Indonesian Journal of Engineering and Technological Innovation
Indonesian Journal of Engineering and Technological Innovation (IJETI) is a peer-reviewed, open-access scientific journal that publishes original research articles, review papers, and short communications in the field of engineering and technology. The journal aims to serve as a platform for academics, researchers, practitioners, and industry professionals to share innovative ideas, findings, and developments in various branches of engineering and applied technology. The journal is published quarterly (March, June, September, and December) by Lembaga Penelitian Cendekia Gagayunan Indonesia. IJETI welcomes manuscript submissions in English from authors worldwide. All submitted manuscripts undergo a double-blind peer review process to ensure academic quality, originality, and relevance. IJETI covers a broad spectrum of topics including but not limited to: Mechanical, Civil, Electrical, and Industrial Engineering, Information Technology and Computer Engineering, Renewable Energy and Environmental Engineering, Robotics, Automation, and Artificial Intelligence, Materials Science and Technological Innovations, Aerospace Engineering, Biomedical Engineering, Drilling Engineering, Electrical Engineering, Food Engineering, Geological Engineering, Hydraulic Engineering, Industrial Engineering, Jet Propulsion Engineering, Knowledge Engineering, Logistics Engineering, Mechanical Engineering, Nuclear Engineering, Ocean Engineering, Petroleum Engineering, Pharmaceutical Engineering, Health Engineering, Quality Engineering, Software Engineering, Robotics Engineering, Telecommunication Engineering, Urban Engineering, Water Resources Engineering, Vehicle Engineering.
Articles
16 Documents
<![CDATA[CRISPR/Cas9 Gene Therapy Innovation: Targeting HPV16 Oncogene Gene for Cervical Cancer Prevention ]]>
<![CDATA[Muhammad Rafi Pratama Shidiq]]>;
<![CDATA[Aghniya Nur Rizka Fadila]]>;
<![CDATA[Alifah Mustari]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 1 (2025): March: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i1.239
<![CDATA[Human Papillomavirus (HPV) is a causative agent of cervical cancer. Approximately 60% of cervical cancers are caused by the infection of HPV-16. Cervical cancer is the second most common cancer affecting women. Various treatments and therapies are being explored to treat cervical cancer, but there is still a need for safer, more effective, and affordable technologies. CRISPR-Cas9 is a modern biotechnology technology derived from bacterial immune mechanisms to combat viruses and phages. This mechanism can be applied as a therapeutic medium, as it allows for specific and precise genome editing. The aim of this literature review is to determine the potential and effectiveness of CRISPR-Cas9 as a therapeutic agent for cervical cancer. The method used involves a literature study, based on searches on official websites such as Pubmed, Google Scholar, and other official journals with the keywords “CRISPR-Cas9” and “Cervical Cancer.” The results indicate that CRISPR can target the Cas9 protein to deactivate the oncogenes E6 and E7 in HPV-16, thereby promoting cell cycle arrest and apoptosis. Various studies have been developed to improve the side effects associated with CRISPR-Cas9. However, research on CRISPR-Cas9 has shown a reduction in cancer tissue and increased apoptosis. This method is effective for cancer treatment and needs further investigation to reduce the incidence of cervical cancer.]]>
<![CDATA[mRNA Vaccines in the COVID-19 Pandemic: Production, Antibody Formation Mechanism and Advantages of mRNA Vaccines ]]>
<![CDATA[Marsya Naranissa Puteri Santoso]]>;
<![CDATA[Hasna Labib Lathiefah]]>;
<![CDATA[Fadly Hidayaturochman]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 1 (2025): March: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i1.240
<![CDATA[Vaccines are antigens that are inactivated or attenuated to produce biological products that can stimulate the immune system. The mRNA vaccine is a new type of vaccine in an effort to deal with the coronavirus disease outbreak. An mRNA vaccine is a vaccine that carries the genetic information of a pathogen that is copied in mRNA This literature review uses an online-based literature study, the library sources selected for use are based on relevance to the topic. The stages of vaccine production include sequence cloning, purification, addition of cap structures, in the delivery of mRNA vaccines formulated in the form of lipid nanoparticles. mRNA vaccines are injected intramuscularly which will then trigger immune cells so that adaptive immune cells are formed. mRNA vaccines can be designed to synthesize quickly, mRNA vaccines do not interfere with cellular function or integrate into the host genome.]]>
