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INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol 20, No 3 (2004)" : 8 Documents clear
OUTCOME SINDROM NEFROTIK PADA ANAK – PENELITIAN PROSPEKTIF STUDI COHORT Subandiyah, Krisni
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.193 KB) | DOI: 10.21776/ub.jkb.2004.020.03.6

Abstract

Nephrotic syndrome (NS) in children is a common recurrent disease. Most of the cases are due to minimal change disease with a favorable outcome. The mayority of children have minimal change disease and 90 – 95% will respond to steroid therapy. Response to steroid therapy carries a greater prognostic weightthan the histologic features. The aim of the studywas to describe the outcome of Nephrotic Syndrome in children and to determine risk factors for these complications. Children with NSwere admitted to Pediatric Department Saiful Anwar Hospital Malang, January 2000 - December 2003 evaluated prospectively for one year. Data was sought on steroid responsiveness, remission, relapse rates, infection, and trombosis. Patients were classified into five categories. Including: relapse, infrequent relapsing (IFRNS), frequent relapsing (FRNS), steroid dependent (SDNS) and steroidresistant (SRNS). Baseline age, gender, clinical manifestation and laboratory finding were used to predict category of the disease. Definition of NS, remission and relapse were based on the ISKDC guidelines. Of 91 children with NS, 75 (82,4%) children had steroid sensitive nephrotic syndrome (SSNS) while 16 (17,6%) children were classified SRNS. In the SSNS group 42 (56%) of children were over 6 years of age and there were 51 (68%) males and 24 (32%) females.
TRANSFEKSI DNA KE DALAM MITOKONDRIA SEL BETA PANKREAS TIKUS DAN SEL PRIMER MYOBLAST MANUSIA: LANGKAH MENUJU REKAYASA DNA MITOKONDRIA DAN TERAPI GEN Lyrawati, Diana
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (367.104 KB) | DOI: 10.21776/ub.jkb.2004.020.03.1

Abstract

The delivery of an exogenous or modified DNA into the mitochondria of mammalian cells has been proposed as an alternative way to prevent or modify mitochondrial genetic defect. In  this study, a lipofection method was developed to transfer exogenous DNA into mitochondria of BRIN BD11 cells, a rat beta pancreas cell line, and human myoblast primary cells. An artificial mini-mitochondrial genome carrying a reporter gene encodes for a mitochondrial green fluorescent protein (mtGFP) was usedto track the fate of the exogenous DNA following its transfection into cellular mitochondria. Epifluorescence microscopic observation was carried out to detect the green fluorescence resulted from the GFPexpression. Immunohistochemical assays were also performed to validate and confirm the GFP expression. Collectively, the results indicate that the exogenous DNA pmtGFP could be  delivered into the mitochondrial compartment and was functional withinthe mitochondria of BRIN BD11 and human myoblast cells. Such achievement is a significant progress as both the artificial DNA construct and the mitochondrial transfection method could serve as a model to study the dynamic of mutant mtDNA as well as to provide a basis for the development of gene therapy for human mitochondrial diseases. Key words: DQAsome, pmtGFP, beta pancreas cell line, human myoblast primary cells
KEDOKTERAN EMERGENSI TANTANGAN, HARAPAN, DAN MASA DEPAN Dradjat, Respati Suryanto
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (77.117 KB) | DOI: 10.21776/ub.jkb.2004.020.03.7

Abstract

The progress of science and technology in globalization era, forcing us to make-up the quality of education and services in the fild of Emergency Medicine (EM). As one of the teaching hospital in Indonesia, Saiful Anwar Hospital – Brawijaya University have developed this education programe. Various challenge, and opportunity have and will be faced to reach the futureof Indonesian Medical services to be able to compete in the era of global standardKey words:emergency, education, services
PENGARUH EKSTRAK BIJI NIMBA (Azadirachta indica) TERHADAP PENURUNAN DERAJAT PARASIT DAN JUMLAH HEMOZOINPADA KULTUR Plasmodium falciparum Aini, Noer; Soebaktiningsih, Soebaktiningsih; Fitri, Loeki Enggar; Kalsum, Umi; Sumarno, Sumarno
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.584 KB) | DOI: 10.21776/ub.jkb.2004.020.03.2

