Article Per Year (5 Year)
p-Index From 2021 - 2026
0.947
P-Index
This Author published in this journals
All Journal MEDIA MEDIKA INDONESIANA Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Andalas Indonesian Journal of Biotechnology INDONESIAN JOURNAL OF PHARMACY Oto Rhino Laryngologica Indonesiana Journal of Community Empowerment for Health Indonesian Journal of Cancer Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Camelia Herdini
Departemen Ilmu Kesehatan Telinga Hidung Tenggorok Bedah Kepala Leher, Fakultas Kedokteran, Kesehatan Masyarakat, Dan Keperawatan Universitas Gadjah Mada, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 17 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 17 Documents
Search

 1   2 
Ekspresi E-cadherin pada metastasis karsinoma nasofaring Taufiqurrahman, Taufiqurrahman; Herdini, Camelia; Hariwiyanto, Bambang; Harijadi, Harijadi
Oto Rhino Laryngologica Indonesiana Vol 45, No 1 (2015): Volume 45, No. 1 January - June 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1946.311 KB) | DOI: 10.32637/orli.v45i1.103

Abstract

Latar belakang: Karsinoma Nasofaring (KNF) adalah keganasan dengan distribusi etnis dan geografis yang khas. KNF memiliki karakteristik yang berbeda dari kanker kepala dan leher lainnya,seperti perilaku pertumbuhan yang cepat, kecenderungan yang tinggi untuk bermetastasis ke kelenjargetah bening (KGB) regional dan organ jauh. E-cadherin memainkan peran penting dalam pemeliharaanadhesiantar sel-sel epitel. Perubahan molekul adhesi sel E-cadherin yang dimediasi oleh sel-sel kankerberkontribusi untuk peningkatan penyebaran sel tumor dan pembentukan metastasis. Tujuan: Untukmengetahui perbedaan ekspresi E-cadherin pada KNF yang telah bermetastasis dengan KNF yang belumbermetastasis. Metode: Desain penelitian adalah studi kasus-kontrol. Subjek penelitian adalah blok parafindari pasien KNF yang telah menjalani biopsi. Blok dari pasien KNF yang telah bermetastasis dikategorikansebagai kelompok kasus, sementara yang tidak bermetastasis sebagai kelompok kontrol. Sampel dari keduakelompok diperiksa dengan metode imunohistokimia (IHK) menggunakan antibodi E-cadherin. Hasil:Sampel 48 blok parafin, masing-masing kelompok terdiri dari 24 blok. Terdapat perbedaan yang signifikanekspresi E-cadherin dengan p<0,001 dan Odds Ratio (OR) 87,4 (95% interval kepercayaan 10,15-2653,26).Terdapat pula hubungan yang signifikan antara penurunan ekspresi E-cadherin dengan status KGB leher(p<0,001), metastasis jauh (p=0,001), dan stadium penyakit (p=0,001). Kesimpulan: Terdapat perbedaanyang signifikan antara ekspresi E-cadherin pada kelompok KNF yang telah bermetastasis dibandingkankelompok KNF yang belum bermetastasis. Kata kunci: Karsinoma nasofaring, ekspresi E-cadherin, metastasisABSTRACT Background: Nasopharyngeal carcinoma (NPC) is a malignancy with distinct ethnic and geographical distribution. NPC has different characteristics from other head and neck cancers, suchas rapid growth behavior, high propensity to metastasize to regional lymph nodes and distant organs.E-cadherin plays an important role in the maintenance of cell adhesion between epithelial cells. Changesin the cell adhesion molecule E-cadherin mediated by cancer cells contributes to increase in the spreadof tumor cells and the formation of metastasis. Purpose: To determine the difference in the expressionof E-cadherin between NPC that has metastasized and NPC that has not metastasized. Method: Acase-control study. Subjects were paraffin blocks from NPC patients who had undergone biopsy. Blocksfrom NPC patients who had metastasized categorized as a group of cases, while not metastasized as acontrol group. Samples from both groups were examined using immunohistochemistry method (IHC)with antibody E-cadherin. Result: Samples were 48 paraffin blocks, each group consisted of 24 blocks.There was a significant difference between the expression of E- cadherin with p<0.001 and Odds Ratio(RO) 87.4 (95% confidence interval 10.15 to 2653.26). There was also a significant correlation betweenreduced expression of E-cadherin with neck lymph node status (p<0.001), distant metastasis (p=0.001),and stage of disease (p=0.001). Conclusion: There was a significant difference between the expressionsof E-cadherin in NPC that had metastasized with the NPC that had not metastasized. Keywords: Nasopharyngeal carcinoma, E-cadherin expression, metastasis
Validity of narrow-band imaging (NBI) nasoendoscopy on nasopharyngeal carcinoma post therapy biopsy Yendri, Veby Novri; Herdini, Camelia; Heriwiyanto, Bambang
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (389.474 KB) | DOI: 10.19106/JMedScie/005004201812

