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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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COMPARISON OF THE ANTITUMOR EFFECT OF KOLHIPRIT-NEO WITH THE EFFECT OF COMMERCIAL DRUGS Makhmudovna Urozov, Enikeeva Zulfiya; Nuriddin Elmuratovich; Agzamova Nigora Alimukhamedovna; Ibragimov Shavkat Narzikulovich; Shakhanova Shakhnoza Shavkatovna
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 11 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i11.1041

Abstract

Objective: In this study, mice with transplanted Sarcoma 180 and Solid Ehrlich tumors (SET) were used to test the antitumor activity of oral K-20 (colchiprit-neo) against different cytostatics. Methods: Antitumor activity was tested in outbred mice with transplanted tumors, treated orally with K-20 and XELODA, and intraperitoneally with doxorubicin, taxol, etoposide, or other cytostatics. Treatment was began on the 4th-5th day post-transplantation, delivered daily for 10 days. Tumor growth inhibition (TGI), animal body and spleen weight, and hematopoietic indices were measured, with statistical significance set at p < 0.05. Results: While other treatments showed significant reductions in hematopoietic parameters, K-20 treatment did not significantly affect body or spleen weight or leukocyte levels. K-20 showed superior antitumor activity, inhibiting tumor growth by 92-94% in Sarcoma 180 and SET models, outperforming doxorubicin (90%) and taxol (84-88%), and demonstrating 27% greater efficacy than XELODA. Novelty: In contrast to conventional cytostatics, K-20's oral administration demonstrated strong anticancer effects along with a good safety record and little influence on hematopoiesis or organ weights.
MODERN USE OF DRUGS IN BRONCHOPULMONARY PATHOLOGY Abdumavljanovna Azizova, Rihsi; Abdulazizovna Valieva, Tamila
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 11 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i11.1042

Abstract

Objective: This study aims to evaluate the rational pharmacotherapy for bronchopulmonary diseases in children with recurrent bronchitis, focusing on treatment effectiveness and safety. Methods: A retrospective analysis of 28 children aged 1.5 to 10 years, diagnosed with acute bronchitis, recurrent bronchitis, and pneumonia, was conducted. The patients were treated at a pulmonology department and underwent clinical, laboratory, and radiological assessments. Treatment regimens included third-generation cephalosporins, glucocorticoids, and antihistamines, administered according to age-based standards. Results: The study revealed that all patients exhibited moderate symptoms upon admission, with many presenting coexisting conditions such as chronic ENT diseases and iron-deficiency anemia. Clinical laboratory tests indicated iron deficiency anemia and mild leukocytosis across all groups, suggesting impaired oxygen delivery and ongoing inflammation. The pharmacotherapy was generally well-tolerated, with notable improvements in respiratory function and recovery in most children. Novelty: This study highlights the importance of personalized pharmacotherapy in managing recurrent bronchitis in children, particularly considering comorbid conditions. It emphasizes the role of comprehensive treatment protocols integrating antibiotics, glucocorticoids, and antihistamines for effective management.
STUDY OF TOXICOLOGY OF THE ANTITUMOR DRUG COLCHIPRIT-NEO (K-20) Leonidovna, Vypova Natalia; Nishanov Danier Anarbaevich; Madaliev Akhror Alievich; Ibragimov Shavkat Narzikulovich; Enikeeva Zulfiya Makhmudovna; Urozov Nuriddin Elmuratovich
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 11 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i11.1045

Abstract

Objective: Colchiprit-neo was administered orally to rats at dosages of 30.0, 61.0, and 120 mg/kg for 30 days in order to assess its chronic toxicity. Methods: The effects on behavior, body weight, peripheral blood composition, kidney function, liver enzyme levels, and internal organ pathology were evaluated after rats were given Colchiprit-neo at the recommended dosages. To assess the reversibility of any possible harmful effects, a one-month recovery time was incorporated. Results: According to the study, rats' behavior, body weight, and blood composition were unaffected by repeated oral treatment of Colchiprit-neo. During therapy, the liver's alanine aminotransferase (ALT) level rose, but during the recovery phase, all tested values went back to normal. The 30 mg/kg dose did not cause any toxicity in the parenchymal organs, according to pathomorphological analysis. Novelty: The findings indicate that Colchiprit-neo is safe for long-term usage because it does not show substantial chronic toxicity at therapeutic levels. This work offers significant preclinical evidence in favor of its possible therapeutic use without endangering the major organ systems.
CAUSES AND CONSEQUENCES OF LATE DIAGNOSIS, TREATMENT OF CONGENITAL HYDRONEPHROSIS IN CHILDREN F. A, Otamuradov; A.Sh , Vakhidov; S. A , Rakhmonov; Z. Kh, Karimova
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 11 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i11.1047

