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FAKULTAS FARMASI UNIVERSETAS JENDERAL ACHMAD YANI Jl. Terusan Jenderal Sudirman PO BOX 148, Cimahi, Jawa Barat, 40531, Indonesia
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INDONESIA
Kartika : Jurnal Ilmiah Farmasi
Published by Universitas Jenderal Achmad Yani
ISSN : 23546565     EISSN : 25023438     DOI : https://doi.org/10.26874/kjif.v6i1.135
Core Subject : Health, Science, Social,
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences
Kartika: Jurnal Ilmiah Farmasi (KJIF) merupakan media publikasi ilmiah dalam bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Jenderal Achmad Yani, bekerjasama dengan Ikatan Apoteker Indonesia (PD IAI Jawa Barat). Ruang lingkup artikel yang diterbitkan adalah: Farmasetika, Kimia Farmasi, Kimia Analisa, Farmasi Fisika, Farmakognosi dan Etnobotani, Natural Produk, Farmakologi dan Toksikologi, Praktik Kefarmasian dan Farmasi Rumah Sakit, Farmakogenomik, Farmakoekonomi, Studi Kasus dan Uji Klinis.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
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Search results for , issue "vol 10 no 1 (2025)" : 5 Documents clear
STUDI FARMAKOEPIDEMIOLOGI VITAMIN PENAMBAH DARAH PADA IBU HAMIL DI KELURAHAN MANGKURAWANG TENGGARONG Mil Hadiyatun Nikmah; Heri Wijaya; Muhammad Marwan Ramadhan; Devi Ristian Octavia
Kartika Jurnal Ilmiah Farmasi Vol 10 No 1 (2025)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v10i1.741

Abstract

Pharmacoepidemiological studies are used to study the use and effects of blood-boosting vitamins and measure the extent of the use and effects of drugs used by pregnant women. This study aims to determine the pharmacoepidemiology of blood-boosting vitamins in pregnant women in Mangkurawang Tenggarong Village. The method used in this research is a descriptive study with a cross-sectional approach. The population in this study were all pregnant women in the Mangkurawang Tenggarong sub-district area. Samples were taken using the total sampling technique. The data analysis used in this research is univariate analysis. The research results showed that 78% of respondents were in the productive age range of 20-35 years, 7% were under 20 years, and 15% were over 35 years. As many as 80% of respondents did not work, and 58% had at least a highschool education, while 20% had tertiary education. Of the supplements used, 57% of respondents used generic drugs provided by the Community Health Center, and 43% used non-generic drugs. As many as 65% of respondents consumed tablets/pills, 35% consumed capsules, 59% preferred tablets/pills, 33% capsules, and 8% syrup. Consumption behavior shows that 63% consume supplements in the morning with water, starting in the first trimester of pregnancy, and 61% obtain supplements from the Community Health Center or Posyandu.
UJI AKTIVITAS ENZIM SUPEROKSIDA DISMUTASE DALAM EKSTRAK ENZIM DAUN STROBERI (Fragaria x ananassa Duchesne) DENGAN METODE RIBOFLAVIN-NITROBLUE TETRAZOLIUM Ira Dwi Astuti; Ana Indrayati; Fransiska Leviana
Kartika Jurnal Ilmiah Farmasi Vol 10 No 1 (2025)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v10i1.969

Abstract

Antioksidan merupakan senyawa yang dapat menghambat aktivitas radikal tersebut. Enzim superoksida dismutase (SOD) dapat mencegah pembentukan radikal bebas. Tanaman stroberi (Fragaria x ananassa Duchesne) merupakan salah satu tanaman yang memiliki aktivitas enzim SOD. Penelitian ini bertujuan untuk mengetahui aktivitas enzim superoksida dismutase dalam ekstrak daun stroberi sebelum pemurnian dan sesudah pemurnian. Penelitian ini menggunakan sampel daun stroberi. Tahap penelitian diawali dengan determinasi tanaman lalu ekstraksi enzim dengan PBS dan disentrifugasi. Pemurnian enzim menggunakan presipitasi amonium sulfat 25%, 50%, dan 75% dan dialisis. Penetapan kadar protein total ekstrak kasar dan ekstrak hasil dialisis menggunakan metode Lowry dan pengujian aktivitas enzim SOD ekstrak kasar dan ekstrak hasil dialisis dengan menggunakan metode Riboflavin-Nitroblue Tetrazolium (RB-NBT) selanjutnya dianalisis one-way ANOVA. Hasil penelitian menunjukkan ekstrak enzim daun stroberi memiliki kadar protein total sebesar 13,558 mg/mL dan ekstraks enzim hasil dialisis konsentrasi amonium sulfat secara berturut-turut adalah 4,080 mg/mL; 8,174 mg/mL dan 14,806 mg/mL. Nilai persen inhibisi ekstrak kasar daun stroberi sebesar 17,885%, ekstrak hasil dialisis berturut-turut sebesar 20,821%; 26,015%; dan 72,086%. Kata kunci :  Antioksidan, fragaria x ananassa duchesne, RB-NBT, superoksida dismutase.   Antioxidants are compounds that can inhibit the activity of these radicals. Superoxide dismutase (SOD) enzymes can prevent the formation of free radicals. The strawberry plant (Fragaria x ananassa Duchesne) is one of the plants that has SOD enzyme activity. This study aims to determine the activity of the superoxide dismutase enzyme in strawberry leaf extract before and after purification. This study used strawberry leaf samples. The research stage begins with plant determination and then enzyme extraction with PBS and centrifuge. Enzyme purification uses 25%, 50%, and 75% ammonium sulfate precipitation and dialysis. The determination of the total protein content of crude extract and dialysis extract was determined using the Lowry method and the testing of SOD enzyme activity of crude extract and dialysis extract using the Riboflavin-Nitroblue Tetrazolium RB-NBT method was then analyzed by one-way ANOVA. The results showed that the enzyme extract of strawberry leaves had a total protein content of 13.558 mg/ml and the enzyme extract from dialysis with ammonium sulfate concentration was consecutively, 4.080 mg/mL 8,174 mg/mL; 14,806 mg/mL. The percentage value of inhibition of crude extract of strawberry leaves was 17.885%, and the extract from consecutive dialysis was 20.821%; 26,01%5; and 72,086%. Keywords: Antioxidants, fragaria x ananassa duchenes, RB-NBT, superoxide dismutase
EFEK ANTIBAKTERI KOMBINASI EKSTRAK KUNYIT (Curcuma domestica Val.) dan JAHE (Zingiber officinale Rosc.) TERHADAP Escherichia coli DENGAN METODE PITA KERTAS Maya Agustina Wijayanti; Ana Indrayati; Fransiska Leviana
Kartika Jurnal Ilmiah Farmasi Vol 10 No 1 (2025)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v10i1.970

