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Michael Raharja Gani
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FACULTY OF PHARMACY UNIVERSITAS SANATA DHARMA Kampus III, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282
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Journal of Pharmaceutical Sciences and Community
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/jpsc
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Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) or J. Pharm. Sci. Community firstly published in 2003, is a peer-reviewed, open access journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy. J. Pharm. Sci. Community is managed and published in Yogyakarta, Indonesia by Faculty of Pharmacy, Sanata Dharma University Yogyakarta
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Articles 21 Documents
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Phytochemical Screening and In Vitro Anti-Inflammatory Activity through Protein Denaturation Inhibition of Tigarun (Crataeva nurvala Buch. -Ham.) Stem Bark Fadlilaturrahmah Fadlilaturrahmah; Mia Fitriana; Alya Hanifa; Resa Amalia Syabana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol. 23 No. 1 (2026)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.v23i1.1089

Abstract

Crataeva nurvala Buch. -Ham. is a medicinal plant commonly found in South Kalimantan, Indonesia. This study aimed to identify the phytochemical constituents and evaluate the in vitro anti-inflammatory activity of the stem bark extract of C. nurvala. The stem bark was extracted by maceration using ethanol and then fractionated by liquid-liquid partition with n-hexane, ethyl acetate, and n-butanol. Phytochemical screening was conducted using standard tube tests. The in vitro anti-inflammatory activity was assessed by measuring the inhibition of protein denaturation using Bovine Serum Albumin (BSA), and the IC₅₀ values were calculated. Phytochemical analysis revealed that the ethanol extract and the ethyl acetate fraction contained alkaloids, flavonoids, triterpenoids, phenols, and tannins. The n-hexane fraction showed the presence of triterpenoids, while the n-butanol fraction contained flavonoids. The IC₅₀ values of the ethanol extract, n-hexane, ethyl acetate, and n-butanol fractions were 122.07 ppm, 55.72 ppm, 96.01 ppm, and 155.88 ppm, respectively. Diclofenac sodium, used as a reference, showed an IC₅₀ of 59.79 ppm. These results indicate that the n-hexane fraction of C. nurvala stem bark possesses the strongest in vitro anti-inflammatory activity among the tested samples.

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