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International Journal of Biomedical Science and Travel Medicine
Published by Universitas Warmadewa
ISSN : 30477441     EISSN : 30477433     DOI : https://doi.org/10.22225/ijbstm
Core Subject : Health,
Medicine & Pharmacology Public Health
International Journal of Biomedical Science and Travel Medicine is published twice (March and September) a year. The objective is to promote articles on biology and medicine. International Journal of Biomedical Science and Travel Medicine publishes original research work related to biological and medicine. The journal publishes Original articles, Short Reports, Case Reports, and Review articles. All articles published in International Journal of Biomedical Science and Travel Medicine (IJBSTM) are peer-reviewed and published online for immediate access and citation. International Journal of Biomedical Science and Travel Medicine (IJBSTM) publishes the Original clinical and experimental research studies, Review articles, Case reports on topics but not limited to: Biocemistry, Genetics and molecular biology, Medicine, Environmental health, Tropical diseases, Diseases in tropics, Global health, Pharmacological sciences, Biomedical sciences, Public health, Infection, Epidemiology and clinical epidemiology, Molecular biology, Microbiology, Travel Medicine
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1 Documents
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Search results for , issue "7-16" : 1 Documents clear
Phytotherapy for Bacterial Vaginosis with Piper Betle: from Mechanism to Safety Satria Bintang Samudra; Prawesty Diah Utami; Grissabel Bethrin Jiantoro; Jessica Euodia Adidharma; Rayhan Ali Fadli
International Journal of Biomedical Science and Travel Medicine 7-16
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.3.1.2026.7-16

Abstract

Background: Bacterial vaginosis (BV) is a prevalent vaginal dysbiosis characterized by depletion of Lactobacillus and overgrowth of anaerobic bacteria, commonly including Gardnerella vaginalis. Clinical management is complicated by high recurrence rates, which are closely linked to polymicrobial biofilm persistence and the limited microbiome selectivity of conventional antimicrobials. This narrative review aimed to synthesize current evidence on the phytotherapeutic potential of Piper betle in BV, focusing on antimicrobial and anti-biofilm mechanisms, modulation of vaginal microbiome ecology, and safety and standardization considerations relevant to translational development and recurrence prevention. Methods: An exploratory literature search (2015–2025) was conducted using PubMed/MEDLINE, ScienceDirect, and Google Scholar, complemented by manual reference screening, and last searched on 30 September 2025. Results: Findings across in vitro studies, observational reports, and mechanistic literature indicate that P. betle extracts and key phenolic constituents, particularly hydroxychavicol and eugenol, exhibit antibacterial activity against BV-associated taxa and anti-virulence effects consistent with biofilm weakening and interference with quorum-sensing–regulated behaviors. Importantly, several studies suggest comparatively limited inhibitory effects on Lactobacillus spp., supporting the plausibility of a microbiome-sparing profile that may facilitate restoration of vaginal eubiosis. Nevertheless, the evidence base is constrained by heterogeneous methodologies, predominance of preclinical models, and substantial variability in phytochemical composition across preparations. Conclusion: Overall, P. betle emerges as a biologically plausible adjunctive or preventive candidate for preventing BV recurrence, warranting standardized formulations, marker-based quality control, and rigorous clinical evaluation with recurrence-focused endpoints.

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