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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 213   214   215   216   217 
Papulopustular demodicosis: a case report Mariyani, Sri; Etnawati, Kristiana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202309

Abstract

Primary demodicosis is an infestation of Demodex colonization >5 mites/cm2 without pre-existing or concomitant inflammatory skin disease. Primary demodicosis is divided into 3 variants i.e. spinulata, papulopustular and nodulocystic. Several topical and systemic agents are used in the Demodex facial treatment. A 22 y.o. man complained of acne on his face three months ago. On physical examination, there were pustules, multiple erythematous papules, ice pick atrophic scars, and box and rolling scars. KOH examination found the Demodex number > 5 mites/cm2. No spores were found. The patient received oral and topical metronidazole therapy. Papulopustular demodicosis is a follicular inflammation caused by Demodex mites. The inflammatory stage shows a predilection for the perioral, periorbital, and periauricular regions. According to the pattern of morphology and localization of the centrofacial area, some cases of demodicosis are often referred to as Rosacea-like (rosaceiform) demodicosis. The treatment goals are to reduce the overall number of mites and treat the underlying condition. This paper reports a case of papulopustular demodicosis of the face. The diagnosis was made by history taking and physical examination using the diagnostic criteria for demodicosis. Clinical improvement was obtained after oral and topical metronidazole therapy for two weeks.
Turnaround time for the provision of packed red cells (PRC) and factors affecting their achievements in the Blood Transfusion Unit of Dr. Sardjito General Hospital, Yogyakarta Kaslam, Surawijaya Bakhtiar; Sukorini, Usi; Triyono, Teguh
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202304

Abstract

Turnaround time (TAT) is defined as the time it takes since request/sample is received at the blood bank until blood is cross-matched/reserved and available for transfusion. Turnround time prolongation affects patient care and satisfaction. This study aimed to evaluate TAT for the provision of packed red cells (PRC) at the Blood Transfusion Unit of Dr. Sardjito General Hospital, Yogyakarta, analyze factors affected in TAT prolongation, and provide solution the prolongation.  It was an analytical descriptive study with a qualitative design, by calculating the time since receipt of the PRC request at the Blood Transfusion Unit or since blood collection from donors until data input of the crossmatch results in Dr. Sardjito General Hospital management information system (SIMETRIS) completed. Moreover, the  delay in the provision of PRC at the Blood Transfusion Unit was also analyzed. There were 3 (1.5%) of 200 ER samples that met TAT for the provision of the PRC, which was 30 min after receipt of the request at the Blood Transfusion Unit in cito conditions. There were 20 (10%) of 200 samples from the wards that met TAT for the provision of the PRC, which was 2 h after receipt of the request at the Blood Transfusion Unit if the blood stock was available. There were 55 (27.5%) of 200 samples from the wards that met TAT for the provision of the PRC, which was 4 h after the blood was collected from the donor. TAT for the provision of the PRC at the Blood Transfusion for the available blood stock group was 179.08 (67.2 – 396.27) min, replacement blood donor group was 485.38 (126.43 – 910.68) min, and cito group was 121.29 (27.68 – 421.38) min. In conclusion, there is TAT prolongation of PRC provision at the Blood Transfusion Unit of Dr. Sardjito General Hospital.
Effect of Surya Namaskar yoga practice on flexibility in the pre-elderly and elderly Karasugi, Ni Made Ayu Regina; Lilis, Lilis; Amita, Angela Shinta Dewi; Novi Handayani, Maria Dara; Prastowo, Nawanto Agung
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202304

Abstract

Anatomical and physiological changes occur along with the aging process. One of the changes is decreased flexibility due to changes in the musculoskeletal system. Upper and lower limb flexibility is closely related to the ability to carry out daily activities, which affects the quality of life of the elderly. Surya  Namaskar yoga is known to help increase flexibility because it integrates stretching components within its movement. This study aimed to investigate the effect of Surya  Namaskar on flexibility in the pre-elderly and elderly. It was is quasi-experimental study with a pre-experimental one-group pretest-posttest research design. A total of 20 participants were selected using consecutive sampling according to the inclusion criteria. Flexibility measurements of the upper and lower limbs were carried out before and after the intervention using the back scratch test and chair sit and reach test methods. Surya  Namaskar intervention was carried out for 8 wk. Data were analyzed using the Shapiro-Wilk normality test, paired t-test, and Wilcoxon test. The results showed that there was a highly significant difference between the mean value of the back-scratch test (for upper limb flexibility) before and after the intervention (p<0.001). Significant differences were also found in the mean values of chair-sit-and-reach test measurements (for lower extremity flexibility) before and after the intervention (p<0.001). In conclusion, Surya  Namaskar exercises can improve the flexibility of the upper and lower extremities in the pre-elderly and elderly. 
Health measurement profile of older adults in Sleman District, Yogyakarta: its correlation with low-grade chronic inflammation in hypertension Adyarini, Dwita Dyah; Rohmah, Siti Nur Rohmah; Sattwika, Prenali Dwisthi; Handayaningsih, Anastasia Evi; Probosuseno, Probosuseno; Sinorita, Hemi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202307