Abstract

Objective: This study aims to analyze the causes and consequences of late diagnosis of congenital hydronephrosis in children, focusing on its impact on renal function and the outcomes of surgical correction in cases diagnosed after the early stages of childhood. Methods: Retrospective analysis was conducted on 99 children (aged 8 months to 17.5 years) diagnosed with hydronephrosis postnatally, from 2010 to 2023, at the SODMC of Termez. All patients underwent clinical, laboratory, and radiological investigations, including ultrasound, CT scans, and urography, to evaluate the extent of renal involvement and determine appropriate surgical interventions. Results: Late diagnosis, primarily after 3 years of age (73.7% of cases), was linked to a latent disease course, often masked by nonspecific symptoms such as pyelonephritis. Hydronephrosis was more prevalent on the right side (51.5%), with 31.3% of children diagnosed with stage IV disease requiring nephrectomy. The most common etiology included aberrant vessels and pyeloternal segment stenosis. Surgical treatments included pyeloplasty (58.6%), antevasal anastomosis (10.1%), and nephrectomy (22.1%). Postoperative recovery was generally uncomplicated, with 68.6% of children showing reduced renal pelvis size and improved kidney function. Novelty: This study highlights the significant risk of renal damage associated with delayed diagnosis and emphasizes the need for early detection and timely surgical intervention to preserve renal function. It provides valuable insights into the management of hydronephrosis in children, particularly in regions with limited access to advanced diagnostic tools.
PARAPROSTHETIC RECURRENT VENTRAL HERNIAS AND THEIR SURGICAL CORRECTION Akmal Aliyarovich, Khaitov; Ishnazar Boynazarovich, Mustafakulov
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 12 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i12.1048

Abstract

Objective: To conduct a comparative analysis of macro- and microscopic morphological changes in tissues in patients with recurrent ventral hernias and to improve surgical methods for managing these cases. Methods: Patients were divided into two groups based on prior hernioplasty techniques: Group I (n=52) received tension methods, while Group II (n=26) underwent non-tension prosthetic methods. Clinical and instrumental analyses, including CT scans and morphological assessments of tissue around prostheses, were performed to evaluate recurrence patterns and inflammation levels. Results: Findings revealed that complete relapses frequently followed tension hernioplasty, while non-tension methods resulted in partial recurrences along the prosthesis contours. Tension methods showed significant void formation and inflammatory responses around the prostheses, while non-tension techniques led to a mature connective tissue response. The recurrence rate was notably lower (3.8%) in patients treated with improved non-tension methods, such as "onlay" without defect suturing and "onlay + sublay" with duplication. Novelty: This study offers insights into morphological differences in tissue responses based on hernioplasty techniques, supporting improved surgical methods for recurrent hernias. By enhancing tension-free techniques, recurrence rates were reduced from 15% to 3.8%, underscoring the clinical benefit of tailored approaches in recurrent ventral hernia management.
NUTRITION AND EARLY DEVELOPMENT: A FRAMEWORK FOR THRIVING CHILDREN Rahmon Aslanovich, Amanov
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 12 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i12.1049

Abstract

Objective: To explore the importance of integrating nutrition and responsive caregiving in promoting child development, particularly in low- and middle-income countries (LMICs), where children face higher risks of malnutrition and developmental vulnerabilities. Methods: The study employed a targeted literature review and qualitative synthesis of key frameworks, including the Nurturing Care Framework and the Conceptual Framework for All Children Surviving and Thriving. It analyzed intervention outcomes focusing on physical, cognitive, and emotional developmental domains. Results: Findings reveal that integrated interventions combining nutrition and responsive caregiving lead to significantly better child development outcomes compared to nutrition-only programs. Children receiving integrated care showed improvements in physical growth, cognitive abilities, socioemotional well-being, and overall development. This underscores the importance of adopting holistic, multisectoral approaches that prioritize nurturing care and early learning alongside physical health. Novelty: This study highlights the critical gap in previous research, which often overlooked the role of nurturing care in cognitive and socioemotional growth. It emphasizes the need for comprehensive, context-specific strategies to scale up integrated child development interventions in LMICs, aiming to address resource constraints and enhance global child health policies.
Withdraw S. Mohammed, Samar
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 12 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i12.1050