<![CDATA[Characteristics of Giant Viruses: Achantamoeba polyphaga Mimivirus, Pandoravirus and Tupanvirus: A Review of the Literature ]]>
<![CDATA[Maya Amini Sukma]]>;
<![CDATA[Tsabitna Amalia Ihsania]]>;
<![CDATA[Cahya Arsya Luthfi]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 1 (2025): March: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i1.241
<![CDATA['Giant viruses' are viruses that have a genome of >200,000 bp and have been shown to infect eukaryotic organisms such as algae and protists. Giant viruses viruses have unique characteristics in addition to being very large in size, these viruses have a complex genome structure so that they are able to reproduce independently in the host cell. independently in the host cell. Some of these viruses are Achantamoeba polyphaga Mimivirus, Pandoravirus and Tupanvirus. This review aims to summarize the research that has been done on the giant viruses that have been have been discovered. Methods used in writing this article were analyzed through searches on scientific databases such as PubMed, ScienceDirect and Google Scholar.]]>
<![CDATA[Curcumin's Potential as a Therapeutic Agent for Hpv-Induced Cancer ]]>
<![CDATA[Triani Nur Fitri]]>;
<![CDATA[Adilla Syahsiyatun Najah]]>;
<![CDATA[Syifa Salsabila Mulyani]]>;
<![CDATA[Wulan Pertiwi]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 1 (2025): March: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i1.242
<![CDATA[Curcumin, the main active compound of turmeric (Curcuma longa), shows potential as a therapeutic agent for Human Papillomavirus (HPV)-induced cancer. This study examines the mechanism of action of curcumin in inhibiting the proliferation of HPV-infected cervical cancer cells, including its anti-inflammatory, anti-cancer, and anti-viral properties reviewed from several references. Curcumin works by suppressing the expression of E6 and E7 oncoproteins, induction of apoptosis, and modulation of signaling pathways that support tumor growth, such as NF-κB. Although curcumin has great potential, the challenges of low bioavailability and rapid metabolism in the body still need to be overcome. Further research is needed to optimize the formulation and delivery method of curcumin as a cancer therapy.]]>
<![CDATA[A Comprehensive Review of Hepatitis A, B, and C Vaccine Comparisons ]]>
<![CDATA[Yahya Ayasy AlMuhandis]]>;
<![CDATA[Nadila Suci Nugraha]]>;
<![CDATA[Rosis Ainin Faqihah]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 1 (2025): March: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i1.243
<![CDATA[Hepatitis is a disease that causes inflammation of the liver due to viral infection or non-infectious factors, such as drug use and metabolic disorders. This disease is divided into hepatitis A, B, and C with hepatitis B and C potentially developing into cirrhosis and liver cancer. This study aims to compare hepatitis A, B, and C vaccines based on virus characteristics, production methods, target recipients, administration methods, mechanisms of action, and effectiveness. The method used is a literature review from scientific databases such as PubMed and Google Scholar. The results show that hepatitis A and B vaccines are widely available with an effectiveness of more than 90%, while hepatitis C does not yet have a vaccine, so its treatment relies on Direct-Acting Antivirals (DAAs) therapy with a success rate of more than 95%. Although the hepatitis B vaccine is effective, challenges remain in global vaccination coverage, especially in developing countries. Public awareness and access to more affordable therapy are important factors in efforts to prevent and control hepatitis.]]>
<![CDATA[Efforts to Improve the Quality of Shrimp Pasted Products through the Implementation of the Plan-Do-Check-Act Cycle and the Root Cause Analysis Method at UD Nurhayati ]]>
<![CDATA[Nando, Fiky Two]]>;
<![CDATA[Avnanta Puteri, Agatha Hannabel]]>;
<![CDATA[Qinthara, Bahij Naufal]]>;
<![CDATA[Fernandy, Dimas Rizah]]>;
<![CDATA[Kurniawan, Aditya Fahrizal]]>;
<![CDATA[Alfani, Achmad Hafis]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 2 (2025): June: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i2.377
