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Kajian Aktivitas Antioksidan: Potensi Ekstrak Air Daun Kelor (Moringa oleifera Lam.) dan Secang (Caesalpinia sappan L.) sebagai Anti Hiperglikemia Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi; Annisa Farida Muti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.7636

Abstract

Ekstrak air daun kelor (Moringa oleifera Lam.) mengandung senyawa aktif flavonoid, fenol, dan tanin yang berperan sebagai antioksidan yang dapat mencegah hiperglikemia dan hiperlipidemia. Secang (Caesalpinia sappan L.) mengandung brazilin yang dapat menurunkan glukosa darah. Aktivitas antioksidan ekstrak air daun kelor dan kayu secang menjadi dasar uji in vivo, oleh karena itu tujuan penelitian ini untuk mengetahui IC50 ekstrak air daun kelor dan kayu secang yang memiliki potensi sebagai antihiperglikemia. Penelitian merupakan studi eksperimental. Perhitungan IC50 menggunakan metode spektrofotometri UV-Visibel dengan DPPH. IC50 ekstrak air daun kelor, kombinasi daun kelor dan kayu secang, dan kayu secang masing-masing sebesar 217,21; 71,89; dan 8,18 ppm. Daya antioksidan kuat dan sedang berpotensi menurunkan kadar glukosa darah melalui mekanisme pengurangan Reactive Oxygen Species (ROS).
SYNERGISTIC EFFECT OF COMBINATION BETWEEN CYANOMACLURIN AND ARTOCARPIN FROM ARTOCARPUS HETEROPHYLLUS HEARTWOODS AGAINSTS STREPTOCOCCUS PYOGENES AND STAPHYLOCOCCUS EPIDERMIDIS Abdi Wira Septama; Eldiza Puji Rahmi, M.Sc
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 1 No 1 (2022): Vol.1 No.1 JUNE (2022)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v1i1.4250

Abstract

Streptococcus pyogenes and Staphylococcus epidermidis are major problem of human health and may generate antibacterial resistance problem. Flavonoid has been used for the treatment of several ailments including bacterial infection. Artocarpus heterophyllus is a potential source of flavonoid compounds such as artocarpin and cyanomaclurin. The study was conducted to observe synergistic effects between flavonoid compounds against S. pyogenes and S. epidermidis. The antibacterial activity of combination of artocarpin and cyanomaclurin isolated from A. heterophyllus heartwoods were evaluated against S. pyogenes and S. epidermidis using broth microdilution methods. Interaction between two compounds in combination was determined using checkerboard assay. Artocarpin showed strong antibacterial activity with MIC value of 1.9 µg/mL. Cyanomaclurin only exhibited moderate activity with MIC value of 15.6 µg/mL. The mixture of compounds in several ratios tended to increase antibacterial activities of cyanomaclurin. There is no antagonistic effect when compounds used together. It can be concluded that flavonoid compounds in combination may enhance antibacterial activity to prevent development of antibacterial resistance.
IN VITRO ACUTE TOXICITY OF DANDELION LEAF EXTRACT (Taraxacum officinale F.H.Wigg) WITH BRINE SHRIMP LETHALITY TEST (BSLT) METHOD Dian Mega Sugiyarto; Annisa Farida Muti; Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.873

