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Journal of Medical Genetics and Clinical Biology (JMGCB)
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcB
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing
Journal of Medical Genetics and Clinical Biology is a peer-reviewed forum for advances at the intersection of human genetics and clinical medicine. The journal welcomes original research, reviews, brief reports, and case reports that translate genomic discoveries into clinical utility—spanning diagnostic workflows, risk stratification, therapeutic decision-making, and implementation in real-world care. Areas of interest include Mendelian and complex disorders, cancer genetics, pharmacogenomics, biomarkers, clinical genomics (panel testing, WES/WGS), bioinformatics and data integration, as well as ethical and counseling considerations. By bridging molecular insights and bedside applications, the journal aims to support precision health and improve outcomes across diverse patient populations.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 372 Documents
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FUNGAL CONTAMINATION IN FRESH RAISIN JUICE IN MOSUL CITY Krmo, May Akram; Al_Rejaboo, Maha Akram Mohammad Ali
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.887

Abstract

Background: Fungal contamination in food and beverages, including fruit juices, poses significant health risks. Specific Background: This study investigates the extent of fungal contamination in fresh raisin juice collected from Mosul City and its suburbs, including Bashiqa, Al-Hamdaniya, Bartella, Al-Shekhan, Aqra, and Dohuk, over a period from January 2023 to April 2024. Knowledge Gap: Despite the potential for fungal contamination in fruit juices, detailed analyses of specific contamination rates and fungal species in this region have been lacking. Aims: The study aimed to identify and quantify fungal contamination in fresh raisin juice samples using Potato Dextrose Agar and Sabouraud Sucrose Agar, and to characterize the fungal isolates morphologically, biochemically, and molecularly. Results: Of the 40 samples tested, 100% were contaminated with fungi, yielding 121 isolates of various species. The highest contamination rates were observed for Candida spp. and Aspergillus spp., each constituting 27.3% of isolates. Other notable contaminants included Wickerhamomyces anomalus (12.39%), Saccharomyces cerevisiae (11.57%), and Rhodotorula spp. (8.26%). Additionally, lower rates of contamination were found for Penicillium spp., Exophiala dermatitidis, and several other species. Novelty: The study revealed a high prevalence of fungal contamination, including the identification of a novel Candida oleophila strain (GenBank accession PP961930.1). Implications: These findings highlight the significant fungal contamination in fresh raisin juice, which could have implications for food safety and quality control. The identification of specific fungal species and the novel strain underscores the need for stringent monitoring and improved processing practices to mitigate contamination risks.
A COMPARATIVE STUDY OF THE QUALITATIVE CHANGES IN THE LEVELS OF IL-4 , IL-6 AND IL-10 AND THEIR RELATIONSHIP TO HEMATOLOGICAL PARAMETERS IN CHILDREN WITH E. VERMICULARIS INFECTION Abbas, Marwa Ismail; Abdulhasan, Rawaa Sahib; Farhan, Zainab Mohammed; A. mohsein, Osama
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.888

Abstract

Background; Enterobiasis (pinworm infection) caused by Enterobius vermicularis is a common parasitic infection prevalent worldwide especially in children. It causes many important symptoms and can lead to digestive problems and lead to malnutrition in children. Aims of the study; Knowing the relationship between levels of cytokine and the severity of infection in children and the extent of the impact of the infection on the child’s health in Iraq. Methodology; A Case-control study included 100 children suffering from infection with the worm E.vermicularis. The ages of the participants ranged from 3 to 10 years. The study included 50 healthy children matched in age and sex to the patient group. 5 ml of blood was collected from each participant at Al-Haboubi Teaching Hospital and at Nasiriyah General Hospital for the period between 3/1/2024 to 10/3/2024. CBC assay using a Sysmex device. Interleukins were examined using enzyme-linked immunosorbent assay. Result; The results showed that there was no statistical significance in age among the participants. While the results of WBC and CRP were significantly high in the patient group, in contrast to PCV and Hb which were significantly low. While interleukin 4 and interleukin 6 results showed a significant increase in the patient group, while interleukin 10 showed a significant decrease. Conclusions; High levels of biomarkers, indicate the immune response that causes by infection with the worm. Anemia due to the pathophysiology of inhibiting appetite and lack of absorption in Intestines for nutrients.
IMPACT OF COVID-19 ON CARDIOVASCULAR COMPLICATIONS IN TYPE 2 DIABETES D.K, Najmutdinova; A, Urunbayeva D.; G, Sadikova N; A, Pulotova S
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.889

