Garuda - Garba Rujukan Digital

ADMINISTRATIVE AND PHARMACEUTICAL SCREENING OF DIABETES MELLITUS PRESCRIPTIONS IN TYPE 2 DIABETES MELLITUS PATIENTS IN THE HOSPITAL X JEMBER. Michael Nicoin DC Michael Nicoin DC; Shinta Mayasari
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.32

AbstractBackground: Pharmaceutical services are drug and clinical pharmacy services that enhance therapeutic effects and minimize the risk of medication errors. A form of pharmaceutical service is prescription screening. Prescription screening is a prescription review which is an activity of pharmacists in reviewing prescriptions which includes administration before the prescription is compounded. Another study conducted by Aryzki entitled "Administrative completeness of prescriptions carried out at Pharmacy X Banjarmasin in January, completeness of 0.26%, incompleteness with a percentage of 99.74% has not met according to PERMENKES number 73 of 2016 concerning pharmaceutical service standards. Objective: To identify the administrative and pharmaceutical screening of DM prescriptions for type 2 DM patients at X Jember Hospital. Methods: Descriptive research using observation method with a total of 125 samples by Random Sampling using the slovin formula. Results: overall administrative completeness is 100% complete written indicators, while most of the pharmaceutical completeness (60%) is incomplete of the five indicators identified as not written, namely the dosage form is still 56.8%, the dosage of the drug is still 91.2%, and overall 100%, the rules of use have not been written. Conclusion: From the total sample taken 125 prescriptions in the administrative aspect were all written completely for the pharmaceutical aspect most of them were not written completely, namely the indicators of drug dosage forms, drug dosages, and rules of use. Keyword : Skrining; Administrative; Phasmaceutical; Indicato

Effectiveness of Ethanol Extract of Mangosteen Leaves (Garcinia mangostana L.) as Anti-diarrhea in Mice Induced by Oleum Ricini Ahmad Khoirul Azwar; Shinta Mayasari; Mohammad Rofiq Usman
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.34

Diarrhea is a condition where a person experiences defecation with a soft or liquid consistency, with more frequent frequency (generally three or more times) a day One of the plants used as treatment for diarrhea is mangosteen leaves (Garcinia mangostana L). The leaves of the mangosteen plant (Garcinia mangostan L.) contain tannin compounds which can be useful as an antidiarrheal. Tannin is a substance that is effective as an adstringents, so it is thought to be able to provide an anti-dare effect. To determine the effectiveness of ethanol extract of mangosteen leaves (Garcinia mangostana L) as antidiarrhea in male white mice (Mus musculus) induced by oleum ricini. This research uses a type of laboratory experimental study using male mice (Muss musculus L) that have been induced with oIeum ricini. There were 15 mice used and divided into 5 groups, namely: negative control group (CMC Na 0.5%), positive control group (loperamide HCl) and treatment groups with dose concentrations of 250 mg/kgBW, 450 mg/kgBW and 650 mg/ kg BW. The research results showed that mangosteen leaves contain flavonoids and tannin compounds. This study shows the antidiarrheal activity value of 3 extract dose groups. There were 4 test parameters with the greatest antidiarrheal activity results at a dose of 650 mg/kgBB. The average result of the onset of diarrhea was 62.3 minutes, then the average result of the frequency of diarrhea was 5 times, while the duration of diarrhea was 85 minutes with an average feces weight of 0.99 grams. The ethanol extract of mangosteen leaves at a dose of 650 mg/kgBW had the most effective antidiarrheal activity in male (mus musculus) mice induced by oleum ricini. Key words: anti-diarrhoea, mangosteen leaves, loperamide; oleum ricini, garcinia mangostana

INHIBITY POWER OF HORN BANANA PEEL EXTRACT (Musa acuminata x Musa balbisiana) TOWARDS Candida albicans FUNGUS Rizky efendi; Dina Trianggaluh; Aliyah Purwanti
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.35

