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Mochamad Nashrullah
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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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COVID-19–RELATED LUNG INJURY: A HISTOPATHOLOGICAL OVERVIEW Alkhirsan, Zainab M Jawad; Alyasiry, Esraa A.; Abdulhadi, Ali M Hussein
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1601

Abstract

Objective: To provide a comprehensive review of the key histopathological features associated with COVID-19–related lung injury and to clarify the extent of vascular and inflammatory involvement in the disease. Method: A literature review analyzing reported histopathological findings in COVID-19 lung specimens, comparing them with other viral infections such as H1N1 influenza, and correlating them with clinical and radiological data. Results: Findings consistently highlight diffuse alveolar damage (exudative and proliferative phases), type II pneumocyte hyperplasia, squamous metaplasia, intra-alveolar hemorrhage, microthrombosis, and occasional osseous metaplasia. Additional observations include inflammatory infiltrates, endothelial injury, and cytokine-related damage (e.g., IL-6 upregulation). COVID-19 shows more extensive alveolar and vascular involvement than many other viral infections, though findings vary across patients and comorbidities. Novelty: The review underscores that although several histopathological features overlap with other viral pneumonias, the severity of vascular injury and the complexity of the inflammatory response in COVID-19 distinguish it. It also stresses the diagnostic value of integrating histopathological, clinical, and radiological evidence to better understand disease pathogenesis.
REPURPOSING ORLISTAT AS A FATTY ACID SYNTHASE INHIBITOR IN BREAST CANCER: IN VITRO EFFICACY, MECHANISMS, AND SYNERGY WITH DOXORUBICIN Rasool, Abeer Mansour Abdel; Rashid, Ammar M. Sheet; Hassan , Emad Hussein Ahmad; Subhi, Abdulhameed
Journal of Medical Genetics and Clinical Biology Vol. 3 No. 1 (2026): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v3i1.1606

Abstract

Objective: This study investigates the therapeutic potential of repurposing Orlistat, a potent irreversible inhibitor of fatty acid synthase (FASN), to enhance cytotoxic efficacy against breast cancer cells, both independently and in combination with doxorubicin. Method: Estrogen receptor-positive MCF-7 and triple-negative MDA-MB-231 cells were treated with Orlistat and doxorubicin individually and jointly, followed by assessments of cell viability (MTT), FASN expression (qRT-PCR and Western blot), apoptosis (Annexin V-FITC/PI flow cytometry and cleaved caspase-3), and drug interactions using the Chou–Talalay combination index. Results: Orlistat monotherapy significantly reduced cell viability in a dose-dependent manner, induced G1 arrest and apoptosis, and suppressed FASN expression and lipid accumulation, confirming metabolic targeting. Doxorubicin alone produced expected cytotoxicity, whereas the Orlistat–doxorubicin combination yielded synergistic inhibition (CI < 1) with markedly enhanced apoptotic signaling. Novelty: This work demonstrates, for the first time, a robust synergistic interaction between Orlistat and doxorubicin through coordinated disruption of lipid metabolism and heightened apoptotic induction, highlighting Orlistat’s promise as a metabolic adjuvant to improve breast cancer chemotherapeutic responses.

Page 38 of 38 | Total Record : 372

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