Abstract

Background: The COVID-19 pandemic, instigated by the SARS-CoV-2 virus, has precipitated unprecedented global health and economic challenges since its identification in late 2019. Specific Background: To date, over 770 million confirmed COVID-19 cases and millions of deaths have been documented worldwide. Individuals with Type 2 Diabetes Mellitus (T2DM) are particularly vulnerable, exhibiting an elevated risk of severe illness and mortality due to exacerbated inflammatory responses and frequent comorbidities such as cardiovascular disease, hypertension, and obesity. Knowledge Gap: Despite the known risks, the precise molecular interactions between SARS-CoV-2 and host cells, and how these may be modified by diabetes and its comorbidities, remain inadequately understood. Aims: This study aims to elucidate the molecular mechanisms underpinning the interaction between SARS-CoV-2 and human cells, with a specific focus on how T2DM influences these interactions. Results: Preliminary findings indicate that the presence of T2DM amplifies the inflammatory response to SARS-CoV-2 infection, likely through altered receptor interactions and exacerbated immune responses. Novelty: This research provides new insights into the differential impact of SARS-CoV-2 on diabetic versus non-diabetic patients, highlighting the role of diabetes-induced alterations in viral pathogenesis. Implications: Understanding these mechanisms is crucial for developing targeted therapeutic and preventive strategies to mitigate the heightened risk faced by individuals with T2DM during pandemics, thereby informing public health policies and clinical practices.
STUDY OF ANTIBODIES TO OPPORTUNISTIC ENTEROBACTERIA IN THE BLOOD OF ADULTS Tursunboy qizi, Fozilova Sarvinoz; Alisher qizi, Ozodbekova Sitara; Abdukayumovich, Adilov Abdujabbor; Rustamovna, Bekchanova Mahfuza
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.890

Abstract

Background: Opportunistic enterobacteria (OE), including various Gram-negative bacteria, are known to cause infections, particularly in immunocompromised individuals. Specific Background: Despite their clinical relevance, there is limited data on the prevalence of antibodies against these bacteria in the general adult population. Knowledge Gap: The extent to which antibodies to opportunistic enterobacteria are present in serum samples from healthy adults has not been thoroughly investigated. Aims: This study aimed to evaluate the presence and frequency of antibodies to seven types of Gram-negative opportunistic enterobacteria in adult serum samples using enzyme-linked immunosorbent assay (ELISA). Results: The analysis revealed a significant prevalence of antibodies against the bacteria E. coli, Proteus vulgaris, Citrobacter freundii, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, and Pseudomonas aeruginosa among the subjects. Novelty: This research provides new insights into the widespread presence of antibodies to OE in a healthy adult population, highlighting previously underexplored immunological responses. Implications: These findings could enhance diagnostic approaches and inform treatment strategies for infections caused by opportunistic enterobacteria, potentially leading to improved management of such infections in clinical settings.
PRODUCTION, PURIFICATION AND DETERMINATION MOLECULAR WEIGHT OF COAGULASE ENZYME FROM STAPHYLOCOCCUS AUREUS ISOLATED FROM CLINICAL SAMPLES AL_ shimmery, Marwa Ali Athab; Authman, Sawsan Hassan; Abo Ksou, Mohammed Fadhil
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.891