Background: Candida albicans is the main cause of candidiasis, where treatment usually uses antibiotics and can cause side effects and resistance. Natural ingredients are chosen as an alternative treatment with low side effects, as for the phytochemical content therein such as, alkaloids, flavonoids, tannins, and saponins, capable of inhibiting Candida albicans fungi. Objective: This study aims to identify and analyze the inhibitory power of Horn banana peel extract extracted using maceration and sokhletasi methods against Candida albicans fungi. Method: This study included laboratory experimental research. Extraction of horn banana peel was carried out by maceration and soxhletation, both using ethyl acetate solvent. The extracts from maceration and soxhletation were each screened for phytochemicals.then tested its ability to inhibit Candida albicans by the well diffusion method. The concentration of extract used was 100% and 50%. As a comparison, a positive control in the form of nystatin suspension and a negative control in the form of 10% DMSO were used. Results: The average value of the extract yield from soxhletation, which is 5.5% is greater than the average value of the maceration yield, which is 2.72%. The average value of the inhibition zone diameter from the soxhletation extract of 100% and 50% and the maceration extract of 100% and 50% are 14.77 ± 0.08 mm; 10.28 ± 0.15 mm; 11.35 ± 0.18 mm and 7.06 ± 0.13 mm, respectively. The results of data analysis showed that there was a significant difference between the extraction method and extract concentration on the inhibition zone. Conclusion: The extracts from maceration and soxhletation were both able to inhibit the growth of Candida albicans fungus, where the soxhletation extraction method produced greater inhibitory power than the maceration extraction method.

COMPARISON OF SOXHLETATION AND MACERATION METHODS AGAINST LEVEL TOTAL FLAVONOID EXTRACT ETHANOL 96% LEAF CIPLUKAN (Physalis angulata) Anisatul Maghfiroh Anisa; Mohammad Rofiq Usman; Dhina Ayu Susanthi
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.36

Leaf ciplukan has known public Indonesia as plant drug. Leaf ciplukan (Physalis angulata) contain secondary metabolite compounds, one of which is flavonoids. Flavonoid compounds from plants are obtained from various processes, one of which is process extraction with method soxhletation And maceration. Objective: Analyzing the differences Soxhletation and maceration methods on total flavonoid content of ethanol extract of ciplukan leaves (Physalis angulata). Method: The extraction process of the simple drug was carried out using the soxhlet method and maceration, follo wed by screening of flavonoid compounds against 96% ethanol extract of ciplukan leaves (Physalis angulata). Quantitative tests were conducted to determine the total flavonoid content of the leaves. Ciplukan (Physalis angulata) was carried out using the UV-Vis spectrophotometry method at a wavelength of wave 665 nm. Results: Phytochemical screening showed that the extracted ethanol extract use method soxhletation And maceration contain compound flavonoid proven with results screening from both of them positive. Level total flavonoid Which extracted use soxhletation method as much as 11 mgQE/g while extracted using the maceration method as much as 3 mgQE/g. Results from test statistics method T-Test known mark sig <0.05. Conclusion: Extraction with method soxhletation produce level total flavonoid Which more tall compared to the maceration method. This proves that soxhletation is a method best used to extract flavonoid compounds in ciplukan leaves (Physalis angulata)

FORMULATION AND DETERMINATION OF TOTAL FLAVONOID CONTENT OF FACE WASH GEL COCOA FRUIT EXTRACT (THEOBROMA CACAO L.) USING UV-VIS SPECTROPHOTOMETRY Ahmad Za'im Nabil; Dhina Ayu Susanthi; Mohammad Rofik Usman
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.37

