%) receiving intensive, multicomponent, and supervised interventions. Future clinical practice should prioritize combined diet-plus-exercise programs, group-based DSME with ongoing contact, and targeted digital tools with provider feedback.
What are The Rates of Mortality, Major Morbidity, and Hospital Readmission Within 30 Days Following Elective Gynecological Procedures in Patients Over 80 Years? : A Systematic Review Melati Ganeza; Yahya Nurlianto; Mutia Juliana
The International Journal of Medical Science and Health Research Vol. 48 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/gj4gt527

Abstract

Introduction: The global population is aging, and more women over 80 years are considered for elective gynecological surgery. However, evidence on short-term postoperative outcomes in this specific age group remains scarce. Methods: We conducted a systematic review following PRISMA guidelines, searching multiple databases for studies reporting 30-day mortality, major morbidity, or hospital readmission after elective gynecological procedures in patients ≥80 years. Observational studies, RCTs, etc were included. Results: The pooled 30-day mortality was 0–1% (Friedman et al., 2006; Fitzgerald et al., 2008). Major morbidity was elevated in elderly patients, particularly medical complications (UTI, respiratory failure, sepsis) (Friedman et al., 2006; Bourgin et al., 2016). No study reported 30-day readmission rates specifically for patients over 80. Length of stay was consistently longer in older patients (Friedman et al., 2006; Gultekin et al., 2015). Minimally invasive and obliterative procedures (e.g., colpocleisis) were associated with better outcomes (Raffone et al., 2021; Sadeh et al., 2022). Discussion: There is a profound evidence gap regarding perioperative outcomes in women over 80 undergoing elective gynecological surgery. Available data suggest low mortality but increased morbidity compared to younger patients. Readmission remains unmeasured. Frailty, hypoalbuminemia, and open surgical approach are key risk factors. Conclusion: Elective gynecological surgery in selected patients over 80 is feasible with low mortality, but major morbidity is higher. No readmission data exist. Future research must include this age group, report geriatric-specific outcomes, and evaluate ERAS protocols.
The Relationship Between Crystalloid Fluid Administration and Electrolyte Balance in Critically Ill Patients : A Comprehensive Systematic Review Bery Andara; Dianalia Nurarifany
The International Journal of Medical Science and Health Research Vol. 48 No. 1 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/rhs4kh24

Abstract

Introduction: The choice between balanced crystalloids and 0.9% normal saline for fluid resuscitation in critically ill patients remains debated. While saline is widely used, concerns exist regarding its electrolyte and acid-base effects. Methods: This systematic review synthesized data from 80 studies (RCTs, etc) examining crystalloid administration in critically ill adults. Outcomes focused on significant positive biochemical and clinical effects of balanced crystalloids over saline. Results: Balanced crystalloids demonstrated consistently significant positive effects on electrolyte balance. Serum chloride was significantly lower with balanced solutions versus saline: mean difference −7 mEq/L in trauma (p<0.05) [30], −5.68 mEq/L in sepsis (p=0.001) [1], and −4.3 mmol/L in pancreatitis (p<0.001) [7]. Base excess and bicarbonate were significantly improved in TBI patients receiving balanced fluids (BE −1.35 vs. −3.20, p=0.049) [3]. In DKA, balanced crystalloids significantly reduced time to resolution by 3.51–5.36 hours [21,22] and lowered post-resuscitation chloride (MD −4.26 mmol/L) [22]. In acute pancreatitis, balanced solutions significantly reduced SIRS (17.0% vs. 29.3%, p=0.024) and increased organ failure-free days [7]. Hyperchloremia at 48 hours independently predicted 30-day mortality in trauma (p<0.001) [14]. However, large RCTs found no significant mortality difference in unselected critically ill adults [9,10,13]. Discussion: The consistent chloride-raising effect of saline is mechanistically explained by Stewart’s strong ion theory. Significant benefits of balanced crystalloids emerge in high-volume contexts (DKA, pancreatitis, trauma), but are diluted in heterogeneous ICU populations. Conclusion: Balanced crystalloids produce significantly superior electrolyte profiles and are recommended as default resuscitation fluids, particularly in DKA, pancreatitis, and traumatic brain injury.

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