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Azis Ikhsanudin
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Faculty of Pharmacy, Kampus 3 UAD, Jalan Prof. Dr. Soepomo, S.H. Janturan Yogyakarta, INDONESIA 55164
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Clinical and Pharmaceutical Sciences Journal
Published by Universitas Ahmad Dahlan
ISSN : -     EISSN : 30895669     DOI : https://doi.org/10.12928/clips.v1i1.307
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology
Clinical and Pharmaceutical Sciences (CliPs) Journal utilizes contributions from academics and practitioner-researchers on Clinical dan Pharmaceutical Sciences. Clinical and Pharmaceutical Sciences Journal is a periodical scientific journal published by Universitas Ahmad Dahlan, Indonesia. The journal encourages interdisciplinary discussions and interactions in various topics related to health and pharmaceutical sciences, within or across disciplines. Clinical and Pharmaceutical Sciences Journal accepts scientific papers in the form of research reports (original article research papers), systematic review, and meta analysis with focus and scope: pharmaceutical technology, pharmacology and toxicology, pharmaceutical chemistry, pharmaceutical biology, clinical and community pharmacy, pharmacoeconomy, pharmacoepidemiology, pharmaceutical care, management of pharmacy, biopharmaceutics, pharmaceutical microbiology and biotechnology, pharmacokinetics, alternative medicines, cosmetic technology, health policy, medicine (miscellaneous), public health, environmental and occupational health, and nursing. This journal provides an innovative platform for researchers, students, practitioners, and educators to learn and contribute to this field. All articles must undergo initial Editorial screening and then undergo a rigorous double-blind peer review process before publication. Open Access Journal: All of the published manuscripts can be accessed online. Rapid Publication: After finishing the review process, revision, and editing, the accepted paper will be published online soon. Editor, reviewer, and author from the International Forum. The published article has a permanent page and Digital Object Identifier (DOI), making it easy to index many databases.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 21 Documents
 1   2   3 
Physical Properties and Antifungal Activity of Red Galangal (Alpinia purpurata K. Schum) Rhizome Extract in Oil-in-Water-Based Cream Against Trichophyton rubrum Mulyaningsih, Sri; Ranila, Suciati; Fatimah, Siti Fatmawati
Clinical and Pharmaceutical Sciences Journal Vol. 1 No. 2 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v1i2.379

Abstract

Trichophyton rubrum is a common fungus that causes a dermatophyte infection known as tinea cruris. More than a fifth of the population in Indonesia suffers from this infection.  Alpinia purpurata K. Schum or well known as red galangal is said to have antifungal properties because of its composition, which includes compounds such as volatile oil, acetyl chavicol, flavonoids, and phenols. This study was aimed to determine the antifungal activity of a oil-in-water-based cream containing red galangal rhizome extract (RGRE) against T. rubrum. RGRE was obtained by macerating the rhizomes in a solvent of 96% ethanol and evaporating until a thick extract was obtained. The extract was then formulated into an oil/water-based cream at concentrations of 10%, 15%, and 20%. The creams were evaluated for their physical properties, including organoleptic properties, homogeneity, pH, viscosity, adhesivity, and spreadability. The antifungal activity was tested using the agar diffusion method against T. rubrum. Data on the physical properties of the creams and their antifungal activity were analyzed using a one-way ANOVA test with a 95% confidence level. The results showed that creams with higher RGRE concentrations exhibited decreased spreadability and pH values but increased the viscosity and adhesivity test. The antifungal activity increased with higher RGE concentrations, starting at 10%, 15%, and 20%, with inhibition diameters of 12.33 mm, 18.83 mm, and 21.66 mm, respectively. Statistical analysis showed that RGE concentration affected the physical properties of the cream, including pH, spreadability, viscosity, adhesivity test as well as antifungal activity (p < 0.05). In conclusion, the water-in-oil-based cream containing 20% RGRE exhibits favorable physical properties and antifungal activity. Keywords: Cream, dermatophyte, diffusion method, viscosity, Zingiberaceae
The Video-Based Education on Complete Basic Immunization Improves Parents' Knowledge, Attitudes, and Practices Regarding Immunization Supadmi, Woro; Nuzulan, Moh. Aji Zulfan; Cahya Putri, Ardana; Rizky Maulana, Nafta; Rahmawati, Priska Ardya; Zukhruf Saputri, Ginanjar; Gustinanda, Rizky; Qomariyah, Nurul; Ari Kristina, Susi; Naguib Ahmed Osman, Ahmed Mohamed Yehia
Clinical and Pharmaceutical Sciences Journal Vol. 1 No. 3 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v1i3.380