Abstract

Toxicity is a characteristic feature of substances that can cause harmful effects. This study aimed to determine the toxicity of dandelion leaves (Taraxacum officinale F.H. Wigg) to Artemia salina Leach larvae within 24 hours. Dandelion leaves were extracted using a maceration method with 50% ethanol. The yield was 5.88%. The results showed that dandelion leaves contain alkaloids, flavonoids, steroids, triterpenoids, and phenols. Toxicity tests were performed using the Brine Shrimp Lethality Test method, where the final result was the LC50 value. Artemia salina Leach larvae were divided into five groups. Each group had ten larvae that underwent three replications. The 50%ethanolic extract of dandelion leaf concentrations in the treatment media were 50 ppm (P1), 100 ppm (P2), 150 ppm (P3), 200 ppm (P4), and 0 ppm (seawater) as the control. Probit analysis of Artemia Salina Leach mortality percentage data. The results indicated that the 50%ethanolic extract of dandelion leaves is harmful to larvae, with LC50 values of 165,223 ppm (toxic) or in the equation y = 2,114x + 0,311, with an R² value of 0,9435. Keywords: Artemia salina, BSLT, Dandelion leaf, LC50, Toxicity
Synergistic Effect Antibacterial Activity of The Combination of Andaliman (Zanthoxylum acanthopodium DC) Fruit Essential Oil and Erythromycin against Streptococcus mutans and Streptococcus pyogenes : Efek Sinergisme Aktivitas Antibakteri Kombinasi Minyak Atsiri Buah Andaliman (Zanthoxylum acanthopodium DC) dan Eritromisin terhadap Streptococcus mutans dan Streptococcus pyogenes Situmorang, Vania Clarissha; Rahmi, Eldiza Puji; Pradana, Dhigna Luthfiyani Citra; Septama, Abdi Wira; Muti, Annisa Farida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16977

Abstract

Background: The concept of synergism is one of the approaches taken to combat the problems related to antibiotic resistance. Objectives: The goal of this study was to determine the synergistic effect of the antibacterial activity of a combination of essential oil of Zanthoxylum acanthopodium DC fruit and erythromycin against Streptococcus mutans and Streptococcus pyogenes. Methods: The broth microdilution assay was used to determine the Minimum Inhibitory Concentration (MIC) of Z. acanthpodium DC fruit essential oil and erythromycin. The synergistic effects were assessed using the checkerboard method. Results: MIC value of Z. acanthopodium DC fruit essential oil against both bacteria was 2500 mg/mL. The combination of Z. acanthopodium DC fruit essential oil and erythromycin had a synergistic effect against S. mutans and S. pyogenes with fractional inhibitory concentration index (FICI) values of 0.375 and 0.0872, respectively. Conclusions: These results suggest that a combination of herbal plants and conventional antibiotics could be used as an alternative therapy for bacterial infections.
Edukasi Pemanfaatan Tanaman Obat Indonesia untuk Penyakit Degeneratif di Meruyung-Depok Rahmi, Eldiza Puji; Muti, Annisa Farida; Revina, Rika; Citra Pradana, Dhigna Luthfiyani
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 5, No 1 (2025): Abdira, Januari
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v5i1.564

Abstract

Currently, degenerative diseases have become a problem for every country throughout the world, including Indonesia. The use of medicinal plants in the surrounding area to prevent degenerative diseases is one strategy to improve public health. This Community Service Activity aims to educate the public in recognizing and utilizing medicinal plants to prevent degenerative diseases. This activity was carried out at the UPNVJ Meruyung Housing Complex, Depok. The method used was community education through counseling by providing explanations about degenerative diseases, conducting socialization of types of medicinal plants, their benefits and applications, in addition the level of knowledge of participants was also measured using questionnaires for pre- and post-tests. This activity was attended by the community, especially women at the UPNVJ Meruyung Depok Housing Complex. The results of the activity provided knowledge about degenerative diseases and the use of Indonesian medicinal plants for degenerative diseases. The knowledge and understanding of the community about degenerative diseases and recognizing and utilizing medicinal plants increased significantly (p 0.001) after the activity by 61.36%.
EDUKASI PEMANFAATAN LIMBAH ORGANIK SEBAGAI ECO-ENZYME UNTUK PRODUK KESEHATAN BAGI MASYARAKAT RAWA KOPI-DEPOK Rahmi, Eldiza Puji; Revina, Rika; Farkhani, Aulia
Jurnal Bakti Masyarakat Indonesia Vol. 6 No. 3 (2023): Jurnal Bakti Masyarakat Indonesia
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jbmi.v6i3.26792