Abstract

Background: Coagulase is a critical enzyme produced by pathogenic strains of Staphylococcus aureus, which plays a significant role in the classification of staphylococci into coagulase-positive (CoP) and coagulase-negative staphylococci (CoNS). This enzyme interacts with prothrombin to induce blood clotting, which is essential for understanding its pathogenic mechanisms. Knowledge Gap: Despite its importance, detailed methods for extracting, purifying, and characterizing coagulase from clinical S. aureus isolates remain underexplored, particularly in relation to optimizing purification conditions and accurately determining its molecular weight. Aims: This study aimed to extract and purify coagulase from Staphylococcus aureus isolated from clinical samples and to determine the enzyme's molecular weight using SDS-PAGE. Methods: A total of 2,000 clinical samples were collected from hospitals in Baghdad, yielding 130 isolates of S. aureus. The optimum conditions for coagulase production were identified as pH 7.5 and 37°C. Coagulase was extracted and purified through ammonium sulfate precipitation (50-80% saturation), SDS-PAGE, ion exchange chromatography with DEAE cellulose, and gel filtration using Sephadex G150. Results: The crude coagulase extract exhibited an activity of 1.7 U/ml. Following purification, the enzyme's specific activity was measured, and the molecular weight of the coagulase was determined to be 36 kilodaltons (kDa). Novelty and Implications: This study provides a detailed protocol for the extraction and purification of coagulase from clinical isolates of S. aureus, along with the molecular weight determination of the enzyme. The findings enhance the understanding of coagulase's biochemical properties and its role in staphylococcal pathogenicity, potentially contributing to improved diagnostic and therapeutic strategies.
EFFECT OF ACUTE IRRADIATION ON MORPHOLOGICAL FEATURES OF THE LUNGS Rakhmatovna , Akhmatova Gulrukh
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.901

Abstract

Background: Acute radiation exposure impacts human health variably depending on the frequency, duration, and radiation sensitivity of different organs. Specific Background: While immune organs, mucous membranes, exo- and endocrine glands, and gonads are known to be highly sensitive to acute radiation, less is understood about the specific effects on less sensitive organs such as the lungs. Knowledge Gap: Despite established knowledge on the sensitivity of various organs to radiation, there is limited research focusing on the morphological changes occurring in the lungs as a result of acute radiation exposure. Aims: This study aims to investigate the morphological alterations in lung tissue following acute radiation exposure to better understand its impact on this organ. Results: The study reveals distinct morphological changes in the lungs under acute radiation conditions, including alterations in cellular structure and tissue integrity. These findings highlight the specific effects of radiation on lung tissue compared to other less sensitive organs. Novelty: This research provides new insights into the impact of acute radiation on lung morphology, contributing to a more comprehensive understanding of radiation effects beyond the commonly studied highly sensitive organs. Implications: Understanding the morphological changes in the lungs due to acute radiation exposure is crucial for improving radiation protection strategies and treatment protocols for individuals exposed to high levels of ionizing radiation.
IMPROVING QUALITY OF LIFE FOR WOMEN WITH GENETIC-RELATED INFERTILITY Salman, Dr. Alaa Abdulateef Mohammed; Khalaf, Dr. Alaa Kamel; Shareef, Dr. Rihab Majeed
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.902

Abstract

Background: Infertility treatments significantly impact the quality of life for women, with poor psychological well-being often leading to higher rates of treatment discontinuation. Specific Background: In vitro fertilization (IVF) is a common intervention for genetically infertile women, yet its effects on quality of life remain underexplored, particularly using comprehensive tools like the Fertility Quality of Life Questionnaire (FERTIQOL). Knowledge Gap: Previous studies have not thoroughly assessed the impact of IVF on quality of life using FERTIQOL among genetically infertile women in specific geographic locations, such as Iraq. Aims: This study aims to evaluate the FERTIQOL among genetically infertile women undergoing IVF to determine its impact on their quality of life. Results: A total of 75 genetically infertile women, aged 20-45 years, were recruited from Baghdad hospitals between April 6, 2023, and October 10, 2024. The study found a 64% prevalence of primary infertility and a 36% prevalence of secondary infertility. Post-IVF complications occurred in 25.33% of cases, and pregnancy loss was reported in 32% of patients. Hormonal levels were recorded as follows: FSH 6.58 ± 0.05 IU/L, LH 6.52 ± 0.61 IU/L, estradiol 161.92 ± 6.18 pmol/L, and progesterone 0.89 ± 0.48 nmol/L. The FERTIQOL scores revealed a mean tolerability score of 76.55 ± 13.20, a treatment FertiQoL score of 67.91 ± 10.83, a relational score of 60.02 ± 8.74, and a Mind/Body score of 68.78 ± 16.59. Novelty: This study is among the first to assess the impact of IVF on quality of life in genetically infertile women using FERTIQOL in an Iraqi setting. Implications: The findings highlight the significant role of IVF in managing genetic infertility and its profound impact on patients' quality of life, underscoring the need for comprehensive support systems during treatment.
PRENATAL INVESTIGATION AND MANAGEMENT OF NON-IMMUNE HYDROPS FETALIS A, Pulatova G; B, Yusupbaev R
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.903

