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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 11 Documents
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Search results for , issue " Vol 2, No 1 (2012): Pharmaciana" : 11 Documents clear
OPTIMASI KOMPOSISI TWEEN 80 DAN SPAN 80 SEBAGAI EMULGATOR DALAM REPELAN MINYAK ATSIRI DAUN SERE (Cymbopogon citratus (DC) Stapf) TERHADAP NYAMUK Aedes aegypti BETINA PADA BASIS VANISHING CREAM DENGAN METODE SIMPLEX LATTICE DESIGN Nurlaela, Endah; Sugihartini, Nining; Ikhsanudin, Azis
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (106.202 KB) | DOI: 10.12928/pharmaciana.v2i1.652

Abstract

The disease of Dengue hemorrhagic fever (DHF) is caused by the bite of femaleAedes aegypti mosquito. Cream of repelan sere leaf essential oils can be used to preventmosquito bites. The cream of volatile oil sere (Cymbopogon citratus (DC) Stapf)required emulsifier to maintain the stability of cream. Tween 80 and Span 80 is a widelyused emulsifier in a cream formula. Aims of this study is to determine the optimumcomposition of Tween 80 and Span 80 as emulsifier in a cream repelan of sere leafessential oils in the basis Vanishing Cream with Simplex Lattice Design methode. ThreeFormula cream is designed based on the Simplex Lattice Design methode with a ratio ofTween 80: Span 80 as follows: FI (100%-0%), F II (50%-50%), F III (0%-100%).Cream was then tested repelan activity and physical properties that includespreadibility, adhesivity and irritation. Data of physical properties and repellantactivity was calculate to get the optimum formula. The validity of optimization methodswas evaluated by comparing experimental results with predicted results in optimumcream formula with t test at 95% level of confidence. The results of study showed that theoptimum composition of Tween 80: Span 80 was 60%:40%. Cream with optimumemulsifier composition was predicted has spreadibility 29.24 cm2; adhesivity 3.512seconds; irritation 0.608; power repelan 41.469 minutes. T test results showed nosignificant differences between the experimental results and predicted results (p<0.05).
POTENSI PERAN FARMASIS DALAM MENINGKATKAN KUALITAS HIDUP PASIEN LANJUT USIA: PERSPEKTIF RAWAT RUMAH Perwitasari, Dyah Aryani; Muttaqien, Arief
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (67.323 KB) | DOI: 10.12928/pharmaciana.v2i1.657

Abstract

The Home Health Care program is getting popular as well. One of the outcomemeasured in this program is patient’s quality of life. Home Health Care program is amultidisciplin program, which need the pharmacist role. The aim of this study was tofind out the potencial pharmacist role in increasing elderly patients’quality of lifeparticipated in Home Health Care program. This study used descriptive design withprospective data sampling. (World Health Organization Quality of Life) We usedWHOQoL as the instrument. The study period was conducted for 13 week in 2009 byvisiting the patients at their homes. The patients were participated in Home HealthCare program of Dr Sardjito hospital, Yogyakarta. Data was descriptively analized.Were recruited seven subjects in this study. In average, their quality of life was low(46,1±4,4). All of the patients received polypharmacy and were found the patientsincompliance in taking the medicines. The role of pharmacist were important in HomeHealth Care program for elderly patients to increase their quality of life. Thepharmacists are supposed to do the drug used monitoring, especially to the elderlypatients with polypharmacy. The advance technique for communication, information,and education is suggested to the pharmacist in this program.
FORMULASI TABLET SERBUK PISANG RAJA (Musa xparadisiaca AAB) SEBAGAI PENUTUP TUKAK LAMBUNG PADA TIKUS Wahyuningsih, Iis
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.362 KB) | DOI: 10.12928/pharmaciana.v2i1.653

