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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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The relationship between sirtuin 1 (SIRT1) expression and tumor size, Proliferating Cell Nuclear Antigen (PCNA) expression and histological grading in rat breast carcinoma induced by dimethylbenz()anthracene (DMBA) Harjadi, Irianiwati, Sitarina Widyarini, Novrita Padauleng Dewajani Purnomosari, Sri Herwiyanti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 04 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2060.833 KB) | DOI: 10.19106/JMedScie004504201301

Abstract

Controversy regarding the role of SIRT1 in pathology of cancers exists and is still under debate.SIRT1 could act as either a tumor supressor or tumor promotor. This study was conducted toevaluate the relationship between SIRT1 expression and tumor size, Proliferating Cell NuclearAntigen (PCNA) expression and histological grading in rat breast carcinoma induced bydimethylbenz(á)anthracene (DMBA). Thirty female Sprague Dawley rats were randomly allocatedinto three groups with 10 rats in each group. Group 1 as negative control was just fed thestandard food. Group 2 as vehicle control was fed the standard food and corn oil. Group 3 asinduction group was fed the standard food and induced with DMBA at dose of 20 mg/kg bodyweight (BW) in corn oil twice a week for five weeks. All rats were palpated weekly to determinethe appearance, size and location of tumors. Sixteen weeks after DMBA induction rats weresacrified and histological preparations of the breast carcinoma tissue were then processed forSIRT1 and PCNA expression examination as well as histological grading. The result showed thatSIRT1 expression was significantly higher in breast carcinoma tissue compared to normal gland(26.12 vs 0.05; p = 0.004). SIRT1-positive was observed mostly in poor histological gradecarcinomas (56.2%), and it was not observed in good histological grade carcinomas. However,there was no significantly difference between SIRT1 and histological grading (p = 0.097; r =0.285). A significant correlation between SIRT1 expression and the tumor size (p =0.009; r=0.877), as well as PCNA expression (p =0.000; r =0.790) was observed. In conclusion, thereis relationship between SIRT1 expression and tumor size as well as PCNA expression in rat breastcarcinoma induced by DMBA.
The effect of active compound isolated from the leaves of kembang bulan [Tithonia diversifolia (Hemsley) A. Gray] on cell cycle and angiogenesis of WiDr cell line Indwiani Astuti, Hajid Rahmadianto Mardihusodo Mae Sri Hartati Wahyuningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 03 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Colorectal cancer is the tenth most common form of malignant tumor of hospital inpatients inIndonesia. Advance approaches in anticancer development is discovery molecular-targeted drugs.Molecular targets for anticancer drug have been identified including genes associated with cellcycle control and angiogenesis. Previously, an active and selective compound against WiDr fromTithonia diversifolia (Hemsley) A. has been isolated. The aim of this study was to evaluate theeffect of the isolated active compound fromT. diversifolia on the WiDr cell cycle and angiogenesis.Isolation of the active compound was performed by preparative thin layer chromatography (TLC)method. WiDr cell cycle was analyzed by flowcytometry using propidium iodide (PI).Antiangiogenesis effect was evaluated by immunocytochemistry method using anti-human VEGFmonoclonal antibody. The results showed that the effect of the isolated active compound onthe WiDr cell cycle depended on the concentration and the incubation time periods. Atconcentration of 4 μg/mL, it inhibited the WiDr cell cycle SubG1 phase after 36 and 48 hoursincubation and G1 phase after 72 hours incubation. While at concentration of 8 μg/mL, it clearlyinhibited the WiDr cell cycle G1 phase after 36, 48 and 72 hours incubation. Furthermore, theisolated active compound at concentration of 4 μg/mL significantly inhibited the VEGF expressionuntil 47.38% compared to control. In conclusion, the isolated active compound fromT. diversifoliainhibited cell cycle and angiogenesis of WiDr cell.
Cost-effectiveness comparison between caudal block and intravenous ketorolac as an early post-operative analgesic in pediatric patients underwent surgery below umbilicus segment Djayanti Sari, Juni Kurniawaty Muhdar Abubakar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 01 (2014)
Publisher : Universitas Gadjah Mada

