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Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : https://doi.org/10.24843/JFU.2025.v14.i02
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana is an electronic journal which is managed by Pharmacy Department Faculty of Mathematic and Natural Science Udayana University. This journal which is a media of research publication and review article on all aspects of pharmaceutical science that is innovative, creative, original and based on scientific . Articles published in this journal include drug discovery, drug delivery systems and drug development. This journal covers specific fields in pharmaceuticals such as medicinal chemistry, pharmacology, pharmacokinetics, pharmacodynamics, pharmaceutical analysis, drug delivery systems, pharmaceutical technology, pharmaceutical biotechnolofies, herbal medicines and active components as well as clinical evaluation of medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 8 Documents
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Search results for , issue "Vol. 14, Issui 2, Tahun 2025" : 8 Documents clear
Review Literatur: Potensi Aktivitas Antidiabetik dan Antioksidan Zyzgium cumini (Jamblang) sebagai Agen Terapi Herbal Ni Putu Maya Ninditha
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p08

Abstract

ABSTRACT Syzygium cumini (Java plum) is a medicinal plant traditionally used in herbal remedies, but its scientific potential as an antidiabetic and antioxidant agent remains underexplored. This study aims to evaluate the pharmacological properties of Syzygium cumini based on recent scientific literature. A systematic literature search was conducted using PubMed, Scopus, and Google Scholar, focusing on studies that investigate antidiabetic and antioxidant activities. Out of 196 articles retrieved, 186 were excluded for not meeting the inclusion criteria. A total of 10 articles were selected for further analysis. The review found that various parts of the plant including fruit, seeds, and leaves contain bioactive compounds such as flavonoids, phenols, and tannins that help lower blood glucose levels, enhance pancreatic β-cell function, and neutralize free radicals. These findings support the therapeutic potential of Syzygium cumini as a herbal agent for managing diabetes mellitus and oxidative stress. Keywords: Antidiabetic; antioxidant; diabetes mellitus, oxidative stress, Syzygium cumini ABSTRAK Syzygium cumini (Jamblang) merupakan tanaman herbal yang telah lama digunakan dalam pengobatan tradisional, namun potensi ilmiahnya sebagai agen antidiabetik dan antioksidan masih perlu dieksplorasi lebih lanjut. Studi ini bertujuan untuk mengkaji potensi farmakologis Syzygium cumini berdasarkan data ilmiah terkini. Penelusuran literatur dilakukan secara sistematis melalui basis data PubMed, Scopus, dan Google Scholar, menggunakan kata kunci terkait aktivitas antidiabetik dan antioksidan. Dari total 196 artikel yang ditemukan, 186 di antaranya dieliminasi karena tidak memenuhi kriteria inklusi. Sebanyak 10 artikel terpilih untuk dianalisis lebih mendalam. Hasil telaah menunjukkan bahwa bagian buah, biji, dan daun Syzygium cumini mengandung senyawa bioaktif seperti flavonoid, fenol, dan tanin, yang berkontribusi dalam menurunkan kadar glukosa darah, meningkatkan fungsi sel β pankreas, serta menetralkan radikal bebas. Kajian ini memperkuat potensi Syzygium cumini sebagai kandidat terapi herbal dalam pengelolaan diabetes melitus dan stres oksidatif. Kata kunci: Antidiabetik; antioksidan; diabetes melitus, stres oksidatif, Syzygium cumini
Review: Potensi Tanaman Obat Dalam Lontar Usada Taru Pramana Untuk Pengobatan Diare Putu Dani Paramartha Wijaya
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p06

Abstract

Diare merupakan masalah kesehatan masyarakat yang serius, terutama di Provinsi Bali, yang mengalami peningkatan kasus dalam beberapa tahun terakhir. Penggunaan obat modern dapat memberikan efek samping dan membebani ekonomi masyarakat. Alternatif alami melalui pengobatan tradisional Bali yang tertuang dalam Lontar Usada Taru Pramana menjadi perhatian. Studi ini merupakan tinjauan literatur yang mengeksplorasi potensi lima tanaman obat: lengkuas (Alpinia galanga), gendola (Basella alba), tenggulun (Protium javanicum), jambu biji (Psidium guajava), dan kecapi (Sandoricum koetjape), yang digunakan secara tradisional untuk mengatasi diare. Metode yang digunakan adalah kajian pustaka dari literatur ilmiah 10 tahun terakhir. Hasil menunjukkan bahwa tanaman tersebut mengandung senyawa metabolit sekunder seperti flavonoid, alkaloid, tanin, dan saponin yang memiliki aktivitas antibakteri. Aktivitas ini ditunjukkan melalui mekanisme seperti merusak membran sel bakteri, mengganggu sintesis protein, dan mendenaturasi enzim bakteri. Simpulan dari kajian ini menunjukkan bahwa tanaman obat dalam Lontar Usada Taru Pramana memiliki potensi antibakteri terhadap bakteri penyebab diare, dan dapat dikembangkan sebagai terapi alternatif berbasis herbal yang aman dan efektif.
REVIEW: TANAMAN LOKAL BALI BERDASARKAN USADA TARU PRAMANA SEBAGAI ANTIINFLAMASI UNTUK NYERI DISMENORE Ni Luh Purnama Kuinasari
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p07