<![CDATA[Micro, Small, and Medium Enterprises (MSMEs) play a vital role in the economy. However, MSMEs often face challenges in maintaining product quality due to limited machinery and suboptimal production process control, leading to losses. One example is the production of shrimp paste at UD Nurhayati, with a capacity of approximately 3 dozen cups per month. Defective products were found due to poorly controlled processing. These defects included uneven shrimp paste texture and high humidity levels that could potentially lead to mold growth. This study aimed to identify the root cause of problems in the production line using the Root Cause Analysis (RCA) method, followed by improvements through the implementation of the Plan, Do, Check, and Action (PDCA) cycle to assist UD Nurhayati in addressing defective products. Based on the results of the application of these methods, this study produced several outcomes, namely a significant reduction in the number of defective products and an increase in production capacity of 33.3% and 14.95%, respectively, compared to the condition before the improvements were made. This study indicates that the application of the PDCA and RCA methods can improve the quality and effectiveness of the production process. These results imply that UD Nurhayati needs to standardize work procedures and provide ongoing training for employees to maintain consistent product quality.]]>
<![CDATA[Optimizing the Production of Micro, Small, and Medium Enterprises Using the Heijunka Method and Single Minute Exchange of Dies ]]>
<![CDATA[Nando, Fiky Two]]>;
<![CDATA[Liwaq, Moch Isabil]]>;
<![CDATA[Rizki, Muhamad Farhan]]>;
<![CDATA[Pambudi, Vava Surya]]>;
<![CDATA[Friski, Auviano Bidana]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 2 (2025): June: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i2.378
<![CDATA[Micro, Small, and Medium Enterprises (MSMEs) producing bags often face production challenges such as long setup times, unbalanced workloads, and excessive inventory, which reduce efficiency and productivity. This study aims to optimize the production process by applying the Heijunka and Single Minute Exchange of Dies (SMED) methods as part of the Lean Manufacturing approach. The analysis was conducted quantitatively based on actual production data of three types of bags over 27 working days with 13 workers and 8 working hours per day. The results show that the Heijunka method successfully leveled production variation into a daily combination of 30 units of Bag A, 33 units of Bag B, and 14 units of Bag C, resulting in a more stable workflow and reduced overproduction. The application of SMED reduced setup time from 1,560 minutes to 327.6 minutes per month, achieving 79% efficiency improvement, and decreased utilization from 105.36% to 102.6%. These findings indicate that the combination of Heijunka and SMED is effective in improving efficiency, flexibility, and production stability in bag SMEs without requiring significant investment, while enabling the company to meet customer demand on time.]]>
<![CDATA[Analysis of the Application of Just in Time and Total Productive Maintenance on Production Efficiency at CV XYZ ]]>
<![CDATA[Nando, Fiky Two]]>;
<![CDATA[Bintang Pamungkas, Mohammad Rafly Rafsyanjani]]>;
<![CDATA[Kusuma, Febiola Alyza]]>;
<![CDATA[Ramadan, Prananda Aditia]]>;
<![CDATA[Sautra, Tri Wahyu]]>;
<![CDATA[Saputra, Mohamad Risfi]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 2 (2025): June: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i2.380
<![CDATA[This study aims to evaluate the implementation of the Just-In-Time (JIT) and Total Productive Maintenance (TPM) methods as an effort to improve production process efficiency at CV XYZ, a metal manufacturing company located in East Java. The research approach was conducted through a case study utilizing primary data, including raw material requirements, ordering and storage costs, machine downtime duration, and product defect percentage. The analysis involved calculating the Economic Order Quantity (EOQ) and Reorder Point (ROP) to determine an optimal raw material procurement strategy, as well as measuring Overall Equipment Effectiveness (OEE) to assess machine performance before and after TPM implementation. Based on the analysis results, the application of JIT produced an EOQ value of 200 tons per order and an ROP value of 280 tons, which led to a reduction in total inventory costs from IDR 