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Scientific Nexus
Published by Institut Teknologi Sumatera
ISSN : -     EISSN : 31103278     DOI : https:/doi.org/10.35472/scinexus
Core Subject : Health, Science,
Astronomy Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology Medicine & Pharmacology
Scientific Nexus is a peer-reviewed scientific journal publishing research articles, review articles, short communications, editorials, and perspectives within the scope of Science, covering but not limited to: Physics Biomedicine Chemistry Drug Discovery and Development Atmospheric and Planetary Science Marine Environmental Science & Marine Biology We welcome a wide range of contributions, including interdisciplinary studies, niche-scope research, negative results, and scientifically justified replications. Interdisciplinary research combining at least two of the above fields is strongly encouraged. To be published with us, a manuscript must be scientifically valid and methodologically robust. We do not judge submissions based on perceived importance, novelty, or potential impact — we believe such evaluations are best made by the research community after publication.
Arjuna Subject : Umum - Umum
Articles 10 Documents
 1 
Photometric determination of asteroid 9 Metis rotation period using the OZT-ALTS robotic telescope Achmad Zainur Rozzykin; Aditya Abdilah Yusuf; Ridlo Wahyudi Wibowo; Adhitya Oktaviandra; Novia Doloyanty Br Sinaga; Zeni Septiani; Muhammad Rafiansyah; Ioga Lazuardi
Scientific Nexus Vol. 1 No. 1 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2248

Abstract

Asteroid 9 Metis, a prominent main-belt object with an irregular shape and diameter of approximately 190 km, provides insights into early solar system formation and evolution. We determined its synodic rotation period through ground-based photometric observations using the OZT-ALTS robotic telescope at Institut Teknologi Sumatera (Itera). Observations were conducted on May 6, 2025, spanning 6.2 hours continuously. We analyzed 125 calibrated light frames using aperture photometry to construct a light curve. Period analysis employed the Lomb-Scargle periodogram method, suitable for unevenly spaced astronomical data. The periodogram revealed a dominant peak at 2.51 hours. However, the folded light curve exhibited characteristic double-peaked structure with two maxima and minima per cycle, indicating this represents half the actual rotation period. The true synodic rotation period was therefore determined as 5.01 ± 1.01 hours. This result agrees with previously reported values (~5.08 hours), confirming that asteroid 9 Metis has an elongated shape or heterogeneous surface reflectivity. Our study demonstrates that accurate rotational periods can be obtained using moderate-sized telescopes and modern photometric techniques for kilometer-scale asteroids. These findings contribute to understanding asteroid rotational dynamics and provide reference data for future shape modeling studies.
Analgetic effectiveness of fenugreek seed extract (Trigonella foenum-graecum L.) in acetic acid-induced male ddY strain mice Riska Okta Via; Dewi Damayanti Abdul Karim; Andreanus Andaja Soemardji; Refsya Azanti Putri
Scientific Nexus Vol. 1 No. 1 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2254

Abstract

Pain represents a significant health challenge, with current nonsteroidal anti-inflammatory drugs (NSAIDs) carrying hepatotoxicity risks that necessitate safer alternatives. This study evaluated the analgesic activity of fenugreek (Trigonella foenum-graecum L.) seed extract using the acetic acid-induced writhing test in male ddY strain mice. Twenty-five mice were randomly allocated into five groups (n=5): negative control (1% Na-CMC), positive control (diclofenac sodium 50 mg/kg), and three fenugreek extract groups (200, 400, and 600 mg/kg). Pain was induced by intraperitoneal injection of 1% acetic acid, and writhing episodes were counted for 180 minutes. Data were analyzed using one-way ANOVA with Tukey's post-hoc test. All fenugreek doses significantly reduced writhing compared to negative control (p < 0.05). The extract demonstrated dose-dependent analgesic activity, with protection rates of 30.8%, 35.9%, and 41.0% for 200, 400, and 600 mg/kg doses, respectively. The highest dose (600 mg/kg) achieved 71% of diclofenac's analgesic efficacy (46.2% protection). Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, steroids, tannins, and polyphenols. These findings suggest fenugreek seed extract possesses significant analgesic properties and represents a promising natural alternative for pain management.
Analyzing sediment characteristics between intertidal and supratidal zones at Kelapa Kunjir Beach, Lampung Indonesia Delilla Suhanda; Mohammad Ashari Dwiputra
Scientific Nexus Vol. 1 No. 1 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2258

Abstract

The differing hydrodynamic processes between the intertidal and supratidal zones significantly influence the distribution of grain size and sediment types. This study aims to analyze the sediment fractions and types based on granulometric parameters in both zones. The method involved collecting sediment samples from five stations in each zone, followed by dry sieving laboratory analysis and granulometric statistical calculations. The results show that the intertidal zone is dominated by gravelly sand, with gravel ranging from 20.4% to 35.5% and sand from 61.3% to 78.7%, with no silt or clay detected. The supratidal zone exhibited more variation, with gravel ranging from 16.4% to 38.2%, sand from 41.3% to 70.6%, and silt from 2.3% to 39.2%. Sorting values ranged from 1.5 to 2.3, skewness from −0.8 to −0.07, and kurtosis between 1.7 and 4.0. Sediment types in the intertidal zone were predominantly gravelly sand, while the supratidal zone consisted of gravelly mud and muddy sand. It is concluded that differences grain size distribution and sediment types between the two zones are influenced by variations in environmental energy. The intertidal zone reflects moderate to high-energy conditions, while the supratidal zone indicates a lower-energy environment with potential for fine material accumulation.
Sol-gel synthesis and characterization of iron- and nitrogen-doped titanium dioxide (TiO2) photocatalysts for enhanced rhodamine B degradation Ilma Maulidina; Dwi Febrianti; Priyan Prayogo; Rifqi Almusawi Rafsanjani; Iin Riananda; Ridho Hidayat; Laila Khafidatul Rosidah; Jesica Violina; Posman Manurung; Herman; Yayat Iman Supriyatna; Okta Ferli Suryadi; Indra Pardede
Scientific Nexus Vol. 1 No. 1 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2276

Abstract

Rhodamine B is a carcinogenic synthetic dye extensively used in textile and food industries, requiring effective removal from wastewater. Conventional titanium dioxide (TiO₂) photocatalysts demonstrate limited effectiveness under solar irradiation due to ultraviolet light activation requirements. This study evaluated strategic modification of TiO₂ electronic structure through low-concentration iron and nitrogen doping to enhance visible-light photocatalytic performance for rhodamine B degradation. Nanoscale TiO₂ materials were synthesized using sol-gel methodology and doped with iron and nitrogen precursors. Comprehensive characterization employed X-ray diffraction, ultraviolet-visible spectroscopy, and scanning electron microscopy to evaluate structural, optical, and morphological properties. Structural analysis confirmed preservation of anatase crystalline phase with 12.94 nanometer average crystallite size. Optical characterization revealed bandgap modifications from 3.27 eV for pure TiO₂ to 2.85 eV for iron-doped and 3.25 eV for nitrogen-doped samples. Nitrogen-doped TiO₂ achieved superior rhodamine B degradation efficiencies of 94.16% under ultraviolet irradiation and 83.34% under visible light, significantly outperforming pure and iron-doped materials. Enhanced performance resulted from optimized charge carrier dynamics balancing improved light harvesting with reduced electron-hole recombination. These findings establish a practical approach for developing cost-effective, solar-responsive photocatalysts for sustainable wastewater treatment applications.
Bioinformatics analysis of andrographolide as an antisquamous cell carcinoma of the cervix Raymond Devara; Sarmoko; Muhammad Salman Fareza
Scientific Nexus Vol. 1 No. 1 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2280

Abstract

Andrographolide, a natural substance isolated from Andrographis paniculata showing anticancer activity can be tested in silico to analyze its target in treatment of squamous cell carcinoma of the cervix. Objective of this study is dentifying andrographolide’s therapeutic target in treatment of squamous cell carcinoma of the cervix. Bioinformatics analysis was done by intersecting genes dysregulated in cancer and genes regulated by andrographolide. Potential therapeutic target genes activity related to cancer was analyzed and probable target genes were docked with andrographolide. Eighty three potential therapeutic target genes were identified and gene ontology and KEGG pathway analysis revealed their role in cancer. Target genes were further selected, resulted in three genes probable to be docked with andrographolide. Binding energy in kcal/mol between andrographolide and MAPK3, MMP9 and JAK2 respectively were -9.954, -9.470 and -8.482. Meanwhile, positive control binding energy were -10.050, -9.459 and -9.422. Andrographolide is shown to interact with a few key amino acid residues, such as Ile48 and Tyr53 in MAPK3, His230, His236, Pro246 and 247 in MMP9 and Leu983 in JAK2. In conclusion, MAPK3, MMP9 and JAK2 are potential therapeutic target genes for andrographolide within the treatment of squamous cell carcinoma of the cervix.
Mathematical modeling of fixed and declining amortization schemes in cooperative loan systems Werry Febrianti; Ainol Yaqin
Scientific Nexus Vol. 1 No. 2 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2320

Abstract

Village cooperatives play a pivotal role in promoting rural economic development by providing accessible microfinance services. This study evaluates two widely applied loan amortization schemes—fixed installment (annuity) and declining balance—within the framework of cooperative finance. By simulating a 12-month loan of IDR 10,000,000 at a 1% monthly interest rate, the paper models and examines the allocation of principal and interest payments under both approaches. The results indicate that although fixed installments ensure stable monthly obligations, they generate higher cumulative interest costs compared to declining balance schemes, which more closely align repayment amounts with the outstanding loan balance. A sensitivity analysis of varying interest rates and loan tenors further offers insights into financial risk management and borrower affordability. These findings can help cooperative managers develop more effective and transparent lending strategies.
Flood susceptibility mapping using GIS-based composite mapping analysis: a multi-district assessment in Lampung Province, Indonesia Muhammmad Rizky Alfajar; Lesi Mareta; Ajeng Utari Siti Saodah
Scientific Nexus Vol. 1 No. 2 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2410

Abstract

Flooding is a recurring hydrometeorological disaster in Lampung Province, Indonesia, particularly affecting Pesawaran Regency, South Lampung Regency, and Bandar Lampung City. This study mapped flood susceptibility using Geographic Information Systems (GIS) with Composite Mapping Analysis (CMA) and scoring methods to support disaster risk reduction planning. Six parameters were analyzed: rainfall, land cover, slope, elevation, soil type, and river buffer distance. Parameter weights were derived objectively through CMA based on spatial analysis of 258 historical flood events (2018-2024). Rainfall data (2015-2024) were interpolated using Inverse Distance Weighting, and spatial analysis was conducted in ArcGIS 10.8. Results show that 90.66% of the study area falls within moderate to high susceptibility classes. Rainfall received the highest weight (20%), followed by elevation (19%), soil type (18%), land cover (16%), river buffer (14%), and slope (13%). Model validation achieved 77.78% accuracy when compared with historical flood locations across 45 sub-districts. High susceptibility areas are characterized by annual rainfall exceeding 2,500 mm, elevations below 50 masl, poor soil infiltration capacity, and dense settlement. The CMA method provides objective parameter weighting while maintaining computational simplicity suitable for resource-constrained settings, offering a practical framework for flood susceptibility assessment in similar tropical regions.
Spatio-temporal pattern analysis and prediction of extreme rainfall frequency in the Lampung region using random forest Ary Ramlan Simangunsong; Wirid Birastri; Ridlo Wahyudi Wibowo; Khanifah Afifi; Ririn Andriyani; Nindhita Pratiwi
Scientific Nexus Vol. 1 No. 2 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2533

Abstract

This study aims to analyze the spatio-temporal patterns and predict the frequency of extreme rainfall (FE) during the December-January-February-March (DJFM) season in the Lampung region. The frequency of extreme events (FE) was determined using the 90th percentile threshold via the Cumulative Distribution Function (CDF). Principal Component Analysis (PCA) was applied to extract the spatio-temporal principal components (PCs) of extreme events. These PCs were then correlated with large-scale atmospheric parameters, including Sea Surface Temperature (SST), zonal and meridional winds at 850 hPa (U850/V850), and the ONI and DMI climate indices. Areas with high correlations were extracted as predictors for the Random Forest model. The model was trained and tested over the period from January 1982 to December 2020 and evaluated using Root Mean Square Error and Pearson correlation (r). Wind patterns and SST showed a significant relationship with FE, while ONI and DMI were weakly correlated. Evaluation of the RF model indicated a tendency for the model to overestimate low FE and underestimate high FE, although the model was able to represent the general patterns of FE. This approach demonstrates potential for developing extreme rainfall frequency predictions based on large-scale atmospheric data, which can contribute to hydrometeorological disaster mitigation in Lampung.
Physicochemical water quality and basic soil parameters of Embung B, Institut Teknologi Sumatera: a preliminary assessment Cindy Moyna Clara LA; Reyhan Puji Putranto; Fatma Fitriyah; Yeni Fingky Claudia Purba; Silvia Rachmadani Putri; Nirmala Mustika Putri; Sherlita Aprianti Simanjuntak; Elisabet Sihotang; Muhamad Allan Serunting
Scientific Nexus Vol. 1 No. 2 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2561

Abstract

This study evaluated the water quality of Embung B by analyzing samples collected from three locations for pH, conductivity, total dissolved solids (TDS), total suspended solids (TSS), and Fe(III) concentrations. TDS and TSS were determined using gravimetric methods, while Fe(III) was quantified colorimetrically via the Fe(SCN)²⁺ complex at 480 nm. TDS values measured with a water quality meter were compared to gravimetric results to examine methodological differences. The pH ranged from 8.31 to 8.83, within the permissible range of 6–9. Conductivity values indicated low ionic content, reflecting minimal particulate matter. Gravimetric TDS ranged from 244 to 39,844 ppm, while meter readings were lower, highlighting method-dependent variation. Fe(III) concentrations were 0.241, 0.230, and 0.178 ppm, all below the national limit of 0.3 ppm for drinking water. According to the pollution index, Embung B is classified as lightly polluted but remains within acceptable ecological conditions. Overall, Embung B exhibits stable water quality, low suspended solids, and safe Fe(III) levels, with pH within regulatory limits. Despite variations in TDS measurements, the reservoir is suitable for environmental and educational purposes. Regular monitoring is recommended to maintain long-term ecological integrity and sustainable management.
Green synthesis of silver nanoparticles using avocado (Persea sp.) peel extract as bioreducing agent: optimization, characterization, stability, and antioxidant activity Amilatusolihah; Demi Dama Yanti; Abdul Aji; Ahmad Anggraria Jaya Agung; Muhammad Yogi Saputra; M. Rofif Nurfaizi; Neng Tresna Umi Chulsum
Scientific Nexus Vol. 1 No. 2 (2025): Scientific Nexus
Publisher : Fakultas Sains Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/scinexus.2562

Abstract

The increasing demand for naturally derived antioxidants has driven interest in green synthesis of silver nanoparticles as a strategy to combine the bioactive properties of plant metabolites with the unique characteristics of nanomaterials. This study reports the green synthesis of AgNPs using avocado peel extract as a bioreducing and stabilizing agent, with optimization of synthesis parameters, physicochemical characterization, colloidal stability evaluation, and antioxidant activity assessment. Optimum synthesis conditions were established at 2 mM AgNO₃, 60 °C, and 60 min reaction time, yielding a characteristic surface plasmon resonance peak at 420 nm. FTIR analysis confirmed the involvement of O–H, C–H, C=C aromatic, and C–O functional groups derived from phenolic and flavonoid compounds in the reduction and nanoparticle stabilization processes. Particle size analysis revealed an average hydrodynamic diameter of 83.5 nm with a polydispersity index of 0.287. Stability studies over six months demonstrated that refrigerated storage at 4 °C in the dark produced the most stable absorbance profile. Antioxidant evaluation by the DPPH radical scavenging assay yielded IC₅₀ values of 126.04 µg/mL for AgNPs and 133.11 µg/mL for the extract, both classified as moderate antioxidant agents. These findings establish avocado peel as a promising, sustainable bioresource for the fabrication of antioxidant-active AgNPs.

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