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Muhamad Salman Fareza
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Journal of Applied Science for Pharmaceuticals and Health
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 31101410     DOI : https://doi.org/10.20884/1.jasph.2025.2.2.16942
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Applied Science for Pharmaceuticals and Health is a peer-reviewed, open-access, inter and multidisciplinary scienctific journal. The journal aims to become a forum for research to publish quality in all disciplines of applied science on pharmaceuticals and health including: Chemistry, Physics, Biology, Pharmacy, Medical Science, Nursing, Public Health, Nutrition, and Sport science. Journal of Applied Science for Pharmaceuticals and Health is a multidisciplinary platform that promotes original, excellent, and scientifically sound research. Original research manuscripts as well as mini-reviews are accepted for submission. The Journal of Applied Science for Pharmaceuticals and Health will be released in June and December of each year. Publication in Journal of Applied Science for Pharmaceuticals and Health is without charge, and open access is available online for all published articles. Authors should refer to the Authors Guidelines for details on how to prepare their manuscript. Submission is performed via the online submission system. Articles can be written bilingually either in Indonesian or English.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 22 Documents
 1   2   3 
Quantitative Structure–Property Relationship (QSPR) of Active Compounds from Momordica charantia as Antidiabetic Agents ani riani hasana
Journal of Applied Science for Pharmaceuticals and Health Vol 3 No 1 (2026): Settings Vol 3 No 1 (2026): Journal of Applied Science for Pharmaceuticals and He
Publisher : Centre of Applied Science for Pharmaceutical Science Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jasph.2026.3.1.19277

Abstract

Latar belakang: Momordica charantia (pare) mengandung beberapa senyawa aktif seperti momordenol, lanosterol, cucurbitacin, stigmasterol, dan cucurbitin yang diketahui memiliki potensi sebagai antidiabetes. Tujuan: Penelitian ini bertujuan untuk menentukan hubungan antara parameter fisikokimia senyawa aktif M. charantia dengan aktivitas antidiabetes yang diprediksi menggunakan model Hubungan Kuantitatif Struktur–Properti (HKSP). Metode: Parameter fisikokimia yang meliputi lipofilik (logP, logS), elektronik (Etot, pKa), dan sterik (MR, BM) dihitung menggunakan perangkat lunak ChemBioDraw 2D, ChemBio3D, dan ChemBio3D Ultra. Molecular docking dilakukan menggunakan program Molegro Virtual Docker (MVD) terhadap protein tirosin kinase reseptor insulin terfosforilasi (PDB ID: 1IR3). Analisis statistik dilakukan menggunakan IBM SPSS untuk memperoleh model regresi HKSP terbaik. Hasil: Persamaan regresi optimum yang diperoleh adalah: Rerank Score = (–0,356 MR) – 33,915 (n = 5; r = 0,995; R² = 0,9908; SE = 1,919; F = 321,35; sig = 0,0003). Parameter fisikokimia yang paling berpengaruh terhadap aktivitas antidiabetes adalah massa molekul relatif (MR). Dari kelima senyawa yang diuji, cucurbitacin menunjukkan afinitas ikatan terbaik dengan nilai rerank score –85,7314. Kesimpulan: Hasil penelitian menunjukkan bahwa senyawa aktif dalam M. charantia, khususnya cucurbitacin, berpotensi dikembangkan sebagai kandidat alami antidiabetes melalui pendekatan komputasi dan eksperimental.
Analysis of Total Phenolic Content, Total Flavonoid Content, and Antibacterial Activity of Ethanol Extract of Katuk Leaves (Sauropus androgynus L.) Against Methicillin-Resistant Staphylococcus aureus (MRSA) Nur Amalia Choironi
Journal of Applied Science for Pharmaceuticals and Health Vol 3 No 1 (2026): Settings Vol 3 No 1 (2026): Journal of Applied Science for Pharmaceuticals and He
Publisher : Centre of Applied Science for Pharmaceutical Science Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jasph.2026.3.1.21649

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen that shows high resistance to many antibiotics, especially beta-lactams. Katuk leaves (Sauropus androgynus L.) contain bioactive compounds such as phenolics and flavonoids that may act as natural antibacterial agents. This study aimed to determine the total phenolic and flavonoid contents and to evaluate the antibacterial activity of ethanol extract of katuk leaves against S. aureus ATCC 25923 and MRSA ATCC 33591. Methods: This experimental laboratory study included sample preparation, maceration extraction with ethanol, total phenolic determination using the Folin-Ciocalteu method, total flavonoid determination using the AlCl3 colorimetric method, and antibacterial testing using the disk diffusion method. Data were analyzed descriptively as mean ± SD. Results: The katuk leaf extract contained 25.74 ± 1.05 mg GAE/g total phenolics and 14.45 ± 0.26 mg QE/g total flavonoids. Antibacterial testing showed weak inhibition against MRSA with a 2 mm zone of inhibition and against S. aureus with a 1 mm zone of inhibition. Conclusion: Ethanol extract of katuk leaves contains relatively high levels of phenolics and flavonoids, but at 10% (w/v) concentration it exhibited weak antibacterial activity against S. aureus and MRSA. Further studies using higher concentrations or combined antibacterial agents are needed to improve inhibitory activity.

Page 3 of 3 | Total Record : 22

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