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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 18 Documents

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Search results for , issue "Vol 1, No 1 (2011): Pharmaciana" : 18 Documents clear

EVALUASI PENGGUNAAN OBAT ANTI HIPERTENSI PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS Woro Supadmi
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The intervention led to various complications in dialysis patients include hypertension intradialitik as a result of hemodynamic changes.The phenomenon of the paradox of which caused activation of endogenous vasopresor due to changes in volume status and antihypertensive medication terdialisisnya factor. This study aims to determine patterns of use of antihypertensive drugs, evaluating the rationality and side effects of antihypertensive drugs based on literarur. This study was performed with the patient’s condition based on the observation of patients to see medical records drug data, laboratory data of patients and patient’s condition.Retrospective study of hemodialysis patients in the hospital PKU Muhammadiyah Yogyakarta year period from 2009 to 2010.Patients according to inclusion criteria, anti-hypertensive drug receipts and complete medical record data.Evaluation of rationality involves the use of antihypertensive drugs right dose, right patient and side effects based on the Drug Information Hand Book 2005, Handbook of Clinical Drug Data, 2002. The study found 60 patients who fit the inclusion criteria.Based on the research patterns of use of antihypertensive drugs in patients with hemodialysis is captoril, furosemide, nifedipine, lisinopril, amlodipine, valsatran and clonidin. Evaluation rationality inappropriate use of drugs dose use of captopril 11 patients of 34 patients and furosemide 18 patients from 52 patients, inappropriate use of captopril patients was 9 patients of 34 patients.Side effects that occur in patients with hypokalemia due to the use of furosemide is 40 patients, cough due to captopril was 13 patients, side effects of nifedipine gastrointestinal disorders cough and 11 patients, 5 patients cough lisinopril.Conclusion:he use of antihypertensive medications in hemodialysis patientsat RSU PKU Muhammadiyah Yogyakarta is rational.

AKTIVITAS SITOTOKSIK ISOLAT 5 FRAKSI ETIL ASETAT EKSTRAK PETROLEUM ETER DAUN Phaleria macrocarpa (Scheff.) Boerl. PADA TURUNAN SEL KANKER SERVIKS MANUSIA (HeLa) Dwi Utami
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cervical cancer is a malignant tumor in cervix which is occupy the second possition that cause the death of Indonesia’s women under the breast cancer. One of the traditional medicine that can be used to cure cancer is Phaleria macrocarpa (Scheff.)Boerl leaves. The petroleum eter extract of Phaleria macrocarpa (Scheff.)Boerl leaves has antiproliferation activity againts cervical cancer cell lines (HeLa) with IC50 9 µg/ml (Kintoko & Azimahtol Hawariah, 2007). This research was aimed to detect cytotoxic activity of isolate 5 of ethyl acetate fraction of petroleum ether extract of Phaleria macrocarpa (Scheff.)Boerl leaves againts HeLa cell lines. Initially, the powder of Phaleria macrocarpa (Scheff.)Boerl was extracted using Soxhlet apparatus with petroleum ether. The extracts was concentrated and partitioned until ethyl acetate fraction was obtained. The fraction of ethyl acetate was isolated using Preparative Thin Layer Chromatography on silica gel F254 as stationary phase and n-hexane : ethyl acetate (9 : 1) as mobile phase. Cytotoxic activity against HeLa cell lines was determinated by LC50 value by direct counting. The isolation by preparative thin layer chromatography resulted five isolate on Rf value : 0,05 ; 0,10 ; 0,20 ; 0,60 ; and 0,90. The LC50 values of isolate 5 (Rf : 0,90) was 123,60 µg/ml.

