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Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
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Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 7 Documents
 1 
Search results for , issue "Vol 21, No 3 (2005)" : 7 Documents clear
PERBEDAAN POLA RESISTENSI Staphylococcus koagulase negatifISOLAT DARAH TERHADAP ANTIBIOTIKA DI RSU Dr SAIFUL ANWAR MALANG TAHUN 2000-2001 DENGAN 2004-2005 Dzen, Sjoekoer M.; Santoso, Sanarto; Roekistiningsih, Roekistiningsih; Santosaningsih, Dewi
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.523 KB) | DOI: 10.21776/ub.jkb.2005.021.03.4

Abstract

Coagulase negative staphylococci (CoNS) are the common bacterias causing hospital-acquired infection manifested as bacteremia. The antibiotics therapy against bacterial infection is mostly empiric, whereas the bacterial pattern and its sensitivity to antibiotics differ between region and from year to year. The objective of this study wasto determine the changes of prevalence and antibiotics sensitivity pattern of CoNS, the etiologic agent of bacteremia in patients hospitalised in Dr.Saiful Anwar General Hospital, Malang. Culture and antibiotic sensitivity test wereperformed on 650 and 1063 blood samples during the year of 2000-2001and 2004-2005 respectively in the Laboratory of Microbiology, Faculty of Medicine, Brawijaya University / Dr.Saiful Anwar General Hospital in Malang following NCCLS  1997. ChiSquare test was used to analysed of data. The result of this study revealed that the CoNS was the most isolate found in the blood samples and its resistance to beta lactam antibiotics tends to increase statistically. Key words:Coagulase negative staphylococci, antibiotics sensitivity pattern
KEGAGALAN KEHAMILAN AKIBAT INFEKSI Toxoplasma gondiiGALUR RH DIPICU OLEH OVERPRODUKSI INTERFERON GAMMA (IFNγ γγ γ) Sardjono, Teguh Wahju
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.428 KB) | DOI: 10.21776/ub.jkb.2005.021.03.5

Abstract

It has been already known that transplacental infiltration of parasites occurred during Toxoplasma infection in pregnancy; but pregnancy failures may due to some other previous mechanisms. Eighty BALB/c female mice were monogamously mated than devided into three pairs of study groupsand a pair of control group. On Day 9thpost mating, three pairs of study groups were intra-peritoneally infected by 10, 50 and 100 tachyzoites of RH strain Toxoplasma gondii, and the control groups were injected by PBS. Effect of treatment on the plasma level of IFNγ(ELISA) and number of litters were evaluated on the day 12thand day 15th-16th, represented second and third period of pregnancy.ANOVA and Path Analysis showed that duration of infection and the increase  of plasma IFNγ level decreased number of litters with coefficients of path of (-0,269; p=0,005) and (-0,377; p= 0,002) respectively. Decreasing number of litters was due toIFNγoverproduction, as response against RH strain of Toxoplasma gondii infection. This study showed that pregnancy failure in Toxoplasma infection is more due to indirect immuno-biochemical aspects rather than direct parasitological aspect. More studies to explain the basic molecular and immunological mechanisms of pregnancy failure in toxoplasmosis are still needed. Key words:Toxoplasmosis, IFNγ-overproduction, pregnancy failure
HUBUNGAN ANTARA HBA1C DAN KADAR LIPID SERUM DENGAN DERAJAT BERAT RETINOPATI DIABETIKA Refa, Safaruddin; Dewi, Nadia Artha
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.154 KB) | DOI: 10.21776/ub.jkb.2005.021.03.6

Abstract

Diabetic retinopathy is a leading cause of blindness in industrial world and is rapidly becoming an important cause in developing countries. Many factors related with theseverity of diabetic retinopathy, such as HbA1c and serum lipid. The study wants to know whether those factors have any  correlation with the severity of diabetic retinopathy or not. The objective this study was to determine the correlation between HbA1c and serum lipid with the severity  of diabetic retinopathy. An analytic cross sectional observational research had been done at Saiful Anwar hospital. The samples (diabetic retinopaty patients) were taken with consecutive sampling. These patient underwent funduscopy, fundus photography, laboratory examination including HbA1c, serum lipid (total serum cholesterol, LDL, HDL, triglycerides), and blood glucose. These patient were questioned about risk factors previously determined by the authors. The laboratory findings were thease are compared to the severity of diabetic retinopathy.
HIPERHOMOSISTEINEMIA SEBAGAI RISIKO PENYAKIT JANTUNG KORONER Astoni, Muhamad Ayus; Irawan, Bambang
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.441 KB) | DOI: 10.21776/ub.jkb.2005.021.03.1