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Abstract

Post-operative pain treatment in pediatric is frequently inadequate that could lead to psychological,physiological and behavioral changes. Therefore, adequate pediatric pain management is needed.Some analgesics such as ketorolac and regional anesthesia techniques such as caudal blockhave been applied to relieve pain. Ketorolac and caudal block have its own advantages anddisadvantages. The aim of study was to compare the cost-effectiveness of ketorolac and caudalblok as a post-operative analgesic in pediatric. This was double blind randomized controlledclinical trial with parallel design conducted in Dr. Sardjito General Hospital. The subjects werechildren who underwent surgery below umbilicus segment. Seventy patients were randomlydivided into two groups with 35 patients in each group. Group I (Caudal block Group) was givencaudal block with bupivacaine 0.12% 1 mL/kg body weight (BW) whereas Group II (KetorolacGroup) was given ketorolac 0.5 mg/kg BW intravenously (IV). The patient’s pain was scored at 0,15, 30, 45 minute and 1, 2, 3 hours after the conscious patients using modified Children’sHospital of Eastern Ontario Pain Scale (mCHEOPS). Furthermore, the cost-effectiveness theboth interventions was also compared. The caudal block was more effective in reducing painthan the ketorolac at minutes 0 (27/8 vs 10/25) and 15 (34/1 vs 18/17) (p<0.05). However, atthird hour the ketorolac revealed more effective than the caudal block (29/6 vs 32/3) (p<0.05).The cost of the caudal block was higher than the ketorolac (IDR 95.860 ± 5.745 vs IDR 7.200± 14.886) (p <0.05). However, the length of stay after the caudal block was shorter than theketorolac (40.43 ± 13.899 vs 48.57 ± 14.068) (p <0.05). Morphine was more needed forrescue analgesic in the ketorolac (p < 0.05) in first hour of operation, whereas after three houroperation paracetamol was more needed in caudal block (p < 0.05). In conclusion, the caudalblock is not more cost-effective than ketorolac in reducing post-operative pain in pediatricpatients underwent surgery below umbilicus segment.
The leucocytes, neutrophils and superoxydes dismutase (SOD) level after consuming guava juice (Psidium guajava L) during aerobic exercise for beginners Zaenal Muttaqien Sofro, Yuliana Noor Setiawati Ulvie Wiryatun Lestariana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 02 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (812.253 KB) | DOI: 10.19106/JMedScie004602201401

Abstract

Physical exercise is important in preventing and adjunctive therapy certain diseases. However,over physical exercise for beginners may cause oxidative stress and muscle injury leads to generatechemoattractants whic enables to attract neutrophil and monocyte towards the injury and stimulatesleucocytes activation. The use of antioxidant-rich fruits to mitigate exercise induced oxidative stresshas been applied. This study was conducted to evaluate the effect of guava juice (Psidium guajavaL) consumption during aerobic exercise on leucocytes, neutrophils and superoxydes dismutase(SOD) level of beginners. Sixteen students of National Land College (Sekolah Tinggi PertanahanNasional/STPN), Yogyakarta who met the inclusion and exclusion criteria were involved in thisstudy. Subjects were divided into two groups i.e. a group given mineral water as control andanother group given 240 mL guava juice 0.67 g/mL daily for 27 days as treatment group. Bothgroups then underwent aerobic exercise for 30 minutes every day for 27 days. Blood samples weretaken before and after exercise on day 1, 7 and 14 for leucocyte and nutrophil count as well as SODanalysis. The leucocyte count and SOD level before and after exercise in both Guava juice andMineral water groups were not significantly different (p>0.05). However, the percentage of neutrophilon day 1 and 7 were significantly higher than that in Mineral water group (p<0.05). Moreover,during the exercise, the percentage of neutrophils in Guava juice group significantly increased(p<0.05), whereas in Mineral water group was not significantly different (p>0.05). It can beconcluded that consuming guava juice during exercise for the beginners does not influence leucocytecount and SOD levels. However, it can increase percentage of neutrophil.
Structural evaluation and animal implantation of porous eggshell wastederived hydroxyapatite graft as bone substitution Rahadyan Magetsari, Yudha Mathan Sakti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 04 (2013)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2484.881 KB) | DOI: 10.19106/JMedScie004504201304