Abstract

Mucoadhesive is a topic of current interest in the design of drug delivery systemand treatment of peptic ulcers. This concept is based on the strength of adhesion of aprotective material to the mucosa. King Banana (Musa xparadisiaca AAB) is oftenused in the treatment of abdominal pain. It has been suspected having muchoadhesivestrength to cover peptic ulcer. The study was armed to formulate king banana tabletwhich has muchoadhesive ability to protect gastric mucosa become ulcer. The aim ofpeptic ulcer cover test was to see the ability of king banana tablet to covered ulcer at thegroups test that received different treatment of the negative control group (solvent), thebanana tablet suspension group, and sucralfate group. The ulcer severity wasdetermined by scoring method. All experimental data were tested by SPSS analyticalstatistics. The result showed that king banana tablet has similar strength to peptic ulcercover of sucralfat and not significantly different.
KAJIAN INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HEMODIALISIS DI BANGSAL RAWAT INAP RSU PKU MUHAMMADIYAH YOGYAKARTA PERIODE TAHUN 2010 Rahmiati, Siti; Supadmi, Woro
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (84.718 KB) | DOI: 10.12928/pharmaciana.v2i1.658

Abstract

Drug interactions are one of the Drug Related Problems (DRPs) that may affectpatient treatment outcomes. Hypertension occurs in approximately 10% to 81.5% ofhemodialysis patients. The purpose of this study was to determine the incidence ofantihypertensive drug interactions in hemodialysis patients in the inpatient wards PKUMuhammadiyah Hospital of Yogyakarta period in 2010. This study descriptive design.Data retrieved retrospectively. Data retrieval were done by taking all the data thatmeet the criteria of existing research on the medical records of hemodialysis patients inPKU Muhammadiyah Hospital of Yogyakarta who received antihypertensive withabove normal blood pressure (= 130/80 mmHg). Data were analyzed based on thedescriptive level of significance, onset, and severity. The results showed that there were54.79% (40 patients) of 73 hemodialysis patients potentially experienced druginteractions. Antihypertensive drugs most widely used in hemodialysis patients wereACEI, CCB, and diuretics. Incidence of antihypertensive drug interactions 27 cases(45.76% were most common at a significance level 3, 48 cases (81.36%) were onsetdelayed, and the severity minor of 44 cases (74.58%). The mechanism of interactionspharmacodynamic were 37 cases (62.71%) of the total 59 events that have druginteractions. Drugs often interactions were furosemide and captopril.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETIL ASETAT DAUN BINAHONG (Anredera scandens (L.) Moq.) TERHADAP Shigella flexneri BESERTA PROFIL KROMATOGRAFI LAPIS TIPIS Wardhani, Lilies Kusuma; Sulistyani, Nanik
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.535 KB) | DOI: 10.12928/pharmaciana.v2i1.636

Abstract

Antibacterial compounds that can be used for the treatment of infections causedby bacteria. Traditionally, Anredera scandens is one of plant used as traditionalmedicine. The aims of this research are to find out the antibacterial activity of ethylacetate extract of Anredera scandens leaf and Minimum Bactericidal Concentration(MBC) against Shigella flexneri and to identify the chemical subtances of the ethylacetate extract found in Anredera scandens. The Anredera scandens leaf was extractedby use of maseration method using ethyl acetate as solvent. The antibacterial assay wasdone using liquid dilution method with varied concentration of Anredera scandens(8,5%, 8%, 7,5%, 7%, 6,5%, 6%, 5,5%, dan 5% w/v) to determine MBC.Chromatography test was done to identify the chemical substances of Anrederascandens extract. The result of this research showed that the MBC of Anrederascandens leaf extract was 8% w/v. The result of the phytochemical screening with tubetest and thin layer chromatogram showed that the extract of Anredera scandens leafcontained, polyphenols, and saponin.
SINTESIS TURUNAN ASETOFENON DARI 1-(4-ASETOKSIFENIL-3-METOKSI)-2-PROPANIL FORMAT Kusmiyati, Kusmiyati; Matsjeh, Sabirin; Jumina, Jumina
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.782 KB) | DOI: 10.12928/pharmaciana.v2i1.654

