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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
 1   2 
Search results for , issue "Vol 50, No 4 (2018)" : 15 Documents clear
Prevalence of urinary incontinence and its association with the body mass index (BMI) among pregnant women in Ternate Island Adi Ariffianto; Ova Emilia; Edi Patmini Siswanti; Abdul Wahab
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.18 KB) | DOI: 10.19106/JMedScie/005004201811

Abstract

Urinary incontinence, a condition where a patient cannot withhold urinating, can cause health, social and psychological problems. This condition is not life threatening but can affect their quality of life due to the difficulties of treatment in the psychological and social problems. Even though this disorder is common in pregnancy, the exact cause is still unknown. Many researchers assert that urinary incontinence is due to multifactorial causes. This study aimed to determine the prevalence of urinary incontinence in pregnant women and its relationship with body mass index (BMI). A cross sectional study involving 224 pregnant women in the primary health centers on Ternate Island was conducted using the Questionnaire for Urinary Incontinence Diagnosis (QUID). Respondents with a history of urinary incontinence without pregnancy or positive urinary tract infection diagnosis were excluded from this study. Data were gathered through interviews and physical examinations. The total prevalence of urinary incontinence was 28.6%. Urge incontinence (39.0%) was the most common type followed by mixed (37.5%) and the least common was stress incontinence (23.4%). There was a significantly association between urinary incontinence and maternal BMI (p=0.045). Urinary incontinence occured as much as 2.167 (95% CI: 1.008 - 4.656) times greater in pregnant women with obesity than those who had an ideal BMI. In conclusion, urge incontinence is the most common type of urinary incontinence. There is a significant correlation between urinary incontinence and the BMI of pregnant women, especially in obese women.
Soursop fruit (Annona muricata Linn.) consumption does not increase serum potassium levels and not significant in cardiovascular risk improvements of prehypertension subjects Alatas, Haidar; Sja'bani, Mochammad; Irijanto, Fredie; Mustofa, .; Mukti, Ali Ghufron; Bawazier, Lucky Aziza; Zulaela, Zulaela
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.714 KB) | DOI: 10.19106/JMedScie/005004201804

Abstract

Patients with chronic kidney disease (CKD) tend to have hyperkalemia. They worry about the consumption of fruit for fear of increased serum potassium levels and therefore require a restricted potassium diet. Soursop fruit (Annona muricata Linn.) is believed to be beneficial for CKD and cardiovascular risk. This study was conducted to investigate the effect of soursop fruit supplement consumption on serum potassium levels and cardiovascular risk in prehypertension subjects from Mlati, Sleman District, Yogyakarta Special Region, Indonesia. A total 143 samples that met to the inclusion and exclusion criteria were subsequently randomized into two groups. Group I was given 2 x 100 g/day of soursop and Group II was without soursop. A laboratory examination from both groups was conducted including potassium, total cholesterol, low density lipoprotein (LDL), high density lipoprotein(HDL), and triglyceride levels at weeks 0; 7; and 13. Regular soursop consumption was evaluated every 2 weeks for 3 months. Data analysis was performed using an independent t test, a nonparametric Mann–Whitney test, and a chi-square test. No significantly different in serum potassium levels between the soursop and non-soursop groups at week 7 and 13 (p=0.073 and p=0.108) was observed. Furthermore, no significantly different in total cholesterol (p=0.254 and p=0.932), LDL (p=0.221 and p=0.710), HDL (p=0.400 and p=0.960), triglycerides (p=0.423 and p=0.580) of both groups was also obsereved. However, in subjects with hypercholesterolemia and hypertriglyceridemia, the mean cholesterol and triglyceride levels decreased compared to no soursop consumption at week 7 and 13. In conclusion, consumption of a soursop fruit supplement of 2 x 100 g/day for 13 weeks does not affect the serum potassium levels of prehypertension subjects. Moreover, the consumption of a soursop fruit supplement is not significantly different compared to those without soursoup in improving cardiovascular risk.
The role of cyclin D1 and vascular endothelial growth factor (VEGF) in radiotherapy response of undifferentiated nasopharyngeal carcinoma Nurhidayat, Ade Apon; Afiati, .; Usman, Hermin Aminah; Hernowo, Bethy Suryawathy
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (844.579 KB) | DOI: 10.19106/JMedScie/005004201802