Abstract

The older adult often experiences a low-grade chronic inflammation that commonly manifests in various conditions without infection, including hypertension. The serum neutrophil-to-lymphocyte ratio (NLR) and hyperuricemia are important markers for various diseases including hypertension. Older adult accounts for 17.33% of the total population of Yogyakarta Special Province, which is the highest compared to other provinces. The study aimed to evaluate the relationship between NLR and hyperuricemia with hypertension among adult patients in Sleman District, Yogyakarta, Indonesia. It was a community-based cross-sectional nested study involving 90 older adults aged ≥70 y.o. living around of the Sleman Health and Demographic Surveillance System (HDSS). Data of demographic and health characteristics of the subjects were collected. Independent t test, and Mann Whitney test were used to analyze mean differences between normotensive and hypertensive groups.  Multivariate analysis with logistic regression was used to analyze correlation between all variables. The results showed 59 respondents (65%) suffered from hypertension and 31 (35%) respondents had normal and pre-hypertension. No significantly different in almost of the subject characteristics between the normotensive and the hypertensive groups was observed (p>0.05). However, significantly different between the normotensive group and the hypertensive group was observed in the history of hypertension, blood pressure/BP, mean arterial pressure/MAP, abdominal circumstance/AC, fasting blood glucose/FBG, triglyceride, and hemoglobin (p<0.05). No significantly different in the NLR and HsCRP levels of the normotensive group compared to the hypertensive groups were observed (p>0.05). However, the uric acid level of the hypertensive group [5.6 (2.9-9.4 mg/dL)] was significantly higher than that the normotensive group [4.7 (2.9-8.0 mg/dL)] (p=0.042), although it was no significantly relationship with hypertension (p>0.05). In conclusion, there is no relationship between NLR, HsCRP and uric acid with hypertension among middle old and oldest old in Sleman District.
Topical anti-aging agents: state-of-the-art review Prakoeswa, Flora Ramona Sigit; Maharani, Faradiba; Satria, Yohanes Aditya Adhi; Awanis, Ghina Shabrina; Febrianty, Astrida Fesky
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202310

Abstract

Skin aging can be divided into intrinsic and extrinsic aging. Even though it is inevitable, symptoms of skin aging are a common concern for patients. As a result, there is a surge in the making of anti-aging cosmeceuticals. However, there is a lack of evidence-based data to support the usage of topical preparations as anti-aging treatments. Therefore, further studies are needed to explore topical treatment options for skin aging. This literature review discusses the mechanism of commonly used topical anti-aging agents and their adverse reactions.
Protective effect of Moringa oleifera leaves extract on cardiac fibrosis of streptozotocin-induced diabetic rats Salsabila, Zadia Maheswari; Suryono, .; Pralampita, Pulong Wijang
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202303

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia that induces excessive reactive oxygen species (ROS) production and  causes oxidative stress. Diabetic cardiomyopathy is a diabetic complication characterized by structural and functional changes of the myocardium. Fibrosis is one of the pathological features of diabetic cardiomyopathy. Moringa oleifera leaves have been reported to possess antidiabetic and antioxidant activities which could prevent diabetic complications such as cardiomyopathy. A previous study reported that M. oleifera leaves extract have protective effects to the kidneys and liver of rats exposed to oxidative stress. This study aimed to investigate the protective effect of the M. oleifera leaves extract on cardiac fibrosis of rats induced by streptozotocin (STZ).  This was an experimental study using a posttest-only control group design. Thirty-three male Wistar rats were randomly divided into three groups i.e. normal control  group (Group 1) were administered normal saline, diabetic control group (Group 2) were administered normal saline, and diabetic treatment group (Group 3) were administered M. oleifera leaves extract. Diabetes induction of rats was conducted by intraperitoneally injection of STZ at dose of 45 mg/kg BW. The M. oleifera leaves extract at a dose of 1000 mg/kg BW was administered orally one time a day for 28 days. Statistical analysis was performed using the Kruskal-Wallis test followed by Mann Whitney. A significant difference in cardiac fibrosis occurrence between three groups was observed (p < 0.05). No cardiac fibrosis was observed in normal control group, meanwhile cardiac fibrosis was observed in all rats (9 rats) of the diabetic control group (G2). Only 2 rats in the treatment group (G3) had cardiac fibrosis. In conclusion, M. oleifera leaves extract can inhibit cardiac fibrosis in STZ-induced diabetic rats.
The correlation between stress level and eating disorder syndrome in preclinical medical students at Faculty of Medicine and Veterinary Medicine, University of Nusa Cendana, Kupang, East Nusa Tenggara Djema, Marceline Consolatrix Cheyene; Sagita, Sidarta; Woda, Rahel Rara; Legoh, Dickson
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202305