135,000,000 to IDR 108,000,000 per year, representing an efficiency improvement of approximately 20%. Meanwhile, TPM implementation increased the average OEE value from 78% to over 85%, accompanied by a decrease in machine downtime and product defect rates. The integration of JIT and TPM proved effective in creating a more consistent production system, reducing the need for safety stock, and improving process reliability and cost efficiency. Overall, the combined implementation of these two methods contributes significantly to enhancing operational efficiency and product quality, making it a potential model for other manufacturing companies in sustainable inventory management and machine maintenance practices.]]>
<![CDATA[Analysis of Production Process Improvement on Automatic Bolt Forming Machine Using Value Stream Mapping and FMEA Approach ]]>
<![CDATA[Nando, Fiky Two]]>;
<![CDATA[Ivander, Davin Danny]]>;
<![CDATA[Sharren, Desti Sagita]]>;
<![CDATA[Yudhistira, Christoforus]]>;
<![CDATA[Remadaniel, Hilbram]]>;
<![CDATA[As Shidiq, Mashudan]]>;
<![CDATA[Sari, A.Anditha]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 2 (2025): June: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i2.381
<![CDATA[This study aims to analyze the production efficiency of an automatic bolt forming machine at PT XYZ using the Value Stream Mapping (VSM) and Failure Mode and Effect Analysis (FMEA) approaches. The Lean Manufacturing concept was applied to identify non-value-added activities and potential failures affecting production quality. Data were collected through direct observation, cycle time measurement, and interviews with operators and supervisors over a three-month period. The VSM results indicate that the total process time of 20,304 seconds consists of 75.64% value-added activities, 11.97% non-value-added activities, and 12.40% necessary but non-value-added activities. These findings show that efficiency improvements are still possible by minimizing non-value-adding processes. The FMEA analysis revealed the highest Risk Priority Number (RPN) of 147, occurring in the forming stage with failures such as improper heading, inaccurate trimming, and die damage. The study concludes that combining VSM and FMEA provides an effective framework for assessing process performance and determining improvement priorities to enhance efficiency and reduce product defects]]>
<![CDATA[Implementation of Kanban and Poka-Yoke to Improve Production Efficiency at CV. XYZ ]]>
<![CDATA[Nando, Fiky Two]]>;
<![CDATA[Priyangga, Dharu Zastia]]>;
<![CDATA[Ramadhani, Akbar]]>;
<![CDATA[Afnan Fairuz, Ferdian Nizar]]>;
<![CDATA[Armalia, Aqillah]]>;
<![CDATA[Putri, Katerina Najwa]]>
<![CDATA[ Indonesian Journal of Engineering and Technological Innovation Vol. 1 No. 2 (2025): June: Indonesian Journal of Engineering and Technological Innovation ]]>
Publisher : <![CDATA[Yayasan Cendekia Gagayunan Indonesia ]]>
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DOI: 10.63142/ijeti.v1i2.382
<![CDATA[XYZ is a household plastic components manufacturer facing elevated defect rates (4–5% daily), accumulation of work-in-process (WIP) in the cooling area, and recurring labeling errors during packaging. This study evaluates the combined application of Kanban as a pull-based material flow control and Poka-Yoke as simple error-proofing devices to improve production efficiency and product quality. A quantitative descriptive approach was employed, using direct observation, time-and-motion measurements, interviews with operators and supervisors, and before–after comparisons of key performance indicators. Kanban sizing was calculated using D = 125 units/hour, L = 4 hours, S = 0.1, and container capacity C = 50 units, yielding an optimal 11 Kanban cards. Poka-Yoke implementations included automatic temperature alarms on molding machines, fixture sensors at finishing stations, and barcode-based label verification at packaging. After implementation, WIP decreased from 280 to 150 units (−46%); inter-process waiting time reduced from 45 to 20 minutes (−56%); daily output increased from 800 to 950 units (+18.7%); defect rate declined from approximately 5% to 1.8%; and labeling errors were eliminated. The results indicate that integrating Kanban and Poka-Yoke can effectively streamline production flow, reduce waste, and enhance productivity in small-to-medium plastic manufacturing operations. Implications, limitations, and recommendations for broader application are discussed.]]>