FORMULASI VANISHING CREAM MINYAK ATSIRI SERE (Cymbopogon citratus (DC) Stapf) DAN UJI SIFAT FISIKNYA SERTA UJI AKTIVITAS REPELAN TERHADAP NYAMUK Aedes aegypti BETINA Azis Ikhsanudin
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Essential oil of sere leaf has been proven as repellant against mosquitoes. This research aims to know about the influence of concentration sere essential oil (Cymbopogon citratus (DC) Stapf) in a vanishing cream bases to physical properties and repellant testing against female Aedes aegypti mosquitoes. Essential oil of sere (Cymbopogon citratus (DC) Stapf) was isolated with steam water distillation and was evaluated the organoleptic appearance and refraction index. Furthermore, the essential oils were formulated in a vanishing cream base with the different formulas, contain formula I: 20% v/w; formula II: 30% v/ w and formula III: 40% v / w. Then this three formulas were evaluated for physical properties including adhesive, dispersive and the repellent activity testing against female Aedes aegypti mosquitoes amount of twenty mosquitoes per cage while seven female volunteers as the probandus. The data have been analyzed using Kolmogorov-Smirnov test and t-test (Main-Whitney), with 95% signifancy level. The results were obtained that the adhesion of formula I: 0.90 ± 0.029 seconds, formula II: 0.60 ± 0.017 seconds, formula III: 0.46 ± 0.040 seconds, while the dispersion of formula I is 64.89 ± 4.559 cm2 , the formula II is 64.71 ± 4.600 cm2 and the formula III is 54.96 ± 14.783 cm2 . The longest time repellent was formula III showed 3014.2 ± 20.163 seconds or 50.23 minutes. It was concluded that the increase of concentration essential oils of sere leaf followed by the increase of repellant activity.

EFEK TOKSISITAS FRAKSI ETIL ASETAT AKAR SENGGANI (Melastoma affine D.Don ) PADA ORGAN HEPAR, GINJAL DAN TESTIS Moch Saiful Bachri
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Melastoma affine (MA) is a medicinal plant commonly found in south East Asia and China. The aim of the study is to investigate the toxicity effect of MA toward vital organs. Thirty two Wistar adult male rats were divided into five groups consisting of six animals each the rats in group except control group, eight animals. The rats in group I (control) were administered 0.5% CMC Na orally, while CMC Na suspension of ethyl acetate fraction of MA root (62.5, 125, 250,and 500 mg/kg body weight) were given to the II, III, IV and V groups, respectively. The CMC Na suspensions of ethyl acetate fraction of MA root were administered for 22 days. Rats were sacrificed at the 23th day. Liver, kidney, testis were collected for histopathological observation. The observation result on liver and kidney showed no difference compare to control groups, meanwhile on testis, the administration of ethyl acetate fraction of MA root at dose (250, 500 mg/kg body weight) caused necrosis on seminiferus tubules and decreasing sperm counting. The conclusion, administration of ethyl acetate fraction of MA root caused toxicity effect on testis with necrosis on seminiferus tubules.

KAJIAN PERESEPAN ANTIBIOTIKA PADA PASIEN DEWASA DI SALAH SATU PUSKESMAS KOTA YOGYAKARTA PERIODE JANUARI - APRIL 2010 Muhammad Muhlis
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

To achieve optimal therapy of antibiotics isonefactor supporting the accuracy inprescribing antibiotics errors in prescribing can cause lack of rationality in the use ofantibiotics . Antibiotic was commonly used in the clinicor in private practice doctorsbut also in the centers of other health services such as polyclinics and hospitals theaim of this study is to assess antibiotic prescribing patterns and the level ofrationality the use of antibiotics in adult patients at one center of Yogyakarta on thebasis of data prescriptions. This Study used descriptive design with retrospective datacollection The data was collected from January to April 2010 Data source is aprescription of antibiotics in adult patients We analyzed the antibiotics prescription inthe study based on the selection appropriate dos age frequency and duration. Werecruited 320 patients receive ing antibiotics. The of antibiotics used were amoxicillin64.5 % ampicillin 11.3 % kontrimoksazol 15.9% chloramphenicol 0.6 % metronidazole2.8 % and etracycline 49 % Most of the Patients received a single antibiotic 97.9 %),while the remaining patients received a combination of antibiotics 2.1 % Allprescribing meet appropriate dosage, and frequency except cotrimoxazole (98%) andampicillin 49%). All prescriptions (100%) improper duration. In general antibioticsprescription for adult patients at one health center in Yogyakarta City is comply withthe standard use of antibiotics in Public Health Centers. However, the duration ofantibiotic utilization still became the perspective of the health providers in PublicHealth Centers.

