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Shinta Mayasari
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INDONESIA
Indonesian Pharmacopeia Journal (IPJ)
Published by Universitas dr. Soebandi
ISSN : 3032     EISSN : 5455     DOI : https://doi.org/10.36858/ipj.v2i2
Core Subject : Health, Science,
Chemistry Health Professions Medicine & Pharmacology
Indonesian Pharmacopeia Journal (IPJ) is a scientific journal published by pharmacy study program at Universitas dr. Soebandi, Indonesia. Releasing two issues annually in January and July, we dedicate our journal to research and development especially in the field of Pharmaceutics. We accept manuscripts that cover research in pharmaceutical biology, pharmaceutics, pharmaceutical chemistry, pharmacology, community and clinics, and pharmaceutical management.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 40 Documents
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Effectiveness of Analgesic Use in Lymphoma Cancer Patients O'on Sekar Arum
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.2

Abstract

Background: Lymphoma is an immunological malignancy originating from lymphotic cells that grow uncontrollably and accumulate in the lymph nodes, so it rarely causes a clinical picture as lymphotic. Lymphoma cancer can occur from several factors such as viral infections, family factors, age, gender. Pain is an uncomfortable sensation of sensory and emotional associated with tissue damage. Pain appears at any stage of the disease and can even be the first symptom felt when a malignancy is diagnosed. The purpose of this study was to determine the effectiveness of analgesics use in lymphoma cancer patients. Method: This study design uses cross-sectional which is a type of observational research design. The sample used in this study was 31 patients which is the total of the population.. The independent variable in this study is the use of analgesics, while the dependent variable in this study is the effectiveness of analgesics. Results: The results of this study obtained a pain scale before using the drug of 4.55 and after the use of the drug of 3.77, this study also used an analysis test using a paired t-test with a p-value of 0.00 which means there is a significant difference between before the use of analgesics to after the use of analgesics. Conclusion: The scale of pain before and after the use of analgesics has significant differences, the results of analytical trials in studies before and after drug use also experienced significant differences.
COMPARISON OF SOXHLETATION EXTRACTION METHODS AND UAE ON ANTIFUNGAL ACTIVITIES Candida albicans ON COCOA BEAN EXTRACT (Theobroma cacao L.) Novi Purwaningtyas
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.3

Abstract

Chocolate beans (Theobroma cacao L.) is the main part of the chocolate fruit and can be consumed after it becomes a food or beverage product. Cocoa beans contain quite high levels of active antioxidant compounds, some of which are 33-42% catechins, 23-25% leukocyanidins, and 5% anthocyanins. One of the bioactive compounds that are efficacious as natural antioxidants and antimicrobials is polyphenols. This study aims to determine the comparison of soxhletation and UAE extraction methods on antifungal activity Candida albicans on cocoa bean extract. The research design is an experimental laboratory. Processed using the soxhletation and UAE extraction methods with methanol as a solvent, then a phytochemical screening was carried out to determine the chemical compound content in cocoa beans and an antifungal test was carried out on Candida albicans by hole cup diffusion method with a concentration of 50%. The results showed that the yield values ​​of the soxhletation and UAE method were 3.81 ± 0.0022 and 4.18 ± 0.0012. Methanol extract of cocoa beans by soxhletation method and UAE contains chemical compounds of alkaloids, flavonoids, saponins, tannins and polyphenols. The results of the antifungal test by the soxhletation and UAE methods with a concentration of 50% produced an average inhibition zone diameter of 5.44 ± 0.5652 mm and 6.60 ± 0.6372 mm. It can be concluded that the extraction method does not affect the content of chemical compounds in cocoa beans and has an effect on antifungal activityCandida albicans which was indicated by the diameter of the inhibition zone but did not show a significant difference.
PROFILE OF MEFENAMIC ACID AND DICLOFENAC SODIUM AS PAIN RELIEVER IN ORAL SURGERY AT DENTAL POLY Muhammad Maulana Ma'sum
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.4

