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Windadari Murni Hartini
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Jl. Beteng KP. Menyanan Kecil No. 307, RT. 004, RW. 002, Kel. Kranggan, Kec. Semarang Tengah, Kota Semarang, Jawa Tengah, Indonesia
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INDONESIA
Prosiding Seminar Nasional Ilmu Kesehatan dan Keperawatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 30635306     EISSN : 30635284     DOI : 10.61132
Core Subject : Health,
Nursing
Prosiding Seminar Nasional Ilmu Kesehatan dan Keperawatan; This a journal intended for the publication of scientific articles published by Asosiasi Riset Ilmu Kesehatan Indonesia This journal contains studies in the fields of Ilmu Kesehatan dan Kedokteran, both theoretical and empirical. This journal is published 1 year 2 times (June and December).
Arjuna Subject : Keperawatan - Keperawatan (Lain-Lain)
Articles 21 Documents
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Rekayasa Nanoselulosa Bakteri sebagai Platform Nano-Biomaterial untuk Terapi Obat dan Antimikroba: Perspektif Pengobatan Modern Zakia Asrifah Ramly
Prosiding Seminar Nasional Ilmu Kesehatan dan Keperawatan Vol. 2 No. 2 (2025): Prosiding Seminar Nasional Ilmu Kesehatan dan Keperawatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/prosemnasikk.v2i2.87

Abstract

Antimicrobial resistance (AMR) continues to rise globally, diminishing the efficacy of conventional antibiotics and driving the need for advanced biomaterial-based therapeutic strategies. Bacterial nanocellulose (BNC) has emerged as a highly promising platform due to its nanoscale fibrillar structure, high porosity, exceptional purity, and excellent biocompatibility. Its large surface area and hydrogel-like properties enable high drug-loading capacity and controlled release, making BNC an ideal matrix for therapeutic delivery. Functionalization of BNC with metallic nanoparticles (AgNP, ZnO, CuO), antibiotics, plant-derived bioactives (e.g., quercetin, curcumin), and innovative agents such as lytic enzymes or metal–organic frameworks has demonstrated markedly enhanced antibacterial and antibiofilm performance. In vitro studies report broad- spectrum inhibition, biofilm reduction up to 95%, and improved drug stability through sustained release. In vivo evaluations using wound models reveal accelerated healing (30–50%), reduced bacterial burden by up to 4 log CFU, and superior tissue regeneration with minimal systemic toxicity. Despite these promising outcomes, gaps remain regarding long-term safety, nanoparticle–host interactions, and standardized testing protocols. Overall, current evidence highlights BNC as a versatile and potent nanobiomaterial for antimicrobial therapy and drug delivery, although successful clinical translation will require comprehensive in vivo validation and methodological harmonization.

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