Abstract

Nasopharyngeal carcinoma (NPC) is the most common malignancy found in the head and neck. It is a unique head and neck cancer due to its radiosensitivity. Therefore, radiotherapy becomes the main modality of therapy. Post-treatment evaluation of NPC is important to assess prognosis. Biopsy that is the gold standard for the evaluation can be performed with a narrow-band imaging (NBI) nasoendoscopy guide. This study aimed to determine the validity of NBI nasoendoscopic examination of NPC post-treatment biopsy. This study was a cross-sectional design for all post-treatment NPC patients who would undergo response assessment at the Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Sardjito General Hospital, Yogyakarta. A total 40 patients during May-June 2018 period who underwent examination sequentially. Biopsy examination was carried out with NBI nasoendoscopy guidance and the results of biopsy were performed histopathological examination. Forty patients showed the results of NBI nasoendoscopic validity on NPC biopsy after treatment included sensitivity (85.7%), specificity (87.8%), positive predictive value (60%), negative predictive value (96.6 %), positive trend ratio (7.07), negative trend ratio (0.16), and accuracy (87.5%). Postoperative NBI nasoendoscopy features appear homogeneous (75%) and inhomogenous (25%). In conclusion, NBI nasoendoscopic validity on postoperative NPC biopsy is good.
Metastasis Leher Tersembunyi pada Karsinoma Lidah T1-T2 Taufiqurrahman Taufiqurrahman; Camelia Herdini
Jurnal Kesehatan Andalas Vol 3, No 3 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i3.200

Abstract

AbstrakKarsinoma lidah memiliki kecenderungan yang tinggi untuk bermetastasis ke limfonodi leher, bahkan pada stadium awal (T1-T2). Tidak ada metode imaging atau pemeriksaan lain yang dapat mendeteksi metastasis leher tersembunyi. Ketebalan atau kedalaman invasi tumor adalah satu-satunya kriteria prediktor metastasis nodal pada karsinoma lidah dengan nilai cut offberkisar antara 3-9 mm. Diseksi Leher Selektif (DLE) level I-III "Diseksi Leher Supraomohioid" (DLSOH) telah direkomendasikan sebagai terapi utama karsinoma lidah stadium awal dengan klinis Node negatif (N0). Hanya pada sebagian kecil kasus yang mengalami metastasis ke level IV yang dikenal dengan “skip metastasis”,extended supraomohyoid neck dissectionlevelI-IV direkomendasikan oleh beberapa penulis. Diseksi leher bilateral harus dilakukan bila telah melibatkan struktur midline lidah.Kata kunci: karsinoma lidah, metastasis leher tersembunyi, diseksi leher supraomohioid AbstractCarcinoma of tongue has a high propensity for nodal metastasis in the neck, even in early stages (T1–T2). There is no method of imaging or other examination that will detect occult nodal metastasis. Tumor thickness or depth of invasion is the only size criterion predictor of nodal metastasis in carcinoma of tongue, the critical cut off values ranged from 3 to 9 mm. Selective dissection of levels I–III “supraomohyoid neck dissection” has been recommended as a primary treatment of neck disease in early carcinoma of tongue with clinically N0 neck. Most of the relatively small number of isolated metastasis to level IV are from primary tumours of the tongue, which are known as “skip metastasis”. Thus an extended supraomohyoid neck dissection of levels I–IV is recommended by some authors for elective treatment of the neck in carcinoma of tongue. Bilateral neck dissection should be performed in elective treatment of tumours involving midline structure.Keywords : carcinoma of tongue, occult nodal metastasis, supraomohyoid neck dissection
Peran Narrow Band-Imaging pada Karsinoma Nasofarings Priyanto Priyanto; Camelia Herdini
Jurnal Kesehatan Andalas Vol 4, No 1 (2015)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v4i1.242

