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Kajian Aktivitas Antioksidan: Potensi Ekstrak Air Daun Kelor (Moringa oleifera Lam.) dan Secang (Caesalpinia sappan L.) sebagai Anti Hiperglikemia Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi; Annisa Farida Muti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.7636

Abstract

Ekstrak air daun kelor (Moringa oleifera Lam.) mengandung senyawa aktif flavonoid, fenol, dan tanin yang berperan sebagai antioksidan yang dapat mencegah hiperglikemia dan hiperlipidemia. Secang (Caesalpinia sappan L.) mengandung brazilin yang dapat menurunkan glukosa darah. Aktivitas antioksidan ekstrak air daun kelor dan kayu secang menjadi dasar uji in vivo, oleh karena itu tujuan penelitian ini untuk mengetahui IC50 ekstrak air daun kelor dan kayu secang yang memiliki potensi sebagai antihiperglikemia. Penelitian merupakan studi eksperimental. Perhitungan IC50 menggunakan metode spektrofotometri UV-Visibel dengan DPPH. IC50 ekstrak air daun kelor, kombinasi daun kelor dan kayu secang, dan kayu secang masing-masing sebesar 217,21; 71,89; dan 8,18 ppm. Daya antioksidan kuat dan sedang berpotensi menurunkan kadar glukosa darah melalui mekanisme pengurangan Reactive Oxygen Species (ROS).
SYNERGISTIC EFFECT OF COMBINATION BETWEEN CYANOMACLURIN AND ARTOCARPIN FROM ARTOCARPUS HETEROPHYLLUS HEARTWOODS AGAINSTS STREPTOCOCCUS PYOGENES AND STAPHYLOCOCCUS EPIDERMIDIS Abdi Wira Septama; Eldiza Puji Rahmi, M.Sc
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 1 (2022): Vol.1 No.1 JUNE (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i1.4250

Abstract

Streptococcus pyogenes and Staphylococcus epidermidis are major problem of human health and may generate antibacterial resistance problem. Flavonoid has been used for the treatment of several ailments including bacterial infection. Artocarpus heterophyllus is a potential source of flavonoid compounds such as artocarpin and cyanomaclurin. The study was conducted to observe synergistic effects between flavonoid compounds against S. pyogenes and S. epidermidis. The antibacterial activity of combination of artocarpin and cyanomaclurin isolated from A. heterophyllus heartwoods were evaluated against S. pyogenes and S. epidermidis using broth microdilution methods. Interaction between two compounds in combination was determined using checkerboard assay. Artocarpin showed strong antibacterial activity with MIC value of 1.9 µg/mL. Cyanomaclurin only exhibited moderate activity with MIC value of 15.6 µg/mL. The mixture of compounds in several ratios tended to increase antibacterial activities of cyanomaclurin. There is no antagonistic effect when compounds used together. It can be concluded that flavonoid compounds in combination may enhance antibacterial activity to prevent development of antibacterial resistance.
IN VITRO ACUTE TOXICITY OF DANDELION LEAF EXTRACT (Taraxacum officinale F.H.Wigg) WITH BRINE SHRIMP LETHALITY TEST (BSLT) METHOD Dian Mega Sugiyarto; Annisa Farida Muti; Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.873

Abstract

Toxicity is a characteristic feature of substances that can cause harmful effects. This study aimed to determine the toxicity of dandelion leaves (Taraxacum officinale F.H. Wigg) to Artemia salina Leach larvae within 24 hours. Dandelion leaves were extracted using a maceration method with 50% ethanol. The yield was 5.88%. The results showed that dandelion leaves contain alkaloids, flavonoids, steroids, triterpenoids, and phenols. Toxicity tests were performed using the Brine Shrimp Lethality Test method, where the final result was the LC50 value. Artemia salina Leach larvae were divided into five groups. Each group had ten larvae that underwent three replications. The 50%ethanolic extract of dandelion leaf concentrations in the treatment media were 50 ppm (P1), 100 ppm (P2), 150 ppm (P3), 200 ppm (P4), and 0 ppm (seawater) as the control. Probit analysis of Artemia Salina Leach mortality percentage data. The results indicated that the 50%ethanolic extract of dandelion leaves is harmful to larvae, with LC50 values of 165,223 ppm (toxic) or in the equation y = 2,114x + 0,311, with an R² value of 0,9435. Keywords: Artemia salina, BSLT, Dandelion leaf, LC50, Toxicity
EDUKASI PEMANFAATAN LIMBAH ORGANIK SEBAGAI ECO-ENZYME UNTUK PRODUK KESEHATAN BAGI MASYARAKAT RAWA KOPI-DEPOK Eldiza Puji Rahmi; Rika Revina; Aulia Farkhani
Jurnal Bakti Masyarakat Indonesia Vol. 6 No. 3 (2023): Jurnal Bakti Masyarakat Indonesia
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jbmi.v6i3.26792