Abstract

Escherichia coli is a pathogenic bacteria that causes diarrheal diseases. Treatment of bacterial infections using antibiotics has the potential to cause resistance. Herbal plants are widely used as alternative medicines, including turmeric rhizomes and emprit ginger which are known to have antibacterial activity. This study aims to determine the effect of the combination of turmeric extract and ginger emprit on E.coli bacteria using the paper tape method. The antibacterial activity test was carried out by the method of dilution, diffusion and its combination effect with the paper tape method. The dilution test showed MBC results at a concentration of 25%. Disc method diffusion test to determine the best combination in inhibiting E.coli growth by combining extracts in ratios (1:1), (1:2), and (2:1). The statistical data show the best combination in comparison (1:2). The effect of the combination tested with the paper tape method showed that the combination of the two was indifferent, meaning that it did not affect each other.
REVIEW ARTICLE: POTENSI SENYAWA LUTEOLIN DALAM MENGATASI PENYAKIT KANKER PAYUDARA (Carcinoma mammae) MELALUI PENDEKATAN IN SILICO DENGAN STUDI MOLECULAR DOCKING Fadhiilah Nur Fariidah; Irma Amalia; Yulia Oktapiana
Kartika Jurnal Ilmiah Farmasi Vol 10 No 1 (2025)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v10i1.1075

Abstract

Kanker payudara merupakan salah satu jenis kanker dengan prevalensi tinggi di dunia, termasuk di Indonesia. Pengobatan konvensional seperti kemoterapi masih menimbulkan banyak efek samping, sehingga diperlukan alternatif terapi yang lebih efektif dan minim toksisitas. Luteolin, senyawa flavonoid yang ditemukan dalam berbagai tanaman, telah menunjukkan potensi sebagai agen antikanker melalui mekanisme induksi apoptosis, penghambatan angiogenesis, dan modulasi jalur pensinyalan sel kanker. Tujuan dari kajian ini adalah untuk mengevaluasi potensi luteolin sebagai agen antikanker payudara melalui pendekatan in silico dengan metode molecular docking. Kajian ini menggunakan metode studi literatur sistematis dari enam artikel ilmiah yang dipublikasikan antara tahun 2021-2024, menggunakan database seperti PubMed, ScienceDirect, dan Google Scholar. Hasil kajian menunjukkan bahwa luteolin memiliki afinitas ikatan yang tinggi terhadap berbagai target molekuler penting dalam kanker payudara seperti aromatase (3EQM), ER-alpha, SGK1, dan PLK1. Luteolin juga menunjukkan aktivitas biologis yang mencakup induksi apoptosis, penghambatan proliferasi dan metastasis sel kanker, serta peningkatan efektivitas saat diformulasikan dengan nanopartikel ZnO. Namun, analisis toksisitas in silico mengindikasikan adanya potensi karsinogenik genotoksik, meskipun tidak menunjukkan sifat toksik secara nongenotoksik. Luteolin memiliki potensi sebagai antikanker payudara multitarget dengan mekanisme kerja yang kompleks dan luas. Dengan demikian, diperlukan penelitian lebih lanjut secara in vitro dan in vivo untuk memastikan keamanan dan efektivitasnya.  Kata kunci: Kanker payudara, luteolin, molecular docking.   Breast cancer is one type of cancer with a high prevalence in the world, including in Indonesia. Conventional treatments such as chemotherapy still cause many  side  effects, so alternative therapies that are more effective and minimize toxicity are needed. Luteolin, a flavonoid compound found in various plants, has shown potential as an anticancer agent through the mechanisms of apoptosis induction, angiogenesis inhibition, and modulation of cancer cell signaling pathways. The purpose of this study is to evaluate the potential of luteolin as a breast anticancer agent through an in silico approach with molecular docking method. This study uses a systematic literature study method from six scientific articles published between 2021-2024, using databases such as PubMed, ScienceDirect, and Google Scholar. The results showed that luteolin has high binding affinity to various important molecular targets in breast cancer such as aromatase (3EQM), ER-alpha, SGK1, and PLK1. Luteolin also exhibits biological activities that include induction of apoptosis, inhibition of cancer cell proliferation and metastasis, and enhanced effectiveness when formulated with ZnO nanoparticles. However, in silico toxicity analysis indicated genotoxic carcinogenic potential, although it did not show nongenotoxic properties. Luteolin has potential as a multitarget breast anticancer with a complex and broad mechanism of action. Thus, further in vitro and in vivo studies are needed to ensure its safety and clinical effectiveness.  Keywords: Breast cancer, luteolin, molecular docking.
PEMANFAATAN LIMBAH KULIT BAWANG MERAH (Allium ascalonicum L.) SEBAGAI ANTIOKSIDAN DALAM SEDIAAN MASKER PEEL-OFF Satwika Budi Sawitri; Indah Tri Lestari; Dinny Meliana Safitri; Septian Maulid Wicahyo
Kartika Jurnal Ilmiah Farmasi Vol 10 No 1 (2025)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v10i1.1119