Abstract

AbstrakKarsinoma nasofarings (KNF) merupakan keganasan yang paling sering ditemukan pada bagian kepala dan leher yang memerlukan kajian jelas dalam penegakkan diagnosis agar penatalaksanaan yang diberikan sesuai dan akurat. Salah satu kendala yang ditemukan pada KNF adalah diagnosis dini dan rekurensi. Narrow Band-Imaging adalah salah satu teknik pemeriksaan noninvasive dan mudah dilakukan, menggunakan teknik optikal terkini dan filter sinar biru dengan panjang gelombang tertentu, yang mampu meningkatkan sensitivitas pemeriksaan nasoendoskopi dengan pengamatan perubahan struktur vaskularisasi akibat pertumbuhan tumor terutama untuk KNF dengan sifat pertumbuhan endofitik. Pola-pola perubahan vaskularisasi yang ditimbulkan oleh KNF dapat diamati dengan jelas melalui pemeriksaan ini dan diharapkan juga mampu memberikan kepastian waktu bagi klinisi dalam menentukan saat yang tepat untuk melakukan tindakan lanjut yang lebih invasif seperti biopsi sehingga diperoleh hasil yang lebih akurat di saat yang tepat.Kata kunci: Narrow Band-Imaging, Karsinoma Nasofarings, Endoskopi AbstractNasopharyngeal carcinoma (NPC) is the most common cancer in the otolaryngology, head and neck region, that needs an accurate examination for the management. An obstacle in management of NPC is the early diagnosis of the disease and recurrency. Narrow-band imaging, is a non-invasive diagnostic technique, which uses optical technique and special long wave blue filter, that will increase the sensitivity of the nasoendoscopy in the diagnosis of NPC by observing the changes in vascularisation, especially in exophitic growth. This creates on better opportunity of clinician to do more invasive diagnostic testing at earlier stage of the cancer.Keywords:Narrow Band-Imaging, Nasopharyngeal carcinoma, Endoscopy
Diversity of Nonribosomal Peptide Synthetase Genes in the AnticancerProducing Actinomycetes Isolated from Marine Sediment in Indonesia Camelia Herdini; Shinta Hartanto; Sofia Mubarika; Bambang Hariwiyanto; Nastiti Wijayanti; Akira Hosoyama; Atsushi Yamazoe; Hideaki Nojiri; Jaka Widada
Indonesian Journal of Biotechnology Vol 20, No 1 (2015)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.873 KB) | DOI: 10.22146/ijbiotech.15266

