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Nanang Yunarto
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Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "VOLUME 4. NOMOR 1 FEBRUARI 2014" : 5 Documents clear
Ekstrak Daun Annona muricata Linn. sebagai Antiproliferasi terhadap Sel Hepar Tikus Terinduksi 7,12 Dimetilbenz [a] antracene (DMBA) Adelina, Rosa; Febriyanti, Rahmi; Oktoberia, Intan Sari; Intan, Putri Reno
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v4i1.2896

Abstract

Annona muricata Linn. atau sirsak yang mengandung senyawa golongan acetogenin mampu menginduksi apoptosis pada secara in vitro dan bersifat sitotoksik. Telah dilakukan penelitian untuk membuktikan potensi ekstrak daun sirsak secara in vivo dalam menghambat perkembangan tumor hepar akibat induksi senyawa kimia 7,12 dimetilbenz [a] antracene (DMBA). Induksi dilakukan selama dua kali seminggu selama lima minggu, pada hewan coba tikus putih (Rattus novergicus) strain Sprague Dawley. Ekstrak daun sirsak diberikan dengan tiga peringkat dosis, yaitu 200, 400, dan 800 mg/kg BB, selama tujuh belas hari setelah dua minggu pemberian DMBA. Hasil pemeriksaan histopatologi dan penentuan aktivitas proliferasi sel hepar dengan AgNOR menunjukkan adanya penurunan aktivitas proliferasi sel hepar secara signifikan. Disimpulkan bahwa ekstrak daun sirsak berpotensi sebagai antiproliferasi pada tumor hepar secara in vivo.
Kebijakan Pengawasan Iklan Pangan Olahan di Indonesia Susyanty, Andi Leny; Supardi, Sudibyo; Handayani, Rini Sasanti; J.Herman, Max; -, Raharni
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v4i1.2897

Abstract

The Act of The Republic of Indonesia Number 7 of 1996 on Food mentioned that every label and or advertisement concerning food to be sold must mention information concerning the food correctly and not misleading. The government shall regulate, supervise and the measure which are needed, in order that an advertisement concerning food which is sold does not contain information which may be misleading. This cross-sectional study was conducted to Identify legislation related to food advertisement. Primary data collection by means of indepth interviews and Round Table Discussion (RTD), as well as secondary data collection concerning institusional report and monitoring documentation has been used. The data were analysed qualitatively. The findings indicate that monitoring of food advertisement only at the provincial level. Monitoring of Processed foodstuff advertisement by testimony in broadcast media, inset in the event program at television and advertising on the Internet is not optimal and it’s required cross-sectoral coordination.
Aktivitas Antidermatofitik Ekstrak Daun Urang-aring (Eclipta alba (L.) Hassk) terhadap Trichophyton mentagrophytes Ikawati, Hartanti Dian
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v4i1.2898

Abstract

Emergence of drug resistance in a fungal infection therapy had driven the need for a search of a new therapeutic agent. Traditional approach is now being marked by most people to combat this resistance problem. Plants can acts as a source of antimicrobial agents. Eclipta alba,L. Hassk leaves has been traditionally used to cure skin illnesses caused by fungal infection. The aim of this study is to analyze the antidermatophytic activity of Eclipta alba, L. Hassk leaves extract against Trichophyton mentagrophytes. Eclipta alba (L.) Hassk leaves were extracted gradually with hexane, ethyl acetate, ethanol and water. A serial concentration 0 mg/ml, 12,5 mg/ml, 25 mg/ml, 50 mg/ml and 100 mg/ml of those four fraction was made subsequently. The antidermatophytic activity was done by gel diffusion method. Zone of inhibition was measured and analyzed with ANOVA continued with DMRT (Duncan Multiple Range Test). The antifungal test showed that hexane, ethyl acetate and ethanolic extract of Eclipta alba, L. Hassk leaves were effective to inhibit the growth of Trichophyton mentagrophytes but not significantly different (p≥0,05). Water extract showed no inhibition on Trichophyton mentagrophytes
Butylated hydroxyanisole sebagai Bahan Aditif Antioksidan pada Makanan dilihat dari Perspektif Kesehatan Fitri, Nyoman
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v4i1.2899

Abstract

Butylated hydroxyanisole (BHA) is widely used since 1947 as antioxidant food additives used to prevent oils, fats and shortenings from oxidative deterioration and rancidity. It has been extensively studied for potential activities and its toxicities. This review summarized experimental studies that had been carried out on animals and humans as well. We also briefly reviewed about its absorptions, metabolisms, excretions and carcinogenicity from health perspective. At present there is sufficient evidence for carcinogenicity of BHA, but there is hardly any indication that BHA is genotoxic. Keywords: Butylated hydroxyanisole, Additive, Ef
Pengaruh Pemberian Kombinasi Ekstrak Rumput Mutiara (Hedyotis corymbosa Lamk) dan Meniran (Phyllanthus Niruri L.) terhadap Jumlah AgNOR Jaringan Adenokarsinoma Mammae Mencit C3H Intan, Putri Reno; Winarno, M. Wien
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cancer is one of the non-communicable diseases that has become a health problem in the world, including in Indonesia. Data World Health Organization (WHO) data in 2010 showed that cancer is the second leading cause of death after cardiovascular disease. Mean while, result at Basic Health Research Riset Kesehatan Dasar (Riskesdas) 2007 showed that cancer ranks sixth in the leading cause of death in Indonesia. Number of cancer patients in Indonesia continues to increase and is expected to be the main cause of the increasing economic burden, for the patient, family, and also country. Types of cancer in Indonesia is dominated by breast cancer (30%) cervical cancer (24%). This study aims to determine the effect of a combination of rumput mutiara (Hedyotis corymbosa Lamk) and meniran (Phyllanthus niruri L) against mammary adenocarcinoma in strain C3H mice. This study is an experimental study. The study sample consisted of 20 strains of C3H mice that were divided into 4 groups: control group (K) and three dose groups ( P1 - P3 ), namely : dose 750 ; 1500; 2250 mg/kg BW. Extract of the test material were given after the tumor is palpable, It was given to the mice for 19 days, once a day orally using a stomach sonde. The results of this study indicate that based on the average number of AgNOR mammary adenocarcinoma, the extract at a dose of 2250 mg/kg BW can reduce the proliferation of mammary tumor cells.

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