Abstract

Kulit bawang merah kaya akan serat, polifenol, flavonoid, terpenoid, steroid, tannin, dan antosianin. Senyawa bioaktif pada tanaman yang bersifat fotoprotektif dapat menyerap sinar UV dan memiliki aktivitas antioksidan adalah flavonoid dan antosianin. Berdasarkan kandungan senyawa aktif dalam kulit bawang merah tersebut dapat dikembangkan menjadi sediaan masker antioksidan. Masker peel-off memberikan manfaat lebih optimal dalam mengangkat sel kulit mati, membersihkan pori-pori, peremajaan kulit, memberikan sensasi segar dan lembap pada kulit serta mengurangi dampak paparan radikal bebas. Penelitian ini bertujuan untuk mengurangi limbah kulit bawang merah dan memaksimalkan pemanfaatannya dengan pengembangan menjadi produk masker antioksidan. Metode penelitian ini menggunakan eksperimental laboratorium dengan konsentrasi ekstrak kulit bawang merah sebesar 5%, 8%, dan 11%. Ekstrak kulit bawang merah dibuat formula masker peel-off kemudian diuji mutu dan aktivitasnya sebagai antioksidan. Hasil penelitian menunjukkan semua sediaan F1 (5%), F2 (8%) dan F3 (11%) telah memenuhi standar mutu sediaan masker peel-off dengan pH pada rentang 4,7-5,6; viskositas berkisar 1.755,6-3.742,6 cPs; waktu mengering 18-30 menit dan kategori sangat kuat sebagai antioksidan dengan IC50 berturut-turut 5,64; 5,50; 4,53 ppm. Berdasarkan penelitian ini, disimpulkan bahwa aktivitas antioksidan tertinggi pada F3 dengan nilai IC50 sebesar 4,53 ppm yang hampir setara dengan aktivitas antioksidan asam askorbat sebesar 4,37 ppm.  Kata kunci:  Antioksidan, bawang merah, masker, peel-off   Shallot skins are rich in fiber, polyphenols, flavonoids, terpenoids, steroids, tannins, and anthocyanins. Flavonoids and anthocyanins are bioactive compounds possessing antioxidant activity and photoprotective properties capable of absorbing UV rays. Given this content of active compounds, shallot skins can be developed into antioxidant peel-off mask formulations. Peel-off masks offer optimal benefits by removing dead skin cells, cleansing pores, rejuvenating the skin, providing a refreshing and moisturizing sensation, and mitigating the impact of free radical exposure. This study aimed to maximize the utilization of shallot skins and reduce waste by developing an antioxidant peel-off mask product. An experimental laboratory method was employed, utilizing shallot skin extract concentrations of 5%, 8%, and 11%. The extract was formulated into peel-off masks, which were subsequently tested for quality and antioxidant activity. The results showed that all formulations F1 (5%), F2 (8%), and F3 (11%) met quality standards for peel-off masks, with pH levels ranging from 4.7 to 5.6, viscosity between 1,755.6 and 3,742.6 cP, and drying times of 18–30 minutes. All formulations exhibited "very strong" antioxidant activity, with IC50 values ​​of 5.64, 5.50, and 4.53 ppm, respectively. The study concludes that the formulation with the highest antioxidant activity was F3, with an IC50 value of 4.53 ppm—a level nearly equivalent to the antioxidant activity of ascorbic acid (4.37 ppm).  Keywords: Antioxidant, red onion, mask, peel-off

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