Abstract

Marine actinomycetes is a group of bacteria that is highly potential in producing novel bioactivecompound. It has unique characteristics and is different from other terrestrial ones. Extreme environmentalcondition is suspected to lead marine actinomycetes produce different types of bioactive compoundfound previously. The aim of this study was to explore the presence and diversity of NRPS genes in 14anticancer-producing actinomycetes isolated from marine sediment in Indonesia. PCR amplificationand restriction fragment analysis of NRPS genes with HaeIII from 14 marine actinomycetes were doneto assess the diversity of NRPS genes. Genome mining of one species of marine actinomycetes (strainGMY01) also was employed towards this goal. The result showed that NRPS gene sequence diversity in 14marine actinomycetes could be divided into 4 groups based on NRPS gene restriction patterns. Analysisof 16S rRNA gene sequences of representatives from each group showed that all isolates belong to genusof Streptomyces. Genome mining result showed that strain GMY01 harboring 10 different NRPS geneclusters that encode secondary metabolites, as pure NRPS or hybrid between NRPS and other compounds.These results indicated that marine actinomycetes having a high potential to be developed as source ofanticancer drugs development.
Photodynamic Therapy As an Adjuvant Therapy for Local-Partial Remission of Nasopharyngeal Carcinoma After Standard Therapy in Sardjito Hospital Yogyakarta A Five-Year-Overall Survival Rate Analysis Study Bambang Hariwiyanto; Sagung Rai Indrasari; Camelia Herdini; Tan IB
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.62 KB)

Abstract

Background: The foremost problems of nasopharyngeal carcinoma (NPC) management are high loco-regional remission, local recurrence and spreading rate post therapy. Photodynamic therapy (PDT) has been done for treatment of tumors less than 1 cm in size and depth in a very difficult location, where radical excision by surgery was not possible. The aim of this study is determining 5-year-overall survival rate of local-partial remission of NPC after standard therapy followed by additional PDT.Method: The survival study is subjected to the 5 years-overall survival rate of local-partial remission. Photosensitizer (FoscanR) 0,15mg/kgBW was injected to NPC patients and followed by 20 joule/cm2, 642 wave length and 100 watts/cm2 irradiants non thermal laser illumination 96 hours after injection. The PDT result was confirmed with biopsy, CT scan, upper abdominal USG, thoracic radiograph and bone survey for 12 weeks after treatment. Follow up was done every 3 months in first year, continued every 6 months in the second year, and followed once a year. The sample collected from January 2005 to December 2010, and 33 cases met the inclusion and exclusion criterias, but only 20 cases were eligible inclusion criteria. The 5 years-overall survival was defined as the time from diagnosis to death from any cause or last follow up, calculated by Kaplan Meier survival analysis.Results: The 5-year-overall survival rate was 50%.Conclusion: PDT as an additional treatment for small local-partial remission in NPC post treatment is an alternative therapy to improve the treatment outcome and survival rate.Keywords: NPC, PDT, 5-year-survival rate ABSTRAK Photodynamic therapy sebagai terapi ajuvan karsinoma nasofaring remisi lokal-parsial setelah terapi standar di RSUP Dr. Sardjito Yogyakarta: Studi analisis angka kehidupan lima tahunLatar belakang: Problem utama terapi standar karsinoma nasofaring (KNF) adalah rendahnya angka keberhasilan terapi, terutama adanya remisi parsial, baik pada tumor primer maupun metastasis. Photodynamic therapy (PDT) telah digunakan untuk pengobatan tumor di superfisial, dengan diameter kurang dari 1 cm, terutama pada tumor yang letaknya tersembunyi dan sulit dioperasi secara radikal. Penelitian ini bertujuan menentukan angka kehidupan 5 tahun pada penderita KNF dengan remisi parsial pada tumorprimernya, setelah diterapi secara standar dan dilakukan PDT sebagai terapi tambahan.Metode: Studi analisis kesintasan terhadap kehidupan 5 tahun penderita KNF yang mengalami remisi lokal-parsial setelah terapi standar dan PDT. Photosensitizer (FoscanR) 0,15mg/kgBW diinjeksikan pada penderita KNF, dan setelah 96 jam, dilanjutkan dengan irradiants non thermal laser illumination sebesar 20 joule/cm2, panjang gelombang 642 dan 100 watts/cm2. Hasil PDT dikonfirmasi dengan biopsi, CT scan, USG abdomen, rontgen thoraks dan bone survey pada 12 minggu setelah terapi. Tahun pertama, dilakukan follow up setiap 3 bulan, di tahun kedua setiap 6 bulan, dan selanjutnya setiap setahun sekali. Sampel didapat dari Januari 2005 sampai Desember 2010, dimana 33 pasien KNF post PDT memenuhi kriteria inklusi dan eksklusi, namun hanya 20 pasien yang memenuhi kriteria inklusi 5-tahun-follow up. Angka kehidupan 5 tahun ditentukan berdasarkan saat diagnosis sampai kematian penderita, atau sampai folllow up terakhir, dihitung dengan analisis kesintasan Kaplan Meier.Hasil: Angka kehidupan keseluruhan selama 5 tahun adalah 50%.Simpulan: PDT sebagai tambahan terapi terhadap KNF yang
Sinonasal or nasopharyngeal undifferentiated Carcinoma?: diagnostic pitfall and the role of Epstein-Barrvirus (EBV) and human papillomavirus(HPV) examination Wahyu Tri Widayati; Ery Kus Dwianingsih; Bustanul Ardianto; Didik Setyo Heriyanto; Sagung Rai Indrasari; Camelia Herdini; . Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 2 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1173.032 KB) | DOI: 10.19106/JMedSci005202202008

