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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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DIAGNOSIS OF LIVER FIBROSIS IN CHRONIC VIRAL HEPATITIS C IN HIV-INFECTED CHILDREN Isakovna, Khadieva Dora
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.962

Abstract

General Background: Chronic viral hepatitis (CH) poses a significant challenge in contemporary healthcare, leading to severe liver diseases such as cirrhosis and hepatocellular carcinoma. Specific Background: Among the known hepatotropic viruses, hepatitis B, C, D, and G are implicated in chronic liver conditions, with hepatitis C virus (HCV) being particularly concerning in co-infected populations, such as children with HIV. Knowledge Gap: While the progression of liver fibrosis in CH is well-documented, the interplay of risk factors affecting fibrosis progression in HIV-infected children remains underexplored. Aims: This study aims to assess the risk factors influencing liver fibrosis in children diagnosed with chronic hepatitis C and co-infected with HIV, emphasizing the need for timely diagnosis and management. Results: Preliminary findings indicate that HIV co-infection significantly exacerbates the progression of liver fibrosis in children with chronic hepatitis C, highlighting age, immune status, and viral load as critical factors. Novelty: This research provides novel insights into the unique clinical presentation of liver disease in pediatric HIV-positive populations, which is often overlooked in current literature. Implications: The implications of this study are profound, suggesting that healthcare providers must prioritize regular screening for liver fibrosis in this vulnerable demographic to improve clinical outcomes and inform therapeutic strategies. Addressing this issue could lead to enhanced management protocols for co-infected children, ultimately reducing morbidity associated with chronic liver disease.
MAIN CHARACTERISTICS OF THE SKIN DERMIS qizi, Shavkatxonova Marjona Fayzullo
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.963

Abstract

General Background: The dermis, the skin's second layer, plays a crucial role in skin health and functionality. Positioned beneath the epidermis, it serves as a structural support for the skin. Specific Background: Comprised primarily of connective tissue, the dermis is rich in proteins such as collagen and elastin, which are essential for maintaining skin integrity and elasticity. Knowledge Gap: Despite the recognized importance of the dermis in dermatological health, detailed understanding of its composition and the role of the extracellular matrix (ECM) in skin aging and disease is limited. Aims: This study aims to elucidate the main characteristics of the dermis, focusing on its structural components and their contributions to skin health. Results: The findings highlight the predominance of collagen and elastin as the primary structural proteins, alongside the crucial role of hyaluronic acid in the ECM, which maintains hydration and resilience of the dermal layer. Novelty: This research offers new insights into the interplay between dermal components and skin aging, suggesting that a better understanding of these elements may inform therapeutic strategies for skin rejuvenation and disease management. Implications: The implications of this study extend to clinical practices, emphasizing the need for targeted interventions that enhance dermal health, thereby contributing to improved aesthetic and functional outcomes in dermatology. This knowledge could pave the way for innovative treatments aimed at preserving skin youth and preventing age-related skin disorders.
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME SCHIFF BASE METAL COMPLEXES Mohammed, Samar S.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.969

Abstract

This study presents the synthesis and characterization of five metal complexes (C1–C5) derived from the reaction of a newly synthesized ligand (HL) with various metal chlorides, specifically Zn, Co, Ni, Mn, and Fe. General Background: Transition metal complexes have garnered significant interest due to their diverse biological activities and potential therapeutic applications. Specific Background: The ligand (HL) was synthesized from equimolar amounts of p-anisidine and salicylaldehyde, yet the influence of different metal ions on the biological properties of such complexes remains underexplored. Knowledge Gap: While several metal complexes exhibit antimicrobial properties, there is limited research on the biological activities of complexes formed with this specific ligand. Aims: This work aims to synthesize and characterize the metal complexes and evaluate their antibacterial activity against various bacterial strains. Results: Characterization via FT-IR and ¹H NMR spectroscopy confirmed the successful formation of the complexes, indicating strong metal-ligand interactions. Preliminary biological testing revealed varying degrees of antibacterial activity among the complexes, with notable effectiveness against certain bacterial strains. Novelty: The study contributes to the understanding of how different metal ions influence the biological properties of metal-ligand complexes. Implications: These findings suggest that the synthesized metal complexes could serve as potential candidates for further development in antimicrobial therapies, prompting additional research into their mechanism of action and broader biological applications.
COMPARATIVE DESCRIPTION OF CYTOPENIC SYNDROME IN VIRUS ETIOLOGY LIVER CIRRHOSIS Z.A, Sayfiddinova; Islamova Z.S; Slamova G.E; Adilov A.A.; Saidmurodov B.S; Nurillayeva G.S
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.970