Abstract

Nowdays with various kinds of needs and demands in life that must be met at any time can cause stress of someone. Medical students are often experience high level of stress due to the demands of high education standards requirements. Continous chronic stress can affect eating behaviour lead to the potential cause of eating disorder syndrome (EDS). This study aimed to evaluate the correlation between stress level and EDS in preclinical medical students of Nusa Cendana University, Kupang, East Nusa Tenggara. It was an analytic observational with a cross sectional design conducting on the preclinical medical students by filling out depression anxiety stress Scale (DASS-42) and eating attitude test (EAT-26) questionnaires. Respondents were selected by the probability sampling method with a stratifies random sampling technique. A total 141 respondents who met the inclusion and exclusion criteria were recruited. Bivariate analysis by using the Wilcoxon Theta correlation test was performed. Among respondents involved in this study, 13 (9.2%) respondents did not experience stress and 128 (90.8%) experienced stress including 43 (30.5%) mild stress, 68 (48.3%) moderate stress, and 17 (12.3%) severe stress. The EDS was observed in 15 (10.6%) respondents. A significant moderate correlation between stress level and EDS was indicated (θ = 0.58). In conclusion, there is correlation between stress level and EDS on preclinical medical students of Nusa Cendana University, Kupang.
High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections Hayati, Hanifah Fajarisna; Satiti, Sekar; Paryono, Paryono; Intansari, Umi; Sutarni, Sri; Subagya, Subagya; Indarwati, Indarwati; Setyopranoto, Ismail
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202306

Abstract

Central nervous system (CNS) infections such as encephalitis, meningitis, or myelitis have high morbidity and mortality in Indonesia. High sensitivity C-reactive protein (hs-CRP) is a sensitive marker of acute inflammation, while albumin is the most abundant protein component in plasma and cerebrospinal fluid (CSS). Infection triggers an inflammatory response so that an increase in the hs-CRP/albumin ratio (CAR) can be a predictor of worsening clinical outcome in patients with CNS infections. However, studies examining the predictor value of serum and CSF CAR on worsening clinical outcomes of patients are limited, particularly in CNS infections. The purpose of this study was to prove the CAR as a predictor of worsening clinical outcome in patients with CNS infections.  It was an observational study using a prospective cohort design. Fifty subjects recruited until October 2021 at Dr. Sardjito General Hospital were involved.  The multivariate regression analysis showed that serum CAR (OR=3.604; 95%CI=1.487-8.736; p =0.005) could be a single predictor. However, by combining three variables, namely serum CAR, CSF CAR, and decreased consciousness at admission, could be a stronger predictor of worsening clinical outcome in patients with CNS infection (AUC = 97.1%; 95%CI = 0.929-1.00; p <0.001). The optimal cut-off value for serum CAR was 1.35 (Youden index = 0.88, sensitivity = 96%, specificity = 92%) while for CSF CAR was 0.14 (Youden index = 0.60, sensitivity = 76%, specificity = 84%). In conclusion, a combination predictive model of three variables, namely serum CAR, CSF CAR, and awareness at admission can be a stronger predictor of clinical outcome in patients with CNS infection than serum CAR alone.
View or download the full issue Sciences, Journal of Medical
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

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Abstract

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Corrigendum: Effects of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one on serum levels of antioxidant enzymes in hyperlipidemic rats Prasetyastuti, .; Gama, Noviyanty Indjar; Ayunda, Rahmah Dara
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/MedSci005503202311

Abstract

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