Abstract

Undifferentiated carcinoma of the head and neck is frequently observed in nasopharynx, however it may also occur in oropharynx, salivary gland and sinonasal. Overlapping lesions in those regionscreate difficulty in determining the origin of the tumor. Thus, it causes diagnostic pitfall not only for pathologists, but also for clinicians. A 40 yearold man, presented with nasal obstruction, epistaxis, diplopia, and headache for a yearand showed nasal cavitysinistra and nasopharynx masses on CT-scan. Lymph node enlargement was not detected. First biopsywas performed and histopathologically diagnosed as nasopharyngeal undifferentiated carcinoma(NPC), extended into nasal cavity. Chemo-radiation protocol for NPC was conducted, and showing uncomplete response. Second biopsy was done, and reviewed with the first biopsy result. Thetumourwas arranged insolid, syncytial and trabecular pattern, with vesicular nuclei, prominent nucleoli, and lack of lymphoplasmacytic infiltrat. Immunohistochemistry (IHC) analysis of p16, EBNA1 and LMP1 were negative. PCR analysis of HPV-18 was positive, while EBV detection showed negative result. General association of EBV with NPC suggests that the presence of latent EBV infection can serve as a positive marker for NPC. Therefore, in this case, the EBV negativity and strong HPV association led to diagnosis of SNUC. The distinction of sinonasal undifferentiated carcinoma (SNUC) or from NPC was important for appropriate management and therapy.
The role of thyroid stimulating hormone level as a predictive factor for advance stage thyroid carcinoma Bambang Udji Djoko Rianto; Anton Sony Wibowo; Camelia Herdini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 4 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.249 KB) | DOI: 10.19106/JMedSci005104201908