Abstract

This article has been withdrawn by the author after publication. The withdrawal was requested due to a technical error identified by the author post-publication. We regret any inconvenience this may have caused and appreciate the author's integrity in addressing the issue
EPIGENETIC REGULATION OF ESTROGEN GENE EXPRESSION IN OVARY CANCER IN HUMAN Salih, Alyaa Abdulhadi
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 12 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i12.1051

Abstract

Objective: This study examines how epigenetic mechanisms control the expression of the estrogen receptor (ER) gene in ovarian cancer, concentrating on DNA methylation, histone modifications, and non-coding RNAs in Iraqi population samples. Method: Bisulfite sequencing was used to measure the DNA methylation levels of the ER gene in tissue samples from ovarian cancer patients and healthy controls, and chromatin immunoprecipitation (ChIP) tests were used to examine histone alterations. Using RNA sequencing, important non-coding RNAs affecting ER pathways were found. The epigenetic variations between malignant and healthy tissues were assessed using comparative analysis. Results: The results showed that the ER gene was significantly more methylated in cancer tissues (67%) than in healthy samples (21%), which resulted in decreased cellular estrogen responses and increased proliferation. Oncogenes were activated by elevated histone H3K9 acetylation levels (1.7 AU vs. 0.8 AU), but tumor suppressor genes were inhibited by elevated H3K27 methylation (2.1 AU). These modifications draw attention to important epigenetic modifications that aid in the development of ovarian cancer. Novelty: By identifying region-specific epigenetic markers in ovarian cancer, this work highlights the significance of population-targeted research in enhancing cancer outcomes and provides insights into tailored therapy approaches.
CONCEPTUAL FOUNDATIONS OF MARKETING ORGANIZATION AND LOGISTICS MANAGEMENT IN AGRIBUSINESS Bekmatovich, Djurayev Bekzod; Egamkulovich , Utapov Nematullo
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 12 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i12.1055

Abstract

Objective: This study aims to explore the impact of marketing and logistics systems on the efficiency of agricultural product production, storage, and sales, focusing on the challenges faced by agricultural producers in Uzbekistan. Methods: The research employs a systematic analysis of the agricultural supply chain, evaluating the role of marketing and logistics in managing the flow of goods, determining production volumes, and assessing market capacities. Data is gathered through literature review, case studies, and qualitative analysis of existing agricultural practices. Results: The findings highlight significant inefficiencies in the current agricultural logistics system, where the lack of proper marketing strategies and logistics infrastructure leads to high production and transportation costs, imbalances in consumer markets, and low competitiveness. The study identifies key areas where improvements in the marketing-logistics framework can reduce costs by 10-15%, enhance production planning, and better align supply with consumer demand. Novelty: This research introduces a comprehensive approach to integrating marketing and logistics systems in agricultural production, emphasizing the importance of strategic coordination between resource suppliers, producers, and market demands. It provides insights into developing a more efficient, market-responsive agricultural sector in Uzbekistan
BREAST CANCER SCREENING IN WOMEN AGED 45-65 IN SAMARKAND REGION, UZBEKISTAN: A CROSS-SECTIONAL ANALYSIS OF DATA FROM 2023 L.Sh., Yorov
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 12 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i12.1059

Abstract

Objective: Breast cancer remains a leading cause of cancer-related mortality among women globally. Early detection through screening significantly reduces both morbidity and mortality. This study aims to evaluate the outcomes of breast cancer screening programs conducted in the Samarkand region of Uzbekistan in 2023, with a focus on participation rates, detection rates, and stage distribution across 17 districts and cities. Methods: Data were collected for women aged 45–65, including annual screening targets, the number of screenings performed, diagnosed cases, and cancer stage distribution (early stages 1–2 vs. late stages 3–4). Statistical analysis was used to determine screening completion and detection rates, as well as to assess regional disparities in program outcomes. Results: The screening program yielded promising results in terms of participation and early-stage cancer detection. A higher proportion of breast cancer cases were identified at early stages (1–2), indicating effective diagnosis in several areas. However, notable regional disparities were observed in both screening completion and detection rates, reflecting unequal access to services across districts. Novelty: This study provides a comprehensive regional analysis of breast cancer screening outcomes in Uzbekistan. It highlights the urgent need to address disparities in healthcare access to ensure equitable early diagnosis and treatment. The findings emphasize the importance of targeted public health interventions aimed at improving screening program effectiveness and reducing the burden of late-stage breast cancer.

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