Cosmetic products for skin care have recently been very popular among consumers, especially women. One type of face wash preparation that is used every day is face wash gel, this preparation is very suitable for dealing with facial skin problems. Plants or natural ingredients that can be used to formulate face wash gel preparations are cocoa fruit (Theobroma cacao L.) These compounds can be grouped into secondary metabolite compounds which are biomolecules that are used as new discovery materials in the development of herbal cosmetics. This research aims to formulate a face wash gel preparation and determine the total flavonoid content of the face wash gel from cocoa fruit extract (Theobroma cacao L.). This research uses a laboratory experimental research design by extracting cocoa pods using the maceration method with methanol solvent. Cocoa fruit extract face wash gel was formulated with a concentration of 2.5%, 5%, 7.5%, the formula was tested for the physical properties of the preparation, namely organoleptic test, homogeneity test, spreadability test, foam height test, pH test and viscosity test. Then the total flavonoid content of formula 3 face wash gel was determined using UV-Vis spectrophotometry. The results of the physical properties of the face wash gel preparations with concentrations of 2.5%, 5% and 7.5% met the test parameter requirements, while the results of determining the total flavonoid content of the formula 3 face wash gel received a value of 0.0005/mg/QE/g. Test of the physical properties of the face wash gel preparation from cocoa fruit extract (Theobroma cacao L.) meets the requirements and the face wash gel preparation in formula 3 cocoa fruit extract (Theobroma cacao L.) contains total flavonoid levels of 0.0005/mg/QE/ g.

FORMULATION AND TEST OF ANTIBACTERIAL ACTIVITY OF LIQUID SOAP EDAMAME SEED EXTRACT (Glychine max. Merr) AGAINST BACTERIAL GROWTH Staphylococcus aureus Wanda Tri Agustin; Dhina Ayu Susanthi; Aliyah Purwanti
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.38

Skin infection can be caused by Staphyloccocus aureus bacteria that attack normal skin. Infections can be prevented by giving antibiotics, but bacterial resistance is reported to be increasing, therefore we must create new product development innovations. One of the product development innovations that will be made is liquid soap of edamame seed extract by utilizing natural ingredients. to formulate and test the antibacterial activity of liquid soap of edamame seed extract against the growth of Staphyloccocus aureus bacteria. This study aims to formulate and test the antibacterial activity of liquid soap of edamame seed extract against the growth of Staphyloccocus aureus bacteria. Ethanol extract of 96% edamame seeds (Glycine max. Merr) was obtained using the UAE method. Furthermore, a liquid soap preparation of edamame seed extract was formulated with concentrations of F1 (5%), F2 (10%), F3 (15%). Then after that, physical properties such as pH test, organoleptics, foam height, dispersion, homogeneity and antibacterial activity were tested using the well diffusion method. The data was analyzed using the One Way anova test method followed by the Post hoc test, namely LSD. Liquid soap of edamame seed extract is tested for physical quality where the results obtained have met all the parameters of the physical quality test. The average antibacterial test results for the concentration of F1 (5%) in the inhibition zone were 14.66 mm, F2 (10%) in the inhibition zone was 15.29 mm, and F3 (15%) in the inhibition zone was 16.57 mm and the Control (+) inhibition zone was 18.83 mm. The results of the One Way Anova analysis on the anti bacterial test with a significant value of 0.199 showed that there was no difference in each concentration on the effect of the inhibitory power of Staphylococcus aureus bacteria. It can be concluded that the liquid soap formulation that has been tested for physical quality has met the predetermined requirements. For the antibacterial test carried out on the three formulations made, the best results were produced by F3 (15%) with an inhibitory zone diameter of 16.57 mm.

Identification of Transcribing Errors in Prescriptions for Type 2 Diabetes Mellitus Patients at Clinic X, Jember Haris Agung; Shinta Mayasari; Fendy Prasetyawan
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.39