Abstract

Thyroid stimulating hormone (TSH) is a cancer growth stimulus factor that have effect on the progression of thyroid carcinoma, common neck head malignancy. This hormonelevel has diagnostic value and can assist in the diagnosis, staging and management of the thyroid carcinoma.This study aimed to investigatethe role of TSH level as a predictor of advance stage thyroid carcinoma. This was case-control study involvingthyroid enlargement subjects who underwent thyroidectomy at Dr. Sardjito General Hospital, Yogyakartafrom 2015 to 2017. Cancer staging examination using AJCC 2102and TSH levels examination were conducted before underwent thyroidectomy.The inclusion criteria for case group were advanced stage(stage III and IV), while for control group wereearly-stage of thyroid carcinoma (stage I and II). The exclusion criteria for both case and control groups were 1) suffering from thyroid hormone disorders requiring therapy before thyroidectomy, 2) receiving thyroid suppression therapy prior to thyroidectomy. Sixty-six post thyroidectomy patients were involved in this study. The patients were divided into case and control groups consisted of 33 patients in each group. Based on receiver operating characteristic curve, the cut of point 1.27 mIU/L for TSH was obtained with sensitivity of 72.7% and specificity of 78.8%. There was statistically significant difference TSH levelsbetween early stage thyroid carcinoma and late stage thyroid carcinoma(p = 0.001;OR: 9.9;95% CI: 3.19-30.15).It can be concluded that TSHlevels ≥ 1.27mIU/L as predictor of advance stage thyroid carcinoma.
SECONDARY BIOACTIVE METABOLITE GENE CLUSTERS IDENTIFICATION OF ANTICANDIDA-PRODUCING Streptomyces Sp. GMR22 ISOLATED FROM WANAGAMA FOREST AS REVEALED BY GENOME MINING APPROACH Camelia Herdini; Sofia Mubarika; Bambang Hariwiyanto; Nastiti Wijayanti; Akira Hosoyama; Atsushi Yamazoe; Hideaki Nojiri; Jaka Widada
Indonesian Journal of Pharmacy Vol 28 No 1, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1110.637 KB) | DOI: 10.14499/indonesianjpharm28iss1pp26

Abstract

Streptomyces are a group of Gram-positive bacteria belonging to the Actinobacteria class, which are among the most important bacteria for producing secondary bioactive metabolites such as antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key methodology for novel compound discovery. Recently, we have isolated the Streptomyces sp. GMR22 from Cajuput rhizospheric soil at Wanagama Forest, Indonesia. GMR22 produced secondary metabolite that inhibited Candida albicans with IC50 of 62,5 μg/mL. The objective of this work was to reveal the novel secondary metabolites from GMR22 by genome mining approach. The antiSMASH 3.0 was used to predict gene clusters that encode the biosynthetic pathways of secondary metabolites in the genome of GMR22, and their core chemical structures. The pylogenomic analysis showed that GMR22 was closely related to Streptomyces bingchenggensis BCW1, as well as to the large genome size (9.5-12.7Mbp) groups of Streptomyces. AntiSMASH 3.0 analysis revealed that the genome of Streptomyces sp. GMR22 harbored at least 63 gene clusters that encode the biosynthetic pathways of secondary metabolites. It was the highest number of gene clusters had been observed among the members of Streptomyces groups, with PKS was predicted as the major groups of the identified gene cluster products. The results suggested that GMR22 could be a strong potential candidate of secondary bioactive metabolites source.
Uji serologi IgA karakter KNF EBNA1+VCA p-18 pada penderita keluhan kronis kepala leher Camelia Herdini; Susanna Hutajulu; Sagung Rai Indrasari; Bambang Hariwiyanto; Jajah Fachiro; Sofia Mubarika; Jaap Middeldorp
Oto Rhino Laryngologica Indonesiana Vol 41, No 2 (2011): Volume 41, No. 2 July - December 2011
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.826 KB) | DOI: 10.32637/orli.v41i2.46

