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TEST ANALGESIC ACTIVITY OF 70% ETHANOL EXTRACT OF STARFRUIT LEAVES (Averrhoa bilimbi L.) ON MALE MICE WITH WRITHING TEST METHOD Manar Syathotho; Wima anggitasari; Gumiarti
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.14

ABSTRACT Introduction: Analgesics are drugs commonly used to reduce or eliminate pain without losing consciousness. Several chemical compounds such as alkaloids, tannins, flavonoids and saponins contained in starfruit leaves have a therapeutic effect in reducing pain (analgesics by inhibiting the cyclooxygenase enzyme in the process of forming prostaglandins. The aim of this research is to determine the analgesic activity of the 70% ethanol extract of starfruit leaves wuluh (averrhoa bilimbi L.) in male mice using the writhing test method. Method: The research was experimental with the writhing test method using experimental mice by observing the writhing of the mice after giving acetic acid induction. Divided into 5 treatment groups, namely positive control paracetamol 65 mg /kgBW, negative control CMC Na 0.5%, group of 70% ethanol extract of starfruit leaves, doses of 100, 300 and 500 mg/kgBW. Results: The results of the study showed that the 70% ethanol extract of starfruit leaves contains chemical compounds, flavonoids, alkaloids, tannins and saponins. The average number of writhing results for CMC Na was 123.6 ± 16,920, paracetamol was 46.6 ± 13,631, and 70% ethanol extract of starfruit leaves at a dose of 100 mg/kgBW was 85.8 ± 18,240, 300 mg /kgBW is 67.2 ± 16,574, and 500 mg/kgBW is 52.6 ± 16,742. Conclusion: Analysis of differences in the number of writhes using the LSD post hoc test, namely doses of 300 mg/kg BW and 500 mg/kg BW, has a significant difference with the CMC Na negative control group and does not have a significant difference with the paracetamol positive control group which shows that this dose is comparable to paracetamol of 65 mg/kgBB as an analgesic. Keywords:Ethanol Extract 70% Starfruit Leaves (averrhoa bilimbi L.), Analgesic, Mice

ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT OF EDAMAME PEEL AND SEEDS (Glycine max (L.) Merr) AGAINST THE GROWTH OF Staphylococcus aureus Rahmadaniah Affelia; aliyah purwanti; Dhina Susanti
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.16

Staphylococcus aureus is the cause of acne disease that is resistant to antibiotics in the long term. Edamame is one of the natural ingredients used as an alternative treatment. Edamame seeds have the potential as antibacterial because they contain saponin compounds, in addition edamame peel waste can also be developed as an antibactetrial. The study aims to identify the profile of compound content from edamame peel and seeds extracts, to identify and analyze the antibacterial activity of the extract against Staphylococcus aureus bacteria. Ethanol extract of edamame peel and seeds were obtained from the Ultrasonic Assisted Extraction (UAE) method using 96% ethanol. Each extract was screened for phytochemicals and than made into concentrations of 10%, 20% and 30% to test antibacterial activity using the well diffusion method. Then continued with the One Way Anova test. Ethanol extracts of edamame peel and seeds obtained an average yield of 17,31%±0,57 and 17,10%±0,51. Edamame peel and seeds extracts contain saponins, tannins, steroids, terpenoids, flavonoids dan phenols but edamame seeds do not contain steroid compounds. Edamame peel extract at concentration of 10%, 20% and 30% can inhibit Staphylococcus aureus with an average inhibition zone diameter of 10,13mm±0,54; 12,80mm±0,67 and 14,74mm±0,78 while ethanol extract of edamame seeds produces an average inhibition zone diameter of 9,32mm±0,67; 11,55mm±0,83 and 13,83mm±0,96. The one way Anova test produced a value (Sig.) 0,000 followed by the Post Hoc LSD test showing that there were significant differences between each group. Edamame peel and seeds extracts contain phytochemical compounds such as flavonoids,steroids, phenols, tannins, terpenoidsa and saponins where each compound has a mechanism of inhibiting the growth of Staphylococcus aureus. The antibacterial activity of edamame peel extract is classified as strong at each concentration, while edamame seed extract is classified as strong at concentration of 20% and 30%, than at the concentration of 10% it is classified as moderate.