Abstract

Pain is a physical disorder caused by tissue damage in the body that causes the body to feel uncomfortable when active. Pain medication may be medications that involve non-pharmacology and pharmacology using analgetics. An analgetic drug helps reduce pain, mainly through its workforce on the central nervous system, and changes a person's response to pain. The study employed an observational design with a quantitative descriptive research design. The population of this study is 1,367 data on the medical records of a patient-dental oral surgery patient in January 2022. The number of samples in the study was 94 data on medical records that had dental pain filled the inclusion crebe. The research is using a total sampling technique. Results have shown that the patients who take the highest levels of mefenamic acid drugs are 26- 45 years old (52.5%) and the patients who take the highest level of diclofenac sodium -45 (49%), followed by patients who take mefenamic acid and 69.1% at a rate of 62.5% and 69.1%, for the dose of the patient taking the mefenamic 2 x 500 mg (45%) and 3 x 500 mg (55%). This study concludes that patients who consume mefenamic acid and diclofenac sodium are aged 26-45 years with the most gender being female with the maximum dose being 3x500 mg for mefenamic acid and 3x50 mg for diclofenac sodium, the duration of which is the same-same 7 days.
EFFECT OF FERMENTATION DURATION ON CAFEIN CURRENCY IN ROBUSTA COFFEE (Coffea canephora) FROM PTPN XII JEMBER Rizka Handayani
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.6

Abstract

Background: Indonesia is one of the largest coffee producing and exporting countries in the world. Jember Regency is one of the areas that develop robusta coffee, especially PT. Perkebunan Nusantara XII in the city of Jember has a coffee plantation area of 10,715 Ha. Coffee contains caffeine compounds. Caffeine is a xanthine alkaloid compound where most people believe that caffeine contained in coffee functions against drowsiness and fatigue. The fermentation process of coffee beans is a process in which the decomposition of complex compounds present in coffee beans, into simple compounds by adding some microorganisms to help release the mucus layer that still covers the coffee beans. BAL is a bacteria that can reduce the caffeine content in coffee. Methods: This research design is true experimental with UV-Vis Spectrophotometry method to determine the caffeine content. The sample used was robusta coffee beans (Coffea canephora) from PTPN XII Jember. Robusta coffee was fermented for 8, 18, 24 hours. Absorbance measurement was performed at a wavelength of 273 nm. Result : Caffeine levels in Robusta coffee that underwent BAL (Lactobacillus plantarum) fermentation process decreased due to the activity of proteolytic acid bacteria that produce protaseae enzymes high enough to cause caffeine levels in coffee to decrease. The results of caffeine levels can be seen in non-fermentation of 0,5212 mg/g, and 8 hours of fermentation time of 0,4437 mg/g, 18 hours of 0,3340 mg/g, and 24 hours of 0,1183 mg/g. Conclusion: The longer the fermentation time, the lower the caffeine content.
THE RELATIONSHIP BETWEEN THE LEVEL OF PUBLIC KNOWLEDGE ABOUT ANTIBIOTICS AND THEIR ADHERENCE TO THE USE OF ANTIBIOTICS AT THE SUKOWONO HEALTH CENTER Mega Cahya Utami
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.7

Abstract

Antibiotics must be used appropriately. Community non-compliance can be caused by a lack of knowledge about antibiotics. At the Sukowono Health Center, 70% low knowledge, 60% low adherence. The purpose of this study was to find out whether there is a relationship between the level of public knowledge about antibiotics and adherence to the use of antibiotics at the Sukowono Health Center. This study used an analytic observational research method with a cross-sectional approach and used a questionnaire. The total population was 217 and the sample was taken using purposive sampling. It obtained a sample of 140 people who visited the Sukowono Health Center and received antibiotic therapy. Data analysis using Spearman's rank. The results of the research on the level of public knowledge about antibiotics were mostly in the sufficient category (47.1%). While the level of public compliance regarding the use of antibiotics was obtained by the majority (60.7%). Based on the Spearman's rank test, there is a relationship between the level of public knowledge about antibiotics and compliance with the use of antibiotics. The level of knowledge was obtained in the sufficient category, while the level of community adherence to the use of antibiotics was also obtained in the sufficient category. There is a relationship between public knowledge about antibiotics and adherence to the use of antibiotics, the higher the knowledge, the higher the level of adherence. Knowledge is sufficient, compliance is also sufficient, and knowledge is low, compliance is also low. It is expected that health workers will provide detailed information about the impact of inappropriate use of antibiotics. Communities are expected to understand the information provided by health workers.
DESCRIPTION OF BLOOD SUGAR LEVELS OF DM PATIENTS WITH ORAL HYPOGLYCEMIC DRUG ADMINISTRATION AT ONE OF THE JEMBER HOSPITALS Khafifah Al Addawiah
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.8

