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Contact Name
Azis Ikhsanudin
Contact Email
azis.ikhsanudin@pharm.uad.ac.id
Phone
+6289506685859
Journal Mail Official
clips@uad.ac.id
Editorial Address
Faculty of Pharmacy, Kampus 3 UAD, Jalan Prof. Dr. Soepomo, S.H. Janturan Yogyakarta, INDONESIA 55164
Location
Kota yogyakarta,
Daerah istimewa yogyakarta
INDONESIA
Clinical and Pharmaceutical Sciences Journal
ISSN : -     EISSN : 30895669     DOI : https://doi.org/10.12928/clips.v1i1.307
Core Subject : Health, Science,
Clinical and Pharmaceutical Sciences (CliPs) Journal utilizes contributions from academics and practitioner-researchers on Clinical dan Pharmaceutical Sciences. Clinical and Pharmaceutical Sciences Journal is a periodical scientific journal published by Universitas Ahmad Dahlan, Indonesia. The journal encourages interdisciplinary discussions and interactions in various topics related to health and pharmaceutical sciences, within or across disciplines. Clinical and Pharmaceutical Sciences Journal accepts scientific papers in the form of research reports (original article research papers), systematic review, and meta analysis with focus and scope: pharmaceutical technology, pharmacology and toxicology, pharmaceutical chemistry, pharmaceutical biology, clinical and community pharmacy, pharmacoeconomy, pharmacoepidemiology, pharmaceutical care, management of pharmacy, biopharmaceutics, pharmaceutical microbiology and biotechnology, pharmacokinetics, alternative medicines, cosmetic technology, health policy, medicine (miscellaneous), public health, environmental and occupational health, and nursing. This journal provides an innovative platform for researchers, students, practitioners, and educators to learn and contribute to this field. All articles must undergo initial Editorial screening and then undergo a rigorous double-blind peer review process before publication. Open Access Journal: All of the published manuscripts can be accessed online. Rapid Publication: After finishing the review process, revision, and editing, the accepted paper will be published online soon. Editor, reviewer, and author from the International Forum. The published article has a permanent page and Digital Object Identifier (DOI), making it easy to index many databases.
Articles 21 Documents
Pharmacokinetic Evaluation of Paracetamol Co-administered with Moringa oleifera and Caesalpinia sappan Extracts Individually in Sprague Dawley Rats Pradana, Dhigna; Nur, Syifa; Hakim, Annisa Ayu Nur; Rahmi, Eldiza Puji; Muti, Annisa Farida; Abdurrahman Munir, Muhammad
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.579

Abstract

Paracetamol is frequently utilized to alleviate pain and fever due to its pharmacological properties as an analgesic and antipyretic. Consuming paracetamol drugs while self-medication might potentially lead to drug interactions when used with other medications, as well as certain foods and herbs. Moringa oleifera and Caesalpinia sappan are popular herbal plants in Indonesia, commonly used to produce herbal food and drinks. These plants contain flavonoids and phenols, which have the potential to impact the metabolism, effectiveness, and toxicity of medications, including paracetamol. This study investigated alterations in the pharmacokinetic characteristics of paracetamol when co-administered with Moringa oleifera and Caesalpinia sappan. The research utilized a true experimental approach with a posttest-only control group design and animal model study is male Sprague-Dawley rats . The control group was administered an oral dose of 9mg/200g body weight of paracetamol. By contrast, the treatment group of male Sprague-Dawley rats was administered an oral dose of 9mg/200g body weight of paracetamol, combined with a dose of 60mg/200g of Moringa leaf extract and sappan heartwood extract at 294 mg/kg body weight. At 30, 60, 120, 180, and 240 minutes, blood samples were collected from the rats' lateral tail vein. Analyzing the concentration of paracetamol in plasma was conducted using a UV-Vis spectrophotometer set at a wavelength of 244 nm. The study showed that combining sappan heartwood extract with paracetamol resulted in a substantial 453.10% increase in the volume of distribution (Vd) (p<0.05). The administration of Moringa leaf extract decreased a little effect the pharmacokinetic profile of paracetamol, as shown by the statistical analysis of the unpaired t-test (p>0.05).

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