The Anti-inflammatory effectiveness of a combination of basil leaf extract (Ocimum americanum L) and turmeric rhizome (Curcuma domestica Val) in mice with carrageenan induction kamalia dafira Dafira; Mohammad Rofiq Usman; Sholihatil Hidayati
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.17

Background : Inflammation is the body's response to tissue injury, usuallycaused by physical trauma, damaging chemicals or microbiological agents.Basil leaves and turmeric rhizomes have been shown to be effective as antiinflammatories. The combination of these plants aims to determine the effectivedose as an anti-inflammatory.Objective: To determine the anti-inflammatory effectiveness of a combinationof basil leaf extract (Ocimum americanum L) and turmeric rhizome (Curcumadomestica Val) in rats with carrageenan induction.Method: This study is an experimental laboratory study using 28 male white ratsof the Wistar strain induced by 1% carrageenan. KN using CMC Na, KP sodiumdiclofenac, EK dose of 10 mg/KgBW, RK extract dose of 600 mg/KgBW andEKRK dose composition (2.5: 450 mg/KgBW, 5: 300 mg/KgBW, and 7.5: 150mg/KgB B ) . Continued with anti-inflammatory power. then data analysis usingSPSS version 26 began with a normality test and a homogeneity test as arequirement for the one-way ANOVA test.Results: The percentage results of anti-inflammatory power of KP 28.71%, EK10 mg/KgBB 33.00%, RK 600 mg/KgBB 33.23%, and EKRK 2.5: 450 mg/KgBB,5: 300 mg/KgBB, dose 7.5: 150 mg/KgBB respectively, namely 31.21%,28.65%, and 28.35% . The data obtained were continued with statistical testsusing SPSS version 26. The results of statistical tests using normality andhomogeneity tests were P> 0.05 and the one-way ANOVA test value was P>0.05.Conclusion: It can be concluded that the results of this study showed that in alltreatment groups it was proven effective as an anti-inflammatory. So it is hopedthat this study can be used as a reference for further research.

Potential Hyperglycemia In Type 2 Diabetes Mellitus Patients Due To Drug Interactions At Hospital Avrillana Dewangi Gea Ayunda Diarso; Shinta Mayasari; Khrisna Agung Cendekiawan
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.19

Background: Hyperglycemia is a medical condition in the form of an increase in blood glucose levels beyond normal limits with a blood sugar concentration of ≥200 mg/dl. Hyperglycemia that is not well controlled can cause serious disorders of the body's systems, especially the nerves and blood vessels. Based on WHO data, the prevalence of type 2 DM with the potential for hyperglycemia in the world in 2019 was 5.3%. This figure is expected to increase to 6.3% in 2030. Objective: This research was conducted to determine the potential for hyperglycemia in type 2 diabetes mellitus patients due to drug interactions at one of hospital in Jember. Method: This research uses a quantitative design with retrospective data collection, namely research obtained based on information from patient medical records. The population in this study was 539 patients suffering from type 2 diabetes mellitus for the period January-December 2022. The sample from this study was type 2 diabetes mellitus patients who met the inclusion criteria. Sampling was calculated using the Slovin formula using random sampling techniques and the results obtained were 84 medical record samples. Analysis using univariate. Data is displayed in frequency and percentage form. Data processing uses Microsoft Excel and SPSS. Results: Most of the drugs received by type 2 diabetes mellitus patients experienced interactions that had the potential to cause hyperglycemia with blood sugar levels ≥200 mg/dl (96.43%) and a moderate clinical significance level of 70.24%. Conclusion: There is a potential for hyperglycemia caused by diabetes drug interactions. Monitoring drug interactions and effective treatment in patients with type 2 diabetes mellitus needs to be carried out to achieve optimal therapy targets and increase awareness of healthy lifestyles in diabetes management.

Profile of Drug Use in Outpatients with Multidrug Resistant Tuberculosis (MDR TB) at RSD dr. Soebandi Jember Nindri Lusiana Safana; Sholihatil Hidayati; Jenie Palupi
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.22

Background: A drug use profile is a description of a drug that can be identified through its characteristics. Multidrug Resistant Tuberculosis (MDR TB) is a tuberculosis disease caused by Myrobacterium Tuberculosis bacteria against two types of OAT drugs, namely rifampicin and isoniazid. Objective:The aim of this study was to determine the profile of drug use in outpatients with Multidrug Resistant Tuberculosis (MDR TB) at RSD dr. Soebandi Jember for the 2023 period. Method:This research is descriptive research with one variable. The research sample was 70 MDR TB outpatients using a random sampling technique. Results: In the results for gender characteristics, the number of male patients was 46 (62%), female 28 (38%). Ages 17-25 years amounted to 10 (13%), ages 26-45 years 31 (42%), ages > 46 years 33 (45%). Length of treatment in initial stage 18 (24%), advanced stage 56 (76%). Combination of 3 drugs bedaquiline - linezoid - cycloserine 14 (31%), bedaquiline - ethambutol - cycloserine 1 (2%), clofazimine - linezoid - bedaquiline 1 (2%), bedaquiline - levofloxacin - ethambutol 14 (31%), ethambutol - levofloxacin - cycloserine 13 (30%), bedaquiline - cycloserine - linezoid 2 (4%), combination of 4 drugs levofloxacin - bedaquiline - ethambutol - clofazimine 10 (34%), clofazimine - ethambutol - bedaquiline cycloserine 12 (42%), clofazimine - bedaquiline - ethambutol - ethionamide 7 (24%). The drug use profile contained 7 types of drugs, namely lefoxloxacin 36 (14%), bedaqualin 60 (24%), Ethambutol 57 (23%), Clofazimine 31 (12%), cycloserine 42 (17%), Linezolid 17 (7%), Ethionamide 8 (3%). Conclusion:In the results, the highest number of male gender characteristics was 46 people (62%), the highest age characteristic was >46 years, 33 people (45%), the highest length of treatment characteristic was the advanced stage, namely the advanced stage, 56 people (67%) , the characteristics of the combination of drugs that are widely used are a combination of 3 drugs, there are 2 groups, including 14 people (31%) of bedaquiline - lienezoid - cycloserine and 14 people (31%) of bequiline - levofloxacin - ethambutol, the profile of the most widely used drug is bedaquiline 60 people (24%).