Abstract

Complete basic immunization aims to establish an effective protection system and herd immunity. Factors that influence immunization programs are parents' knowledge, perceptions, and attitudes. Efforts to improve parents' understanding can be done through education using easily accessible video media. This study aims to determine the effect of complete basic immunization education based on video on parents' knowledge, attitudes, and practices regarding immunization. This study employs a quasi-experimental design with a one-group pretest-post-test design. Data collection was conducted in April 2024. A total of 361 participants were recruited for this study, with inclusion criteria including parents of children aged up to 1.5 years residing in the service area of the Public Health Center in Yogyakarta City, and who had provided informed consent. The measurement of parents' knowledge, attitudes, and practices regarding child immunization was assessed at the pre-test and post-test intervention stages, specifically on day 1 after recruitment and the post-test on day 7 after the educational intervention. The data collection instrument used a questionnaire on parents' knowledge, attitudes, and practices, which had previously undergone validity and reliability testing. Statistical data analysis used the Wilcoxon test. The level of respondents' knowledge after receiving the intervention using educational videos showed an increase in the good criteria from 80.1% to 97.2%, attitude good criteria from 83.1% to 97.0%, while practice showed good criteria from 92.8% to 96.7%. The Wilcoxon test results for knowledge and attitude showed positive ranks of 62 and 50 respondents, respectively, who experienced an increase in knowledge with a p-value of 0.000, while for complete basic immunization practices, there was an increase of 3 respondents with a p-value of 0.083. There was a significant effect of education through videos about complete basic immunization on parents' knowledge and attitudes with a p-value of 0.000, but there was no significant effect on practice.
The Effect of Titanium Dioxide and Porang Starch (Amorphophallus oncophyllus) Combination on the SPF Value and Physical Properties of Sunscreen Lotion Formulation Fauzia, Afifah Hasna; Vanda Pertiwi, Deasy; Saputri, Asti Rizki; Khoirunnisa, Afifah; Bestari, Angi Nadya
Clinical and Pharmaceutical Sciences Journal Vol. 1 No. 3 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v1i3.381

Abstract

Optimization of Dispersible Diclofenac Potassium Tablet Formula with a Combination of Explotab and Avicel PH-101 Kurniawan, Dhadhang; Andiani, Nauli Marsha; Utami, Vitis Vini Fera Ratna
Clinical and Pharmaceutical Sciences Journal Vol. 1 No. 3 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v1i3.382

Abstract

Diclofenac potassium is a nonsteroidal anti-inflammatory drug (NSAID) frequently employed as an analgesic therapy for inflammatory conditions and pain associated with Osteoarthritis and Rheumatoid Arthritis. It is formulated as a dispersible tablet, requiring dispersion in solution prior to administration to expedite onset and facilitate use, particularly for patients with difficulty swallowing intact tablets. This study aims to investigate the effects of the optimal combination and proportion of Explotab and Avicel pH-101 in the formulation of diclofenac potassium dispersible tablets using the Simplex Lattice Design (SLD) method with two factors. The tablet formulations, based on the SLD method with Explotab (A) and Avicel pH-101 (B) as excipients, are as follows: FI (100% A), FII (75% A:25% B), FIII (50% A:50% B), FIV (25% A:75% B), and FV (100% B). The tablets were prepared via direct compression and subsequently evaluated for their physical properties, including hardness, friability, size uniformity, weight uniformity, disintegration time, dispersion time, wetting time, and content determination. The study's findings indicated that the combination of Explotab and Avicel pH-101 affected the physical properties of the tablets, notably decreasing weight uniformity, enhancing tablet hardness, reducing friability, and prolonging both disintegration and dispersion times of the diclofenac potassium dispersible tablets. The optimal formula was identified as comprising 40% Explotab and 60% Avicel pH-101. This optimal formulation was determined based on the highest total response value calculated using the Simplex Lattice Design with two factors
The Effect of Turmeric Simplicia’s (Curcuma longa L.) Washing Treatment on Total Ash, Total Plate Count, Yeast and Mold Count and Curcumin Level Harnanda Putri, Margaretha; Kawiyanto, Joko; Hartati, Puji; Nurraudah, Siti; Ahmad, Nazir
Clinical and Pharmaceutical Sciences Journal Vol. 1 No. 3 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v1i3.472