Abstract

Waste from the production process in the community around Rawa Kopi, Depok, is one of the problems in their environment that requires further processing. Eco-enzyme is a potential organic waste processing technology and can be an effort to achieve the 12th SDGs goal regarding sustainable production and consumption patterns. This technology involves a fermentation process of organic waste combined with brown sugar/molasses and air in a certain ratio. The eco-enzyme liquid produced is an active ingredient that can be used for various purposes. This community service activity aims to provide outreach and education in utilizing waste, especially organic waste, which can be processed into eco-enzymes for the community around Rawa Kopi, Depok. The activity began with giving a pretest, then socialization about eco-enzymes through lectures and interactive discussions. Evaluation is carried out on the process, including attendance, enthusiasm/enthusiasm, participants' responses to training activities, and post-test material education. The results of the activity will provide knowledge to utilize organic waste around us into eco enzymes, which can then be further utilized into materials such as fertilizer, disinfectant, hand sanitizer and others. Community knowledge and understanding in utilizing organic waste around us into eco enzymes can increase after the activity. The results of the activity were able to provide knowledge about degenerative diseases and the use of Indonesian medicinal plants for degenerative diseases. Community knowledge and understanding of degenerative diseases and recognizing and utilizing plant medicines can increase significantly (p<0.001) after the activity up to 77.57%. ABSTRAK; ABSTRAK Limbah dari proses produksi pada UMKM masyarakat sekitar Rawa Kopi, Depok, menjadi salah satu permasalahandi lingkungan mereka yang memerlukan pengolahan lebih lanjut. Eco-enzyme adalah salah satu teknologipengolahan sampah organik yang potensial dan dapat menjadi salah satu upaya mencapai tujuan SDGs ke-12terkait pola produksi dan konsumsi yang berkelanjutan. Teknologi ini melibatkan proses fermentasi sampah organikyang dikombinasikan dengan gula merah/molase dan air dengan perbandingan tertentu. Cairan eco-enzim yangdihasilkan merupakan bahan aktif yang dapat digunakan untuk berbagai kepentingan. Kegiatan pengabdian kepadamasyarakat ini bertujuan untuk memberikan sosialisasi dan edukasi dalam memanfaatkan limbah terutama limbahorganik yang dapat diolah menjadi eco-enzyme bagi masyarakat sekitar Rawa Kopi, Depok. Kegiatan dimulaidengan pemberian pretest, selanjutnya sosialisasi mengenai eco-enzyme melalui ceramah dan diskusi interaktif.Evaluasi dilakukan terhadap proses yang meliputi kehadiran, semangat/antusiasme, dan respon/tanggapan pesertaterhadap kegiatan pelatihan, serta posttest materi edukasi. Hasil kegiatan diharapkan mampu memberikanpengetahuan untuk memanfaatkan sampah organik di sekitar kita menjadi eco enzyme yang selanjutnya dapatdimanfaatkan lebih jauh menjadi bahan-bahan seperti pupuk, desinfektan, hand sanitizer dan lain-lain.Pengetahuan dan pemahaman masyarakat dalam memanfaatkan sampah organik di sekitar kita menjadi eco enzymebisa meningkat setelah kegiatan. Hasil kegiatan mampu memberikan pengetahuan tentang pemanfaatan limbahorganik sebagai eco-enzyme untuk produk kesehatan. Pengetahuan dan pemahaman masyarakat meningkat secarasignifikan (p<0,001) setelah kegiatan hingga 77,57%.
COMPARATIVE TEST OF EFFECTIVENESS OF ALCOHOL MIXTURE BASE HAND SANITIZER WITH CHLORHEXIDINE MIXTURE BASE ON ESCHERICHIA COLI AND SHIGELLA SONNEI BACTERIA rahmi, eldiza puji; Farida Muti, Annisa; Pradana, Dhinga Luthfiyani; Valentino, Mikhael; Cahyadi, Salwa Nisrina; Andini, Putri; Ferdian, Muhamad; Widjaja, Tiyon; Razan Fachrudin, Brooklyn; Nabila, Annisa Hasna; Wandira, Salsabilla Puteri; Marliah Saputri, Sirly; Azzahra, Khayla Shifa; Kusumaningrum, Alfina Aprilia; Shabrina, Cut Laila Nur; Nurjannah, Rabbiah Putri
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 1 (2023): Vol.2 No.1 JUNE (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i1.7013

