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Arifah Sri Wahyuni
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Pharmacon: Jurnal Farmasi Indonesia
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : https://www.doi.org/10.23917/pharmacon
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Universitas Muhammadiyah Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Volume 21, No 2 (2024)" : 15 Documents clear
Advances in Antibiotic-Loaded Nanofibers for the Treatment of Bone Infections: A Review Imanto, Teguh; Nonni Soraya Sambudi; Khadijah Zai; Teuku Nanda Saifullah Sulaiman
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.6986

Abstract

Antibiotic-loaded nanofiber-based drug delivery systems represent a novel approach to treating complex bone infections, particularly osteomyelitis caused by antibiotic-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). These systems offer localized, sustained drug release, significantly reducing systemic side effects and mitigating the development of antibiotic resistance. This review evaluates advancements in electrospun nanofibers with biodegradable polymers like Poly(lactic-co-glycolic acid) (PLGA) and Polycaprolactone (PCL), which ensure controlled drug release while supporting bone regeneration. A systematic search using PRISMA guidelines across ScienceDirect and ACS Publication databases (2020-2024) identified 42 relevant studies. The inclusion of bioactive agents such as hydroxyapatite in nanofibers was found to enhance antibacterial properties and accelerate tissue regeneration. The review demonstrates that antibiotic-loaded nanofibers offer a promising, targeted therapeutic alternative to conventional treatments, particularly for osteomyelitis and similar challenging bone infections. Future research directions will focus on optimizing nanofiber compositions and functionalities to better meet clinical needs, ensuring more efficient and personalized management of severe bone infections.
Literature Review: Formulation and Characterization of Nanoemulgel for Anticellulite Treatment Ulayya, Hanidya Fidela; Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.7157

Abstract

Cellulite, a skin condition characterized by a dimpled, orange-peel appearance, commonly affects the thighs, abdomen, hips, and buttocks. Nanoemulgel, a combined system of nanoemulsion and gel, has gained attention as an effective topical drug delivery system, particularly for lipophilic drugs. This review examines the potential of nanoemulgel formulations in treating cellulite, focusing on their physical characteristics, drug delivery efficiency evaluated through skin penetration and anti-cellulite effects, specifically their ability to inhibit adipogenesis and reduce triglycerides. A total of 5 articles were selected for further review as they met the eligibility criteria, including nanoemulgel formulations containing active ingredients with potential anti-cellulite properties and in vitro or in vivo testing for anti-cellulite effectiveness. The results show that nanoemulgel formulations could be a new way to deliver lipophilic drugs to specific areas of the skin for treating cellulite.
Phytopharmaceutical modification of papaya (Carica papaya) seed extract on sperm quality using self-nano emulsion as contraception potential : Phytopharmaceutical of papaya seed extract self-nano emulsion as contraception Shiyan, Shaum; Nuria , Siti Azzahra; Alzuraiqi, Lutfi Muhammad; Pratiwi, Galih; Nalindra, Wahyu Naga; Aisyah , Jasmine Rani
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.7467

Abstract

Carica papaya is known to reduce the quality of spermatozoa in morphology and viability of spermatozoa. Biochemical compound in Carica papaya is unstable and can easily degraded in disgetive track. Formulation of papaya seeds in the form of self-nano emulsion (SNE) is an alternative drug delivery system to increase bioavailability by lipophilic means. The sample consisted of 18 rats which were divided into 3 groups, namely the control group which was not given any treatment; the treatment group which was given papaya seed ethanol extract as much as 100 mg/kgBW and the treatment group which was given papaya seed extract-SNE as much as 100 mg/kgBW, the administration was carried out orally for 28 days. Examination of the quality of rat spermatozoa includes morphology, motility, and viability. Data analysis using One Way ANOVA and Chi-Square test. The results of the analysis showed that the decrease in morphology and viability of spermatozoa was significantly different with a result (p < 0.05) between treatment groups. As for motility, it does not have a significant difference with a result (p > 0.05) between treatment groups.. Based on the results of the study, it can be concluded that the administration of papaya seed ethanol extract and papaya seed SNE extract significantly reduces the quality of spermatozoa in the form of morphology and viability, and does not significantly reduce the motility of Wistar strain white rat spermatozoa.
Perception And Readiness Of Pharmacy Faculty Students in Surakarta Central Java About Interprofessional Education Mutmainah, Nurul; Anisa Rachma Priyastiningrum; Nurus Hasta Rani
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.7521

Abstract

Interprofessional Education (IPE) is an important approach in health education to prepare students to work collaboratively in interprofessional teams in clinical practice. This study aims to determine the perception and readiness of Interprofessional Education among students of the Faculty of Pharmacy in Surakarta, Central Java and to determine the factors that influence differences in perception and readiness. This study used descriptive and cross sectional design. The population used was Pharmacy undergraduate students and pharmacist professional students. Sampling using purposive sampling technique. Measurement of perception using the IEPS (Interprofessional Education Perception Scale) questionnaire, while measuring readiness using the Readiness for Interprofessional Learning Scale (RIPLS) questionnaire. Data were analyzed using the Kruskall Wallis test. Of the 219 respondents, 87.2% were female, 81.2% were undergraduate students, 72.1% had one IPE experience. From the results of measuring perceptions, 96.7% had good perceptions and 3.2% had moderate perceptions. While from the measurement of readiness it was found that 99.5% had high readiness and 0.5% moderate readiness. From the IEPS results, the value of p=0.304 (gender), p=0.909 (student batch) and p=0.699 (IPE experience) was obtained and results on RIPLS obtained a value of p=0.122 (gender), p=0.58 (student batch) and p=0.693 (IPE experience) so it can be concluded that there are no differences in perception and readiness between gender, batch and IPE experience.
Optimization of Microgel Formula Combination of Snail Mucus and Catechin to Accelerate Wound Closure Azizah, Adinda Fayi; Astuti, Ika Yuni; Syarifah, Arini; Kumalasari, Raudia; Agistya, Lusyahaura; Talitarahma, Anindya Tian
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.7562

Abstract

Incised wound healing is a crucial process that requires effective treatment solutions. A microgel containing snail mucus and catechin seems a promising approach to accelerate healing and improve recovery outcomes. This study aimed to develop a microgel preparation contain snail mucus (Achatina fulica) and catechin. Formulation design is assisted using the Design Expert SLD method. The optimum formula was achieved with a carbopol to TEA ratio of 1.589:0.411, with estimated values of pH (4.506), viscosity (18,873 cPs), spread ability (5.477 cm), and adhesion (2.068 second). These estimated values showed no significant difference from the actual values obtained in the laboratory experiments. To evaluate the quality of the preparation, in vivo testing was performed on white mice, and the data were analysed using one-way ANOVA. The snail mucus and catechin microgels were proven to be effective in treating deep incision wounds.

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