Abstract

General Background: Liver cirrhosis is a severe complication of chronic viral hepatitis, significantly impacting hematological parameters and leading to cytopenic syndromes. Specific Background: While both Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are known to cause liver cirrhosis, the comparative hematological features associated with these viral etiologies remain inadequately explored. Knowledge Gap: Current literature lacks comprehensive analysis on the differences in cytopenic manifestations in patients with liver cirrhosis of HBV versus HCV origin. Aims: This study aims to evaluate and compare the cytopenic syndromes present in patients with liver cirrhosis attributed to HBV and HCV, with a focus on blood parameters, coagulation factors, and protein fractions. Results: The analysis included 50 patients diagnosed with viral etiology liver cirrhosis. Findings revealed significant decreases in blood platelets, blood coagulation factors, and protein fractions, alongside the presence of hemorrhagic syndromes of various origins. Novelty: This study provides a comparative perspective on the hematological implications of liver cirrhosis due to HBV and HCV, highlighting specific deficiencies in blood components linked to each viral etiology. Implications: Understanding the distinct cytopenic features in liver cirrhosis patients with HBV and HCV may guide more tailored clinical management strategies and improve patient outcomes by addressing the unique hematological challenges associated with each viral infection
ALTERATIONS IN HEMATOLOGICAL INDICES IN ANTENATAL AND POSTNATAL MOTHERS WITHIN KERKUK PROVINCE, IRAQ Azeez, Sarah T.; Bayatli, Feedan J.; Bazzaz, Ayoub; Chelebi, Noorhan A.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 10 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i10.985

Abstract

Background: Variations in some blood indices at antenatal and postnatal periods in Iraqi women are investigated within Kirkuk Province, Iraq. Materials and Methods: The experimental group included 300 pregnant women at third trimester and another 300 postnatal women attended Azadi Hospital, Kirkuk for the period of 12 months compared with 60 control non-pregnant women selected from Kirkuk University students. The blood parameters were analyzed using automated analyzing machine. Results: Hemoglobin (Hb%) had significantly dropped down to (11.83gm/dL±1.04) in comparison with control; however, it significantly (p≤0.022) raised to 12.4gm/dL±1.6) postnatally. Similarly, the packed cell volume (PCV) had significantly (p≤0001-0.03) dropped in pregnant women at antenatal stage to (34.11±7.76%) in comparison with non-pregnant women (37.11±3.33%), but was significantly (p≤0.022) rose, postnatally. Meanwhile, counts of white blood cells (WBC) was significantly (p≤0.001) increased to (11.69x106/dL) in the pregnant than in control (7.42x106/dL); but further rose postnatally to (15.82±4.7x106/dL). Simultaneously, the count of PCV% had significantly (p≤0.037) dropped down in pregnant women (34.11±7.76%) in comparison with their counterparts the control (37.11±3.33%), respectively; but insignificantly rose postnatally, to 36.67±3.8%, and an insignificant decrease was detected in PLT in comparison with their counterparts, the control group, respectively. Conclusion: In almost all healthy pregnant women the hematological indices could normally be altered as a response to nonpathogenic physiological changes in their health status and would soon be recovered, to certain extend, postnatally, though these insights would help in improving health monitoring as well as risk assessment during pregnancy.
GENETIC VARIATION OF HOUSEKEEPING GENES IN MULTIDRUG RESISTANT PSEUDOMONAS AERUGINOSA Hassan, Baraa Adnan; Hamada, Yasir Hamad; Abdullah, Iman Tajer
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 10 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i10.986