Abstract

Background: Diabetes Mellitus (DM) is a chronic disease caused by impaired metabolism of fat, carbohydrates and proteins, characterized by high blood sugar levels that exceed normal limits. The incidence of DM will increase every year, the increasing incidence of DM can be caused by risk factors, such as obesity, physical activity and age. This study aims to determine the use of metformin and glimepiride along with a picture of blood sugar levels of diabetes mellitus patients before and after administering single metformin and glimepiride drugs at one of the hospitals in Jember. Methods: This study includes non-experimental research, namely obervasional with analytical descriptive research design with cross sectional methods. Samples were taken using a total sampling technique that met the inclusion criteria of 32 outpatients. Data were taken using observation sheets and recapitulation sheets. Research Results: The use of metformin and glimepiride drugs in type 2 DM patients in one of the hospitals in Jember is metformin as much as 15.6% while glimepiride is 84.4%. The data showed the difference in the average blood sugar levels of patients before using metformin which was 233.2 mg / dl and after using metformin which was 168.4 mg / dl and the difference in the average blood sugar levels of patients before using glimepiride was 246.7 mg / dl and after using glimepiride was 181.5 mg / dl. Conclusion: The use of metformin and glimepiride alone drugs in patients with type 2 diabetes showed that almost all patients used a single glimepiride drug which was 84.4%. Single metformin and glimepiride drugs were also able to lower blood sugar levels of type 2 diabetes patients in one of the medical record rooms of the outpatient hospital installation in Jember.
STUDY ON THE USE OF ANTIEMETIC DRUGS IN BREAST CANCER PATIENTS UNDERGOING CHEMOTHERAPY Vincensia Vonny Fredianto Putri
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.9

Abstract

Breast cancer is a malignant disease that most commonly attacks women. Therapies used in the treatment of breast cancer are divided into local and systemic therapies. Local therapy, namely surgical therapy and radiotherapy, for systemic therapy, namely hormone therapy, chemotherapy. Chemotherapy is a treatment option for breast cancer that has metastasized or is at an advanced stage. The most common side effect of chemotherapy is nausea, vomiting, so to prevent nausea and vomiting due to chemotherapy, do antiemetic therapy before and after chemotherapy. The design of this research is non-experimental research, namely descriptive quantitative, the population in this study was 150 and the sample in this study was 39 patients. From the results of data analysis, it was found that the most widely used class of premedication drugs before chemotherapy was a combination of ondansetron injection 4 mg, ranitidine injection 100 mg and dexamethasone injection 15 mg. Meanwhile, the use of post-medication medication after chemotherapy uses a single therapy of 8mg ondansetron injection, and for oral medication taken home by the patient uses a single therapy of 4mg ondansetron, The use of antiemetic drugs to treat nausea and vomiting is given pre-chemotherapy and post-chemotherapy drugs.
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF CHINESE BETEL (Peperomia pellucida L. Kuntha) LEAF EXTRACT IN GEL AGAINST Propionibacterium acnes Saubah Suud
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.10