Abstract Background: Clinical Pharmacy Services play an important role in health services in hospitals. Pharmaceutical service standards are direct and responsible services to patients related to pharmaceutical preparations with the aim of achieving definite results to improve the quality of life of patients. Medication error (ME) is an incident that causes or has an impact on inappropriate drug services or endangers patients when the drug is under the control of health workers or patients. Transcribing Error (TE) is an error in reading a prescription before entering the dispensing stage. TE includes changes to the drug name, drug formulation, route, dose, dosage regimen to prescription orders. According to the East Java Health Service in 2021, Diabetes Mellitus (DM) sufferers in East Java were 2.6 of the population aged 15 years and over. Health services for diabetes mellitus sufferers at first-level health facilities (FKTP) in 38 districts/cities throughout East Java reached 867,257 cases (93.3% of the estimated DM sufferers. Based on dataBasic Health Research, 2021cases of diabetes mellitus in Jember amounted to 1.4%. This study aims toIdentifying transcription errors in prescriptions for type 2 DM patients at clinic x, Jember district. This research uses research descriptive using observation method The data source taken from this study is data from outpatient prescriptions for type 2 Diabetes Mellitus for the period January - December 2022-2024 at clinic x Jember district. The population of this study was 37 medical prescriptions for outpatients with type 2 DM for the period January - December 2022-2024 at clinic x Jember. The sample in this study was prescription data for patients diagnosed with type 2 DM who met the inclusion and exclusion criteria with a total of 37 samples by total sampling. The results of this study were obtained. Data from the identification of transcription errors still contained errors. From the total sample taken, 37 prescriptions, the results of the identification of transcription errors still contained errors including no medical record number (89.2%) no patient age (45.9%) no dosage form (43.2%). While the parameters of patient name, drug name, dosage, duration of administration, route of administration, date of prescription request have been complete, there are no errors.From the discussion above, it can be concluded that the results of transcription error identification still contain errors. Keywords:Medication error, transcribing error, DM type 2

An OVERVIEW OF ANTIHYPERTENSION MEDICATION USE IN HYPERTENSION PATIENTS IN THE OUTPATIENT UNIT BALADHKA HUSADA HOSPITAL Shyntia Aurelia Fajratul Hikmah; Iski Weni Pebriarti; Jamhariyah
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.40

ABSTRACT Background: Hypertension is one of the cardiovascular diseases characterized by systolic blood pressure >140 mmHg and diastolic blood pressure >90 mmHg. This condition poses the highest risk as the leading cause of death due to cardiovascular diseases in Indonesia. According to Riskesdas data in 2018, the prevalence of hypertension in Indonesia reached 34.1%, an increase compared to Riskesdas 2013 at 25.8%. The management of hypertension can be conducted through pharmacological and non-pharmacological therapies. Pharmacological therapy involves the use of various classes of antihypertensive drugs tailored to each patient's clinical condition. Objective: This study aims to analyze the use of antihypertensive drugs based on the type of therapy, drug class, drug name, and the doses prescribed to hypertension patients in the outpatient unit of Baladhika Husada Hospital. Method: The samples for this study were collected using a simple random sampling technique. Results: The study conducted at Baladhika Husada Hospital in Jember during the period from September to November 2023, involving a total of 77 patient samples, showed that the most commonly used therapy was a combination of three drugs, found in 53 prescriptions (68.83%). The most commonly used drugs belonged to the beta-blocker class, specifically bisoprolol at a dose of 2.5 mg. Conclusion:The most dominant therapy for hypertension involves the combination of three drugs. The most frequently prescribed drug class is beta-blockers, with bisoprolol at a dose of 2.5 mg being the most widely used drug. Keywords: antihypertensive; hospital; hypertension; outpatient

ANTIBACTERIAL ACTIVITY OF 50% AND 96% ETHANOL EXTRACT OF HORN BANANA PEEL (Musa acuminata x Musa balbisiana) AGAINST Propionibacterium acnes Vanisa Al Maghfiro; Nuri; Aliyah Purwanti
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.42

