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Trends in Infection and Global Health
Published by Universitas Syiah Kuala
ISSN : 2806646x     EISSN : 2806646x     DOI : https://doi.org/10.24815/tigh.v1i2.23580
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
TIGH publishes primary research papers, review articles, short communications and letters on the following topics: Tropical diseases Microbiology Epidemiology Public health Population health One Health Immunology Chronic diseases Surgical disease and surgical care Chemotherapy and pharmacology Maternal and child health Clinical tropical medicine
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 2, No 1 (2022): June 2022" : 5 Documents clear
Cytokine storm in SARS-CoV-2 infection and the potential treatments Ade Oktiviyari; Zinatul Hayati; Tjut Mariam Zanaria
Trends in Infection and Global Health Vol 2, No 1 (2022): June 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i1.25901

Abstract

Cytokine storm is one of main features during respiratory distress caused by COVID-19 infection. Acute Respiratory Distress Syndrome (ARDS) is directly linked with elevated number of COVID-19 mortality cases. Extreme amounts of pro-inflammatory cells are found in the lung of dead patients, mainly macrophages and IL-17 cells. A high level of IL-6 was found in the plasma COVID-19 patients and indicated the severity of diseases. Some other chemokines, such as CXCL10, IL6, CCL2, CXCL1, and CXCL5, were upregulated as well as in COVID-19 patients and regulate the disease. In this review, we discuss the feature of cytokine storms and the current treatments used. We found that IL-6 has a significant role in exacerbated patients’ condition, and the suppression of this cytokine most likely benefits the patient. Another treatment with various targets has been proposed and proven as effective as well. Some of them are corticosteroids, anakinra, plasmapheresis, and interferons.
Balance nutrition and vaccination as efforts to prevent COVID-19 in the community: A cross-sectional study Sausan Syadza; Husnah Husnah; Sitti Hajar; Iflan Nauval; RM Agung Pranata Atmaja
Trends in Infection and Global Health Vol 2, No 1 (2022): June 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i1.23125

Abstract

The increasing cases of COVID-19 are worrying because of its rapid spread and fatality. Efforts are needed to prevent the spread of COVID-19, such as increasing immunity of the body by enforcing vaccination programs, fulfilling balanced nutritional intake, and increasing knowledge about balanced nutrition for the community. This is a descriptive cross-sectional study conducted from August 5 to 10, 2021. A cluster sampling technique was used to recruit respondents and 106 respondents were obtained. Perceptions of balanced nutrition and vaccination were assessed by a self-composed questionnaire while nutritional intake was assessed using the Food Frequency Questionnaire (FFQ). The results of the study showed that 89 respondents (84%) had a good perception of balanced nutrition and  55 respondents (51.9%) had a good perception of vaccinations. Seventy-nine respondents (74.5%) had a good eating habits while 61 respondents (57.5%) had received vaccination. Most participants (84%)  chose family/friends as sources of information about nutrition while (94.3%) chose mass media as an important sources of information on vaccination. 
Microbial assessment of indoor air of the applied microbiology laboratory, Nnamdi Azikiwe University, Awka, Nigeria Ezemba AS; Nwabisi CM; Udemezue IO; Ezemba CC; Osuala OJ
Trends in Infection and Global Health Vol 2, No 1 (2022): June 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i1.24475