Abstract

ABSTRACT Hand sanitizer is a hand cleanser which is easy and practical in use. Using hand sanitizer can be an alternative for washing hands if in condition without water and soap. Hand sanitizer is used to clean pathogens on hands. The ability to kill pathogens in hand sanitizers is due to the active substance content in them. In this research, the effectiveness of 2 hand sanitizers on the market was tested. The test aims to see the effect of the active substances in each preparation on the effectiveness of killing pathogens. Testing was carried out using the Kirby Bauer method and on 2 bacterial media, namely Escherichia coli and Shigella sonnei. Hand sanitizer 1 has a composition consisting of 70% ethyl alcohol and 0.5% chlorhexidine. Hand sanitizer 2 has a composition consisting of 55% ethyl alcohol and 18% isopropyl alcohol with a total of 73% alcohol. Based on observations, it was found that hand sanitizer 1 was more effective than hand sanitizer 2. The chlorhexidine content in hand sanitizer 1 increased its effectiveness in killing pathogens.
ASSESSMENT OF KNOWLEDGE AND SELF-MEDICATION PRACTICE OF DYSMENORRHEA AMONG PHARMACY UNDERGRADUATE STUDENTS: A CROSS-SECTIONAL STUDY Rahmi, M.Sc, Eldiza Puji; Ananda, Bella; Prabowo, Imam; Pradana, Dhigna Luthfiyani Citra
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 2 (2023): Vol.2 No.2 DECEMBER (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7207

Abstract

Dysmenorrhea is pain during menstruation that is experienced during adolescence caused by uterine muscle spasms. Data on knowledge of dysmenorrhea and self-medication practice among undergraduate student at Universitas Pembangunan Nasional Veteran Jakarta (UPN Veteran Jakarta) are scarce. This study aimed to assess and determine the relationship between the level of knowledge and primary dysmenorrhea self-medication practice. A cross-sectional study was carried out among female undergraduate Pharmacy Student of UPN Veteran Jakarta. A total of 107 unmarried and nulliparous female students were included in this study using the stratified random sampling technique. Based on the results of the study, 47 students (43.9%) had adequate knowledge, 46 students (43.0%) had moderate knowledge, and 14 students (13.1%) had inadequate knowledge. Forty female students (37.4%) had good practice, 40 female students (37.4%) had moderate practice, and 27 female students (25.2%) had poor practice regarding dysmenorrhea, and in this study, the value of confidentiality (p< 0.05). It is considered significant, with the intention that there is a relationship between the level of knowledge and primary dysmenorrhea self-medication.
THE RELATIONSHIP OF COMPLIANCE WITH MEDICATION ON BLOOD PRESSURE STABILITY IN HYPERTENSION PATIENTS AT CINERE DISTRICT HEALTH CENTER 2023 Sumantri, Salsabila; rahmi, eldiza puji; Rifkia, Via; Pradana, Dhinga Luthfiyani
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 2 (2023): Vol.2 No.2 DECEMBER (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7416

Abstract

Several reasons for hypertension sufferers who do not comply with taking medication will slow down healing time and worsen the patient's condition and can even cause death. This study aims to determine the characteristics of hypertensive patients at the Cinere Community Health Center, the results of antihypertensive therapy at the Cinere Community Health Center and to determine the relationship between adherence to medication use and the success of therapy at the Cinere Community Health Center. This research uses a correlational analytical research design. Based on the discussion above, it can be concluded that the characteristics of hypertensive patients at the Cinere Community Health Center are the majority aged 45-65 years, female with the highest education level being elementary school and having suffered for > 1 year. The majority of medication adherence among hypertensive patients at the Cinere Community Health Center is still relatively low. The success of therapy in hypertensive patients at the Cinere Community Health Center resulted in a reduction in blood pressure of 31 people and in patients who did not reduce blood pressure there were 71 people. There is a relationship between adherence to taking medication and blood pressure stability in hypertensive patients at the Cinere Community Health Center
COMPARING ANTIMICROBIAL EFFICACY OF DIFFERENT HAND SANITIZERS IN PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS Ramdhan, Zeashafa Zafira; Roqayyah; Salma Ika Rahmadani; Nasyia Qaanita; Anggita Virginia Naulina Manurung; Tirta Fitri Aryani; Nafis Ikhwana; Anggita Cahya Ningrum; Nasywa Dwi Ayu; Afdhal Raziq Hanania; Deskia Amanda Fitriyani; Kharazi Farand Vitonova; Pradana, Dhigna Luthfiyani Citra; Rahmi, Eldiza Puji; Muti, Annisa Farida
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 1 (2024): Vol.3 No.1 JUNI (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7017