Abstract

Background: Pseudomonas aeruginosa is a prominent opportunistic pathogen responsible for nosocomial infections, particularly among immunocompromised individuals. Specific Background: Its ability to develop multiple antibiotic resistance poses a significant clinical challenge, highlighting the need for a deeper understanding of its genetic diversity and virulence factors. Knowledge Gap: While previous studies have explored antibiotic resistance mechanisms, there is limited research on the genetic diversity of Pseudomonas aeruginosa isolates in specific geographic regions, such as Kirkuk. Aims: This study aimed to investigate the genetic diversity of Pseudomonas aeruginosa isolates from clinical samples obtained from Kirkuk Civil Hospitals, utilizing Multi-Locus Sequence Typing (MLST) for genetic analysis. Results: Fourteen P. aeruginosa isolates were confirmed through biochemical tests and the VITEK-2 system, with an alarming 85.71% (12/14) exhibiting antibiotic resistance. Molecular analysis revealed the presence of several housekeeping genes, although some genes did not amplify. Notably, two new serotypes (PS3:id:9797 and PS4:id:9796) were identified and added to the MLST database, along with three new genes registered in NCBI. Phylogenetic analysis indicated a divergent cluster among three isolates. Novelty: This research contributes new insights into the genetic diversity of Pseudomonas aeruginosa, identifying novel serotypes and genes, which are critical for understanding its epidemiology and resistance mechanisms. Implications: The findings underscore the importance of ongoing surveillance of Pseudomonas aeruginosa in clinical settings to inform treatment strategies and public health policies aimed at managing antibiotic resistance and improving patient outcomes.
DEVELOPMENT OF MAGNETIC RESONANCE IMAGING (MRI) TECHNIQUES FOR STUDYING NEUROLOGICAL CHANGES ASSOCIATED WITH BRAIN DISEASES Abdalrahman Ahmed Yassen Mahmoud; Marwan Khaled Ibrahim Ahmed; Teba Haitham Jameel Mohammed; Athraa Mahmoud Mohamed Hani; Halah madhor Mahmoud
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 10 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i10.987

Abstract

General Background: The advent of advanced Magnetic Resonance Imaging (MRI) techniques has transformed the exploration of neurological alterations linked to brain diseases. Specific Background: MRI serves as a non-invasive modality for visualizing brain structure and function, crucial for identifying abnormalities associated with conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. Knowledge Gap: Despite the advancements, the precise relationships between these imaging modalities and specific neurological changes remain inadequately understood, necessitating further investigation. Aims: This review aims to examine the latest developments in MRI techniques, particularly functional MRI (fMRI), diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS), and their applications in assessing neurological disorders. Results: The integration of fMRI facilitates the capture of real-time brain activity through blood oxygen level-dependent (BOLD) signals, while DTI provides insights into white matter integrity and neural connectivity. MRS enhances our understanding of biochemical alterations by measuring metabolic changes within the brain. Novelty: This synthesis of advanced MRI methodologies underscores their complementary roles in elucidating the intricacies of brain structure and function, particularly in the context of disease progression and treatment response. Implications: By delineating subtle changes in brain activity and composition, these MRI techniques not only enhance early diagnosis but also inform clinical strategies for the management of brain diseases, ultimately contributing to improved patient outcomes. This review highlights the potential of advanced MRI modalities in bridging existing knowledge gaps and advancing both research and clinical practices in neurology.
FORENSIC ASPECTS OF CIRCULATORY DISORDERS IN BRAIN INJURIES Jumanazarovich, Jarimbetov Rashid
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 10 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i10.988

