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Baidillah Zulkifli
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Trends in Infection and Global Health
Published by Universitas Syiah Kuala
ISSN : 2806646x     EISSN : 2806646x     DOI : https://doi.org/10.24815/tigh.v1i2.23580
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
TIGH publishes primary research papers, review articles, short communications and letters on the following topics: Tropical diseases Microbiology Epidemiology Public health Population health One Health Immunology Chronic diseases Surgical disease and surgical care Chemotherapy and pharmacology Maternal and child health Clinical tropical medicine
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 44 Documents
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Unmasking Vibrio vulnificus: Emerging “flesh-eating bacteria” and its health implications Galo Guillermo Farfán-Cano
Trends in Infection and Global Health Vol 3, No 2 (2023): December 2023
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v3i2.35244

Abstract

Recent media reports in the USA have raised concerns about dubbing Vibrio vulnificus as the "flesh-eating bacteria," which is traditionally associated with treptococcus pyogenes. This review aimed to explore V. vulnificus as an emerging pathogen, its role in human infections, and its association with necrotizing fasciitis in wound infections. A systematic review was conducted of articles published between 2013 and 2023, focusing on V. vulnificus and its role in human infections. The inclusion and exclusion criteria were rigorously applied. The search  identified 16 articles of which seven studies included in the review, with 77 V. vulnificus-induced necrotizing fasciitis cases reported over the past decade. Demographic and diagnostic data were analyzed, highlighting the need for further research due to regional variations. This comprehensive review highlights the emerging significance of V.vulnificus as a pathogen, particularly in the context of necrotizing fasciitis and emphasizes the need for region-specific research. Understanding V. vulnificus infection is crucial for timely intervention and improved public health outcomes.
A case of extensive verrucosis in 45-year-old women and CD4 lymphopenia treated with electrodessication using general anesthesia and isoprinosine Wahyu Lestari; Sri Lestari
Trends in Infection and Global Health Vol 2, No 2 (2022): December 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i2.27913

Abstract

The human papilloma virus (HPV) is a viral infection that has a broad variety of clinical manifestation. The clinical manifestation really depends on the type of HPV virus and the immunity status of the host, particularly the cell-mediated immunity. Extensive verrucosis is one of the significant clinical manifestation of a disseminated HPV infection that is related with a severe immunodeficiency status. Electrodessication or laser surgery is a method of treatment that could directly destroy the lesion in one time. We described a case of a 45 years-old woman with extensive verrucosis. The patient complained multiple warts lesion on the hands, face, neck, lower arms and lower extremities since eight years ago. Physical examination revealed on the dorsum and palmar hands, both of finger nails (I, II, III, and IV), face (forehead and cheeks), anterior of neck, lower arms and 2/3 distal of lower extremities part anterior, there were single and groups of flesh coloured papules and flesh coloured plaques, skin colour papules with flat topped, greyish papules and greyish plaques with verrucous surfaces and brownish crusts. The CD4 count of the patient was 91 cells/µL. Skin biopsy and histopathology examinations showed hyperkeratosis, papillomatosis, and acanthosis with vacuole cell (koilocytes). The patient was treated with electrodessication using general anaesthesia and isoprinosine 3x500 mg. The result after two weeks post-treatment showed that there were no new lesions appeared on post electro surgery site. This case highlights the importance of the treatment for the success of extensive verrucosis with CD4 lymphopenia.
The pandemic of COVID-19 decreased adherence to treatment among hypertension patients at Dr. Zainoel Abidin Hospital Ghina Salsabila Rahman; Muhammad Ridwan; Hilwah Nora; Maimun Syukri; Fitri Dewi Ismida
Trends in Infection and Global Health Vol 1, No 2 (2021): December 2021
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v1i2.22418

Abstract

Hypertension is one of the leading causes of mortality and morbidity worldwide. Treatment adherence is an essential factor in controlling blood pressure among hypertensive patients. This study aimed to evaluate the effect of the Coronavirus disease 2019 (COVID-19) pandemic on treatment adherence among hypertensive patients at Dr. Zainoel Abidin Hospital, Aceh, Indonesia, as well as to determine its associated factors. A cross-sectional study was conducted at the Cardiac Center by utilizing medical records of hypertensive patients visiting during the period of April-July 2019 and December 2020-March 2021. Bivariate analysis using the Kruskal-Wallis test was employed to examine the effect of the COVID-19 pandemic on patients’ adherence. The results showed that the number of patients adhering to treatment significantly decreased (p=0.000) by 22.7%, from 179 patients in 2019 to 64 patients in 2020. The data also suggested a significant positive association between residential and patient adherence before the pandemic (p=0.006); however, no significant difference was observed between residential and patients’ adherence after the pandemic (p=0.282). Furthermore, our study found no association between age and adherence before and after the pandemic (p=0.690 in 2019 and p=0.125 in 2020). In conclusion, the pandemic of COVID-19 significantly affected treatment adherence among patients with hypertension at Aceh provincial hospital, with a decreased number in patient visits up to 22.7%.  
Phenomenon of vaping in Generation Z women Teuku Renaldi; Agung Pranata; Rima Novirianthy; Shabrina Masturah; Sabila Qurasifa; Medika BN. Soenoe; Eyiuche D. Ezigbo; Rovy Pratama
Trends in Infection and Global Health Vol 4, No 1 (2024): June 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i1.39144