Abstract

Malaria infection is still one of world health’s problems that cause a high death rate (20.9% - 50%). One of the reason is Plasmodium falciparum resist to conventional anti-malarial drugs. Neem seeds extract had been reported has antimalarial effect by decreasing parasitemia, but there has not been any report on its effect in inhibition hemazoin formation. The aimof this research was to find the effect of Neem seeds extract on parasitemia and hemazoin level in Plasmodium falciparum culture. Laboratory experiment was done by using Papua isolate of Plasmodium falciparum (2300) from NAMRU 2 Jakarta. After synchronized, malarial culture was divided into 4 groups namely Control group (culture medium only), Chloroquine group, Artemisinin group, and Neem seeds extracts group. Each treatment group was devided into 5 drug doses of 6.25 µ/ml, 12.5 µ/ml, 25 µ/ml, 50 µ/ml and 100 µ/ml respectively. Parasitemia was measured by Pyridine-hemochrome methods using spectrophotometer  λ560 nm. Statistical analysis was done involving one-way-ANOVA followed by Tukey HSD and Pearson’s Correlation. A significant difference was found between control and treatment groups in parasitemia and hemozoin level. Different dose in treatment groups didn’t show any significant difference in both parasitemia (p=0.99) and hemozoin level (p=0.985). Tukey test between treatment groups didn’t show a significant difference decrease of hemazoin level and parasitemia (r=0.970). The conclusion was Neem deeds extract can inhibit P. falciparum growth by decreasing parasitemia and hemazoin level. Key words: Neem seeds extract, parasitemia, hemazoin level, P. falciparum
PENGARUH PEMBERIAN KAPSUL EKSTRAK GARLIK TERHADAP PERUBAHAN TEKANAN DARAH DAN JUMLAH TROMBOSIT PADA PENDERITA PREEKLAMPSI RINGAN Irwanto, Yahya; Wahyudi, Imam; Soewarto, Soetomo
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.327 KB) | DOI: 10.21776/ub.jkb.2004.020.03.8

Abstract

The objectives is to investigate the efectivity of  extract garlic capsule compared to standart therapytoward the changes of blood presure and thrombocyt level in the mild-preeclampsy patients. This study was a single-blind randomised clinical trial. The subject of study were the mild-preeclampsy pregnant women within 20 – 36 weeks of gestational age whose came to the Poli Hamil RSUD dr. Saiful Anwar. The subject divided into 2 groups, the treatment group received both of the standart therapy of mild-preeclampsy and extract garlic capsule, while the controlling grouponly received the standart therapy of mild-preeclampsy. After 2 weeks, the blood pressure and the trombocyt count was evaluated. Thesystolic blood pressure of the treatment group wasdecrease at average of 10.12 mmHg, from 140.25 ± 5.57 before treatment to 130.12 ± 10.84 mmHg after treatment, while in thecontrololling group there was an increase at average of 5.56 mmHg from 140.44± 6.14 mmHg to 146±13.81 mmHg. The T Test and ANCOVA analyzing showed a significant result (P value were 0.001 and0.0008).
EFEK EKSTRAK BUNGA KENANGA (Canangium odoratum) SEBAGAI AGONIS PADA RESEPTOR ADRENERGIK-β ββ βDI PARU TERPISAH MARMUT (Cavia porcellus) Charisti, Pherenice; Loekito, Retno M; Karyono, Setyawati S
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (158.237 KB) | DOI: 10.21776/ub.jkb.2004.020.03.3