Abstract

Waste from the production process in the community around Rawa Kopi, Depok, is one of the problems in their environment that requires further processing. Eco-enzyme is a potential organic waste processing technology and can be an effort to achieve the 12th SDGs goal regarding sustainable production and consumption patterns. This technology involves a fermentation process of organic waste combined with brown sugar/molasses and air in a certain ratio. The eco-enzyme liquid produced is an active ingredient that can be used for various purposes. This community service activity aims to provide outreach and education in utilizing waste, especially organic waste, which can be processed into eco-enzymes for the community around Rawa Kopi, Depok. The activity began with giving a pretest, then socialization about eco-enzymes through lectures and interactive discussions. Evaluation is carried out on the process, including attendance, enthusiasm/enthusiasm, participants' responses to training activities, and post-test material education. The results of the activity will provide knowledge to utilize organic waste around us into eco enzymes, which can then be further utilized into materials such as fertilizer, disinfectant, hand sanitizer and others. Community knowledge and understanding in utilizing organic waste around us into eco enzymes can increase after the activity. The results of the activity were able to provide knowledge about degenerative diseases and the use of Indonesian medicinal plants for degenerative diseases. Community knowledge and understanding of degenerative diseases and recognizing and utilizing plant medicines can increase significantly (p<0.001) after the activity up to 77.57%. ABSTRAK; ABSTRAK Limbah dari proses produksi pada UMKM masyarakat sekitar Rawa Kopi, Depok, menjadi salah satu permasalahandi lingkungan mereka yang memerlukan pengolahan lebih lanjut. Eco-enzyme adalah salah satu teknologipengolahan sampah organik yang potensial dan dapat menjadi salah satu upaya mencapai tujuan SDGs ke-12terkait pola produksi dan konsumsi yang berkelanjutan. Teknologi ini melibatkan proses fermentasi sampah organikyang dikombinasikan dengan gula merah/molase dan air dengan perbandingan tertentu. Cairan eco-enzim yangdihasilkan merupakan bahan aktif yang dapat digunakan untuk berbagai kepentingan. Kegiatan pengabdian kepadamasyarakat ini bertujuan untuk memberikan sosialisasi dan edukasi dalam memanfaatkan limbah terutama limbahorganik yang dapat diolah menjadi eco-enzyme bagi masyarakat sekitar Rawa Kopi, Depok. Kegiatan dimulaidengan pemberian pretest, selanjutnya sosialisasi mengenai eco-enzyme melalui ceramah dan diskusi interaktif.Evaluasi dilakukan terhadap proses yang meliputi kehadiran, semangat/antusiasme, dan respon/tanggapan pesertaterhadap kegiatan pelatihan, serta posttest materi edukasi. Hasil kegiatan diharapkan mampu memberikanpengetahuan untuk memanfaatkan sampah organik di sekitar kita menjadi eco enzyme yang selanjutnya dapatdimanfaatkan lebih jauh menjadi bahan-bahan seperti pupuk, desinfektan, hand sanitizer dan lain-lain.Pengetahuan dan pemahaman masyarakat dalam memanfaatkan sampah organik di sekitar kita menjadi eco enzymebisa meningkat setelah kegiatan. Hasil kegiatan mampu memberikan pengetahuan tentang pemanfaatan limbahorganik sebagai eco-enzyme untuk produk kesehatan. Pengetahuan dan pemahaman masyarakat meningkat secarasignifikan (p<0,001) setelah kegiatan hingga 77,57%.
PENDAMPINGAN KADER KESEHATAN KECAMATAN CINERE DEPOK DALAM UPAYA MENCEGAH STUNTING DENGAN METODE CARA BELAJAR INSAN AKTIF Pradana, Dhigna Luthfiyani Citra; Sartika, Luthfiah Dewi; Rahmi, Eldiza Puji; Muti, Annisa Farida; Syarifah, Andiri Niza; Ilmi, Primayanti Nurul
Jurnal Serina Abdimas Vol 1 No 4 (2023): Jurnal Serina Abdimas
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jsa.v1i4.28336