Abstract

The elevation of total plasma homocysteine is associated with increase of risk for cardiovascular disease, cerebrovascular disease, and atherothrombosis in peripheral arteries. Several prospective and retrospective studies had conformed the positive association between hyperhomocysteinemia and risk for cardiovascular disease. However, it whether hyperhomocysteinemia is an independent riskfactor for cardiovascular disease associated with  the others risk factors still become a question. The aim of this study was to identify the association between hyperhomocysteinemia and increased risk for cardiovascular disease. A matched case-control study based on 50 consecutive adult  patients aged more than 18 years old who admitted in Dr. SardjitoGeneral Hospital by first acute coronary syndrome.Fifty comparison control subjects were randomly selected age and gender group-matched patients admitted caused by conditions other than cardiovascular disease to the same hospital. Each case was enrolled, and comparison subject was randomly selected. Fasting blood samples for homocysteine were obtained from both groups. Chi square test, McNemar chi square test, and independent t test had been used in univariate analysis. Confounding factors had been analysed using
PROFIL LAMA DIARE PADA ANAK DENGAN PEMBERIAN MINYAKKELAPA MURNI Kusuma, Rahma J.
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.816 KB) | DOI: 10.21776/ub.jkb.2005.021.03.7

Abstract

Diarrhea in children is still one of the ten major  diseases in chirldren. Diarrhea can cause undernutrition, while the undernutrition itself can also cause diarrhea. Until the year of 2000, the prevalence of diarrhe had been decreased, but due to multidimentional crisis it increased up to 27.5% in 2003. Giving the drugs which directly stop  the diarrhea are not recommended, while knowing the definite cause of diarrehea to find the causative treatment still needsseveral days. Virgin coconut oil (VCO) which contained medium chain saturated fitty acid was used because of its contains of lauric acid and capriac acid, which had antibacterial, antiviral and antiprotozoal action. It also could increase nutritional absorbtion without using enzyme. This longitudinal study was done to know the the profile of duration of diarrhea in children who treated with VCO as an alternative therapy without waiting for laboratory result. Among 42 children under 5 years old who observed in this study, 37 and 5 of them were suffered of acute and chronic diarrhea respectively.
PENGARUH PEMBERIAN EKSTRAK BIJI JINTEN HITAM (Nigella sativa) TERHADAP KADAR GSH, MDA, JUMLAH SERTA FUNGSI SEL MAKROFAG ALVEOLAR PARU TIKUS WISTAR YANG DIPAPAR ASAP ROKOK KRONIS Marwan, Marwan; Widjajanto, Edi; Karyono, Setyawati
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (380.463 KB) | DOI: 10.21776/ub.jkb.2005.021.03.2

Abstract

Cigarette smoke is the main risk factor of chronic  obstructive pulmonary disease (COPD). Several studies about COPD has focused on the oxidative stress in lung. Oxidative stress was related to inactivation of antiprotease enzymes, airway epithelial destruction and proinflammatory genes expression. Antioxidant may useful for treatment of COPD. Black seed (Nigela sativa) studies have showed that black seedhas antioxidant activity. The aim of this research  was to prove that black seed crude extract can protect wistar rat lung from oxidative stress which was caused by chroniccigarette smoke exposure. This experimental research used randomizedcomplete design with control group. Thirty wistar strain of Rattus novergicus, 2.5 to 3 months old, 150 – 250 grams ofweight were divided into five groups. First group  was used as negative control group (without any treatment), second group as positive control group (only cigarettesmoke exposure treatment), third group as cigarette smoke exposureand black seed crude extract dose 0.6 gr/kilogram  of body weight/day (group A), cigarette smoke exposure and  black seed crude extract dose 1.2 gr/kilogram of body weight/day (group B) and cigarette smoke exposure and black seed crude extract dose 2.4 gr/kilogram of body weight/day (group C). After 3 months five parameters were measured in this research.
PERBEDAAN EFEKTIFITAS PEMBERIAN VITAMIN E 100 IU DENGAN ASPIRIN 81 MG UNTUK PENCEGAHAN PREEKLAMSIA PADA PRIMIGRAVIDA Baktiyani, Siti Candra Windu; Wahjud, Imam
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (647.95 KB) | DOI: 10.21776/ub.jkb.2005.021.03.3

Abstract

Preeclampsia is a specific disturbance of human pregnancy, that diagnosed by the onset of hypertension and proteinuria in the third trimester. It occurs more in developing countries, due to the fact that developed countries have better prenatal care. The objective of this study was to assess the difference effectiveness of preventing preeclampsiaand giving vitamin E 100 iu and aspirin 81 mg. This study used prospective with single randomaised clinical trial. The place of this study is on Maternity care unit of RSUD Dr. Saiful Anwar Malang from October 2000 to October 2001. Fourty samples primigravidas between the age of 19-35 years were used in this study. Twenty four samples were treated  with vitamin E and 24 samples were treated with aspirin started atthe eighteenth weeks of pregnancy until delivery.  The changes, of blood presure, albuminuri and oedema were observed.The result showed that during the observation the incidence rate of mild preeclampsia of vitamin E was 4 samples or(16,7%), mild preeclampsia was 1 sample or (14,2%)by the time of the normal delivery. On the other hand, the mild preeclampsia of the control group of aspirin was 3 samples or (12,5%) and mild preeklampsia was 2 samples or (8,3%) at  the normal delivery. There is no significant difference in preeclampsia occurance between vitamin E and aspirin group. Key words: Vitamin E, Aspirin, preeclampsia

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