Abstract

The Synthesis of acetophenone derivative from 1-(4-acetoxyphenyl-3-methoxy)-2-propanyl formate through Fries Rearrangement in order to produceortho hidroxy acetophenone derivative as starting material of Flavanoid compound hasbeen done. The reaction of 1-(4-acetoxyphenyl-3-methoxy)-2-propanyl formate wasdone by heating at 120 °C for 3 hours under AlCl3, dichloromethane as the catalyst andsolvent, respectively. The structure of the compound was identified using Infra Redspectrometry (IR) dan GC-MS. Fries rearrangement of 1-(4-acetoxyphenil-3-methoxy)-2-propanyl formate produce 1-(2-hyidroxy-3-methoxy-5-propenyl)-acetophenone and 1-(2-hyidroxy-3-methoxy-5-propanyl)-acetophenone as sideproduct with product rendemen were 43.26% and 9.48%, respectively.
KAJIAN INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HEMODIALISIS DI BANGSAL RAWAT INAP RSU PKU MUHAMMADIYAH YOGYAKARTA PERIODE TAHUN 2010 Rahmiati, Siti; Supadmi, Woro
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Abstract

Interaksi obat merupakan salah satu Drug Related Problems (DRPs) yang dapatmempengaruhi luaran terapi pasien. Hipertensi terjadi pada sekitar 10% sampai81,5% pasien hemodialisis. Tujuan penelitian ini adalah untuk mengetahui kejadianinteraksi obat antihipertensi pada pasien hemodialisis di bangsal rawat inap RSU PKUMuhammadiyah Yogyakarta periode tahun 2010. Penelitian ini merupakan penelitiandengan rancangan deskriptif. Data diambil secara retrospektif. Pengambilan datadilakukan dengan cara mengambil semua data yang memenuhi kriteria penelitian yangada pada rekam medik pasien hemodialisis di RSU PKU Muhammadiyah Yogyakarta.Pasien mendapat antihipertensi dengan tekanan darah diatas normal atau = 130/80mmHg. Data dianalisis secara deskriptif berdasarkan tingkat signifikansi, onset, danseverity. Hasil penelitian menunjukkan bahwa terdapat 54,79% (40 pasien) dari 73pasien hemodialisis berpotensi mengalami interaksi obat. Obat antihipertensi yangpaling banyak digunakan pada pasien hemodialisis adalah ACEI, CCB, dan diuretik.Kejadian interaksi obat antihipertensi yang paling banyak terjadi adalah pada tingkatsignifikansi 3 terdapat 27 kasus (45,76%), Onset yaitu delayed sebesar 48 kasus(81,36%), dan severity yaitu minor sebesar 44 kasus (74,58%). Mekanisme interaksiterbanyak yaitu farmakodinamik 37 kasus (62,71%) dari total 59 kejadian yangmengalami interaksi obat. Jenis obat yang sering berinteraksi adalah furosemid dankaptopril.Kata kunci : Interaksi obat, antihipertensi, hemodialisis
UJI SITOTOKSITAS DAN ANTIPROLIFERATIF SEL KANKER PAYUDARA T47D DAN SEL VERO BIJI Nigella sativa, L. Nurani, Laela Hayu
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.413 KB) | DOI: 10.12928/pharmaciana.v2i1.637