Propionibacterium acnes is the main bacterium responsible for acne, with over 50% of its strains resistant to synthetic drugs. Treatment with natural substances, such as horn banana peel extract, can be an alternative. The polarity of the solvent, influenced by ethanol concentration, affects the compounds extracted and their antibacterial activity. This study aims to identify secondary metabolite compounds in 50% and 96% ethanol extracts of horn banana peel, evaluate the antibacterial activity of both extracts against Propionibacterium acnes, and determine the differences in antibacterial activity based on variations in solvent concentration. The banana peel extract was obtained using the Microwave Assisted Extraction (MAE) method. Phytochemical screening was conducted using the tube test method. Antibacterial activity was assessed using the well diffusion method. The 50% ethanol extract of horn banana peel had a higher yield (16,12%) compared to the 96% ethanol extract (10,02%). Both extracts contained active compounds such as alkaloids, flavonoids, tannins, polyphenols, and saponins. The 50% ethanol extract at concentrations of 5%, 10%, and 15% exhibited greater antibacterial activity against Propionibacterium acnes, with average inhibition zones of 18,68±1,32 mm, 14,11±0,35 mm, and 11.07±0.32 mm, respectively. In contrast, the 96% ethanol extract showed average inhibition zone diameters of 15,17±1,33 mm, 11,35±0,92 mm, and 8,06±0,86 mm. The differences in antibacterial activity are believed to be due to the varying polarities of the two solvents, with 50% ethanol being the more polar solvent. Two-way ANOVA analysis revealed a significant difference between the two factors (ethanol concentration and extract concentration) concerning the inhibition zones (p-value 0,004). The results indicate that both 50% and 96% ethanol extracts of horn banana peel contain secondary metabolite compounds such as alkaloids, flavonoids, tannins, polyphenols, and saponins. Both extracts exhibit antibacterial activity against Propionibacterium acnes, with a significant difference in activity between the 50% and 96% ethanol extracts.

FORMULATION OF KATUK (Sauropus androgynus L. Merr) LEAVEN EXTRACT EFFERVESCENT AID WITH VARIATIONS OF PEG 6000 LUBRICANT CONCENTRATION Eka Fitri Yanti; Revano Arnawinata; Nuri; Mohammad Rofik Usman
Indonesian Pharmacopeia Journal Vol. 2 No. 1 (2025): January 2025
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v2i1.44

Katuk leaves are one type of herbal galactagogue that can increase prolactin and oxytocin levels, and contain nutrients that can be used to facilitate breast milk. This study aims to determine the optimal PEG 6000 Lubricant concentration variation that produces effervescent tablet physical properties that meet the physical properties test requirements. This research is a preexperimental laboratories research. The concentration variation of PEG 6000 lubricant used was 1%, 2% and 3%. Tablets were evaluated for their physical properties including organoleptics, weight uniformity, dissolving time, hardness, pH and fragility. The results of this study indicate that the physical properties of effervescent tablets from katuk leaf extract (S. androgynus) with varying concentrations of PEG 6000 Lubricant meet the requirements of physical properties of Organoleptics, Weight Uniformity, Dissolving Time and Fragility. However, the physical properties of hardness and pH value have not met the requirements of the physical properties test set, the effect of variations in the concentration of PEG 6000 Lubricant on the physical properties of effervescent tablets, namely on Weight Uniformity, Dissolving Time, Hardness test, pH test and Friability test. But in the Organoleptical test, Weight Uniformity, Dissolving Time does not give the effect of differences in lubricant concentration variations

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Shinta Mayasari

Contact Email
shintamayasari@uds.ac.id

Phone
+6282244338126

Journal Mail Official
ipj@uds.ac.id

Editorial Address
Jl dr Soebandi No 99, Cangkring, Patrang-Jember

Location
Kab. jember,

Jawa timur

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Shinta Mayasari

Contact Email shintamayasari@uds.ac.id

Phone +6282244338126

Journal Mail Official ipj@uds.ac.id

Editorial Address Jl dr Soebandi No 99, Cangkring, Patrang-Jember

Location Kab. jember, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Shinta Mayasari

Contact Email
shintamayasari@uds.ac.id

Phone
+6282244338126

Journal Mail Official
ipj@uds.ac.id

Editorial Address
Jl dr Soebandi No 99, Cangkring, Patrang-Jember

Location
Kab. jember,

Jawa timur

INDONESIA