Abstract

The vaping phenomenon among Generation Z (Gen Z) women has increased in popularity as an alternative to traditional cigarettes. As a group that has grown up in the digital era, they have easier access to information via the internet and social media, which has influenced their lifestyles and choices, including when it comes to smoking and vaping. The aim of this study was to understand how the vaping phenomenon affects Gen Z women. To address this question, our research provides an overview of the vaping-related phenomena occurring among Gen Z women. We conducted a literature review of eight publications covering five years, 2019–2024. The data indicated phenomena such as an increase in the number of vape users among women and an increase in aggressive vape advertising. Our study also explored the factors that lead to this phenomenon occurring and how the surrounding environment plays a very large role in this issue. Data suggested that the increase in vaping among Gen Z women is primarily due to environmental and peer influence factors. Therefore, to have better prevention and intervention strategies, peer influence should be taken into account.
Ramadan and Eid al-Fitr: Population movement, mass gathering and escalating of COVID-19 – A perspective from Indonesia Dian Sidik Arsyad; Firzan Nainu; Abram L. Wagner; Kuldeep Dhama
Trends in Infection and Global Health Vol 1, No 1 (2021): June 2021
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v1i1.22421

Abstract

In Indonesia, the most populous Moslem-majority country, despite the possibility of underreported coronavirus disease (COVID-19) cases, 6,248 confirmed cases and 535 deaths have been recorded. With upcoming Ramadan and Eid al-Fitr, between 18-23 million of Indonesians may move from urban locations (with high counts of COVDI-19) to rural areas with fewer cases currently but less laboratory capacity to diagnose cases. This review summaries the current situation of CO.VID-19 in Indonesia and discusses the possible impacts of mass population movement, Ramadan-related activities, and Eid al-Fitr celebration days on COVID-19 transmission in the country.
The effect of counseling on parent’s knowledge and attitudes towards stunting in toddlers: A quasi-experimental study Cut Ridzky Amelia Putri; Husnah Husnah; Nora Sovira; Marisa Marisa; Heru Noviat Herdata
Trends in Infection and Global Health Vol 3, No 1 (2023): June 2023
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v3i1.30105

Abstract

Stunting is a condition where toddlers are too short for their age. One of the preventions is by giving health education about stunting to the parents. The aim of the study is to determine the effect of counselling on parents' knowledge and attitudes towards stunting at Lhoknga Health Center, Aceh Besar. The study was conducted from November 7 to 23, 2022. This type of study was quasi-experimental with a one-group pre-test-post-test pre-experimental design. The participants were parents who were the main caregivers of toddlers in Lhoknga Health Center area, Aceh Besar. A total of 105 respondents were recruited for this study. In regards to knowledge about stunting, pre-counseling test showed that most respondents (71.5%) had sufficient knowledge while post-test showed that all respondents (100%) had good knowledge. Meanwhile, 92.4% respondents had good attitude towards stunting prior to the counseling, and increased to 100% after the education session. The Wilcoxon test showed an increased in the average knowledge score, from 12.83 during pre-test to 18.67 on post-test. An increased in the average attitude score was also found, from 72.05 to 92.77. Statistical analysis showed that there was an effect of counseling on increasing parents’ knowledge (p0.001) and attitudes (p0.001) towards stunting. It can be concluded that counseling can increase parent's knowledge and attitudes towards stunting.
Cytokine storm in SARS-CoV-2 infection and the potential treatments Ade Oktiviyari; Zinatul Hayati; Tjut Mariam Zanaria
Trends in Infection and Global Health Vol 2, No 1 (2022): June 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i1.25901