SUITABILITY OF PRESCRIPTION WRITING WITH HOSPITAL FORMULARY IN HEART DISEASE PATIENTS AT CITRA HUSADA HOSPITAL Della Utami Inayaturrahman; sutrisno; Sholihatil Hidayati
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.23

Introduction: The hospital formulary contains a list of drugs that have been agreed upon by the medical staff and compiled by the Therapeutic Pharmacy Team (TFT) which is determined by the hospital director. The hospital formulary serves as a quality and cost control for drugs that will facilitate rational drug selection, reduce medical costs, and optimize services to patients. Objective: This study aims to identify the suitability of standardized prescription writing with the hospital formulary. Methods: This study used a descriptive observation method with the source of medical record data for inpatients and outpatients with heart disease in October-December 2023 as many as 154 with total sampling technique. Results: The results of this study showed that the suitability of prescription writing with the hospital formulary was 98.93% and those that were not in accordance with the hospital formulary were 1.03%. Conclusion: The conclusion in this study is that almost all prescriptions for heart disease patients are in accordance with the Hospital Formulary.

Potential Hypoglycemia in Patients With Type 2 Diabetes Mellitus Due to Drug Interactions in Citra Husada Hospital Elisa wardatul awaliya; shinta mayasari; khrisna agung cendekiawan
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.24

Diabetes mellitus (DM) is a metabolic disorder disease characterized by an increase in blood glucose due to decreased insulin secretion by pancreatic beta cells, insulin disorders or resistance. The main risks that are commonly found in every patient diagnosed with DM disease include hypoglycemia. In a study conducted at a public hospital in Jakarta, 186 incidents of interaction of antidiabetic drugs with other drugs that have hypoglycemia potential with a moderate clinical significance level of 83.8% were found. The potential for drug interactions in DM patients is still very frequent. This can be caused by the number of drugs that are often used (Polipharmacy or multiple drug therapy). The purpose of this study is to identify the potential for hypoglycemia in type 2 DM patients due to drug interactions at Citra Husada Jember hospital. This type of research is qualitative research with retrospective data collection. The design of this study uses a cross-sectional design. The population of this study is 662 medical record data of outpatients with type 2 diabetes for the period of January – December 2022. Data analysis uses univariate analysis. In this study, most patients have the potential to experience hypoglycemia.

Anti-inflmatory Activity Test of Ethanol Extract of Betel Leaves Green (Piper betle L.) Against White Male Rats Carrageenan Induced Meilinda EkaFujiyanti; Sholihatil Hidayati; Dhina Susanti
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.27

Background: Inflammation is an attempt by the body to eliminate invading organisms, preparation for tissue preparation, and to eliminate irritants. The use of anti-inflammatory drugs can reduce the symptoms of inflammation. One of the natural ingredients as an alternative treatment that can be used as an anti-inflammatory is green betel leaves (Piper betle L.). Purpose: To determine the most effective dose (100, 200, and 400 mg/kgBB) of green betel leaf ethanol extract (EEDSH) as an anti-inflammatory based on the volume of edema in the feet of white male rats induced by carrageenan. Methods : The extract was made by maceration method using 70% ethanol solvent. The research used was a laboratory experiment using white male rats as test animals divided into 5 groups, namely negative control (CMC Na), positive control (Sodium Diclofenac), EEDSH treatment group with doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/KgBW with 1% carrageenan induction. Anti-inflammatory activity was analyzed by % anti- inflammatory power calculated based on measurements of edema volume. Analysis of research data using SPSS 25 using One Way ANOVA (p <0.05). Results: The results of the percentage of anti-inflammatory power of positive control, EEDSH doses of 100 mg/KgBB, 200 mg/KgBB, and 400 mg/KgBB were 29.13%, 31.43%, 32.66%, 31.45%. The results of statistical testing obtained a value of 0.366 (P>0.05) which means there is no significant difference. Conclusions: Ethanol extract of green betel leaves has anti-inflammatory activity against white male rats induced by carrageenan with the most effective dose being a dose of 100 mg/KgBW which has an anti-inflammatory effect that is not significantly different from the positive control