Abstract

Human activities every day have a lot of physical contact with the environment, this can cause various kinds of diseases. These diseases can come from various types of microorganisms such as bacteria, fungi and viruses. Examples of bacteria that can cause disease are Escherichia coli and Staphylococcus aureus. Escherichia coli and Staphylococcus aureus are Gram-positive and Gram-negative bacteria that most commonly cause diarrhoea. To avoid these bacteria, humans need to wash their hands using soap and clean running water. However, washing hands cannot be done every time and in every place. Therefore, there is an innovation of hand sanitizer without using running water, namely hand sanitizer. Hand sanitizer is a waterless hand sanitizer innovation that contains antiseptic substances. Hand sanitizer works as an antibacterial in inhibiting and even killing bacteria. Antiseptics are chemical compounds used to inhibit or kill microorganisms in living tissue. The purpose of using antiseptics is to inhibit or kill bacteria by inhibiting bacterial enzymes and reducing the permeability of bacterial cell membranes through bacterial precipitation, oxidation, and halogenation. Antiseptics usually contain alcohol, chlorhexidine, and anilides. Antiseptics that are widely used in the medical world are antiseptics with alcohol content based on the ability of alcohol to kill bacteria.
Pengembangan Metode Edukasi dan Pengawasan Kepatuhan Minum Obat Hipertensi di Kecamatan Gunung Sindur Marchia, Delphia Hermada; Maria, Ima; Ilmi, Primayanti Nurul; Rahmi, Eldiza Puji
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 1 (2025): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i1.25417

Abstract

Hipertensi di Indonesia sering ditemukan pada pelayanan kesehatan primer. Prevalensi hipertensi di Kabupaten Bogor Tahun 2019, terhadap jumlah penduduk usia ≥ 15 tahun yaitu sebesar 1.313.562 kasus. Terapi hipertensi merupakan terapi yang harus dilakukan seumur hidup, namun berdasarkan Laporan Riskesdas tahun 2018 mendapatkan hasil bahwa kepatuhan dalam minum obat pada pasien hipertensi tergolong rendah. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian edukasi terhadap tingkat kepatuhan minum obat hipertensi di Puskesmas Gunung Sindur Kabupaten Bogor. Desain penelitian ini adalah kuasi eksperimen dengan satu grup pre-post test. Variabel independen dalam penelitian ini adalah pemberian edukasi terhadap pasien hipertensi dan variabel dependennya adalah kepatuhan minum obat pada pasien hipertensi setelah hari ke-21 pemberian edukasi. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh pemberian edukasi terhadap tingkat kepatuhan minum obat (p < 0,0001) dan penurunan terhadap tekanan darah sistol responden (p < 0,0001) serta diastol (p < 0,003). Pemberian edukasi dapat memengaruhi tingkat kepatuhan minum obat serta tekanan darah pasien hipertensi secara signifikan.
Synergistic Effect Antibacterial Activity of The Combination of Andaliman (Zanthoxylum acanthopodium DC) Fruit Essential Oil and Erythromycin against Streptococcus mutans and Streptococcus pyogenes : Efek Sinergisme Aktivitas Antibakteri Kombinasi Minyak Atsiri Buah Andaliman (Zanthoxylum acanthopodium DC) dan Eritromisin terhadap Streptococcus mutans dan Streptococcus pyogenes Situmorang, Vania Clarissha; Rahmi, Eldiza Puji; Pradana, Dhigna Luthfiyani Citra; Septama, Abdi Wira; Muti, Annisa Farida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16977

Abstract

Background: The concept of synergism is one of the approaches taken to combat the problems related to antibiotic resistance. Objectives: The goal of this study was to determine the synergistic effect of the antibacterial activity of a combination of essential oil of Zanthoxylum acanthopodium DC fruit and erythromycin against Streptococcus mutans and Streptococcus pyogenes. Methods: The broth microdilution assay was used to determine the Minimum Inhibitory Concentration (MIC) of Z. acanthpodium DC fruit essential oil and erythromycin. The synergistic effects were assessed using the checkerboard method. Results: MIC value of Z. acanthopodium DC fruit essential oil against both bacteria was 2500 mg/mL. The combination of Z. acanthopodium DC fruit essential oil and erythromycin had a synergistic effect against S. mutans and S. pyogenes with fractional inhibitory concentration index (FICI) values of 0.375 and 0.0872, respectively. Conclusions: These results suggest that a combination of herbal plants and conventional antibiotics could be used as an alternative therapy for bacterial infections.