Abstract

Turmeric (Curcuma longa L.) is one of the traditional plants of Indonesia that has antibacterial activity, helps reduce fever, osteoarthritis, and digestive disorders. The washing process of simplicia is one of the sorting processes in post-harvest handling. This study aims to obtain the best washing method for simplicia with several washing treatments against the total ash content, Total Plate Count (TPC), Yeast and Mold Count (YMC), and curcumin content in turmeric simplicia and turmeric extracts. The study was conducted experimentally with 6 variations of simplicia washing treatments, namely without washing, washing with running water, washing with water at 50°C, washing with 0.2% NaOH, washing with 0.05% HCl, and washing with 2.0% acetic acid. The results showed that washing with 2.0% acetic acid produced the lowest total ash content of the extract at 1.87%. Washing with 50°C water provided the lowest TPC value test data of 6.7 CFU/g, washing with 50ºC water provided the highest curcumin content test data of 9.38%. Based on several parameters of the test results, the washing process chosen was washing the simplicia using 50ºC water which showed high curcumin levels, TPC and YMC values that met the requirements, as well as the ease and safety of the washing method.
A Review of Ethnopharmacological Practices Among Two Indigenous Communities In Sumatra: The Anak Dalam And Mentawai Tribes Anasri, Fadhil Mubarak; Syafri, Suryati
Clinical and Pharmaceutical Sciences Journal Vol. 1 No. 3 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v1i3.478

Abstract

Indonesia is a country rich in biodiversity and high culture, including traditional knowledge such as the use of medicinal plants. This study examines ethnopharmacological practices in two indigenous communities on the island of Sumatra: the Anak Dalam tribe in Jambi and the Mentawai tribe in West Sumatra. The study reviewed several articles on medicinal plants on Google Scholar related to the plant species used, plant parts utilized, processing methods, and indications for their use in traditional medicine. The review results show that both tribes utilize various plants to treat ailments such as fever, diarrhea, coughs, wounds, digestive disorders, and infections. Some of these are supported by scientific evidence regarding their pharmacological activities, such as Zingiber officinale, Psidium guajava, Curcuma longa, and Eurycoma longifolia. The results of this review confirm that the traditional knowledge of both communities has excellent potential for development in pharmacy and conventional medicine. Documentation and scientific study of medicinal plants are crucial for cultural preservation and the development of traditional medicine.
Unveiling Global Research Trends and Collaboration Patterns in Alzheimer’s Disease: A Bibliometric Perspective Prasetyaning Amukti, Danang; Pratami, Ria Indah; Estiningsih, Daru; Saiful Bachri, Moch; Muhammad Ma’ruf; Djaka Purwanto, Barkah; Sukma Ananda, RA Dewinta; Suminingtyas, Ifa Aris; Akbar, Imam
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.556

Abstract

Alzheimer's disease is one of the most common forms of dementia and poses a major challenge to global health, especially as the aging population increases. With the high research interest in this topic, a scientific mapping is needed to identify trends, major contributors, and current research focuses in the field of Alzheimer's. This study uses a bibliometric approach with a Scopus database published in the period 2023 to 2025, then the data is analyzed using bibliometrix software. The results show an annual publication growth rate of 19.67% with an average of citations per document of 3,524. The most productive journals are alzheimer's and dementia (1,093 documents), followed by Journal of Alzheimer's Disease (817 documents). The most active authors are Wang Y (493 documents), Zhang Y (437), and Li Y (410). The most affiliations come from University of California And Harvard Medical School, while the countries with the largest contributions are the United States, China, and India. Alzheimer's research shows rapid development in terms of quantity and international collaboration. The United States and China are the main centers of scientific contribution, both in terms of the number of publications and citations. These results are important as a basis for making research policies, cross-country collaborations, and determining the direction of future research in efforts to overcome alzheimer's disease.
Potential Drug–Drug Interactions in Antihypertensive Therapy Among Outpatients with Comorbidities: Prevalence, Severity, and Clinical Implications Prita Anggraini Kartika Sari; Rahayu, Ade Rahmawati; Noor Faridah, Imaniar; Supadmi, Woro; Sari, Andriana; Ahmed, Bilal
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.563

Abstract

Hypertension is a condition that frequently coexists with comorbidities, often necessitating polypharmacy and consequently increasing the risk of drug-drug interactions (DDIs). This study aimed to analyze the pattern and severity of potential DDIs among hypertensive outpatients with comorbidities at North Lombok Regional General Hospital in 2024. This study employed a descriptive observational design with retrospective data collection. A total of 100 outpatient medical records meeting the criteria were selected via probability sampling from the hospital database during January to December 2024. Among the included patients, 50% were aged >60 years, 60% were female, and 91% were covered by the National Health Insurance. Potential DDIs were assessed using the Drugs.com drug interaction checker and categorized based on severity into major, moderate, and minor. A total of 257 potential DDI events were identified, consisting of 19 major interactions (7.4%), 205 moderate interactions (79.8%), and 33 minor interactions (12.8%). The most frequent major interaction was the combination of spironolactone and candesartan, which poses a significant risk of hyperkalemia and hypotension. Moderate interactions were predominantly observed with the combination of furosemide and bisoprolol, which may increase the risk of hyperglycemia and hypertriglyceridemia. Meanwhile, the most frequent minor interaction was aspirin with bisoprolol, which may reduced beta-blocker antihypertensive effect. In conclusion, this study found that moderate severity potential DDIs were the most prevalent and could significantly impact therapeutic outcomes in hypertensive patients with comorbidities. These findings highlight the critical role of clinical pharmacists in identifying and mitigating clinically significant interactions through rigorous prescription monitoring, patient education, and optimization of drug therapy. Strengthened monitoring and evaluation of drug regimens are recommended to minimize the risk of adverse drug reactions and enhance patient safety.
In Silico Analysis of Bioactive Compounds from Water Extract of Gelidium spinosum as COX-2 Inhibitor : In Silico Analysis of Bioactive Compounds from Water Extract of Gelidium spinosum Warsi, Warsi; Jaswir, Irwandi
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.565

Abstract

Water Extract of Gelidium spinosum (WEGs) contains various bioactive compounds which potential as anti-inflammatory agent. This study was aimed to predict anti-inflammatory potential of bioactive compounds from WEGs as COX-2 inhibitor through in silico analysis. The in silico analysis was conducted using AutoDock Vina. The protein originated from the Protein Data Bank, and the metabolites were gathered from PubChem. 2-Acetyl-3-methylbenzo[b]thiophene (1) (-7.1 kcal/mol), and ethyl p-methoxycinnamate (3) (-7.1 kcal/mol) were demonstrated a higher binding affinity compared with the other ligands and phenidone (-6.7 kcal/mol). Potential of these ligands were weaker than tolfenamic acid (-9.1 kcal/mol). According to this in silico analysis, bioactive compounds from water extract of G. spinosum possesses an anti-inflammatory potential mediated COX-2 receptor inhibition.
Identification of Genetic Variations Associated with Leprosy Risk as Potential Therapeutic Targets Adnan; Dania, Haafizaah; Mohammed, Marwa
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.572

Abstract

Page 2 of 3 | Total Record : 21

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