Abstract

General Background: The analysis of forensic medical reports reveals persistent challenges in accurately identifying and assessing craniocerebral injuries. Specific Background: Repeated and additional forensic examinations often highlight shortcomings and errors attributed to a lack of understanding among experts regarding contemporary concepts related to traumatic brain injury (TBI), including its mechanisms, clinical manifestations, and differential diagnosis. Knowledge Gap: Despite advancements in medical knowledge, there remains a significant gap in the expertise of forensic professionals regarding the complexities of TBI, leading to inconsistencies in forensic assessments. Aims: This study aims to evaluate the current practices in forensic medical examinations of craniocerebral injuries and identify areas for improvement in the methodology of assessment. Results: The findings indicate that insufficient knowledge of TBI mechanisms and a lack of standardized approaches contribute to errors in forensic evaluations, ultimately affecting the quality of forensic medical reports. Novelty: This research emphasizes the need for enhanced training and a unified methodological framework for forensic experts to better understand and assess craniocerebral injuries. Implications: By addressing these deficiencies, the study underscores the importance of improving forensic practices, which could lead to more accurate diagnoses and assessments of TBI, thereby enhancing the reliability of forensic medical reports in legal contexts. This work advocates for the development of standardized guidelines and continuous education for forensic experts in the field.
CLINICAL-IMMUNOGENETIC RELATIONSHIP IN CHILDREN WITH CHRONIC TONSILLITIS AND ASSOCIATED DISEASES Aminjonovich, Asrorov Akmal
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 10 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i10.989

Abstract

General Background: Chronic tonsillitis is a prevalent condition in children, often linked to various immunogenetic factors that influence its pathogenesis and associated diseases. Specific Background: The role of HLA (Human Leukocyte Antigen) system A and B loci in chronic tonsillitis remains inadequately understood, particularly regarding their clinical significance and the immunogenetic correlations with related conditions. Knowledge Gap: While prior studies have examined the genetic factors associated with chronic tonsillitis, there is a lack of comprehensive research focusing on the specific HLA loci and their implications for clinical outcomes in affected children. Aims: This study aims to determine the indicators of HLA A and B loci in children with chronic tonsillitis and to explore the clinical-immunogenetic correlations with associated diseases. Results: The findings demonstrate significant associations between specific HLA alleles and the severity of chronic tonsillitis, highlighting potential immunogenetic predispositions that influence disease progression and comorbidities. Novelty: This research introduces a novel perspective by linking HLA system indicators directly to clinical outcomes, thereby providing new insights into the immunogenetic mechanisms underlying chronic tonsillitis in children. Implications: The identification of these immunogenetic factors could enhance the understanding of chronic tonsillitis pathophysiology and inform personalized treatment strategies, ultimately improving patient management and outcomes in pediatric populations.
BLOOD VISCOSITY AND GIT DISORDERS OF HCV PATIENTS Mubark, Nawras Najah; Rasha Ibrahim Salman; Shahad Q. Al-Hamadiny
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 10 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i10.990

Abstract

Background: Hepatitis C virus (HCV) infection is a blood-borne viral illness responsible for significant morbidity and mortality all over the world. The current study aims to determine the role of HCV in increasing blood viscosity that is accompanied by attacks and serious heart disorders, in addition to knowing the effect of this infection on irritations and disorders of the digestive system. Methods: The practical side included collecting blood samples from 50 HCV infected persons and 50 healthy persons as a control group. Laboratory and clinical tests were carried out at Al-Diwaniyah General Teaching Hospital, where HCV was determined by checking for antibodies using the ELISA test, while blood viscosity was determined by knowing the percentage of red blood cells (hemocrit) as part of the complete blood test. Gastrointestinal tract (GIT) diseases were diagnosed using gastroendoscopy and x-rays, in addition to investigations Helicobacter pylori (H. pylori). Result: ulcers and stomach acidity with colitis together (A,B,D) were in high rates in patients (58%) compared with healthy people (6%) and produced this is a clear statistical difference (p<0.05). Moreover, Blood viscosity increased (71.54%) with a rise titer of HCV in patients blood (18.38 logIU/mL) that associated with appearance of strong positive linear correlation (r= 0.965, p= 0.004). In conclusion: HCV leads to serious complications, especially the digestive system and circulation, and the risk of these disorders increases with the increased survival of the virus C in the patient's liver. Therefore, it is necessary to use appropriate treatments, especially effective modern treatments represented by Harvoni.

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