UJI EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KACAPIRING (Gardenia augusta, Merr) PADA TIKUS PUTIH JANTAN GALUR WISTAR Farida Baroroh; Nurfina Aznam; Hari Susanti
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kaca piring leaf (Gardenia augusta Merr.) was often used in traditional drugs fortreatment diabetes mellitus. This research aim to know the antihiperglycemic effectethanolic extract of kacapiring leaf on white rats male strain of Wistar and how muchantihiperglycemic effect compared with glibenklamid. This study used oral glucosetolerance test method with loading glucose 4,5 g/kgW. Tested animal where 24 whitemale rats strain of Wistar age 2-3 months with weight 180-250 gram, devided into 4groups, each groups consist of 6 rats. Group I was as negative control group givenCMC-Na 1%, group II was as positive control group given glibenklamid dose 1,35mg/kgBB, group III and IV where given ethanolic extract of kacapiring leaf dose 500mg/kgBB and 250 mg/kgBB. Glibenklamid and exstract are given orally 60 minutesbefore glucose. Blood was taken from orbitalis sinus at minute (-90), (-60), 0, 30, 60,120, 180, 240, and 300. Blood glucose level was determined with GOD PAP enzymaticmethod, absorbance was observed using spectrophotometer at 500 nm. The result of the study was performed by giving ethanolic extract of kacapiring leaf dose 500 mg/kgW and 250 mg/kgW had antihiperglycemic effect. Ethanolic extract of kacapiring leaf dose500 mg/kgW and 250 mg/kgW could reduce blood glucoce level 58,97% and 80,60% compared with glibenklamid dose 1,35 mg/kgW could reduce blood glucoce level73,93%.

REAKSI PENATAAN ULANG FRIES PADA EUGENIL ASETAT kusmiyati kusmiyati; Sabirin Matsjeh; Jumina Jumina
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Fries Rearrangement of eugenyl acetate in order to study allilic substituentgroup influence has been done. Fries rearrangement of eugenyl acetate was done byheating at 120°C for 3 hours under AlCl3, dichloromethane as the catalyst and solvent,respectively. The structure of the compound was identified using Infra Redspectrometry (IR) and GC-MS. The result of te research showed that rearrangementfries of eugenyl acetate are not formed, but yielded lightly brown oil of dimmer.

EFEK EKSTRAK ETANOL RIMPANG TEMUGIRING (Curcuma heyneana val) TERHADAP KADAR TRIGLISERIDA Wahyu Widyaningsih
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The study of effect ethanolic extract Curcuma heyneana rhizoma as antihypertrigliserida examine of rats after given by dietary of high fat has been carried out. This experiment use 28 white male Wistar grooved rats with weight about 150-200 gram body weight, at about 2 -3 months old. They were divided into seven group randomly and each group 4 rats. The first group was given by standart treatment of dietary (BR II) and aquadest, the second group was given by dietary of high fatty and aquadest, the third group was given by CMC Na solution, the fourth was given by gemfibrosil in CMC Na suspension, the fifth group, the sixth group and the seventh were orally given by of ethanolic extract with dose 10g/kgBW; 20 g/kgBW; and 40 g/kgBW. Hyperlipidemia was treated with higth dietary fatty (5 gram fat cows and 10 gram egg yolk) at the second period (two weeks). The treatment of ethanolic extract Curcuma heyneana rhizoma was given after hyperlipidemia. The trigliserida content determined with GPO (Glycerol-3-Phosphate Oxidase) test. The trigliserida level in the serum analyzed on the before treatment, during the treatment and after treatment. The result of the research showed that ethanolic extract Curcuma heyneana rhizoma 2 weeks can decrease trigliserida level.

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Muhammad Syahrir

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA