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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 8 Documents
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Search results for , issue "Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)" : 8 Documents clear
Support Vector Machine, Naive Bayes, and Artificial Neural Network Back Propagation Comparison in Detecting Brain Tumor Triadyaksa, Pandji; Ahmad, Harisma Zaini; Marhaendrajaya, Indras
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.45462

Abstract

Brain tumors are abnormal tissue that grow uncontrolled and affect a patient's neurological function. Brain tumors come in different shapes and characteristics. Moreover, its location also differs for each patient. Brain tumors can be detected using machine learning algorithms using magnetic resonance imaging (MRI) images. However, a different machine-learning comparison is limited and needs further investigation. This study aims to compare three machine-learning methods, i.e., Support Vector Machine (SVM), Naive Bayes (NB), and Artificial Neural Network Back Propagation (ANN-BP) algorithms for detecting brain tumors. Before the comparison started, MRI image quality was enhanced by performing denoising, histogram equalization, and thresholding. After that, Gray Level Co-occurrence Matrix feature extraction was performed. MRI brain images in JPEG format were acquired from an open-access database. One thousand brain tumor and 1000 normal tumor images are used as the training data, while 100 brain tumor and 100 normal tumor images are used as testing data. Each algorithm's accuracy, precision, sensitivity, and Matthews Correlation Coefficient (MCC) are evaluated and reported. The study showed that the SVM algorithm acquired the highest performance in detecting brain tumors, followed by ANN-BP and NB. The highest accuracy, precision, sensitivity, and MCC values for testing in SVM were 98,75%, 98,22%, 99,30%, and 0,9751, respectively. Meanwhile, in testing, the highest accuracy, precision, sensitivity, and MCC values were 90.50%, 98.80%, 82.00%, and 0.8220, respectively. In conclusion, this study showed the superiority of the SVM algorithm in detecting brain tumor compared to ANN-BP and NB by performing image enhancement steps and GLCM feature extraction before its detection.
Recent Updates of Stem Cell Therapy in Spontaneous Intracerebral Haemorrhage Patients: A Review Article Niryana, I Wayan; Wibawa, Ida Bagus Adiguna; Kusuma, Gede Febby Pratama
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.44046

Abstract

Background: Spontaneous intracerebral haemorrhage (sICH) is a severe neurological condition with high disability and mortality rates globally. Effective therapeutic strategies to overcome the acute and long-term problems caused by sICH are still lacking. Mesenchymal stem cell (MSCs) therapy with the neuroprotective and neuroregenerative properties has the potential to overcome the complex brain injury mechanisms caused by sICH.Objective: This review highlights the recent pre-clinical and clinical findings about MSCs therapy in sICH case and their mechanisms in promoting neurological recovery.Methods: This is a literature review study. Study reports available from various accredited database such as PubMed and Google Scholar are collected using the following keywords: ((“stroke” or “intracerebral haemorrhage”)) and (“stem cell”).Results: Pre-clinical studies proved that MSCs therapy can resolved the secondary brain insult caused by sICH and improved the brain functional and clinical status. The clinical studies proved that MSCs therapy are safe and well tolerated in human bodies. There were also beneficial MSCs therapy effects in sICH patients. However, the clinical studies results were still lacking and some were inconclusive.Conclusion: The preclinical studies of stem cell therapy in spontaneous intracerebral haemorrhage showed promising evidences and the potential of stem cell therapy for clinical use. However, the clinical studies were still lacking. Further clinical studies are needed to confirm the neuroprotective and neuroregenerative benefits of MSCs therapy from the pre-clinical studies.
Comparison of Intravenous Indocyanine-Green and Inflation-Deflation Method in Lung Segmentectomy: A Meta-Analysis Al Asrory, Haidar Ali Robbani; Imania, Hana
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.44956

Abstract

Background: Inflation-deflation technique had been a conventional method for delineating the intersegmental plane during lung segmentectomy. Over the last decade, the use of icg has shown a significant increase as an alternative method. According to the European Society of Thoracic Surgeons' (ESTS) newly released expert consensus recommendations, Systemic ICG is the preferred method for performing ISP delineation. Objective: This study aimed to determine the safety of intravenous ICG in lung segmentectomy compared to inflation-deflation method. Methods: PubMed, Science direct, and Scilit were systematically reviewed. Studies comparing ICG with inflation-deflation method in lung segmentectomy were included. The main outcome included operation time while blood loss, length of hospital stay, and air leakage event became secondary. Odd Ratio (OR) and Mean Difference (MD) with 95% of Confidence Interval (CI) were applied for dicotomous and continous variable, respectively. Heterogeneity was assessed using Cochrane Q and I statistics, as reviewers also manually tested for heterogeneity with sensitivity analysis. Results: Six studies with a total of 839 patients were retrieved. All of them were retrospective comparative studies, mainly with a diagnosis of pulmonary nodules. Most studies utilized peripheral vein injections of 2.5 mg/mL ICG solution, which had a dosage range of 3–10 mL. Intravenous ICG administration was associated with a noticable operation time [MD = -19.30, 95% CI -28.29 to -10.31, p < 0.00001], length of hospital stay [MD = -0.61; 95% CI -1.16 to -0.06, p = 0.03], as well as a significant OR observed in the number air leakage [OR = 0.39; 95% CI 0.20 to 0.75, p = 0.005]. Meanwhile, there was no significant difference in the amount of bleeding between the inflation-deflation group and the ICG group [MD = -5.18, 95% CI -12.08 to 1.72, p = 0.14]. Conclusion: This meta-analysis has demonstrated statistically that the duration of surgery, length of hospital stay, and the probability of postoperative air leak are significantly lower with the application of ICG in lung segmentectomy.
Application of Plant-Based Metal Nanomedicine in Treatment of Various Types of Cancer: A Review Hernawan, Jihan Nurafifah; Sardjono, Ratnaningsih Eko
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.42787

Abstract

Background: Plant-based nanomedicine is a rapidly growing field of research that utilizes plant-derived nanoparticles for the treatment of cancer. Nanoparticles from plant extracts have a number of advantages over synthetic nanoparticles, including biocompatibility, low toxicity, and ease of synthesis Objective: This article comprehensively explores the synthesis, characterization, and anticancer activities of silver nanoparticles (AgNPs), zinc oxide nanoparticles (ZnO-NPs), and gold nanoparticles (AuNPs) synthesized using various plant extracts Methods: The research method used in this article is Systematic Literature Review (SLR). The research method used in this article is the Systematic Literature Review (SLR). The data are collected using Harzing’s Publish or Perish. The included literature sources discuss the synthesis and characterization of plant-based nanoparticles as anticancer, are published within the last 5 years, and are indexed in Google Scholar Results: Various synthesis methods influence the properties and cytotoxic effects of silver, zinc oxide, and gold nanoparticles derived from plant extracts. Characterization techniques provide insights into their synthesis, morphology, crystalline structure, surface chemistry, and stability. Conclusion: The results of this study reveal that silver nanoparticles (AgNPs), zinc oxide nanoparticles (ZnO-NPs), and gold nanoparticles (AuNPs) synthesized from plants have great potential in the treatment of various types of cancer.
COMPARISON of BMI and HbA1c 3 MONTHS POST ROUX-EN-Y GASTRIC BYPASS and SLEEVE GASTRECTOMY at SUMBER WARAS HOSPITAL JAKARTA Setyadi, Julia Clairine; Jeffrey, Jeffrey
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.45768

Abstract

Background: Obesity is a chronic condition that is closely linked to type 2 diabetes mellitus. Bariatric surgery is deemed to be an effective method to reduce weight and induce diabetes remission. Laparoscopic Roux-en-Y Gastric Bypass (RYGB) and laparoscopic Sleeve Gastrectomy (SG) are the most commonly performed surgical procedures. Objective: This study aimed to find out the efficacy of bariatric surgery including the more effective method between Roux-en-Y Gastric Bypass and Sleeve Gastrectomy in lowering BMI and improving HbA1c levels. Methods: This study is a cohort retrospective study of 64 patients who underwent laparoscopic RYGB  and SG in January 2020 – September 2023 in Sumber Waras Hospital. Data regarding BMI and HbA1c pre- and 3 months post-surgery were collected and analyzed using SPSS with statistical significance defined as p <0.05. Results: Greater decrease of IMT (p=0,000) and HbA1c (0,013) were observed in patients post laparoscopic RYGB. Meanwhile, in morbidly obese patients (BMI pre-op > 35kg/m2), no significant differences were found in HbA1c changes in both groups (p=0,240).  Conclusion: Laparoscopic RYGB is more effective in lowering BMI and HbA1c compared to laparoscopic SG. However, this comparison does not apply in morbidly obese patients.  
The Relationship Between Social Media Addiction and Self-Esteem in Medical Students of Diponegoro University Subiyakto, Difa Maulana; Saktini, Fanti; Sumekar, Tanjung Ayu
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.41836

Abstract

Background: In the modern era, social media has become a necessity in carrying out daily activities. Playing social media too often can have negative effects. These negative effects include addiction. Social media addiction can interfere with daily activities and affect the level of self-esteem. Objective: To prove the relationship between social media addiction and selfesteem among medical students at Universitas Diponegoro. Methods: This research was an analytical observational investigation utilizing a cross-sectional methodology. The study was carried out over a span of one month, involving 90 participants from the medical students batch 2022 at Universitas Diponegoro. The  questionnaires used were the Social Media Addiction Scale-Student Form (SMAS-SF) and Rosenberg Self Esteem Scale (RSES). The assessment of the correlation between social media addiction and self-esteem using the Spearman test. Results: 2.2% of respondents had a very low level of social media addiction; 52.2% had a low level; 44.4% had a high level; and 1.1% had a very high level. In terms of self-esteem, the data revealed that 84.4% of respondents had a high level of self-esteem, while 15.6% had a low level. In the correlation test between demographic factors, social media addiction, and self-esteem,  an insignificant relationship was found with a p-value greater than 0,05. Meanwhile, a significant relationship was found in the correlation test between social media addiction and the level of self-esteem (p=0.001, r=-0.335). Conclusion: A significant relationship exists between social media addiction and the level of self-esteem among medical students at Diponegoro University.
Histopathological Study of Sinonasal and Nasopharyngeal Lesions in Sumber Waras Hospital Jakarta from 2017-2023 Dewi, Yunita; Sugiharto, Sony
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.45913

Abstract

Background: Various non-neoplastic and neoplastic lesions arise from the sinonasal tract and nasopharynx. Polyps are the most frequently reported sinonasal lesions, with a prevalence of 2 %. Nasopharyngeal carcinoma is a common malignancy in Indonesia, with 19.943 new cases. Histopathological examination is the gold standard for diagnosis because management and prognosis vary among different lesions. Objective: The aim is to determine the incidence of various non-neoplastic and neoplastic lesions and to study the histopathological features with regard to age and gender. Methods: This study was a descriptive observational study with a cross-sectional design. The sample was retrieved from the histopathological records in Sumber Waras Hospital Jakarta from February 2017 to December 2023. The inclusion criteria were all patients with sinonasal or nasopharyngeal lesions that have been biopsied and then done histopathological examination at Sumber Waras Hospital Jakarta. The exclusion criteria were incomplete data and patients with histopathological diagnoses of necrotic tissue and inflammation. The sample consisted of 73 patients with a total of 76 cases, as 3 patients had multiple diagnoses. The data collected were later analyzed with SPSS software. Results: Among 73 patients, 54 were males and 19 were females. A maximum number of cases were diagnosed in the age group of 51-60. Among 43 sinonasal lesions, 25 (58,2%) were non-neoplastic and 18 (42%) were neoplastic lesions. Inflammatory polyps (42%) were the most common among the sinonasal lesions. Of 33 nasopharyngeal lesions, there were 2 (6,1%) non-neoplastic and 31 (93,9%) neoplastic lesions. The majority of these were of nasopharyngeal carcinoma (84,8%). Conclusion: Histopathological examination is essential for diagnosing and classifying sinonasal and nasopharyngeal lesions.
The Effect of Moringa Leaves Extracts on MDA Level in Male Mice Exposed to Electromagnetic Radiation of Mobile Phones Amalia, Nadia Ilmi; Budisulistyo, Trianggoro; Wibowo, Dhega Anindita; Sareharto, Tun Paksi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.43905

Abstract

Background: The use of cell phones causes anxiety about the effects of electromagnetic wave radiation emitted because of the production of free radicals in the body is increased by cell phone electromagnetic wave radiation. This escalation results in an elevated production of Reactive Oxygen Species (ROS), resulting in elevated Malondialdehyde (MDA) levels due to lipid peroxidation, which is toxic to the body. One way to reduce MDA levels is to introduce antioxidants into the body. Previous studies have found that Moringa leaf extract can be used as a good source of antioxidants.Objective: The aim of this research was to assess the impact of Moringa leaf extract administration on the MDA levels in BALB/C mice subjected to electromagnetic waves emitted by cell phones.Methods: This study employed an experimental study with a post-test only control group design. The research involved 23 male BALB/c mice, divided into four groups. The healthy control group received no treatment, while the negative control group was exposed to cell phone electromagnetic waves for 2 hours/day. Groups P1 and P2 received Moringa leaf extract at doses of 100 mg/kgBW and 400 mg/kgBW, respectively, in addition to being exposed to cellular phone electromagnetic waves for 2 hours/day. The treatment was administered for 30 days following a 7-dayadaptation period. On the 31st day, blood plasma samples were takenfrom all mice and examined for MDA levels. The data underwent analysis through non-parametric One-Way ANOVA and subsequent Pos Hoc LSD tests. Significance is acknowledged for p-values less than 0.05.Results: The highest MDA levels were found in the K (-) group, namely 0.43 ± 0.18 ppm, and the lowest MDA levels were observed in the P1 group, with values of 0.19 ± 0.08 ppm. A significant difference was noted between the K (-) group and the P1 group (p = 0.05), while no significant difference were observed in the other groups.Conclusion: Administering Moringa leaf extract at a dose of 100 mg/kgBW/day can reduce MDA levels in mice exposed to electromagnetic waves from cell phones.

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