Abstract

The development of hydroxyapatite graft with high economically value is needed for orthopedic practice in developing countries. Eggsell waste is well known as natural substance for calcium resource. It has been used as raw material in producing hydroxyapatite. This study was conducted to synthesize porous hydroxyapatite from eggshell waste and evaluate its activity as bone substitution. The porous hydroxyapatite graft was manufactured from eggshell and sugar as a raw material using hydrothermal process. The porous eggshell waste-derived hydroxyapatite (EW-HAP) graft was characterized using X ray difractometer (XRD) and analytical scanning electron microscope (SEM) and compared with commercial hydroxyapatite (HAP) JCPDS 09-432 graft (Bangros®) as standard. The porous EW-HAP graft obtained was then implanted on critically sized femoral defects surgically created in the right thigh of male Wistar rats (Rattus norvegicus) with Bangros® as control. Radiological examination using XRD and histological examination using hematoxyline-and-eosin staining of the bone femour were performed at 28 days after implantation. The results showed that the XRD pattern for EW-HAP was likely similar with the HAP standard. However, the SEM examination showed that the pasticle size of EW-HAP graft (2.5-3 μm) was higher than those HAP standard graft (1.5-2 μm). Radiographs according to the International of Limb Salvage (ISOLS) radiological evaluation system between EW-HAP graft (6.1 ± 1.45) and HAP control graft (6.9 ± 2.10) was not significantly different (p>0.05). Moreover, histological examination according to Lane and Shandu scoring system between the both graft (4.0 ± 0.94 versus 4.4 ± 0.92) was also not significantly different (p>0.05). It can be concluded that the structure EW-HAP graft is similar with HAP graft standard. The both grafts have also equal outcome as bone substitution.
Comparison of the effectiveness between 2% and 4% nicotinamide gel in reducing melanin index Lisa Murtisari, Lisa Murtisari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 03 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Nicotinamide is a safe agent inhibiting melanosome transfer in vitro therefore it can reduce skin pigmentation. Two percent nicotinamide cream combined with sunscreen as a lightening agent in-creases skin lightness in vivo. Measurement of skin colour changes can be performed by mexameter to measure melanin index (MI).Objective: This study was aimed to compare the effectiveness of 2% and 4% nicotinamide gel as a lightening agent in reducing MI.Materials and Methods: This study was a double blind, randomized controlled trial involving 54 subjects. Two percent or 4% nicotinamide gel was applied on extensor right or left lower arm in each subject. MI was measured at week 0 and the end of week 1, 3, 5 and 7. MI in the evaluation weeks was compared to MI at week 0 in the 2% and 4% nicotinamide gel groups and was analyzed using paired-t test. MI decrease in the evaluation weeks between 2% and 4% nicotinamide gel groups were analyzed using independent t test. All statistical tests used a 5% and CI 95%.Result: Statistical analysis in the 2% nicotinamide gel group showed significant decrease in MI until week 7. However, in the 4% nicotinamide gel group there were significant MI decrease in the week 5 and 7. Statistical analysis showed significant decreased MI between 2% and 4% nicotinamide gel groups at week 1, 3, 5, 7.Conclusion: It was concluded that 4% nicotinamide gel had higher effectiveness compared to 2% in reducing MI as lightening agent.Key words: nicotinamide gel, melanin index, skin colour, lightening agent
Plagiator: Zombi dalam Ilmu Pengetahuan Anonim, Anonim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 01 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

KataKunci: Palagiator
Pengaruh Gangguan "Circadian" Terhadap Struktur Histologik Testis dan Ovarium Tikus Putih (Rattus norvegicus) Daryanto, Daryanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 20, No 03 (1988)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The effect of the total solar eclipse on the testicular and ovarian tissues of the albino rats has been investigated.Thirty adult male and female albino rats, Lembaga Makanan Rakyat (LMR) strain, were used in this investigation, and consisting of 15 male and 15 female albino rats and divided into three main groups.The first group, consisting of 5 male and 5 female albino rats were used as control group and to be decapitated one hour before the total solar eclipse occurred. The second group, consisting of 5 male and 5 female albino rats were used as a treatment group, which experienced a total solar eclipse and to be decapitated exactly when the eclipse finished. The third group consisting of 5 male and 5 female albino rats were used as a second control group, and to be decapitated one hour after the total solar eclipse finished.The results of this investigation revealed that there is no significant differences in the structure and function of testicular tissues as well as of ovarian tissues of the albino rats.Key Words: circadian rhythm - total solar eclipse - testis - ovarium - photoperiodicity
The occurence of complication in post punctured vasectomy vs standard method Ishandono Dachlan, Ishandono Dachlan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 04 (1999)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Punctured Technique of Vasectomy is a simple and refined method of vasectomy. This method was introduced to make fewer complications and to remove the fear of surgical knife.Objective: This study was aimed to assess the ease of procedure, safety, and effectiveness of Punctured Technique of Vasectomy.Methods: A prospective study of 80 acceptors has been done at Dr. Sardjito Hospital Yogyakarta from January 1991 up to Jury 1991. These subjects were randomly distributed into two groups, Punctured Method (39) and Standard Method (41). Duration of operation and complication done during operation was recorded. The follow up for complication was recorded in the second week post-operative, and sperm analyses was done in the tenth week post-operative.Results: Duration of Punctured Method (9,7179 ± 2,9731 minutes) was significantly different (p-value =0,0006) compared to that of Standard Method (12,1951 ± 3,2421 minutes). There were two complications during Punctured Method operation compared to six complications during Standard Method operation (RR =1,54; 95%Cl: 0,97 - 2,46). In the second post-operative week, there was no complication in the Punctured Method group, while there was one wound infection in the Standard Method group. Sperm analysis both groups showed no active spermatozoon.Conclusion: Punctured Method is easier than Standard Method, and there was no difference of effectiveness in both methods.Key words: punctured vasectomy - complications - sperm - analysis
Beberapa masalah penanganan klinikososial kanker ginekologis R. Soeprono, R. Soeprono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 9, No 01 (1977)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

keywords: kanker ginekologis, terapi, diagnosa awal.

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