cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
subdirektoratpublikasi.unwar@gmail.com
Phone
+628113960099
Journal Mail Official
editorial.ijbstm@gmail.com
Editorial Address
Universitas Warmadewa, Jl. Terompong 24 Tanjung Bungkak Denpasar Bali, Indonesia
Location
Kota denpasar,
Bali
INDONESIA
International Journal of Biomedical Science and Travel Medicine
Published by Universitas Warmadewa
ISSN : 30477441     EISSN : 30477433     DOI : https://doi.org/10.22225/ijbstm
Core Subject : Health,
Medicine & Pharmacology Public Health
International Journal of Biomedical Science and Travel Medicine is published twice (March and September) a year. The objective is to promote articles on biology and medicine. International Journal of Biomedical Science and Travel Medicine publishes original research work related to biological and medicine. The journal publishes Original articles, Short Reports, Case Reports, and Review articles. All articles published in International Journal of Biomedical Science and Travel Medicine (IJBSTM) are peer-reviewed and published online for immediate access and citation. International Journal of Biomedical Science and Travel Medicine (IJBSTM) publishes the Original clinical and experimental research studies, Review articles, Case reports on topics but not limited to: Biocemistry, Genetics and molecular biology, Medicine, Environmental health, Tropical diseases, Diseases in tropics, Global health, Pharmacological sciences, Biomedical sciences, Public health, Infection, Epidemiology and clinical epidemiology, Molecular biology, Microbiology, Travel Medicine
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1 Documents
 1 
Search results for , issue "50-55" : 1 Documents clear
The active compound of the sponge Niphates olemda against Plasmodium falciparum phosphoethanolamine methyltransferase (pfpmt) based on in silico study F. Frederick; Prawesty Diah Utami; Olivia Mahardani Adam; Fitri Handajani
International Journal of Biomedical Science and Travel Medicine 50-55
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.1.2.2024.50-55

Abstract

Antimalarial drug resistance to P. falciparum has become a global problem in recent decades. This encourages the need for exploration to find alternative treatments, which come from marine product like Sponge Niphates olemda that contain active substrat. This research was conducted to determine the activity sponge Niphates olemda on P. falciparum phosphoethanolamine methyltransferase (PfPMT) through an in silico study.This research is a pure experimental research using the One Shot Experimental Study research design method. Observations were only made once between the variables studied through three analyzes, namely molecular docking analysis, ADME prediction analysis, and active compound toxicity analysis.The results showed that there were 4 active compounds (Niphateolide A, Kapakahine A, Kapakahine B, and Kapakahine F) that had a better binding affinity than artemisinin so that they had antimalarial potential. However, only Niphateolide A met Lipinski's criteria in ADME analysis, but was more toxic than the other three active compounds and also artemisinin. Based on the results of molecular docking analysis, it was found that the active compound Niphateolide A from the sea sponge Niphates olemda has antimalarial potential on target protein Plasmodium falciparum phosphoethanolamine methyltransferase.

Page 1 of 1 | Total Record : 1

 1 

Filter by Year

0000


Reset
Filter By Issues
All Issue 60-64 56-60 52-59 50-55 46-51 45-49 41-45 37-44 35-40 30-36 27-34 24-29 24-28 19-26 19-23 17-23 14-18 12-18 7-16 7-13 7-11 1-6 More Issue