Abstract

Artikel ini membahas potensi tanaman herbal Bali berbasis Usada Taru Pramana sebagai agen antiinflamasi alami untuk mengatasi nyeri dismenore. Dismenore merupakan kondisi umum yang sering dialami remaja wanita, disebabkan oleh peningkatan prostaglandin yang memicu kontraksi otot rahim, sehingga menimbulkan nyeri. Penggunaan obat sintetis seperti NSAID memang efektif, namun berisiko menimbulkan efek samping. Oleh karena itu, diperlukan alternatif pengobatan yang lebih aman dan alami. Melalui studi literatur, artikel ini menyoroti lima tanaman tradisional Bali, kayu manis, pepaya, jeruk purut, andong, dan cengkeh yang secara turun-temurun digunakan dalam pengobatan dismenore. Kandungan senyawa aktif seperti flavonoid, tanin, saponin, dan minyak atsiri dalam tanaman-tanaman tersebut memiliki aktivitas antiinflamasi dan relaksan otot yang berperan dalam meredakan nyeri haid. Kata kunci: Antiinflamasi; Dismenore; nyeri haid; pengobatan tradisional; tanaman herbal Bali; Usada Taru Pramana
Literatur Review: EFEKTIVITAS ANTIBAKTERIAL DAUN JAMBU BIJI (Psidi guajava L.) TERHADAP Streptococus mutans PENYEBAB KARIES GIGI I Gede Bayu Surya Ekayana
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p05

Abstract

Oral health is an essential component of overall health and significantly affects quality of life. One of the most common oral health problems is dental caries, which is the destruction of tooth tissue caused by enamel demineralization triggered by acid produced from carbohydrate metabolism by plaque bacteria, particularly Streptococcus mutans. Guava leaves (Psidium guajava L.) are known to contain active compounds with antibacterial properties. Research has shown that these active compounds can inhibit the growth of Streptococcus mutans and disrupt dental biofilm formation, making them a potential preventive agent against caries. Articles were collected from PubMed, Google Scholar, and ScienceDirect using Boolean search techniques. Of the 538 articles identified, 10 were selected based on inclusion criteria and topic relevance. The review results show that guava leaf extract can reduce Streptococcus mutans colony counts both in vitro and in vivo, demonstrating effectiveness comparable to 0.2% chlorhexidine without adverse side effects. Furthermore, combining guava leaf extract with other agents, such as nanosilver and guava bark extract, has been shown to enhance antibacterial activity through synergistic mechanisms. Therefore, it can be concluded that guava leaves have strong potential as a natural, effective, and safe alternative for the prevention of dental caries.
GAMBARAN KEPATUHAN PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK (PPOK) DALAM PENGGUNAAN TERAPI INHALER DI INSTALASI RAWAT JALAN RSD DR. A. DADI TJOKRODIPO (RSDADT) BANDAR LAMPUNG Nurul Irna Windari; Nadiaishla Dzakia Hanan; Muhammad Hilmi Fathurrahman
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p01

Abstract

Penyakit Paru Obstruktif Kronik (PPOK) merupakan penyakit kronis tidak menular dengan angka kematian tinggi. Kepatuhan terhadap terapi inhaler sangat penting dalam pengobatan PPOK, namun kepatuhan pengobatan terhadap penggunaan inhaler umumnya buruk. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik dan kepatuhan penggunaan inhaler pasien PPOK. Penelitian ini dilakukan di RSD Dr. A. Dadi Tjokrodipo (RSDADT) Bandar Lampung pada periode September – Oktober 2024 dengan jumlah sampel yang memenuhi kriteria inklusi dan eksklusi sebanyak 46 sampel dari total populasi sebanyak 53 pasien PPOK. Penelitian ini merupakan penelitian deskriptif non eksperimental dengan pendekatan cross sectional dengan teknik total sampling menggunakan kuesioner Test of Adherence to Inhaler (TAI) dan dianalisis secara univariat. Hasil penelitian menunjukkan karakteristik 46 responden didominasi oleh usia ≥60 tahun (76,1%), jenis kelamin laki-laki (91,3%), tingkat pendidikan SD (34,8%), bekerja (58,7%), dan sudah berhenti merokok (89,1%). Berdasarkan kepatuhan penggunaan inhaler pasien PPOK didapatkan kepatuhan baik (39,1%), kepatuhan sedang (43,5%), dan kepatuhan rendah (17,4%). Hasil menunjukkan kepatuhan didominasi oleh pasien dengan kategori kepatuhan sedang.
The Inhibitory Activity Test of Green Amaranth (Amaranthus hybridus L.) Leaf Ethanol Extract Using Ultrasound-Assisted Extraction (UAE) Method Against the Growth of Staphylococcus epidermidis Anhar Muflih; Nita Triadisti; Annisa Salsabela; Islan Nor
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p04