Abstract

Cytokine storm is one of main features during respiratory distress caused by COVID-19 infection. Acute Respiratory Distress Syndrome (ARDS) is directly linked with elevated number of COVID-19 mortality cases. Extreme amounts of pro-inflammatory cells are found in the lung of dead patients, mainly macrophages and IL-17 cells. A high level of IL-6 was found in the plasma COVID-19 patients and indicated the severity of diseases. Some other chemokines, such as CXCL10, IL6, CCL2, CXCL1, and CXCL5, were upregulated as well as in COVID-19 patients and regulate the disease. In this review, we discuss the feature of cytokine storms and the current treatments used. We found that IL-6 has a significant role in exacerbated patients’ condition, and the suppression of this cytokine most likely benefits the patient. Another treatment with various targets has been proposed and proven as effective as well. Some of them are corticosteroids, anakinra, plasmapheresis, and interferons.
Irrational use of azithromycin in typhoid endemic areas: A challenge on multidrug-resistant typhoid treatment Irfan Ullah; Kiran Shafiq Khan; Qasim Mehmood; Muhammad Junaid Tahir; Muhammad Irfan Malik; Ali Ahmed; Muhammad Usman Munir
Trends in Infection and Global Health Vol 1, No 2 (2021): December 2021
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v1i2.23580

Abstract

Typhoid is a food-borne fatal disease caused by Salmonella typhi. It causes inflammation of the intestine, resulting in diarrhoea, fever, headache, cough, and muscle pain. Improved hygiene has resulted in a marked decline in typhoid fever cases in many developed countries. However, significant typhoid cases emerge in low and middle-income countries annually, including Pakistan. Typhoid fever accounts for a larger percentage of acute febrile illnesses in Pakistan. Azithromycin is the only effective drug used in multidrug-resistant typhoid. The emergence of drug resistance typhoid has been of more significant concern in recent years due to its irrational use of azithromycin. It is considered the last antibiotic to eradicate multidrug-resistant typhoid fever from Pakistan. In this article, we express our concern of the irrational use of azithromycin in Pakistan and its effect on typhoid in the country.
Pattern of acceptability to yellow fever vaccination among skilled and unskilled workers in selected African countries Seyi Samson Enitan; Akele Richard Yomi; Eyiuche Doris Ezigbo; Esther Ngozi Adejumo; Kirellos Said Abbas; Rawan Raad Hassan Elrufai; Solomon Umukoro; Tsague Metago Causette Laura; Samuel Sunday Eke; Seto Tunrayo Aladenika; Abiodun Emmanuel Durosinmi; Grace Eleojo Itodo; Eguagie Osareniro Osakue; Effiong Joseph Effiong; Nafisat Eleojo Abubakar; Ernest Chiuike Ohanu; Gbise Daniel Sudan; Emmanuel Ochigbo Udeh; Adesola Oyekunle Oyekale; Imoleayo Elijah Olorunnisola
Trends in Infection and Global Health Vol 3, No 2 (2023): December 2023
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v3i2.36003

Abstract

Yellow fever still represents a major public health threat in Africa largely due to inadequate vaccine supply, insufficient vaccine coverage, increase in people without of vaccination living in endemic areas and occupation of individuals. The aim of this study was  to assess the acceptability to yellow fever vaccination among skilled and unskilled workers in selected African countries. This cross sectional online survey was carried out between 19 January 2022 and 31 December 2022, in five African countries (Cameroon, Egypt, Nigeria, Sudan and the Gambia). The responses to the survey were collected by Survey Monkey and the links were distributed via Facebook, Twitter, and WhatsApp. Data were collected using self-administered structured questionnaire, and analysed. A total of 1340 respondents (601 skilled workers, 739 unskilled workers) participated in the survey of which 616 of them indicated had yellow fever vaccination. Proportion of the unskilled workers with history of vaccination was less than those of the skilled workers (35.5% vs 58.9%). Location (OR=31.04, p=0.000), age (OR=146.95, p=0.001), religion (OR=24.42, p=0.012), education (OR=116.41, p=0.001), marital status (OR=68.83, p=0.001) and monthly household income (OR=87.62, p=0.001)  were significantly associated with acceptance to receive  YF vaccine. In addition, more of the skilled workers were very willing to receive the YF vaccine compared to their unskilled counterparts (p0.001). This study suggests that unskilled workers are less likely to be vaccinated against yellow fever than skilled workers, hence the need for strategic public health interventions to reach this category of people in the society.
SARS-CoV-2 infection and male fertility problems Ika Inda Bani; Zulkarnain Zulkarnain; Gholib Gholib; Dedy Syahrizal; Fauzul Husna; Winda Yulia; Mulkan Azhari
Trends in Infection and Global Health Vol 2, No 2 (2022): December 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i2.29426

Abstract

In 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has killed more than 6.6 millions of people around the world as of end of 2022. The long-term impact of COVID-19 is persisted, including its impact on male reproduction. SARS-CoV-2 enters into host cells using the angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) receptors. Both of these receptors are expressed more in men, and therefore men are more susceptible to SARS-CoV-2. COVID-19 potentially cause infertility by damaging testicular tissues and interfering with the process of spermatogenesis. A decrease in serum levels of testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as a decrease in sperm quality in men with COVID-19 compared to healthy men of the same age has been reported in several studies. Utilizing existing research data, this study aims to explore in detail of how SARS-CoV-2 tends to affect male fertility.

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