Abstract

Malnutrition in children who are stunted occurs from the baby in the womb to after birth or commonly called the First 1,000 Days of Life (HPK). Stunting prevention is more effective than stunting treatment. Therefore, the purpose of this community service is to assist health cadres of Cinere sub-district in preventing stunting. The method used in this community service is education on how to learn active people and participants are given pre-test and post-test. The activeness of community service participants is expected to make it easier to understand stunting prevention education by seeing and discussing vitamins and minerals needed in stunting prevention. The results of community service were followed by 113 people divided into 4 villages in Cinere District, Depok City. Most of the participants were mothers so that information and implementation of stunting prevention could be seen immediately. There was a significant difference of 0.000 between pretest and posttest values analyzed using the Wilcoxon test on SPSS. The results of the pre-test and post-test assessments, attitudes and understanding of health cadres in Cinere sub-district increased by an average of around 87, so it can be assumed that the participants had understood the educational material for stunting prevention in Cinere sub-district, Depok city. Kekurangan gizi pada anak yang mengalami stunting terjadi sejak bayi dalam kandungan hingga setelah lahir atau biasa disebut 1.000 Hari Pertama Kehidupan (HPK). Pencegahan stunting lebih efektif dibandingkan pengobatan stunting. Oleh karena itu tujuan dari pengabdian masyarakat ini adalah untuk mendampingi kader Kesehatan kecamatan cinere dalam mencegah kejadian stunting. Metode yang digunakan dalam pengabdian masyarakat ini yaitu edukasi cara belajar insan aktif serta para peserta diberikan pre-test dan post-test. Keaktifan para peserta pengabdian masyarakat diharapkan dapat memudahkan untuk memahami edukasi pencegahan stunting dengan melihat serta mendiskusikan vitamin dan mineral yang dibutuhkan dalam pencegahan stunting. Hasil pengabdian masyarakat diikuti 113 orang yang terbagi menjadi 4 kelurahan di Kecamatan Cinere Kota Depok. Sebagian besar peserta adalah seorang ibu sehingga informasi dan penerapan pencegahan stunting langsung dapat dilihat hasilnya. Terdapat perbedaan yang signifikan 0,000 antara nilai pretest dan posttest yang dianalisis menggunakan uji Wilcoxon pada SPSS. Hasil penilaian pre-test dan post-test sikap dan pemahaman kader kesehatan di Kecamatan Cinere meningkat rata-rata sekitar 88 sehingga dapat diasumsikan bahwa para peserta telah paham materi edukasi pencegahan stunting di kecamatan cinere kota depok.
RATIONALITY OF ANTIBIOTIC PRESCRIPTIONS AMONG OUTPATIENTS IN THE INTERNAL MEDICINE CLINIC AT PERSAHABATAN GENERAL HOSPITAL JULY–SEPTEMBER 2023 Artanti, Astrid Nada; Maria, Ima; Rahmi, Eldiza Puji; Citra Pradana, Dhigna Luthfiyani; Diliana, Diliana
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antibiotic use has increased in both developing countries, such as Indonesia, and developed countries, such as Japan and Australia. This trend may lead to a rise in antibiotic resistance if antibiotics are used irrationally. This study aimed to evaluate antibiotic prescribing patterns using the Gyssens method among adult outpatients in the Internal Medicine Clinic at Persahabatan General Hospital during the period of July–September 2023. This was a descriptive study with a cross-sectional design. Data were collected retrospectively from the medical records of adult outpatients attending the Internal Medicine Clinic during the study period. Of the 30 patient records that met the inclusion and exclusion criteria, the age group 51–60 years represented the largest proportion of antibiotic prescriptions (46.67%). Levofloxacin was the most frequently prescribed antibiotic (30.3%). Based on the Gyssens method, 88.8% of prescriptions were classified as rational, while 11.1% were irrational. In conclusion, 88.8% of antibiotics prescribed for adult outpatients in the Internal Medicine Clinic at Persahabatan General Hospital during July–September 2023 were deemed rational according to the Gyssens method. Keywords : antibiotics, gyssens method, outpatient DOI : 10.35990/mk.v8n4.p400-411
Pharmacokinetic Evaluation of Paracetamol Co-administered with Moringa oleifera and Caesalpinia sappan Extracts Individually in Sprague Dawley Rats Pradana, Dhigna; Nur, Syifa; Hakim, Annisa Ayu Nur; Rahmi, Eldiza Puji; Muti, Annisa Farida; Abdurrahman Munir, Muhammad
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.579