Abstract

The cananga flower (Canangium odoratum) is one of the herbal medicine used for asthma bronchiale. Cananga extract have been proved to relax the isolated guinea pig’s tracheal  and bronchus smooth muscle. The relaxation of the tracheal smooth muscle could be inhibited by propanolol 10-9M, however propanolol 10-9M could not inhibit the relaxation of the bronchialsmooth muscle. Therefore the objective of this study is to investigate the effect of cananga extract on relaxation of isolated  guinea pig’s lung strip through  β-adrenergic receptor. Three different dose of propranolol was used as  β-adrenergic receptor antagonist. This study was an experimental research using guinea pig’s isolated lung strip. The control group was given histamine and cananga extract. The first group of treatment was administrated histamine, propanolol 10-9M and cananga extract. The second group of treatment was given histamine, propanolol 10-8M and cananga extract. The third group of treatmentwas given histamine, propanolol 10-7M and cananga extract. The results of this study showed that cananga extract caused relaxation of lung strip and there was a reduction in the relaxation of lung strip after administration of propanolol. The reduction in relaxation lung strip caused by propranolol inhibition was found to be significant using regression testing. In conclusion, cananga extract works as a partial agonist to β-adrenergic receptors in bronchial smooth muscle of guinea pigs since the dosage response curve showed shift to the right but it was not paralel. Keyword :cananga extract, relaxation of lung strip, β-adrenergic receptor.
LUAS DEFEK MENINGOKEL BERHUBUNGAN DENGAN KADAR TRANSFORMING GROWTH FACTOR β1 (TGF-β1)DAN INSULINE-LIKE GROWTH FACTOR-1 (IGF-1) DALAM TULANG E.S., Moch. Istiadjid
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.775 KB) | DOI: 10.21776/ub.jkb.2004.020.03.4

Abstract

Meningocele pathogenesis is based on skull defect that occurs since the first three month of fertilization period. Through that defect, mening, cerebrospinal liquid, and cerebral parenchym is protruded. Meningocele can cause by folic aciddeficiency that had proved correlation with TGF-β1 and IGF-I level, both in maternal blood or baby rat’s skull. Folic acid deficiency also causes increasing the number of apoptosis and necrosis cells death in baby’s skull. TGF-β1 and IGF-I one growth factors thatstimulate bone synthesis. The purpose of this study is to explore the correlationbetween TGF-β1 and IGF-I level in skull on side defect of meningocele patients and the wide of skull defect to obtain the role of the  two growth factors in meningocele teratogenesis perspectively. Eight meningocele patients that were performed excision by standard procedure have taken a few of bone speciment on sidedefect to count TGF-β1 and IGF-I levels with immunochemistry technic. Wide defect was determined by measuring defect’s diameter, using Martin anthropometer. The correlation between TGF-β1 and IGF-I skull level and defect’s wide was analyzed by SEM (structuralequation modeling) statistic. There was significant negative-correlation between that variable, that mean the lower of the two growth factors level is wider of skull defect. TGF-β1: r = -0.648, p =0.009; IGF-I: r = -0.426, p =0.025. Key words:Meningoencephalocele, Skull defect, TGF-β1, IGF-I.
HUBUNGAN ANTARA DERAJAT OBSTRUKSI SALURAN NAFAS SERANGAN AKUT ASMA DENGAN JUMLAH SEL-SEL INFLAMASI DARAH TEPI Kusuma, HMS. Chandra; Kalim, Kusworini Handono; Muid, Masdar
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.483 KB) | DOI: 10.21776/ub.jkb.2004.020.03.5

Abstract

There now exists compelling evidence of a role for  cell-mediated immunity in the pathogenesis of asthma, but little information is available as to what extent this process participates in the disease severity. The hypothesized of this reseach that the severity of acute asthma exacerbation in children is associatedwith the activation of T-lymphocytes whose products regulate, at least in part, the mobilization and recruitment of eosinophyls and thereby disease severity. The aims of this research, therefore, were to compare the peripheral blood T-lymphocytes from acute asthmaticand no asthmatic normal control children matched for age and sex, and to attempt to correlate the percentages of T-lymphocytes in the asthmatic with the numbers of peripheral  blood eosinophyls and with disease severity. Fifty one children with acute asthma exacerbation were compared with thirty one no asthmatic, normal children matched for age and sex. Peripheral blood CD4+ and  CD8+ T-lymphocytes was measured using immuno histochemical staining. Peripheral blood eosinophils were measured using anautomated laser cytometer. Asthma exacerbation severity was assessed by a symptom score and spirometri. The absolute numbers  of eosinophils and CD4+ T-lymphocytes of the asthmatic were elevated as compared to the non-asthmatic normal control, whereas the numbers of CD8+ T-lymphocyte decreased significantly.

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