Abstract

Air is made up of enormous number of microorganisms mainly fungi and bacteria spores. Their estimation is important as an indication of cleanliness of any particular environment. The present study was carried out to assess microorganisms in indoor air of the Applied Microbiology laboratory of Nnamdi Azikiwe University, Awka. Prepared plates of Sabouraud Dextrose agar (SDA), Nutrient agar (NA), and Blood agar were exposed for ten minutes for culturing of microorganisms. The NA and Blood agar plates were incubated at 37oC for 24h while the SDA plate was incubated at room temperature for 48h. A total of ten (10) microorganisms were isolated from the samples. These include six (6) bacteria and four (fungal) species. The bacterial isolates include; Staphylococcus aureus, Bacillus sp., Pseudomonas aeruginosa, Escherichia coli, Streptococcus sp., and Proteus sp. The fungal isolates include Aspergillus sp., Penicillium sp., Fusarium sp., and Rhizopus sp. The most frequently isolated bacteria were Staphylococcus aureus and Bacillus sp. with 25% and 35% occurrence. Proteus sp., Streptococcus sp., E. coli, and P. aeruginosa had 20%, 10%, 5%, and 5% percentage occurrences respectively. Aspergillus and Penicillium sp. were the most frequently isolated fungal isolates with 40% and 30% occurrence respectively. Fusarium sp. and Rhizopus sp. both had 20% and 10% occurrence respectively. With this result, attention must be given to control those environmental factors which favor the growth and multiplication of microbes in the indoor air of the laboratory and air sterilization should be carried out to safeguard the health of users and workers.
Characteristics of referred patients to the Emergency Department in Aceh before COVID-19 pandemic Meilya Silvalila; Nurul Huzaifi; Shefina Pyeloni Harnold; Reza Akbar
Trends in Infection and Global Health Vol 2, No 1 (2022): June 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i1.25687

Abstract

As an important entry point for referral patients, the management of the Emergency Department to care and implement the best possible treatment are required. The Emergency Department of provincial hospital plays a vital role as a referral hospital of all district-level hospitals to provide initial treatment for a broad spectrum of illnesses and injuries. In Aceh, many referral issues were encountered at the Emergency Department of Dr. Zainoel Abidin Hospital, which categorized the referral patient's condition that was considered to improve clinical care to patients referred. This quantitative study aims to determine the characteristics of patient referral and the referral issues encountered at the Emergency Department of dr. Zainoel Abidin. In total, 1674 patients were recruited using the purposive sampling method from April to June 2019. The results showed that most referral patients arrived at the Dr. Zainoel Abidin Hospital emergency room during the night and very few arrived in the morning. Most patients arriving at the Emergency Department of Dr. Zainoel Abidin Hospital at night were from Aceh Singkil and Gayo Lues. Meanwhile, patients from Aceh Besar, Aceh Jaya, Banda Aceh, Pidie, and Pidie Jaya mostly arrived at the Emergency Department Dr. Zainoel Abidin Hospital during the afternoon. Most patients from Sabang and Simeulu came in the morning. The most commonly referred patients were adult and elderly patients, aged 46-65 years. Most of the patients had been treated in the daycare unit at the previous hospitals with the longest hospital stay was 36 days before being referred to Dr. Zainoel Abidin Hospital. Head injuries and strokes were the most frequent diagnosis led to Emergency Department Dr. Zainoel Abidin Hospital. Furthermore, our study found that 51% of the referral care system issue was that the patient did not arrive at the Emergency Department of Dr. Zainoel Abidin Hospital after being confirmed to be referred through telephone. Most of this issue happened in June for an unknown reason. At the same time, another 23% was due to the unavailability of intensive care.
3D molecular structure analysis of NS2B/NS3 proteases derived from dengue virus and Zika virus Arli Aditya Parikesit; Stefanus Bernard
Trends in Infection and Global Health Vol 2, No 1 (2022): June 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i1.25485

Abstract

Both dengue and Zika viruses have infected millions of people worldwide, urging the development of efficacious drugs and vaccines to fight the infection. Unfortunately, current research is yet to elucidate the structural proteomics comparison of the NS2B/NS3 from both viruses. Therefore, the main objective of this study was to comparatively study the structural proteins between dengue and Zika viruses by leveraging standard homology modelling tools. Our data provide 3D molecular structure overviews of NS2B/NS3 derived from the foregoing viruses. Sequence alignment indicated that the viruses share a 56% similarity rate of protein structures. However, in terms of function, both have NS2B that is pivotal for the activation of NS3 proteases.

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