Abstract

Paracetamol is frequently utilized to alleviate pain and fever due to its pharmacological properties as an analgesic and antipyretic. Consuming paracetamol drugs while self-medication might potentially lead to drug interactions when used with other medications, as well as certain foods and herbs. Moringa oleifera and Caesalpinia sappan are popular herbal plants in Indonesia, commonly used to produce herbal food and drinks. These plants contain flavonoids and phenols, which have the potential to impact the metabolism, effectiveness, and toxicity of medications, including paracetamol. This study investigated alterations in the pharmacokinetic characteristics of paracetamol when co-administered with Moringa oleifera and Caesalpinia sappan. The research utilized a true experimental approach with a posttest-only control group design and animal model study is male Sprague-Dawley rats . The control group was administered an oral dose of 9mg/200g body weight of paracetamol. By contrast, the treatment group of male Sprague-Dawley rats was administered an oral dose of 9mg/200g body weight of paracetamol, combined with a dose of 60mg/200g of Moringa leaf extract and sappan heartwood extract at 294 mg/kg body weight. At 30, 60, 120, 180, and 240 minutes, blood samples were collected from the rats' lateral tail vein. Analyzing the concentration of paracetamol in plasma was conducted using a UV-Vis spectrophotometer set at a wavelength of 244 nm. The study showed that combining sappan heartwood extract with paracetamol resulted in a substantial 453.10% increase in the volume of distribution (Vd) (p<0.05). The administration of Moringa leaf extract decreased a little effect the pharmacokinetic profile of paracetamol, as shown by the statistical analysis of the unpaired t-test (p>0.05).
Acute Oral Toxicity of Methanolic Extracts from the Fruit and Leaf of Parijoto (Medinilla speciosa Blume) in Mice Annisa Farida Muti; Refian Ariesta Eka Maulana; Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24762

Abstract

Medinilla speciosa Blume, or parijoto, contains flavonoids, saponins, alkaloids, and tannins with pharmacological potential. However, information regarding its safety profile, particularly acute toxicity data, is still very limited, so research is needed to evaluate its safety level. This study aims to evaluate the acute oral toxicity of M. speciosa leaf and fruit extracts in ddY mice. This study used a true experimental design. M. speciosa leaf and fruit extracts were obtained by ultrasonic-assisted extraction with methanol as a solvent. The acute oral toxicity test was conducted with a fixed-dose method at a single dose of 2000 mg/kgBW. Parameters observed for 14 days included mortality, clinical symptoms of toxicity, body weight changes, relative organ weights, and histopathological analysis of the liver and kidneys. The findings indicated an absence of fatalities across all treatment groups. The LD50 values for both extracts were determined to exceed 2000 mg/kgBW, categorising the fruit and leaf extracts as mildly toxic (category 5). Mild toxic symptoms were only observed in the treatment group receiving the fruit extract. Histopathological analysis of the liver and kidneys revealed mild cellular changes that were not statistically significant. Therefore, a single oral administration of M. speciosa fruit and leaf extracts at doses up to 2000 mg/kgBW is relatively safe.