Abstract

Background: Nasopharyngeal carcinoma (NPC), especially the WHO type III, is correlated almost100% with Epstein Barr Virus (EBV) infection. This is indicated by high IgG and IgA antibody responsesagainst viral capsid antigen (VCA), early antigen (EA) and Epstein Barr Nuclear antigen (EBNA).Increased IgA NPC character antibodies may be detected 2-10 years before the presence of the tumor. Thisoccurs as a result of reactivation of EBV infection. Purpose: To find out the level of IgA NPC characterantibodies (EBNA1+VCA p-18) in patients with chronic symptoms in the head and neck and to determine whether the level of IgA can be used as an early sign of NPC. Methods: Observational analytic study on 218 patients with chronic symptoms in the head and neck. The research was conducted from July 2006to September 2010. ELISA technique was used as serology test for IgA (EBNA1+VCA p-18). Result: Samples were 90 males and 128 females. High level of IgA by ELISA was found in 28 males (31.1%) and 45 females (35.2%). The IgA level tended to increase with age. The most common chronic symptoms inthe head and neck were chronic rhinitis (15.6%) and nasal obstruction (7.8%). From all patients who hadhigh level of IgA, 3 patients (4.1%) were found positive of early stage NPC. Conclusion: More than 33%of patients with chronic symptoms of head and neck had high level of IgA NPC character. This methodcan be used as an early detection of NPC. Keywords: serology test in NPC, EBNA1, VCA p-18, NPC symptoms in head and neck Abstrak :  Latar belakang: Karsinoma nasofaring (KNF) terutama tipe WHO III berkorelasi hampir 100%dengan infeksi Epstein Barr Virus (EBV). Hal ini ditunjukkan dengan tingginya respons antibodi IgGdan IgA terhadap viral capsid antigen (VCA), early antigen (EA) EBV serta antibodi Epstein BarrNuclear Antigen (EBNA). Kenaikan antibodi IgA dengan karakter KNF dapat terjadi 2-10 tahun sebelumterjadinya tumor. Hal ini terjadi sebagai akibat adanya reaktivasi infeksi EBV. Tujuan: Mengetahui kadarIgA karakter KNF (EBNA1+VCA p-18) pada penderita dengan gejala kronis di daerah kepala dan leherdan mengetahui apakah kadar IgA dapat digunakan sebagai tanda awal terjadinya KNF. Metode: Suatukajian analitik observasional terhadap 218 penderita dengan gejala kronis di daerah kepala dan leher.Penelitian ini dilakukan Juli 2006 sampai dengan September 2010. Pemeriksaan serologi IgA (EBNA1+VCA-p18)dilakukan denganteknik ELISA.Hasil:Terdapat90penderita laki-lakidan128 penderitaperempuan.HasiltesserologiIgAELISAdengankadartinggiditemukanpada28laki-laki(31,1%)dan45perempuan (35,2%). Kadar IgA cenderung meningkat pada peningkatan usia. Gejala kronis yangterbanyak dikeluhkan penderita adalah rinitis kronis, yaitu sebanyak 34 penderita (15,6%), diikuti denganobstruksi hidung sebanyak 17 penderita (7,8%). Pemeriksaan klinis lebih lanjut dari penderita yangmempunyai kadar IgA tinggi menunjukkan bahwa 3 penderita (4,1%) positif terkena kanker nasofaringstadium awal. __ Lebih dari 33% penderita dengan gejala kronis di daerah kepala dan lehermemiliki kadar IgA karakter KNF yang tinggi. Kadar IgA karakter KNF yang tinggi dapat digunakansebagai penanda awal kejadian KNF. Kata kunci: uji serologi KNF,EBNA1, VCA p-18, gejala KNF
Co-Authors Akira Hosoyama Akira Hosoyama Alamanda, Monik Anak Agung Istri Sri Wiadnyani Anton Sony Wibowo Asti Widuri, Asti Atsushi Yamazoe Atsushi Yamazoe Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Hariwiyanto Bambang Udji Djoko Rianto Bustanul Ardianto Daniswara, Deoni Danu Yudistira Didik Setyo Heriyanto Ery Kus Dwianingsih Fles, Renske Harijadi Harijadi Heriwiyanto, Bambang Hideaki Nojiri Hideaki Nojiri Ika Fidianingsih Inawati Bobot Indrasari, SR Irianiwati Widodo Jaap Middeldorp Jajah Fachiro JAKA WIDADA Kenny Kenny Mary, Cynthia Nastiti Wijayanti Nastiti Wijayanti Rizka Fakhriani Rosmawati, Ima Dewi Sagung Rai Indrasari Sagung Rai Indrasari Sagung Rai Indrasari Sagung Rai Indrasari Shinta Hartanto Sofia Mubarika Haryana Susanna Hutajulu Tan IB Tan, I. Bing Taufiqurrahman Taufiqurrahman Taufiqurrahman Taufiqurrahman Wahyu Tri Widayati Wirata, I Komang Praba Edi Yendri, Veby Novri