Abstract

Black cumin seeds contain oil classes atisiri, terpenes, and alkaloids that can beused for traditional medicine as anticancer. The purpose of this study was to assess thecytotoxic effects of ether extract, ethanol, and infusa seed Nigella sativa, L. (Blackcumin) to inhibit the growth of T47D and normal (Vero) cells and its effect on thekinetics of T47D breast cancer cells proliferation. This study were used extracts ofether, ethanol, and black cumin seeds infusa that obtained by maceration method andinfundasi. Cytotoxicity test was performed by incubating T47D breast cancer cells at a2 x 104 density with concentrations series of 2000; 1000; 500: 250: 125; 62.5; 31.25and 15.625 microg/ml for 24 hours. Vero cell with a density of 2 x 104 withconcentrations series of 4000; 2000; 1000; 500; 250; 125 and 62.5 microg/ml. Thenumber of cells was calculated by direct counting method and the calculated the deathpercentage. The LC50 values calculated using probit analysis. Observations on thenature of the growth inhibition were done by observing kinetics of cell proliferationwith the addition of trypan blue at-24, 48 and 72 to determine its doubling time. Theresults showed that the ether extract, ethanol, and black cumin seeds infusa arecytotoxic to T47D breast cancer cells with successive LC50 of 32.63: 10.02, and 23.82mg mL. Vero cell cytotoxicity test to produce successive LC50 of 300.6; 328.41, and778.64 g/ml. Antiproliferative test results showed that in 62.5 ug/ml and 31.625microg/ml prolong the doubling time. Ethanol extract of cumin seeds have a higherpotential due to the highest security index compared to ether extract and infusa.
PENETAPAN KADAR FENOLIK TOTAL EKSTRAK METANOL KELOPAK BUNGA ROSELLA MERAH (Hibiscus sabdariffa Linn) DENGAN VARIASI TEMPAT TUMBUH SECARA SPEKTROFOTOMETRI Alfian, Riza; Susanti, Hari
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (79.741 KB) | DOI: 10.12928/pharmaciana.v2i1.655

Abstract

The purpose of this research is to determine the total phenolic content of Hibiscussabdariffa calyx in variations of growing area. Red Rosell calyxs were collected fromGlagah, Kediri, and Samigaluh. Phenolic compounds of Hibiscus sabdariffa calyx wereextracted using maceration method with methanol. Total phenolics content weredetermined using visible spectrophotometry method with Folin Ciocalteau reagent. Theprinciple of this method is the formation of blue complex compound fromphospomolybdate-phosphotungstate reduced by phenolic compound in the basiccondition, which can be measured by spectrophotometry. Galic acid was used ascomperator in this research. Total phenolic content in red calyx Glagah, Kediri andSamigaluh were respectively 1.40 g GAE/100 g extract, SD 0.06 (n=12), 1.41 gGAE/100 g extract, SD 0.07 (n=12) dan 2.12 g GAE/100 g extract, SD 0.05 (n=15).Based on this results it could be concluded that growing area affected total phenoliccontent in the methanol extract of red calyx Rosell.
EFEK PROTEKTIF EKSTRAK ETANOL HERBA PEGAGAN (Centella asiatica (L.) Urban) TERHADAP PEMBENTUKAN KATARAK TIKUS WISTAR YANG DIINDUKSI SODIUM SELENIT Yuliani, Sapto
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.209 KB) | DOI: 10.12928/pharmaciana.v2i1.638

Abstract

Cataract is one of the eye pathology that can cause blindness. Oxidative stresshas been identified as an initiating factor of cataract. The objective research was tostudy the protective effect of ethanol extract Centela asiatica toward cataract formationon Wistar rat induced by sodium selenite. Cataract was induced in 9 days old Wistarrat, which 5 groups of 7 each. Group I got injection aquadest and the test groups gotinjection CMC-na (group II), vitamin E dose 378 IU/kg bw (group III), ethanol extractGotu cola herb dose 100 mg/kg bw (group IV), and 200 mg/kg bw (group V), 400mg/kgbw, subcutaneously, respectively, for 3 days. After 4 hours, all rats got injection asingle dose 50 ug/kg of BW sodium selenite intraperitoneally. Then eyes were observedin all groups on postnatal day 16, when the eyes of the rat first opened. Then percentageof cataract incidence were calculated. Finally, rats were executed and eyes were takenfor lens histophatological analyses with hematoxiline eosin staining. Based onmacroscopic and microscopic analyses it can be concluded that ethano extract ofCentella asiatica had protective effect toward cataract formation on Wistar rat inducedby sodium selenite. The least cataract incidence was showed at dose 200 mg/kg bw.

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