DESCRIPTION OF CLINICAL POLYPHARMACY PRESCRIPTIONS IN TYPE 2 DIABETES MELLITUS PATIENTS AT HOSPITAL X JEMBER DISTRICT Nurul Fathona; Shinta Mayasari; Nafisah Isnawati
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.29

Background: Diabetes mellitus (DM) is a metabolic disease caused by insulin resistance and pancreatic beta cell dysfunction. Polypharmacy is the use of three or more drugs every day is very common in patients with diabetes mellitus. WHO data shows that the prevalence of Diabetes Mellitus (DM) polypharmacy will reach 7.4% - 43.4% by 2023. Objective: This study aims to determine the clinical picture of polypharmacy prescriptions in patients with type 2 diabetes mellitus at X Hospital, Jember Regency. Method: This study used a descriptive non-experimental method by observation, involving 80 samples. Samples were selected by random sampling and data were analysed and displayed in the form of frequencies and percentages using Microsoft Excel and SPSS. Results: The results of this study are the description of the most polypharmacy prescriptions, namely prescriptions with 3 drug items as many as 3 prescriptions (7.5%), and the description of the least polypharmacy prescriptions, namely prescriptions with 4 drug items, and prescriptions with 10 drug items as many as 1 prescription (1%). In addition, the results of this study also contained drug interactions as many as 72 interacting prescriptions. Conclusion: From the discussion above, it can be concluded that, in the study at Hospital X, Jember Regency, polypharmacy was found from the samples analysed, all of which were polypharmacy prescriptions. This study also found that prescriptions for type 2 diabetes mellitus patients experienced drug interactions with moderate interactions being the most common. These interactions can reduce the effectiveness of treatment and increase risks for patients.

Test of Anti-Inflammatory Activity of 70% Ethanol Extract of Binahong Leaves (Anredera cordifolia) in Male White Rats (Rattus norvegicus) Induced with Carrageenan Marsanda Dara Paquita Imani; Wima anggitasari; Dhina Susanti
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.30

Inflammation is a protective response to tissue damage due to physical trauma. Steroid treatment can reduce prostaglandin release but often increases the risk of diabetes as a side effect. NSAIDs can address inflammation by inhibiting COX-1 and COX-2 enzymes, but may cause gastrointestinal damage. Therefore, there is a need for traditional and natural medicine alternatives that can stabilize free radicals and prevent cell damage, such as the binahong plant. This plant contains flavonoid compounds with high antioxidant properties, which can neutralize free radicals.This study aims to determine the anti-inflammatory activity of 70% ethanol extract of binahong leaves (Anredera cordifolia) in male white rats (Rattus norvegicus) induced with carrageenan. This study employs a laboratory experimental design with 20 test animals divided into 4 treatment groups, with extraction performed using the maceration method. In the screening test, a tube method is used, and anti-inflammatory testing is conducted by observing changes in the volume of rat paws before and after carrageenan injection. Data processing and analysis are performed using ANOVA in SPSS software. The percentage of edema was found to be 7.41% for the 200 mg/kg BB dose, 6.98% for the 400 mg/kg BB dose, 7.60% for the positive control, and 19.76% for the negative control. Normality and homogeneity tests showed normal and homogeneous results. ANOVA results indicated no significant differences, while LSD tests showed significant differences between the negative control and all treatment groups. Screening results (+) indicated the presence of flavonoid compounds.The ethanol extract of binahong leaves has anti-inflammatory activity as evidenced by the percentage of edema (7.41% and 6.98%) in male white rats induced with carrageenan. The most effective extract dosage is 200 mg/kg BB. Keywords: Anti-inflammatory, Binahong Leaves, Carrageenan, Anredera cordifolia

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Shinta Mayasari

Contact Email
shintamayasari@uds.ac.id

Phone
+6282244338126

Journal Mail Official
ipj@uds.ac.id

Editorial Address
Jl dr Soebandi No 99, Cangkring, Patrang-Jember

Location
Kab. jember,

Jawa timur

INDONESIA

Abstract

Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Shinta Mayasari

Contact Email shintamayasari@uds.ac.id

Phone +6282244338126

Journal Mail Official ipj@uds.ac.id

Editorial Address Jl dr Soebandi No 99, Cangkring, Patrang-Jember

Location Kab. jember, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Shinta Mayasari

Contact Email
shintamayasari@uds.ac.id

Phone
+6282244338126

Journal Mail Official
ipj@uds.ac.id

Editorial Address
Jl dr Soebandi No 99, Cangkring, Patrang-Jember

Location
Kab. jember,

Jawa timur

INDONESIA