Abstract

Nasopharyngeal carcinoma (NPC) has a high incidence and mortality rate in SoutheastAsia included in Indonesia. Radioresistance is a major obstacle for a successful treatmentof NPC. DNA repair in the cell cycle and angiogenesis factors affect the response oftumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and vascularendothelial growth factor (VEGF) as an angiogenesis factor are considered to play arole in the occurrence of radioresistance. The objective of this study was to evaluatethe association between cyclin D1 and VEGF expressions with radiotherapy responsein undifferentiated NPC. This study used a retrospective case control analysis design.Secondary data from medical records of patients diagnosed as undifferentiated NPC whoreceived a complete radiotherapy at the Department of Radiation Oncology, Dr. HasanSadikin General Hospital, Bandung. There were 44 samples divided into radiosensitive(22 samples) and radioresistant (22 samples) groups. Immunohistochemical examinationof cyclin D1 and VEGF expressions was performed on paraffin blocks of patients’nasopharyngeal biopsy. Data analysis used Chi-Square test with p ≤0.05. Cyclin D1 wasexpressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitivegroup (p<0.05), VEGF was strongly expressed in 77.3% of the radioresistant group and54.5% in the radiosensitive group (p>0.05). In conclusion, there is significant associationbetween cyclin D1 expression with radiotherapy response in undifferentiated NPC.However, there is no association between VEGF expression with radiotherapy response.
Breast reconstruction with autologous tissue following mastectomy: two case reports of a delayed conventional transverse rectus abdominismyocutaneous (TRAM) and latissimus dorsi myocutaneous (LDM) flap surgery Seswandhana, Rosadi; Wicaksana, Aditya; Wahdini, Siti Isya; Dachlan, Ishandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1504.075 KB) | DOI: 10.19106/JMedScie/005004201813

Abstract

Breast cancer is the most common malignant tumor and the leading cause of death among females. Most women with breast cancer will undergo breast-conserving surgery (BCS) or lumpectomy, simple or total mastectomy, modified radical mastectomy or bilateral mastectomy. Breast reconstruction solves many of the problems. The goal is to return the patient to a near-normal state so that she is not handicapped in her daily living. Breast reconstruction is also intended to offer psychological benefits to women treated by mastectomy following a diagnosis of possibly terminal cancer. In these case reports, we reported two successful cosmetic reconstruction cases. The first case was a 39-years-old female with non-recurrent breast cancer consulted and was referred by the oncology surgeon to the Plastic Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Dr. Sardjito General Hospital. She wanted to undergo breast reconstruction. We planned to operate three years following mastectomy. She was diagnosed with 3B-stage of right breast cancer before. After the surgery, the patient received six series of chemotherapy. She also underwent radiotherapy 25 times and hormonal therapy. We decided to perform a transverse rectus abdominis myocutaneous (TRAM) flap surgery on her with 22 months follow up. The procedure provided good results, and the patient was satisfied. The second case was a 32-year-old woman who after excision of a phyllodes tumor and wanted breast reconstruction. Reconstruction was performed four years after tumor removal using latissimus dorsi myocutaneous (LDM) flap. The surgery provided good results, and the patient was satisfied. We reported two successful cosmetic reconstruction cases of non-recurrent 3B-stage of right breast cancer post-mastectomy after pedicled TRAM flap surgery and left breast post excision of phyllodes tumor after LDM flap surgery.
Validity of narrow-band imaging (NBI) nasoendoscopy on nasopharyngeal carcinoma post therapy biopsy Yendri, Veby Novri; Herdini, Camelia; Heriwiyanto, Bambang
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (389.474 KB) | DOI: 10.19106/JMedScie/005004201812

Abstract

Nasopharyngeal carcinoma (NPC) is the most common malignancy found in the head and neck. It is a unique head and neck cancer due to its radiosensitivity. Therefore, radiotherapy becomes the main modality of therapy. Post-treatment evaluation of NPC is important to assess prognosis. Biopsy that is the gold standard for the evaluation can be performed with a narrow-band imaging (NBI) nasoendoscopy guide. This study aimed to determine the validity of NBI nasoendoscopic examination of NPC post-treatment biopsy. This study was a cross-sectional design for all post-treatment NPC patients who would undergo response assessment at the Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Sardjito General Hospital, Yogyakarta. A total 40 patients during May-June 2018 period who underwent examination sequentially. Biopsy examination was carried out with NBI nasoendoscopy guidance and the results of biopsy were performed histopathological examination. Forty patients showed the results of NBI nasoendoscopic validity on NPC biopsy after treatment included sensitivity (85.7%), specificity (87.8%), positive predictive value (60%), negative predictive value (96.6 %), positive trend ratio (7.07), negative trend ratio (0.16), and accuracy (87.5%). Postoperative NBI nasoendoscopy features appear homogeneous (75%) and inhomogenous (25%). In conclusion, NBI nasoendoscopic validity on postoperative NPC biopsy is good.

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