Abstract

Background: Acne is a disease that often occurs due to bacterial infection PropionibacteriumAcne. Chinese betel leaf (Peperomia pellucida L Kunth) is a type of betel which has various chemical compounds such as alkaloids, flavonoids, sponins, tannins, triterpenoids which are useful for curing acne. MAE(Microwave Assited Exstraction) is an extraction process that uses microwave radiation. Wells are a bacterial testing process by placing holes in the media. Method: The design of this research is a laboratory experiment using the MAE method for extraction. Sample of Chinese betel leaf extract(Peperomia pellucida L Kunth).Which is included in the gel preparation formulation 3%, 5%, 7% and tested for physical and antibacterial quality using a well test. Results: The final result of the MAE process was a yield of 60.37g from the sample tested, this result was used in the formulation of gel preparations with concentrations of F1 (3%), F2 (5%), F3 (7%). The results of the research on the physical test showed that all tests met the physical test requirements, and the antibacterial test results showed that the inhibition zone was at K+(kentoconazole)=28.50 mm, F1=8.43mm, F2=8.96mm, F3=10.37mm. Conclusion: There is an effect by adding a concentration of 96% ethanol extract of Chinese betel leaves(Peperomia Pellucida L Kunth)in gel formulations in testing the physical properties of the preparation and antibacterial testing.
RATIONALITY PROFILE THE USE OF ANTIBIOTICS IN THYPOID FEVER PATIENTS AT HOSPITALIZATION BPM CLINIC (BHAKTI PRATAMA MAYANG) Novi Ahdina
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.11

Abstract

Background: Typhoid fever is an infectious disease. In Bhakti Pratama Mayang Clinic (BPM) is first from 10 diseases treated, for the first 6 months in 2022. In the treatment, the 3rd generation cephalosporin class is the main choice at BPM clinic. Irrationality in accuracy of the drug, accuracy of the dose, including the duration of antibiotic administration at BPM Clinic may occur. The purpose this study is to provide an overview the rationality using antibiotics in typhoid fever patients. Method: descriptive research design with secondary data population medical record of typhoid fever patients at BPM Clinical Inpatient in 2022. The sample used 96 medical record with total population technique, checklist measuring instrument and data recapitulation sheet with descriptive analysis of frequency distribution and percentage. Results: The types of antibiotics used for typhoid fever inpatients at BPM Clinic are almost all of cephalosporin class, namely most (53%) cefotaxime and (44%) ceftriaxone. The rationality of antibiotics used in typhoid fever inpatients all rational, namely Right Diagnosis, Right Patient, Right Route of Administration, and almost all for Right Dosing Regimen (95%) and Right Time of Administration (88%). Discussion: Chloramphenicol is the first-line antibiotic for the treatment for typhoid fever, in BPM Clinic 3rd generation cephalosporin used. Conclusion: Cephalosporin class (cefotaxim and ceftriaxone) are the main choice of antibiotics for typhoid fever patients at BPM Clinic and the rationality of giving antibiotic therapy for 3 appropriate ones is all 100% (Diagnosis, Patient, Route of Administration), and the other 2 are almost all for the Dosage Regimen (95%) and duration of administration (88%)
THE USE OF ANTIHYPERTENSIONS IN HYPERTENSION PATIENTS AT X HOSPITAL IN JEMBER Ni Kadek Rani Kusuma Dewi
Indonesian Pharmacopeia Journal Vol. 1 No. 1 (2024): Januari
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i1.12

Abstract

Background: Hypertension is the most common and common disease suffered by society. According to WHO (2023), hypertension is the third cause of death, because 1.28 billion people in the world suffer from hypertension. Hypertension sufferers at X Hospital Jember in 2022 are 4,774 patients. The increase in hypertension can be caused by risk factors, such as age, gender, obesity, lack of physical activity, smoking, stress, and consuming high levels of fat. The aim of the research is to determine the use of antihypertensive drugs in hypertensive patients at X Hospital Jember in 2023. Methods: This research is a non-experimental study with a retrospective descriptive research design. The data source in this research is the patient's electronic medical record data. Samples were taken using a total sampling technique which met the inclusion criteria as many as 44 patients. This research was conducted in the medical records room at X Hospital Jember with data for January-December 2022. Data is displayed in frequency and percentage form. Research results: During the research, it was found that almost half of the drug categories used a single drug with a percentage of 48%, and a small number of drug categories used a combination of three groups with a percentage of 11%. Based on drug class, almost half of them use ARB class drugs with a percentage of 27.3%. Based on drug type, almost half of the patients use candesartan drugs with a percentage of 27.3%. Based on the drug dose, a small percentage received a prescription for candesartan at a dose of 8 mg once a day with a percentage of 18.4%. Conclusion: Almost half of the use of antihypertensives in hypertensive patients at X Hospital in Jember is the ARB group, namely candesartan 8mg given once a day.

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