Abstract

Background: Advances in medicine have significantly improved our ability to address various diseases affecting the unborn child, with fetal medicine emerging as a rapidly evolving field. Specific Background: Nonimmune hydrops fetalis, a severe antenatal pathology requiring advanced minimally invasive treatment techniques, exemplifies the critical challenges and progress in fetal medicine. Knowledge Gap: Despite advancements, there remains a need for a comprehensive review of nonimmune hydrops fetalis, encompassing its etiology, clinical presentation, and management, particularly with regard to recent data from specialized fetal medicine departments. Aims: This article aims to review the multifaceted aspects of nonimmune hydrops fetalis, including its causes, diagnostic approaches, and treatment options, while providing insights from recent cases managed within a fetal medicine department. Results: The review covers the etiology of nonimmune hydrops fetalis, which can be attributed to a range of genetic, cardiac, and infectious factors. It discusses the clinical presentation and highlights advancements in antenatal diagnosis and management. Additionally, the article presents case studies from the fetal medicine department, illustrating contemporary approaches and outcomes. Novelty: This review provides an updated synthesis of nonimmune hydrops fetalis management and diagnosis, integrating recent case studies and technological advancements. Implications: The findings underscore the importance of continued research and innovation in fetal medicine to enhance the diagnosis and management of nonimmune hydrops fetalis, ultimately improving outcomes for affected pregnancies.
SKIN THERAPY USING COLD ATMOSPHERIC PLASMA Jassim, Muntadher Ghanem; Hussein Ali Mujbil; Azhar Awad Jabr; Munif; Mutab Jarad; Karar Khazal Jarad; Hassan Ali Naeem; Ismail Nouri
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 8 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i8.904

Abstract

Background: Maintaining skin integrity is essential for protecting against external agents, microorganisms, and dehydration, while also serving social and aesthetic functions. Recent advancements in skin care have introduced innovative technologies, including Cold Atmospheric Plasma (CAP), which shows promising results in dermatology. Specific Background: CAP technology, based on physical principles, has emerged as a novel approach in skin treatments, offering potential benefits for aging prevention and skin care. This interdisciplinary field encompasses physics, biology, chemistry, and biochemistry, presenting a complex landscape. Knowledge Gap: Despite its potential, there is limited comprehensive analysis of CAP's interactions with skin, its effects, and its practical applications in cosmetic dermatology. Aims: This research aims to provide a broad survey of CAP's interactions with skin by discussing the basic structure and functions of the skin, the foundational principles of CAP, and its physical and chemical properties. The study will analyze CAP parameters to highlight known effects and explore potential applications in skin treatment. Results: The review reveals that CAP exhibits versatile applications in dermatology, including direct treatment of superficial lesions, indirect treatment via plasma-activated media, and combined use with other therapies. CAP has shown promise in optimizing intact skin, facilitating transdermal drug delivery, and minimizing side effects. However, challenges remain in integrating CAP into routine clinical practice. Novelty: This overview synthesizes current knowledge and emerging potential of CAP technology in skin biology, offering a comprehensive evaluation of its effects and applications. Implications: The findings underscore CAP's potential to revolutionize skin care and dermatological treatments. Addressing the existing challenges and expanding research could enable CAP to become a valuable tool in both therapeutic and cosmetic dermatology.
DIABETES MELLITUS AND COVID-19. CARDIOVASCULAR COMPLICATIONS AND COURSE OF TYPE 2 DIABETES MELLITUS AFTER CORONAVIRUS INFECTION D.K, Najmutdinova; D.A , Urunbayeva; N.G, Sadikova; S.A, Pulotova
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 9 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT. Antis International Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i9.906

Abstract

The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has had profound effects on global health and economics since its emergence in late 2019. Over 770 million confirmed cases of COVID-19 have been reported worldwide, with millions of deaths attributed to the virus. Studies have shown that individuals with T2DM are at a higher risk of severe illness and mortality if they contract COVID-19. The presence of diabetes, especially when poorly controlled, can exacerbate the inflammatory response to the virus. Patients with T2DM often have comorbidities such as cardiovascular disease, hypertension, and obesity, which further increase the risk of severe COVID-19 complications

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