Abstract

Staphylococcus epidermidis is a microorganism often found on almost all skin surfaces. Uncontrolled growth of S. epidermidis can cause skin dysbiosis such as acne. Generally, doxycycline, clindamycin, and tetracycline are used as synthetic antibiotic agents for S. epidermidis, but the search for new natural antibiotic agents to treat acne due to S. epidermidis needs to be developed, such as green spinach leaf extract (Amaranthus hybridus L.). Green Spinach is known to have antioxidant, antianemia, anti-inflammatory, antihyperlipidemic, antidiuretic, antifungal and antimicrobial activities, duet to the presence of secondary metabolites, such as alkaloids, steroids, tannins, saponins, and flavonoids. This study aims to analyse the antibacterial activity of green spinach leaf ethanol extract by considering the extract's inhibition zone. Green spinach leaves were extracted by Ultra Assisted Extraction (UAE) with 96% ethanol, and testing was carried out using the disc diffusion method. The results of this study showed that spinach leaf extract with concentrations of 15%, 30%, and 45% gave sequential results of 11.3 ± 0.06 mm, 12.2 ± 0.1 mm, and 12.5 ± 0.1 mm, including the category of strong inhibitory response.
Literatue Review : Biochemical and Pharmacological Prospects of Enhalus acoroides as a Source of Antifibrotic Compounds for National Drug Development Vivi Shofia
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p02

Abstract

Fibrosis is a progressive pathological process characterized by excessive accumulation of extracellular matrix and represents a major cause of organ failure, including in the kidney, liver, and lung. Currently available antifibrotic therapies have limited efficacy and are associated with potential adverse effects, highlighting the urgent need for new drug candidates derived from natural sources. The seagrass Enhalus acoroides, which is abundant in Indonesian waters, has been reported to contain flavonoids, polyphenols, sterols, and bioactive fatty acids that may modulate oxidative stress and inflammation, two key mechanisms involved in fibrogenesis. This review aims to evaluate the biochemical and pharmacological potential of E. acoroides as a source of antifibrotic compounds for national drug development. The methodology involved a literature review of scientific databases focusing on phytochemical profiles, pharmacological activities, and molecular mechanisms related to fibrosis. The findings indicate that E. acoroides exhibits significant antioxidant and antibacterial activities, contains major secondary metabolites (notably flavonoids and phenolics), and shows mechanistic relevance to the TGF-β/Smad signaling pathway, a central regulator of fibrogenesis. In conclusion, E. acoroides has promising potential as a candidate antifibrotic phytopharmaceutical; however, further validation through in vitro, in vivo, and advanced pharmaceutical formulation studies is required
Formulasi Lotion Ekstrak Etanol Daun Kopi Arabika (Coffea arabica L.) dan Ekstrak Etanol Daun Perepat (Sonneratia alba Sm.) Sebagai Antioksidan Maizatul Ummah
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p03

Abstract

Skin damage can be triggered by exposure to free radicals, making antioxidants important as skin protection agents. Arabica coffee leaves (Coffea arabica L.) and perepat leaves (Sonneratia alba Sm.) are known to have potential as natural sources of antioxidants. This study aims to formulate and evaluate lotion preparations containing ethanol extracts of these two leaves based on their physical characteristics and antioxidant activity. Four lotion formulas were prepared, namely K (without extract addition), FI (0.1% Arabica leaves + 1.0% perepat leaves), FII (0.5% Arabica leaves+ 0.5% perepat leaves), and FIII (1.0% Arabiva leaves + 0.1% Perepat leaves). The evaluation was conducted using an accelerated test (cycle test) on organoleptic properties, homogeneity, stability, pH, spreadability, adhesion, viscosity, emulsion type, and antioxidant activity, which were then analyzed descriptively. The results showed that formulas FII and FIII met the physical stability requirements. The antioxidant activity test showed that formula FIII had the highest activity with an IC₅₀ value of 45.41 ± 0.52 ppm compared to FI and FII. Based on these results, it can be concluded that lotion formula FIII is the best formulation in terms of stability and antioxidant effectiveness.

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